drugbank_id	name	groups	pubchem_ids	description	indications	targets
DB00663	Flumethasone	approved; vet_approved	16490	-	"For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions"	P04150
DB05107	16-Bromoepiandrosterone	investigational	71613	-	"Investigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria."	P11413
DB05104	Asimadoline	investigational	179340	-	"Investigated for use/treatment in irritable bowel syndrome (IBS)."	P41145
DB05103	AN-9	investigational	60748	-	"Investigated for use/treatment in liver cancer, lung cancer, melanoma, and leukemia (lymphoid)."	Q6IT96; Q13547
DB05102	Rupintrivir	investigational	6440352	-	"Investigated for use/treatment in viral infection."	P03303
DB05100	Prinomastat	investigational	466151	-	"Investigated for use/treatment in brain cancer, lung cancer, and prostate cancer."	P09237; P45452; P08253; P03956
DB09167	Dosulepin	approved	5284550	-	"Indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required."	P08172; P08173; P11229; P18825; P28223; Q01959; P25100; P08912; P18089; P20309; P08908; P35367; P31645; P23975; P35348
DB09166	Etizolam	approved	3307	-	"Indicated for the treatment of generalized anxiety disorder with depression, panic disorder and insomnia."	P28472; P18507; P25105; P47870; P47869; P14867; P31644; P34903
DB01410	Ciclesonide	investigational; approved	6918155	-	"For the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older."	P04150; P08185
DB13954	Estradiol cypionate	investigational; approved; vet_approved	9403	-	"Depo-Estradiol intramuscular depot injection is indicated for the treatment of moderate to severe vasomotor symptoms and hypoestrogenism due to hypogonadism."	Q15596; Q14457; Q92731; Q99527; P03372; P62508; O75469; P00846; P43681; P37059
DB01178	Chlormezanone	investigational; approved; withdrawn	2717	-	"Used in the management of anxiety and in the treatment of muscle spasm."	O60885; P30536
DB01179	Podofilox	approved	10607	-	"For treatment of external genital warts (<i>Condyloma acuminatum</i>)."	P04150; Q9BVA1; P68366; P68363; P68371; Q5SU16; Q9BQE3; Q6PEY2; Q3ZCM7; Q9H4B7; P07437; Q13885; Q13509; Q71U36; P08684; Q13748; P11388; Q9BUF5; P04350
DB01176	Cyclizine	approved	6726	-	"For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems)."	P08172; P08173; P28335; P35462; P27338; P10635; P28223; Q01959; P25100; P08912; P08913; P41595; P20309; P35367; P49888; P11229
DB01415	Ceftibuten	investigational; approved	5282242	-	"Used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB01174	Phenobarbital	investigational; approved	4763	-	"For the treatment of all types of seizures except absence seizures."	Q13002; P47870; P18507; O60391; Q494W8; P48169; P09619; P16234; Q05940; P47869; P14867; O75469; P36544; Q16348; P31644; P34903; Q16445; P43681; P42261; P42262; P10721
DB01175	Escitalopram	investigational; approved	146570	-	"Labeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients. "	P11229; P10635; P28335; Q01959; P33261; P35367; P31645; P23975; P35348
DB01172	Kanamycin	investigational; approved; vet_approved	6032	-	"For treatment of infections where one or more of the following are the known or suspected pathogens: <i>E. coli</i>, <i>Proteus</i> species (both indole-positive and indole-negative), <i>E. aerogenes, K. pneumoniae, S. marcescens,</i> and <i>Acinetobacter</i> species."	B5YVV7; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; B1LHB1; B1LHB0; P0A7T7; C4ZUG9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; Q1R4V6; B1XDV2; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; P68683; P68680; B6I211; B7LRT5; B7LS48; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B7MTL9; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; A7MPH8; A9MN70; P60624; P60625; P60626; Q1R4N3; A6TE47; B4SXD8; B7NDS9; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; B1LHB3; B7UK21; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; C4ZUG3; C4ZS29; A8A539; B1LE15; B1LQM1; B6I208; Q5PK01; B1LE14; A8AQC0; C0Q2L0; B7N192; A8A5E9; Q57GI9; P0A7W0; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; B7N199; A4THT0; P0A7W8; B4T4N0; B4T4N1; P0A7N7; B7M1L8; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; Q57J49; B4TGH4; Q0T9J1; B4TAV0; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; P62401; B4TGH3; B5QUQ1; P0AG47; B5FN11; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; P0C020; B6I2A8; A9N5Y8; A7ZMI4; A7MPI4; A6TG05; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; Q0TCE2; P68686; B7MCV7; A1AGJ3; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; B7UPA5; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; P68681; P0A7L8; A9MSY1; A9MSY7; A9MSY4; Q1RD68; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; A7ZSK8; Q32B55; Q32B54; A7ZSK4; B7MCT0; B7N1A3; A7ZSK3; A7ZSK0; B7MCT4; B5R285; P0A7K2; B5R286; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; B7UK52; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; B7MCS6; B5FJA6; A8A5A1; A8A5A2; B7MCS1; B5F7T9; A7ZSK6; B5F7T1; B5F7T4; B7NR05; A8AQL8; P0A7S3; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; A1AGI5; Q329M1; P60422; B1X6G3; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; Q1R609; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B5BGX2; B2VCV9; B5R0S0; B5EYX3; A6TAI4; P0A7S7; B7UK18; A1AGI8; Q32B52; A1AGI7; B7M1N1; B7N0V1; B7NDK8; B4TKL4; P68679; B4TKL0; B5RAX1; Q57HZ9; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; P0A7Q8; Q5PGT9; Q57J53; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; B7LRS4; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B4TXC8; B1LHD1; Q5PJ56; A9MKN8; B1LHD0; B7LLY4; B4TXF0; Q0THB3; B6I437; B7MCT2; B7NEU0; B7NLL4; B7NLL7; B7NLL6; A8A5A4; P0C018; B4SUT9; B1LF57; P0A7N4; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; P0A7Q6; Q2NWE7; A7MPH5; A9MJT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; C5BF78; P02413; A9MN54; Q1C365; B7M1C4; B7L4K6; A9MN59; P0A7M6; P0A7M2; P0A7M9; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; B7LR53; A1ABQ0; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B7MCT1; B6I229; B6I228; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; B7MJ76; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B1LHD3; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; B7MCR9; A1AGM9; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A8ARM4; B7N0L5; B1LGQ0; B7L847; Q0TCN6; B5YXA7; B7NGD6; Q5PKU5; B1X6F8; B4SYA9; Q0THB2; B1X6F1; Q0TCS4; Q32B57; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; B7N1A0; B7LQD9; B5YTM5; B7M092; B5BGY5; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B5FJK0; A8AQJ1; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7T8; B5R280; A9MGD1; A4WEK0; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; P61176; P61175; Q1R632; Q32B24; P0A7T9; B7NDH0; B1IPL2; B1IPL1; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; A8A5C2; Q5PC32; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0A7R5; P0AG44; P0AG45; P0A7R0; A6THB3; A8A5B3; B7N1C3; P60438; B7MLK7; B7MFJ7; B7NJS8; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B5BG21; Q5PK05; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B1LHC8; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5F7F9; A9MFK9; A9N240; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B1IPZ6; B1IPZ0; B1IPZ1; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; B1X6F6; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; A1AGK6; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; A7ZSI6; B6I218; A8APV6; Q57PV1; Q57PV0; B6I210; Q1R612; A7ZRU7; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; C0Q0A5; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; P0A7W4; P0A7W3; P0A7W2; P0A7W1; B7N190; P0A7W9; B7N198; C0Q1W9; B4F277; C4ZR79; B7MCS3; A8GJV2; B7M9G4; B5FJA5; Q1CME3; B5RFY6; P0A7N1; B5YTM9; B5Y306; B7LX23; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B5QZ45; Q57IA6; B5YTM7; B1X6E8; B1X6E9; C0Q0C4; P0A7S6; P02358; P02359; P0A7X2; P0A7X3; P0A7X0; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; B1X6G8; A9MPV4; B5F8E7; Q1RB79; B5F3B9; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; P68919; C4ZSS5; B5RBB1; B1LK73; B7N2E8; B7UJ79; B7UK39; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B1IT04; P0C019; A8A501; B2VGJ7; A4WFD5; B5REG7; A9N241; B7NDT2; B7NF20; Q1R626; B7UMH0; B7M1C5; B7NDT7; C0Q644; C4ZUH0; B7NDT6; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0AG55; P0A7S2; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; P0A7J7; B7NDT5; Q1R627; B5R290; P0A7J3; B7NDT8; B5R299; P62399
