Covid-19 Peptide Repository

SARS-CoV-2 RBD-ACE2 Peptides

Interface ACE2/SARS-CoV S protein interface (A_peptides):
Peptides derived from structure of the complex of SARS-CoV-2 Spike protein and ACE2 (PDB code: 6M17 and 6lzg). These peptides are designed to target the surface of the RBD of SARS-CoV-2 that recognizes ACE2 receptor.

Image rendered from coordinates deposited in PDB databank: PDB code 6M17

ACE2 dimerization interface (D_peptides):
Peptides derived from the structure of the complex of full-length ACE2 in dimeric form (PDB code: 6m17). These peptides are designed to target the dimerization interface of ACE2 receptor.

Image rendered from coordinates deposited in PDB databank: PDB code 6M17

SARS-CoV RBD - ACE2 interface (F_peptides):
Peptides derived from the structure of the RBD of SARS-CoV in complex with extracellular domain of ACE2 (PDB code: 2ajf). These peptides are designed to target the surface of the RBD of SARS-CoV that recognizes ACE2 receptor.

Image rendered from coordinates deposited in PDB databank: PDB code 6M17

SARS-CoV-2 RBD – mAb CB6 interface (I_peptides):
Peptides derived from the structure of the RBD of SARS-CoV-2 in complex with neutralizing monoclonal antibody CB6 (PDB code: 7c01). These peptides are designed to target the surface of the RBD of SARS-CoV-2 that recognizes mAb which overlays with the surface that recognizes ACE2

Image rendered from coordinates deposited in PDB databank: PDB code 7C01

SARS-CoV-2 RBD – ACE2 + mAb CB6 interface (J_peptides):
Peptides derived from combining the structures of the RBD of SARS-CoV-2 in complex with ACE2 (PDB code: 6lzg) and neutralizing monoclonal antibody CB6 (PDB code: 7c01). These peptides are designed to target the surface of the RBD of SARS-CoV-2 that both recognizes mAb and ACE2

Image rendered from coordinates deposited in PDB databank: PDB code 7C01

SARS-CoV-2 RBD – Nanobody H11 D4 interface (K_peptides):
Peptides derived from the structure of the RBD of SARS-CoV-2 in complex with nanobody H11-D4 (PDB code: 6yz5). These peptides are designed to target the surface of the RBD of SARS-CoV-2 that recognizes nanobody which overlays with the surface that recognizes ACE2

Image rendered from coordinates deposited in PDB databank: PDB code 6YZ5

SARS-CoV-2 RBD – mAb C102 interface (L_peptides):
Peptides derived from the structure of the RBD of SARS-CoV-2 in complex with a neutralizing monoclonal antibody C102 (PDB code: 7k8m). These peptides are designed to target the surface of the RBD of SARS-CoV-2 that recognizes mAb which overlays with the surface that recognizes ACE2

Image rendered from coordinates deposited in PDB databank: PDB code 7K8M