Cis2 His2 zinc finger (C2H2-ZF) proteins are the largest family of transcription factors in human and higher metazoans.
They are involved in many biological processes as well as diseases and they provide a platform for genome editing.
However, the DNA-binding preferences of many of these proteins remain unknown.
We have developed a computational method to predict these DNA-binding preferences.
You can access the paper here.
In this web you will find:
Plots of PAIR and ZPAIR statistical potentials profiles
Profiles and PWMs of C2H2-ZF single domains F2 and F3
Profiles and PWMs of examples of transcription factors in JASPAR
Profiles and PWMs for structures of Human CTCF
Heatmap plots of the number of aminoacid~dinucleotides and their environments
Server to obtain the PWM of an input structure
Server to obtain the modelled structure from an input TF sequence