DB01173	Orphenadrine	approved	4601	-	"Indicated for the treatment of Parkinson's disease."	Q05586; P25021; P10635; Q9UQD0; P28223; Q99250; Q14524; O15399; P11229; Q12809; Q9UI33; P08912; P08913; Q15858; P08172; P08173; P28335; P18089; Q01118; Q9Y5Y9; P41595; P35367; Q14957; Q9NY46; P23975; O60391; Q13224; Q12879; Q8TCU5; P20309; P35499; P31645; P35498
DB01170	Guanethidine	approved	3518	-	"For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension."	P18825; P25100; P08913; P18089; P35368; P23975; P35348
DB01171	Moclobemide	investigational; approved	4235	-	"For the treatment of major depressive disorder and bipolar disorder [A31901]."	P21397; Q99572; Q12809; P27338; O00257; P08908
DB01488	Dimethyltryptamine	illicit; experimental	6089	-	"Some people use this compound as a psychedelic inducing agent."	P50406; Q99720; P28223; P28221
DB01956	Taurine	approved; nutraceutical	1123	-	"The use of diet supplements containing taurine is indicated for the nutritional support of infants and young pediatric patients requiring total parenteral nutrition via central or peripheral routes. The usage of diet supplements containing taurine prevents nitrogen and weight loss or to treat negative nitrogen balance in pediatric patients where the alimentary tract cannot be done through oral, gastrostomy or jejunostomy administration, there is impaired gastrointestinal absorption or protein requirements are substantially increased.[FDA label]"	P23416; Q9UN88; P23415; P37610; Q13224; Q8TCU4; O75311; P54965; Q9UBS5
DB00579	Mazindol	investigational; approved	4020	-	"Used in short-term (a few weeks) treatment of exogenous obesity in conjunction with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in patients with a body mass index of 30 kg of body weight per height in meters squared (kg/m<sup>2</sup>) or in patients with a body mass index of 27 kg/m<sup>2</sup> in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia."	P42858; Q99720; P18440; Q01959; Q05940; P35367; P31645; P23975
DB11125	Benzethonium	approved	2335	-	"Indicated as an antiseptic agent. No therapeutic indications for clinical use. "	P08172; P08173; P22303; P28335; P11229; P18825; Q12809; Q01959; P18089; P08912; P08913; P04626; P28223; P20309; P31645; P06241; P23975
DB01000	Cyclacillin	approved	19003	-	"For the treatment of bacterial infections caused by susceptible organisms."	P0AEB2; P08506; P02918; P02919; Q8XJ01; P24228; P0AD68; Q8DR59; P0AD65
DB01001	Salbutamol	approved; vet_approved	2083	-	"For symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD. "	P08588; P35346; P13945; P07550
DB01006	Letrozole	investigational; approved	3902	-	"For the extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy. Also for first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer. Also indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy."	P06401; P11511; P15538; P03372
DB01007	Tioconazole	approved	5482	-	"For the local treatment of vulvovaginal candidiasis (moniliasis)."	Q16850; P10613; P05093
DB01004	Ganciclovir	investigational; approved	3454	-	"For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised patients."	P04293; P03176
DB01005	Hydroxyurea	approved	3657	-	"For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia."	P00918; P51686; P35218; Q7LG56; Q16790; P23921; P31350
DB01558	Bromazepam	illicit; investigational; approved	2441	-	"For the short-term treatment of insomnia, short-term treatment of anxiety or panic attacks, if a benzodiazepine is required, and the alleviation of the symptoms of alcohol- and opiate-withdrawal."	Q9UN88; P24046; P28472; P18507; P18505; A8MPY1; Q99928; O14764; P48169; Q16445; P28476; Q8N1C3; P31644; P14867; P47869; P34903; O00591; P47870; P78334
DB01559	Clotiazepam	illicit; approved	2811	-	"For the treatment of anxiety disorders."	Q9UN88; P24046; P28472; P18507; P28476; A8MPY1; Q16445; P18505; P48169; P47870; Q8N1C3; P31644; P14867; P19793; P47869; O14764; P34903; Q99928; O00591; P78334
DB00573	Fenoprofen	approved	3342	-	"For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain."	P35354; Q8N695; P23219; P37231; Q07869
DB01009	Ketoprofen	approved; vet_approved	3825	-	"For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain."	P20594; P25024; Q8N695; P46663; P23786; P35354; P23219
DB00575	Clonidine	approved	2803	-	"May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD)."	Q9UL51; Q9Y2I1; O15245; P18825; P35368; P25100; O60741; P08913; P18089; P08908; Q9Y3Q4; P35348
DB00574	Fenfluramine	illicit; investigational; approved; withdrawn	3337	-	"For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction."	P18825; P28221; P28222; P28223; P11229; Q99720; P34969; P08913; P08172; P08173; P28335; P41595; P08588; P18089; P35368; P31645; P35348; P17752; P02746; P20309; P08908; P07550
DB00577	Valaciclovir	investigational; approved	60773	-	"For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals."	Q9QNF7; P04293
DB00576	Sulfamethizole	investigational; approved; vet_approved	5328	-	"For the treatment of urinary tract infection"	P0AC13
DB00751	Epinastine	investigational; approved	3241	-	"For the prevention of itching associated with allergic conjunctivitis."	Q12809; P28223; P25021; P50406; P08913; P34969; P35367; P35348
DB00750	Prilocaine	approved	4906	-	"Used as a local anaesthetic and is often used in dentistry."	Q9Y5Y9; Q01118; Q14524; Q9UQD0; P11413; P26992; Q9UI33; P35498; Q99250; P35499; Q15858; Q9NY46
DB00753	Isoflurane	approved; vet_approved	3763	-	"For induction and maintenance of general anesthesia."	P62158; P57789; Q9NPC2; P29371; P98194; Q09470; P18505; B4DJ51; P47869; Q16445; P78334; P0DP24; P0DP25; P18507; Q7Z418; P0DP23; P41595; P30049; P14867; P23415; O95069; O00591; O14649; Q8N1C3; Q9UN88; P48167; P28472; O14764; P48169; P34903; P47870; P31644; Q99928; P42261
DB00752	Tranylcypromine	investigational; approved	5530	-	"For the treatment of major depressive episode without melancholia."	P21397; P27338; P35626; Q01959; P08908; O60341; P23975
DB00755	Tretinoin	investigational; approved; nutraceutical	5538	-	"For the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant), For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.), For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage."	P10826; O43174; Q6V0L0; P48443; P10276; P29590; Q9NY56; P00352; O94788; P51843; Q16654; O60760; P28702; P13631; P02753; P49116; Q9NR63; P41595; P19793; Q03181; P31025; Q8NFJ5; P49788
DB00978	Lomefloxacin	investigational; approved	3948	-	"For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: <i>S.pneumoniae</i>, <i>H.influenzae</i>, <i>S.aureus</i>, <i>P.aeruginosa</i>, <i>E. cloacae</i>, <i>P. mirabilis</i>, <i>C. civersus</i>, <i>S. asprphyticus</i>, <i>E.coli</i>, and <i>K.pneumoniae</i>."	P0AES4; P0AES6; P11388; P43700; P43702; Q02880
DB00757	Dolasetron	investigational; approved	3033818	-	"For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses of chemotherapy. Also used for the prevention of postoperative nausea and vomiting. This drug can be used intravenously for the treatment of postoperative nausea and vomiting."	Q70Z44; Q12809; A5X5Y0; Q8WXA8; O95264; P46098
DB00208	Ticlopidine	approved	5472	-	"Used in patients, who have had a stroke or stroke precursors and who cannot take aspirin or aspirin has not worked, to try to prevent another thrombotic stroke.
 "	Q04759; P18825; P10635; Q99720; P18089; P20813; P35354; P08913; P23219; Q9H244
DB00975	Dipyridamole	approved	3108	-	"For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina."	Q7RTT9; Q01064; P02763; Q14432; P53805; Q08493; O95263; P16499; Q08499; Q13946; P18545; O76083; Q9Y233; Q13370; O43924; P35913; O60658; P54750; O76074; Q9NP56; Q14123; P27815; Q13956; O00408; P00813; P51160; Q07343; Q99808
DB00206	Reserpine	investigational; approved	5770	-	"Foe the treatment of hypertension"	P14416; P08908; P35372; Q99250; Q05940; P21728; P35498; P35462; P54219; P31645; O15392; Q9NY46; E7CU85
DB00977	Ethinyl Estradiol	approved	5991	-	"For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive."	P04150; P41145; P10275; P29274; P04278; Q01959; P03372; P33261; P35372; O75469; Q92731; P31645; P23975
DB00976	Telithromycin	approved	3002190	-	"For the treatment of <i>Pneumococcal</i> infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia."	B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; C4ZUG3; B5F3B9; P0A7T7; B7UPA5; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; Q1R4V6; B5FHU4; B1IRQ1; P68686; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B7LS48; B7LRT1; B1X6G0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; P60423; B7NLN3; B5BG21; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B7MTL9; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B7UMH0; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; A7MPH8; A9MN70; B7M1C4; B7M1C5; P60626; Q1R4N3; A6TE47; B4SXD8; B7NDS9; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; B1LHB3; B5FJK0; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B7NDH0; C4ZS29; A8A539; B1LE15; B1LQM1; B6I208; B7NJS8; P0A7W4; B5BGY5; A8AQC0; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; P0A7W0; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; A7ZSC4; A7MNZ2; B7N199; A4THT0; B7N198; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; P0A7V7; Q57J49; P62401; Q0T9J1; A9MN59; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; B4TGH4; B4TGH3; B5QUQ1; P0A7R5; B5FN11; A9MFC1; Q1R616; B7NLM7; B7NLM5; B7NLM8; Q12809; P0C021; P0C020; B6I2A8; B7NLM3; P0A7M9; A7ZMI4; A7MPI4; A6TG05; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; B5RAX1; Q0TD41; B7N1C3; A1AGJ3; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A1AGJ5; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1IPY3; A1AGM9; P0AG67; B1IPY2; Q0TCN6; Q0THB3; Q0THB2; Q32B57; A7ZSK5; B7N1A3; A7ZSK3; A7ZSK0; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; B7M1M3; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8GJV2; B7MCS1; B5F7T9; A7ZSK6; B7NLN0; B5F7T1; B7M1M5; B5F7T4; B7NR05; A8AQL8; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; B7N0V1; Q329M1; P60422; B1X6G3; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; B6I228; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; Q57IA6; A9MN66; B5BGX2; B2VCV9; B5R0S0; P0AG55; A6TAI4; B7UK18; A1AGI8; A1AGI7; B7M1N1; A1AGI5; B7NDK8; B4TKL4; B4TKL0; Q0TCE2; Q57HZ9; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; Q5PGT9; Q57J53; A8A5A2; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; Q1RD68; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; A1AGK6; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; P0A7V8; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B1LHD3; B1LHB0; B6I437; B7MCT2; B7NEU0; B7NLL4; B7NLL7; B7L6I9; P0C018; P0A7V0; B1LF57; P0A7N4; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; B1XHK3; B7UK52; Q0TCF8; A9MJT9; B4SUT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; P02413; A9MN54; Q1C365; P60624; P60625; P0A7M6; P0A7M2; A9N5Y8; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; C0Q0C4; B1IPY0; B1XHG2; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; B7MJ76; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; B1LHD1; B1LHD0; B4TXF0; C4ZUE9; P0A7R9; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0AG65; B7NLP7; B7MCR9; P0AG66; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; A8ARM4; B4TAV0; B7N0L5; B1LGQ0; B7L847; A7ZSK8; B5YXA7; B7NGD6; Q5PKU5; B7LRT0; B1X6F8; B4SYA9; Q32B54; B1X6F1; B7NDR8; B7MCT1; B7UK28; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B5EYX3; B7N1A1; B5YRA5; B7LI05; B7N1A0; B7LQD9; B5YTM5; B7M092; B5YTM7; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B7UK21; B5YTM9; P60725; P60724; P60727; B5R286; B5FSA3; P60723; P0A7T8; B5R280; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; C4ZUH1; P61175; Q32B24; P0A7T9; B1IPL2; B1IPL1; A4WFC2; Q328J7; B4TKK1; B4TKK4; B7UQL1; B4TFD7; B4TKK9; A8A5C2; Q5PC32; Q2EEQ2; Q0TBH3; P0ADY3; P0ADY7; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; B7MCV7; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; Q5PK05; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5RH21; B1X6H0; A9MFK9; A9MGD1; B5REG7; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B1IQ03; B7M555; Q665U4; B1IV14; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; B1IPZ0; B1IPZ1; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; B1X6F6; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; B7LRS7; P68679; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; C0Q0A5; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; B1LE14; P0A7W3; B7N192; P0A7W1; B7N190; P0A7W9; P0A7W8; C0Q1W9; B4F277; C4ZR79; C5BF78; B7LHP9; B7M9G4; P0A7L8; B5FJA5; Q1CME3; B5RFY6; B1IPZ5; A8AQJ1; B5Y306; B7LX23; B4TXD1; B7M1M2; Q1RB79; B7M1M0; B5EXE1; P0A7S2; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B5QZ45; P0A7S7; P0A7N7; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P60726; P0A7X2; P0A7X3; P0A7X0; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; B1X6G8; A9MPV4; A8A5A1; B5F8E7; B1LHC8; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; P68919; C4ZSS5; B5RBB1; Q32B47; B1LK73; B7UJ79; B7UK39; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; P0C019; A8A501; B2VGJ7; A4WFD5; A9N240; A9N241; P0A7J7; B7NF20; B7NDT5; B7L4K6; B5R290; C0Q644; C4ZUH0; B1IT04; P61176; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0A7S3; Q1RB78; P0A7S1; P0A7S0; P0AG51; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; B7MCS6; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; B7NDT2; Q1R626; Q1R627; B7NDT7; B7NDT6; B7NDT8; P62399; B5R299
DB00203	Sildenafil	investigational; approved	5212	-	"For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH). "	Q01064; Q14432; Q08493; P16499; Q08499; Q13946; O15440; Q9Y233; Q12809; Q13370; P29274; P30542; O60658; P54750; O76074; P18545; Q9NPD5; Q14123; P27815; Q13956; O00408; P51160; Q07343
DB00202	Succinylcholine	approved	5314	-	"Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)"	P08172; Q9GZZ6; P11229; P02708; P11230; P07510; P20309; Q04844; Q07001; P06276
DB00201	Caffeine	approved	2519	-	"For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants."	P22303; P21817; Q15413; P42338; P42336; Q12809; Q13315; Q92736; P78527; P0DMS8; P35913; Q07343; P33765; Q14573; P29274; P29275; P30542; O00329
DB00972	Azelastine	approved	2267	-	"For the symptomatic treatment of seasonal allergic rhinitis and non-allergic rhinitis, as well as symptomatic relief of ocular itching associated with allergic conjunctivitis."	P35367; Q12809; Q9Y5N1; P35348; P35368
DB00683	Midazolam	illicit; approved	4192	-	"The midazolam injection is indicated for preoperative sedation/anziolysis/amnesia. It is also an agent for sedation/anziolysis/amnesia prior to or during diagnostic, therapeutic, or endoscopic procedures. Midazolam can also be given intravenously for induction of general anaesthesia. "	Q9UN88; P24046; Q16445; P18507; P28476; A8MPY1; O00591; P18505; P48169; P14867; Q8N1C3; P31644; P47870; P28472; P08684; P47869; O14764; P34903; Q99928; P78334
DB00682	Warfarin	approved	54678486	-	"For the treatment of retinal vascular occlusion, pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, transient cerebral ischaemia, arterial embolism and thrombosis."	P11712; P04070; O75469; P07225; Q9BQB6; Q8N0U8; P08684
DB00680	Moricizine	investigational; approved; withdrawn	34633	-	"Used to treat irregular heartbeats (arrhythmias) and maintain a normal heart rate."	Q14524; Q9UQD0; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q9UI33; Q15858; Q9NY46
DB00687	Fludrocortisone	investigational; approved	31378	-	"For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome."	P04150; P10275; P08235; O75874
DB00686	Pentosan Polysulfate	approved	37720	-	"For the relief of bladder pain or discomfort associated with interstitial cystitis."	P09038; P05230; P08620
DB00685	Trovafloxacin	investigational; approved; withdrawn	62959	-	"For treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by <i>Neisseria gonorrhoeae</i> as well as non gonoccocal urethritis and cervicitis due to <i>Chlamydia trachomatis</i>."	P0AFI2; Q01959; Q02880; P0AES4; P0AES6; P11388; P43700; P43702; P20083
DB00684	Tobramycin	investigational; approved	36294	-	"For the treatment of pseudomonas aeruginosa lung infections. Also being investigated for use in the treatment of sinus infections."	B7UK52; B5RH07; Q9HWE0; C1DKN6; A1AGM9; Q9HWE3; Q02NN8; Q9I5V8; B4SUU8; B7V309; Q1IFW1; Q02T76; Q02T75; Q02T72; Q02T70; B7M1P3; Q9HVC4; B7L4L7; B1LHE2; B7V666; B5BGZ4; B7NDV0; A6UZI7; Q4K538; Q3K5Z3; A6VD47; B4TKM3; A4XZ85; Q5PIW1; Q9HVL6; Q9HVL7; B4TXF0; Q9HXP9; A6UZJ2; A6UZJ3; B7V654; B7V652; Q9HWF0; B7NLP7; C0Q0C4; Q02T57; Q02TI4; Q9HZ71; B5F8G0; Q9HTN8; Q9HTN9; Q9HZN4; A6V488; B7V649; A5VXQ2; Q9HVM1; B7V643; Q9HXQ2; O52761; A8A5E9; Q9HWF8; B1JDV9; Q9HWF4; Q9HWF7; Q9HWF6; Q9HWF1; C3K2X1; Q9HWF3; Q9HWF2; Q9HV58; Q9HUM9; P0A7S7; Q1R5U1; P29436; Q1IFW7; A6UZL1; O52759; O82850; Q9HWE8; Q9HWE9; B7V648; Q32B24; Q9HWE1; Q9HWE2; Q9HWD8; Q9HWE4; Q9HWE5; Q9HWE6; Q9HWE7; B7LS48; B7V1Z7; A6UZ82; B5FJM2; Q9HUD0; Q9HWD7; Q9HWD6; Q9HWD5; Q9HWD4; Q9HWD1; Q9HWD0; C1DIY4; Q9HWD9; B1IPV7; B7V4G5; A6VF47; Q9HVY3; Q9HVY2; Q02F84; B7N1C3; B7MCV7; Q9I0A1; Q9I0A2; A4WFD5; Q88QN0; B0KK72; Q9HWC6; Q9HWC7; Q9HWC5; Q9HWC8; A6UZJ6; P0A7S8; Q9HUN2; Q9HUN0; P0A7S3; Q9HY26; Q9HY25; A7ZSL7; P0A7S6; P0A7S5; P0A7S4; Q57J24; B6I242; Q02T81; B5YTP9; B5R299
DB00689	Cephaloglycin	approved	19150	-	"For treatment of severe infections caused by susceptible bacteria."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB00688	Mycophenolate mofetil	investigational; approved	5281078	-	"For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. Mycophenolate mofetil should be used concomitantly with cyclosporine and corticosteroids. "	P20839; P12268
DB00373	Timolol	approved	33624	-	"In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma."	P07550; P00720; P08588; P13945; P08908
DB00372	Thiethylperazine	withdrawn	5440	-	"For the treatment or relief of nausea and vomiting."	P08172; P08173; P28335; P11229; Q99720; P28223; P08912; P41595; P21728; P14416; P21917; P20309; P08908; P35367; P35348; P35462
DB00371	Meprobamate	illicit; approved	4064	-	"For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety."	Q9UN88; B0YJ76; P28472; P18507; P18505; P00374; O00591; O14764; P48169; P47870; Q02156; Q8N1C3; P31644; P14867; P47869; P34903; Q16445; Q99928; P78334
DB00370	Mirtazapine	approved	4205	-	"For the treatment of major depressive disorder."	P18825; P28223; P08913; P35462; P46098; P11229; P34969; Q01959; P21728; P08588; P14416; P23975; Q9Y5N1; P08172; P41145; P28335; P41595; P21918; P18089; P31645; P35367; P35348; P25100; Q9HBA0; P08908; P07550
DB00377	Palonosetron	investigational; approved	6337614	-	"For the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy, as well as prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy. Also used for the prevention of postoperative nausea and vomiting for up to 24 hours post operation."	P10635; O95264; P46098
DB00376	Trihexyphenidyl	approved	5572	-	"Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs."	P08172; P08173; P11229; Q13164; Q13163; P10635; Q99720; P08912; P36897; P20309
DB00374	Treprostinil	investigational; approved	6918140	-	"For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise."	P43119; Q13258; P34995; P43115; P35408; P43116; P37231; Q03181; Q9H244
DB00379	Mexiletine	investigational; approved	4178	-	"For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation."	Q9NY46; Q14524; P35869; Q9UQD0; Q12809; P41595; P30556; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q9Y3Q4; Q15858; Q9UI33
DB00378	Dydrogesterone	investigational; approved; withdrawn	9051	-	"Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions."	P06401; Q13882
DB06235	Vadimezan	investigational	123964	-	"Investigated for use/treatment in solid tumors, lung cancer, ovarian cancer, and prostate cancer."	Q9H2X6; Q86V86; P35968
DB06237	Avanafil	approved	9869929	-	"Treatment of erectile dysfunction in males. "	P51160; O76074
DB04852	Implitapide	investigational	5745206	-	"For the treatment of atherosclerosis."	P55157
DB04853	Binodenoson	investigational	9576912	-	"For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease."	P29274; P33765; P30542; P0DMS8; P29275
DB04850	Posizolid	investigational	213049	-	"For the treatment of gram-positive infections, including multiresistant strains."	P21397
DB04851	Biricodar dicitrate	investigational	9963148	-	"Administered intravenously, biricodar dicitrate is to be used in combination with cancer chemotherapy agents."	P33527; Q2M3G0; Q9UNQ0
DB04856	Dexloxiglumide	investigational	65937	-	"For the treatment of Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD)."	P32238
DB04857	Brasofensine	investigational	9614919	-	"For the treatment of Parkinson's Disease."	P14416
DB04854	Febuxostat	approved	134018	-	"For the treatment of hyperuricemia in patients with gout."	Q12809; P47989
DB04855	Dronedarone	approved	208898	-	"Management of paroxysmal or persistent atrial fibrillation via restoration of normal sinus rhythm. "	P10827; P18825; Q9UQD0; P08913; Q99250; O60840; Q9Y3Q4; P22460; O43526; Q9UL51; Q14524; P63252; Q12809; Q08289; O60741; Q9UI33; P08588; Q02641; Q01668; Q15858; Q9NY46; P18089; Q01118; Q13698; Q9Y5Y9; P35498; P35368; O95069; P35348; P54284; P25100; Q13936; P35499; Q9P1Z3; O00305
DB01615	Aceprometazine	approved	26035	-	"Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders."	P35367
DB01099	Flucytosine	investigational; approved	3366	-	"For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections)."	P0CS13; P26358; P28223; P12461
DB04859	Zanapezil	investigational	198752	-	"For the treatment of dementia in subjects with Alzheimer?s disease."	P22303
DB09389	Norgestrel	approved	4542	-	"Norgestrel in combination with ethinyl estradiol is indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception."	P10275; P06401; P18405; P03372
DB04690	Camptothecin	experimental	24360	-	"Investigated for the treatment of cancer."	P11387
DB00199	Erythromycin	investigational; approved; vet_approved	12560	-	"For use in the treatment of infections caused by susceptible strains of microorganisms in the following diseases: respiratory tract infections (upper and lower) of mild to moderate degree, pertussis (whooping cough), as adjunct to antitoxin in infections due to <i>Corynebacterium diphtheriae</i>, in the treatment of infections due to <i>Corynebacterium minutissimum</i>, intestinal amebiasis caused by <i>Entamoeba histolytica</i>, acute pelvic inflammatory disease caused by <i>Neisseria gonorrhoeae</i>, skin and soft tissue infections of mild to moderate severity caused by <i>Streptococcus pyogenes</i> and <i>Staphylococcus aureus</i>, primary syphilis caused by <i>Treponema pallidum</i>, infections caused by <i>Chlamydia trachomatis</i>, nongonococcal urethritis caused by <i>Ureaplasma urealyticum</i>, and Legionnaires' disease caused by <i>Legionella pneumophila</i>."	B5YVV7; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; P0A7T8; B5F3B9; P0A7T7; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; Q1R4V6; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; B7UK52; P68680; B6I211; B7LRT5; B7LS48; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; P02768; B7MTL9; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; Q57J49; B1IQ03; B1IQ02; B1IQ00; B1IQ05; O43193; C4ZQY2; A6TEW0; A7MPH8; A9MN70; P60624; P60625; P60626; C0Q0C4; B4SXD8; B7NDS9; P62401; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; B1LHB3; B5FJK0; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; B7NDH0; P0A7W6; P0A7T9; P0A7W5; B1LQM1; B6I208; P11413; B7NJS8; A8ARM4; B5BGY5; A8AQC0; C0Q2L0; B7N192; A8A5E9; C4ZUG9; P0A7W0; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; B6I3L3; B4TXD1; A7MNZ2; P0A7S2; P0A7W9; A4THT0; B7N198; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; A9MVN1; B4TGH4; Q0T9J1; P0C020; A9MN59; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; A9MX79; B4TGH3; B5QUQ1; P0A7R5; B5FN11; A9MFC1; Q1R616; B7NLM7; B7NLM5; B7NLM8; Q12809; P0C021; B4TFD7; B6I2A8; B7NLM3; P0A7M9; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; B5RAX1; P68686; B7MCV7; A1AGJ3; B6I242; B7MCS3; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; A8A5A8; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; P68681; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; Q0TCN6; Q32B55; Q0THB2; Q32B57; B7MCT0; B7N1A3; A7ZSK3; A7ZSK0; A9MGD1; B5R285; P0A7K2; B5R286; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; B1IPY3; A8A5A9; B7MCS9; B7MCS6; B5FJA6; A8A5A1; A8A5A2; B7MCS1; B5F7T9; A7ZSK6; P60727; B5F7T1; B5F7T4; B7NR05; A8AQL8; P0A7S3; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; B7N0V1; Q329M1; P60422; B1X6G3; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B7LRR4; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B5BGX2; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; B7UK18; A1AGI8; C4ZUF2; A1AGI7; B7M1N1; A1AGI5; Q1R609; B7NDK8; B4TKL4; P68679; B4TKL0; Q0TCE2; P0A7M6; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; P0A7Q8; Q5PGT9; Q57J53; P0A7S4; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; Q57HZ9; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; A9MJT9; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; P0A7V0; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; B1LHD1; A9MKN8; B1LHD0; B7LLY4; B1LHD3; Q0THB3; B1LHB0; B6I437; B7MCT2; B7NEU0; B7NLL4; B7NLL7; B7NLL6; P0C018; P0C019; B1X6G0; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; P0A7Q6; B7MGC4; A7MPH5; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; P02413; A9MN54; Q1C365; B1LL30; A1JQX1; B7M1C5; Q5PJ56; P0A7M2; A9N5Y8; A1AGJ2; B1IPY8; B7N0U4; B7LVJ7; A1AGJ5; B1IPY0; B1XHG2; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B7MCT1; B6I229; B6I228; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B4TXF0; C4ZUE9; P0A7R9; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; B7NLP7; B5RFY6; A1AGM9; P0A7J3; A6TE47; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B4TAV0; B7N0L5; B1LGQ0; B7L847; A7ZSK5; A7ZSK8; B5YXA7; B7NGD6; P60438; B4SYA9; Q32B54; B1X6F1; B7NDR8; A7ZSK4; B7UK28; B7MCR9; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; Q32B52; B7LQD9; B5XZP7; B7M092; B5YTM7; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B7UK21; A8AQJ1; P60725; P60724; B1IT04; Q1R632; B5FSA3; P60723; B5R280; B7N2E8; A4WEK0; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; P61176; P61175; B5QZ45; Q32B24; P0AG51; B1IPL2; B1IPL1; A4WFC2; Q328J7; B4TKK1; B4TKK4; B7UQL1; B4TKK9; A8A5C2; Q5PC32; A8A539; Q2EEQ2; A1AGK6; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; A8A5B3; B7N1C3; B1X6F8; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B7UK41; B5BG21; Q5PK05; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B1X6F6; P0AA10; B7ND54; B7M1N3; B7MCT4; Q32BE7; B7M1N0; Q1R5U1; A1AGJ7; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B1LHC8; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B1X6H0; A9MFK9; B5REG7; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; Q2NWE7; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7LRS4; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B7LX23; B1IPZ0; P0A7N5; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; A7ZSI6; B6I218; A8APV6; Q57PV1; Q57PV0; B6I210; Q1R612; A7ZRU7; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; C0Q0A5; Q5PIV8; P0A7W7; A8A5A4; B1LE15; B1LE14; P0A7W3; P0A7W2; P0A7W1; B7N190; B7N1A0; B7N199; P0A7W8; C0Q1W9; B4F277; C4ZR79; C5BF78; A8GJV2; B7M9G4; B5FJA5; Q1CME3; P0A7W4; P0A7N1; B5YTM9; B5Y306; B1IPZ6; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; P0A7N4; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; C4ZUG3; B7MJ76; Q57IA6; P0A7N7; B1X6E8; B1X6E9; P0A7S6; P02358; P02359; P60726; P0A7X2; P0A7X3; P0A7X0; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; B1X6G8; A9MPV4; B5F8E7; Q1RB79; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; P68919; C4ZSS5; B5RBB1; B1LK73; B7UJ79; Q1R6R5; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; Q1R620; B7M1C4; B4SUT9; A8A501; B7LCR3; A4WFD5; A9N240; B5BKL1; P0A7J7; B7NF20; Q1R626; B7UMH0; B7L4K6; B5R290; C0Q644; C4ZUH0; Q1R4N3; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0AG55; Q1RB78; P0A7S1; P0A7S0; P0A7S7; P0AG50; P0A7S5; B7UPA5; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; B7NDT5; Q1R627; B7NDT7; B7NDT6; B7NDT8; P62399; B5R299
DB00198	Oseltamivir	approved	65028	-	"Oseltamivir (Tamiflu) is for the treatment of uncomplicated acute illness due to influenza infection in patients 1 year and older who have been symptomatic for no more than 2 days. It is also used for the prophylaxis of influenza in adult patients and adolescents 13 years and older."	P03474; P11485; Q99519; P23141; P03468; Q9Y3R4
DB00197	Troglitazone	investigational; withdrawn	5591	-	"For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise."	P00918; P21397; Q99808; P37231; P11474; O60488; P27338; P41595; Q07869; P62508; P08684; P15121; Q03181; P09211; Q9HCF6; P05121
DB00196	Fluconazole	investigational; approved	3365	-	"For the treatment of fungal infections."	P10613; P08684
DB00195	Betaxolol	investigational; approved	2369	-	"For the management of hypertension."	P07550; P08588; P17342; P16066; O60479
DB00194	Vidarabine	investigational; approved	21704	-	"For treatment of chickenpox - varicella, herpes zoster and herpes simplex"	P09250; P04293; P09884; P27487; P23921; P31350; Q9QNF7; P03198
DB00193	Tramadol	investigational; approved	33741	-	"Indicated in the treatment of moderate to severe pain. Consider for those prone to constipation or respiratory depression. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis."	P41145; P41143; P28335; Q8TCU5; P35372; P20309; P31645; P23975
DB00192	Indecainide	approved	52195	-	"For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia."	Q9Y5Y9; Q14524; Q9UQD0; Q01118; P35499; P35498; Q99250; Q9UI33; Q15858; Q9NY46
DB00191	Phentermine	illicit; approved	4771	-	"For the treatment and management of obesity."	P31645; P23975; Q01959; P18440
DB00190	Carbidopa	approved	34359	-	"For treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism"	P06241; P20711; P06239
DB02132	Zenarestat	experimental	5724	-	"Investigated for use/treatment in neuropathy (diabetic)."	P10275; P15121; Q8TDV5
DB01096	Oxamniquine	approved	4612	-	"For treatment of Schistosomiasis caused by <i>Schistosoma mansoni</i>"	P27987; P23677
DB05109	Trabectedin	investigational; approved	108150	-	"Indicated for treatment of advanced soft tissue sarcoma in patients refractory to or unsuitable to receive anthracycline or ifosfamide chemotherapy in Europe, Russia and South Korea. Approved for orphan drug status by the U.S. FDA for treatment of soft tissue sarcomas and ovarian cancer. Investigated for use/treatment in cancer/tumors (unspecified), gastric cancer, ovarian cancer, pediatric indications, sarcoma, and solid tumors."	P12931
DB06698	Betahistine	investigational; approved	2366	-	"For the reduction of episodes of vertigo association with M?ni?re's disease."	P35367; Q9Y5N1
DB06699	Degarelix	approved	16136245	-	"Degaralix is used for the management of advanced prostate cancer. "	P30968
DB06696	Arbekacin	investigational; approved	68682	-	"Arbekacin is used for the short term treatment of multi-resistant bacterial infections, such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)."	A8A5E9; B4TKM3; B7UK52; B1IPV7; B5RH07; Q32B24; Q5PIW1; B4SUU8; A1AGM9; B4TXF0; B7N1C3; B7MCV7; A7ZSL7; A4WFD5; B7NLP7; C0Q0C4; B7M1P3; B5F8G0; P0A7S8; B7L4L7; P0A7S3; Q1R5U1; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B1LHE2; B7NDV0; B7LS48; Q57J24; B6I242; B5FJM2; B5BGZ4; B5YTP9; B5R299
DB06694	Xylometazoline	investigational; approved	5709	-	"It is used for treating nasal congestion and minor inflammation due to allergies or colds."	P18825; P28221; P28222; P25100; P08913; P18089; P35368; P35348
DB06695	Dabigatran etexilate	approved	6445226	-	"Dabigatran is indicated for the prevention of venous thromboembolic events in patients who have undergone elective hip or knee replacement surgery (based on RE-NOVATE, RE-MODEL, and RE-MOBILIZE trials). In 2010, it was approved in the US and Canada for prevention of stroke and systemic embolism in patients with atrial fibrillation (approval based on the RE-LY trial). Contraindications: severe renal impairment (CrCL < 30 ml/min), haemorrhagic manifestations, bleeding diathesis or spontaneous or pharmacologic impairment of haemostasis, lesions at risk of clinically significant bleeding (e.g. extensive cerebral infarction (haemorrhagic or ischemic) in the last 6 months, active peptic ulcer disease), concomitant treatment with P-glycoprotein inhibitors (e.g. oral ketoconazole, verapamil), and those with known hypersensitivity to dabigatran, dabigatran etexilate or any ingredient used in the formulation or component of the container. As of December 2012, dabigatran is contraindicated in patients with mechanical prosthetic heart valves. "	P00734; Q5NV56; P35030; P07478; P00747; P00750; P00742; P07477
DB06693	Mevastatin	experimental	64715	-	"Not used therapeutically due to its many side effects. "	P04035
DB06691	Mepyramine	approved; vet_approved	4992	-	"Mepyramine is a first generation antihistamine used in treating allergies, ymptomatic relief of hypersensitivity reaction, and in pruritic skin disorders."	P28335; Q8IU57; P28223; P10635; Q99720; Q12809; Q01959; P41595; P08913; P35367; P31645
DB00997	Doxorubicin	investigational; approved	31703	-	"Doxorubicin is used to produce regression in disseminated neoplastic conditions like acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms? tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin?s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer."	P06241; P11229; Q14978; P04626; P06239; P11387; P11388
DB00996	Gabapentin	investigational; approved	3446	-	"For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy."	Q9UBN1; O00555; Q06432; Q9Y698; O60840; O75899; Q9UBS5; Q00975; Q14524; Q9BXT2; Q08289; Q9P0X4; Q7Z3S7; P08913; O43497; P62955; Q01668; Q9UF02; P30542; Q15878; Q8WXS5; Q8IZS8; O60391; Q02641; O00305; O95180; Q9NY47; P54284; P54289; Q8TCU5; Q13936; Q13698; O60359
DB00995	Auranofin	investigational; approved	70788951	-	"Used in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as adult rheumatoid arthritis."	P04150; P09917; P18089; P30044; P08913; P35462; Q16881; O75762; P06241; O14920
DB05232	Tetrodotoxin	investigational	21733122	-	"For the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence."	Q9UQD0; Q9NY46; Q99250; P35498
DB00993	Azathioprine	approved	2265	-	"For use in rheumatoid arthritis, preventing renal transplant rejection, Crohn's disease, and colitis."	P12268; Q06203; P20839; P51580; P00492; P63000
DB00992	Methyl aminolevulinate	investigational; approved	157922	-	"For topical use, in combination with 570 to 670 nm wavelength red light illumination, in the treatment of non-hyperkeratotic actinic keratoses of the face and scalp in immunocompetent patients when used in conjunction with lesion preparation (debridement using a sharp dermal curette)."	P12314; P22830
DB00991	Oxaprozin	approved	4614	-	"Used to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis."	P23786; P35354; P23219
DB00990	Exemestane	investigational; approved	60198	-	"For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy."	Q6NYC1; P10275; P11511; P03372
DB00999	Hydrochlorothiazide	approved; vet_approved	3639	-	"For the treatment of high blood pressure and management of edema."	P00918; P22748; P00915; P55017; Q16790; O43570; Q12791
DB00998	Frovatriptan	investigational; approved	77992	-	"For the acute treatment of migraine attacks with or without aura in adults."	P28221; P28222; P08908
DB00542	Benazepril	investigational; approved	5362124	-	"For the treatment of hypertension. It may be used alone or in combination with thiazide diuretics."	P12821
DB05246	Methsuximide	approved	6476	-	"For the control of absence (petit mal) seizures that are refractory to other drugs."	Q9P0X4; O95180; O43497
DB03348	Huperzine B	investigational	5462442	-	"Under investigation for the treatment of Alzheimer's disease."	P22303
DB05482	7-ethyl-10-hydroxycamptothecin	investigational	104842	-	"Investigated for use/treatment in colorectal cancer."	Q969P6; P11387
DB13165	Ripasudil	approved	9863672	-	"Ripasudil has been proven to be effective in the twice daily treatment of glaucoma and ocular hypertension. It is currently in studies to be approved for both diabetic retinopathy and diabetic macular oedema. 
 "	O75116; Q13464
DB05806	Cositecan	investigational	148202	-	"Investigated for use/treatment in brain cancer, lung cancer, and melanoma."	P11387
DB01177	Idarubicin	approved	42890	-	"For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7."	P11388
DB00427	Triprolidine	approved	5282443	-	"For the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis, allergic conjunctivitis, and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold."	P35367
DB01129	Rabeprazole	investigational; approved	5029	-	"For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use."	P20648; P05023; P28221; P18089; P33261; P21860; P35462; P51164; Q15303
DB09345	Pramocaine	approved	4886	-	"It is indicated for  temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders. "	Q99720; P35498; Q99250; Q9NY46
DB09343	Tipiracil	investigational; approved	6323266	-	"Tipiracil, in combination with trifluridine, is indicated for the treatment of refractory mestastatic colorectal cancer patients who keep progressing despite of treatment with standard chemotherapy and biologics.[A31256]"	P19971
DB09342	Propoxycaine	approved	6843	-	"Propoxycaine is a local anesthetic medication.  It was used beginning in the 1950s during dental procedures [L1591].  It has been combined with procaine to accelerate its onset of action and provide longer-lasting anesthetic effect [L1592].
 
 It was produced for use when amide local anesthetics were contraindicated due to allergy or when several amide anesthetics were unsuccessful [L1592]."	Q9Y5Y9; Q14524; Q9UQD0; Q01118; Q9UI33; P35498; Q99250; P35499; Q15858; Q9NY46
DB00347	Trimethadione	approved	5576	-	"Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications."	Q9P0X4; O95180; O43497
DB12332	Rucaparib	investigational; approved	9931954	-	"Indicated as monotherapy for the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies. Select patients for therapy based on an FDA-approved companion diagnostic for rucaparib."	P09874; P10635; Q9Y6F1; P05177; Q9UGN5
DB08502	Capravirine	investigational	1783	-	"Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections and HIV infection."	P04591; P04585
DB01619	Phenindamine	approved	11291	-	"Used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching, and other symptoms of allergies and the common cold."	P35367
DB01604	Pivampicillin	approved	33478	-	"or the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia), ear, nose and throat infections, gynecological infections, urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci, gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis. "	Q8XJ01
DB01764	Dalfopristin	approved	6323289	-	"For the treatment of bacterial infections (usually in combination with quinupristin)."	B5YVV7; B5RH07; B1XG23; B1XG24; A7ZSI6; C0PYY2; B5F3B9; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; C4ZUG3; B1LHB0; P0A7T7; C0Q0A5; Q57GI9; B1X6G8; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; P0AG51; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; B7UK52; P68680; B1X6G3; B7LRT5; B1IPL2; B7LRT1; A1ABQ0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; Q57J49; Q5PIU7; B7UMH0; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; Q0TCF5; A9MN70; B1LL30; P60625; P60626; C0Q0C4; B4SXD8; B7NDS9; B7NDS5; B7MTL9; B5FJK8; B5FJK9; B7N0W8; C4ZUG1; B5FJK0; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; B7NDH0; A8A539; B1LE15; B1LQM1; B6I208; Q5PK01; A8ARM4; A8AQC0; B7LHT8; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; B7N190; P0A7T3; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; P50870; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; B6I3L3; B4TXD1; A7MNZ2; P0A7S2; P0A7W9; A4THT0; B7N198; B4T4N0; B4T4N1; Q2NWE7; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; P0A7V7; A9MVN1; P62401; Q0T9J1; P0C020; B4TAV0; P0ADY7; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; A9MX79; B4TGH3; B5QUQ1; P0AG47; C5BF78; A9MFC1; A7ZSI8; Q1R616; B7NLM7; B7NLM5; B7NLM8; P0C021; B4TFD7; B6I2A8; B7NLM3; A9N5Y8; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; B5RAX1; P68686; B7MCV7; A1AGJ3; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; P68681; A9MGD1; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1XHG2; A1AGM9; P0AG67; B1IPY2; Q0TCN6; A7ZSK6; Q0THB2; A7ZSK4; B7MCT0; B7N1A3; A7ZSK3; B7N1A1; B7N1A0; B5R285; P0A7K2; B5R286; Q1R635; B5R280; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; Q32B54; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; B7MCS6; B5FJA6; B7MCS3; A8GJV2; B5FJA5; B5F7T9; Q32B57; B5F7T1; B5F7T4; B7NR05; A8AQL8; P0A7S3; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; C4ZUF2; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; A1AGI5; Q329M1; P60422; P60423; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B6I211; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; B1X6E9; B7UK18; A1AGI8; Q32B52; A1AGI7; Q32BE7; B7N0V1; B7NDK8; B4TKL4; P68679; B4TKL0; Q0TCE2; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; Q57HZ9; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; A9MJT9; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; P0A7W4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; P0A7V8; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B4TXF0; Q0THB3; B6I437; B7NEU0; C4ZUE9; B7NLL7; B7NLL6; A8A5A4; P0C018; B4SUT9; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; P0A7Q6; B7MGC4; P0A7V5; A7MPH5; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; B1X6F8; P02413; A9MN54; Q1C365; P60624; A9MN59; P0A7M6; P0A7M2; P0A7M9; B7MCR9; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; A6TE47; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; Q1R604; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; B1LHD1; B1LHD0; B1LHD3; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; A1JQX1; P0A7V6; P0AG65; Q1R6R5; B7NLP7; P0AG44; B5RFY6; P0AG66; B7LRR4; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7NDS7; B7L847; A7ZSK8; B5YXA7; B7NGD6; B7LRT0; Q32B55; B4SYA9; B7MCT2; B1X6F1; Q0TCS4; B7MCT1; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; B7MCT4; P0A7W8; B7LQD9; B5XZP7; B7M092; B5BGY5; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B7UK21; B5YTM9; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7T8; P0A7K6; B7N2E8; A4WEK0; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; C4ZUH0; P61176; P61175; Q1R632; B5QZ45; Q32B24; P0A7T9; B6I228; B7LS48; B1IPL1; A4WFC2; Q328J7; B4TKK1; B4TKK4; B7UQL1; B4TKK9; Q0TCG7; Q2EEQ2; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0A7R5; Q1R4V6; P0AG45; P0A7R0; A6THB3; Q0TCG2; B2VGJ7; A8A5B3; B7N1C3; P60438; B7MLK7; B7MFJ7; B7NJS8; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B5BG21; Q5PK05; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B1X6F6; P0AA10; B7ND54; B7M1N3; B7M1N1; B7M1N0; Q1R5U1; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; A8A5C2; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5F7F9; B7LCR3; A1AGJ5; B5REG7; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; B5YTM7; Q0TCG5; Q0TCG4; B2K2I4; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7LRS4; B7L4L7; A6TEN8; B5YS75; B1IQ03; B7M555; Q665U4; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B7LX23; B1IPZ0; B1IPZ1; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; B7L4K6; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; B7L4K8; B6I218; A8APV6; Q57PV1; Q57PV0; B6I210; Q1R612; A7ZRU7; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; B1LE14; P0A7W3; B7N192; P0A7W1; P0A7W0; Q1R626; B7N199; A8AQJ8; C0Q1W9; B4F277; C4ZR79; B5FN11; B5FHU4; A8A5A2; B7M9G4; P0A7L8; B7MCS1; Q1CME3; B1IPZ5; A8AQJ1; B5Y306; B1IPZ6; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; P0A7N4; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B7MJ76; Q57IA6; B1IPZ3; B1X6E8; B1IT04; P0AG50; P02358; P02359; P0A7R9; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; A8A5A1; B5F8E7; Q1RB79; B1LHC8; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; P68919; C4ZSS5; B5RBB1; B1LK73; B7UJ79; A1AGK6; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B7M1C4; P0C019; A8A501; A9MFK9; A4WFD5; A9N240; A9N241; P0A7J7; B7NF20; B4TGH4; B7M1C5; B7NDT7; C0Q644; P61177; B7NDT6; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0AG55; Q1RB78; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; B7NDT2; B7NDT5; Q1R627; B5R290; Q1R4N3; B7NDT8; B5R299; P62399
DB01618	Molindone	approved	23897	-	"Molindone is used for the management of the manifestations of psychotic disorders."	P34969; P11229; P18825; P20309; Q99720; P28223; P18089; P14416; P08913; P35462; P08908; P35367; P28335; P35348
DB05116	Thymectacin	investigational	6440764	-	"Investigated for use/treatment in colorectal cancer."	P04818; Q53Y97
DB01367	Rasagiline	approved	3052776	-	"For the treatment of the signs and symptoms of idiopathic Parkinsons disease as initial monotherapy and as adjunct therapy to levodopa."	P21397; P10415; P27338
DB01366	Procaterol	investigational; approved	688561	-	"For the treatment of asthma and chronic obstructive pulmonary disease (COPD)."	P07550
DB01365	Mephentermine	approved	3677	-	"Used to maintain blood pressure in hypotensive states."	P18825; P08913; P18089; P25025; P08588; P25100; P35368; P07550; P35348; P13945
DB01364	Ephedrine	approved	9294	-	"Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia."	P07550; P22303; P23975; P35348; Q05940
DB01012	Cinacalcet	approved	156419	-	"For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma."	P41180; P23415
DB01369	Quinupristin	approved	5388937	-	"For the treatment of bacterial infections (usually in combination with dalfopristin)."	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; P0A7T8; B5F3B9; P0A7T7; C0Q0A5; Q57GI9; B7N102; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; B5FHU4; B1IRQ1; P68686; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B1IPL2; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B7UMH0; B7LHP9; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; A7MPH8; A9MN70; B7M1C4; P60625; P60626; Q1R4N3; A6TE47; B4SXD8; B7NDS9; B1IPL1; P62401; B7NDS5; B7MTL9; B5FJK8; B7UK28; B7N0W8; C4ZUG1; B5FJK0; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B1LHB1; P0A7T9; P0A7W5; B1LQM1; B6I208; B7NJS8; A8ARM4; B5BGY5; Q5PK05; B7LHT8; C0Q2L0; B7N192; A8A5E9; C4ZUG9; P0A7W0; P0A7T3; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; P0A7W9; B1LE14; A4THT0; P0A7W8; C4ZSS5; B4T4N1; B7M1L8; B7M1C5; C0Q6G0; Q57J46; Q57J43; B5RGF1; Q57J49; A9MX79; Q0T9J1; C4ZSW8; C4ZS29; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; B4TGH4; B4TGH3; B5QUQ1; P0AG47; B5FN11; P0AG44; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; P0C020; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; Q0TCE2; Q0TD41; B7N1C3; B1IPY8; B6I242; B7MCS3; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A1AGJ5; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; A1AGM9; P0AG67; P0ADZ0; Q0TCN6; Q0THB3; B7MCT2; B7MCT1; A7ZSK5; B7N1A3; A7ZSK3; B7N1A1; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; P60624; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; A8A5A1; A8GJV2; B5FJA5; B5F7T9; Q32B57; B5F7T1; B5F7T4; B7NR05; A8AQL8; B7L6J0; A8AQL3; B7MST2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; B7N0V1; Q329M1; P60422; P60423; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B7N554; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B6I211; B7MJ76; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; Q57IA6; A9MN66; B5BGX2; B2VCV9; B5R0S0; B5EYX3; A6TAI4; B7UK18; A1AGI8; C4ZUF2; A1AGI7; Q32BE7; A1AGI5; B7NDK8; B4TKL4; B4TKL0; B5RAX1; B7M1M3; B1XG70; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; A9MJT9; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; Q32FI2; B7M0U2; P0A7V8; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B1LHD3; B1LHB0; B6I437; B7NEU0; B7NDH0; C4ZUE9; B7NLL7; B7L6I9; P0C018; P0C019; B1X6G0; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7UK52; P0A7V5; Q0TCF8; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; B7N198; Q0TCF7; P0A7J6; B1X6F8; P02413; A9MN54; Q1C365; B1LL30; A9MN59; P0A7M6; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; A7ZRU7; C0Q0C4; B1IPY0; B1IPY3; B1IPY2; B1IPY5; B1IPY4; Q329B5; P0ADZ4; B7LR53; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; Q1R604; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; B1LHD1; B1LHD0; B4TXF0; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; B7NLP7; B7MCR9; P0AG66; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7NDS7; B7L847; A7ZSK8; B7MCS6; B5YXA7; B7NGD6; A7ZSK6; B4SYA9; Q32B54; B1X6F1; Q0TCS4; A7ZSK4; B1X6F6; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; B7N1A0; B7LQD9; B5YTM5; B7M092; B5YTM7; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B7UK21; A8AQJ1; P60725; P60724; B1IT04; B5R286; B5FSA3; P60723; B5R280; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; C4ZUH1; P61175; Q32B24; B4TUF2; B6I228; B7LS48; B5BG21; A4WFC2; Q328J7; B1IPZ0; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q0TCG7; A8A539; Q2EEQ2; A1AGK6; Q0TBH3; P0ADY3; P0ADY7; P0AG48; P0AG49; P0AG46; P0A7R5; Q1R4V6; P0AG45; P0A7R0; A6THB3; A8A5B3; B7MCV7; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; A8AQC0; Q57J33; B7LRR3; B7LRR1; P60727; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; B7M1N1; B7M1N0; Q1R5U1; A1AGJ7; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; A8A5C2; B1LHC9; A8A5C0; A8A5C1; B4TXC8; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B1X6H0; B7LCR3; A9MGD1; A9N240; B5FM60; A9N241; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7LRS4; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; B7LRS7; P68679; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; Q1R612; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; P0A7W6; B1LE15; P0A7W4; P0A7W3; P0A7W2; P0A7W1; B7N190; B7N199; Q5PKU5; C0Q1W9; B4F277; Q0THB2; C4ZR79; C5BF78; A8A5A2; B7M9G4; B7MCS1; Q1CME3; B5RFY6; B1IPZ5; B5YTM9; B5Y306; B7LX23; B7M1M2; P0AG55; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; C4ZUG3; B5QZ45; P0AG51; B1IPZ3; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P0A7R9; P60726; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; Q1RB79; B1LHC8; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; P68919; B4T4N0; B5RBB1; B1LK73; B7UJ79; B1X6G3; Q1R6R5; Q57JQ0; B1IPV7; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; Q1R620; B4SUT9; A8A501; A9MFK9; A4WFD5; B5REG7; B5BKL1; B7NDT2; B7NF20; B7NDT5; B7L4K6; B5R290; C0Q644; C4ZUH0; B7NDT6; P61176; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0A7S3; P0A7S2; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; P0A7J7; Q1R626; Q1R627; B7NDT7; P0A7J3; B7NDT8; P62399; B5R299
DB08439	Parecoxib	approved	119828	-	"Used for short term perioperative pain control."	P35354; P23219; P02788
DB06820	Sulconazole	approved	5318	-	"Sulconazole solution 1.0% is indicated for the treatment of tinea cruris and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis, and for the treatment of tinea versicolor. Effectiveness has not been proven in tinea pedis (athlete?s foot)."	P10613; P28223; P11229; P08173; P18825; P10635; P28335; Q01959; P18089; Q96RI1; P08913; P08684; P41595; P20309; P08912; P31645; P06241; P23975; P35462
DB01108	Trilostane	investigational; withdrawn; approved; vet_approved	656583	-	"Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible."	Q92731; P26439; P14060; P03372
DB01103	Quinacrine	investigational; approved	237	-	"For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions."	P08172; P08173; P22303; P11229; P18825; Q15111; P28223; P25021; P18089; P47712; P08912; P20309; P25100; P35462; O60733; Q99250; P23975; Q9NY46; P08913; P35498
DB01102	Arbutamine	approved	60789	-	"Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately."	P07550; P08588; P13945
DB01101	Capecitabine	investigational; approved	60953	-	"For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated."	Q12882; P04818; Q53Y97
DB01100	Pimozide	approved	16362	-	"Used for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment."	Q12809; P0DP25; P18825; P28221; P28223; P35372; P35462; P0DP23; O95180; Q16322; Q99720; P34969; Q9H3Y6; Q9P0X4; P21728; P08913; B4DJ51; O43497; P10635; P0DP24; P41145; P14416; P41143; P28335; P18089; P21918; P35367; P35348; P21917; P23415; P62158; P20309; P08908
DB01107	Methyprylon	illicit; approved; withdrawn	4162	-	"For the treatment of insomnia."	Q9UN88; P28472; P18507; P18505; Q99928; O14764; P48169; P14867; Q8N1C3; P34903; P47870; P47869; P39086; Q13002; Q16445; O00591; P31644; P78334
DB01106	Levocabastine	investigational; approved	54385	-	"As an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis."	P35367; O95665
DB01105	Sibutramine	illicit; investigational; approved; withdrawn	5210	-	"For the treatment of obesity."	P18825; Q9UK17; Q01959; P18089; P31645; P23975
DB01104	Sertraline	approved	68617	-	"For the management of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD) with or without agoraphobia, premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD) [FDA Label]. 
 
 It may be used for premature ejaculation and vascular headaches as off-label indications. "	P08172; P08173; Q12809; P11229; P18825; Q99720; P28223; Q01959; P18089; P08912; P08913; P41595; P20309; P31645; P28335; P23975; P35348
DB12243	Edaravone	investigational; approved	4021	-	"Indicated for improving neurological symptoms and damage from acute ischemic stroke and delaying disease progression of ALS."	P10415
DB00566	Succimer	approved	2724354	-	"For the treatment of lead poisoning in pediatric patients with blood lead levels above 45 &micro,g/dL. May also be used to treat mercury or arsenic poisoning."	P11413
DB00567	Cephalexin	investigational; approved; vet_approved	27447	-	"For the treatment of respiratory tract infections caused by <i>Streptococcus pneumoniae</i> and <i>Streptococcus pyogenes</i>, otitis media due to <i>Streptococcus pneumoniae</i>, <i>Haemophilus influenzae</i>, <i>Staphylococcus aureus</i>, <i>Streptococcus pyogenes</i>, and <i>Moraxella catarrhalis</i>, skin and skin structure infections caused by <i>Staphylococcus aureus</i> and/or <i>Streptococcus pyogenes</i>, bone infections caused by <i>Staphylococcus aureus</i> and/or <i>Proteus mirabilis</i>, genitourinary tract infections, including acute prostatitis, caused by <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, and <i>Klebsiella pneumoniae</i>."	Q8DR59; P0AEB2; P08506; P0A3M6; P02918; P02919; P0AD68; P24228; P0AD65
DB00564	Carbamazepine	investigational; approved	2554	-	"For the treatment of epilepsy and pain associated with true trigeminal neuralgia. "	Q15822; Q9UQD0; P30450; P01889; Q99250; P17787; Q9Y5Y9; Q14524; P30466; Q15858; P18507; P30443; Q01118; P14867; Q9UI33; P35498; P31645; P35367; P01892; Q9NY46; P04439; P30926; P47870; P35499; O75469; P43681
DB00565	Cisatracurium besylate	approved	62886	-	"For inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU."	Q15822; P11230; P07510; P02708; Q04844; Q07001
DB00562	Benzthiazide	approved	2343	-	"For the treatment of high blood pressure and management of edema."	P00918; P22748; P00915; P55017; Q16790; O43570; Q12791
DB00563	Methotrexate	approved	126941	-	"Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents.  Methotrexate is also indicated in the treatment of meningeal leukemia. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types.  Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin?s lymphomas. Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis. Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis. "	P00374; P41440; B0YJ76; Q53Y97; P04818
DB00560	Tigecycline	approved	54686904	-	"For the treatment of infections caused by susceptible strains of the designated microorganisms in the following conditions: Complicated skin and skin structure infections caused by <i>Escherichia coli</i>, <i>Enterococcus faecalis</i> (vancomycin-susceptible isolates only), <i>Staphylococcus aureus</i> (methicillin-susceptible and -resistant isolates), <i>Streptococcus agalactiae</i>, <i>Streptococcus anginosus</i> grp. (includes <i>S. anginosus</i>, <i>S. intermedius</i>, and <i>S. constellatus</i>), <i>Streptococcus pyogenes</i> and <i>Bacteroides fragilis</i>. Complicated intra-abdominal infections caused by <i>Citrobacter freundii</i>, <i>Enterobacter cloacae</i>, <i>Escherichia coli</i>, <i>Klebsiella oxytoca</i>, <i>Klebsiella pneumoniae</i>, <i>Enterococcus faecalis</i> (vancomycin-susceptible isolates only), <i>Staphylococcus aureus</i> (methicillin-susceptible isolates only), <i>Streptococcus anginosus</i> grp. (includes <i>S. anginosus</i>, <i>S. intermedius</i>, and <i>S. constellatus</i>), <i>Bacteroides fragilis</i>, <i>Bacteroides thetaiotaomicron</i>, <i>Bacteroides uniformis</i>, <i>Bacteroides vulgatus</i>, <i>Clostridium perfringens</i>, and <i>Peptostreptococcus micros</i>."	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; A7ZSI6; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; C4ZUG3; B1LHB0; P0A7T7; C0Q0A5; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; B7UK52; P68680; P68681; B7LRT5; B7LS48; B7LRT1; B1X6G0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; B7NLN3; B1IPL1; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B7UMH0; B4TKM3; B6I1U8; B5R1G3; Q57J49; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; Q0TCF5; A9MN70; B1LL30; B7M1C5; P60626; A6TE47; B4SXD8; B7NDS9; P62401; B7NDS5; B7MTL9; B5FJK8; B7UK28; B7N0W8; B1LHB3; B5FJK0; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B7NDH0; A8A539; P0A7W5; B1LQM1; B6I208; B7NJS8; B1LE14; A8AQC0; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; A7ZSC4; A7MNZ2; P0A7S2; B7N199; A4THT0; B7N198; C4ZSS5; B4T4N1; Q2NWE7; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; P0A7V7; A9MVN1; A9MX79; Q0T9J1; C4ZSW8; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; A9MN59; P0A7R5; P62400; B4TGH4; B4TGH3; B5QUQ1; P0AG47; C5BF78; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; P0C020; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; Q0TCE2; P68686; B7N1C3; B1IPY8; B6I242; B7MCS3; B7UK39; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; A1AGJ5; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1IPY3; A1AGM9; P0AG67; P0ADZ0; A7ZSK8; A7ZSK6; B7MCT2; B7MCT1; A7ZSK5; B7N1A3; A7ZSK3; B7N1A1; B7MCT4; B5R285; P0A7K2; B5R286; Q1R635; B5R280; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; P60624; Q32B54; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; B7MCS6; B5FJA6; A8A5A1; A8GJV2; B5FJA5; B5F7T9; Q32B57; B5F7T1; B5F7T4; B7NR05; A8AQL8; P61175; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; C4ZUF2; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; B7N0V1; Q329M1; P60422; P60423; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; Q1R609; B7LG22; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B6I211; Q32FI2; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; B5R0S0; B5EYX3; A6TAI4; B1X6E9; B7UK18; A1AGI8; Q32B52; A1AGI7; B7M1N1; A1AGI5; B7NDK8; B4TKL4; P68679; B4TUF2; B5RAX1; B7M1M3; B1XG70; B4TKL0; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; P0A7Q8; P0A7X0; Q57J53; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; A9MJT9; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B1IPY4; B7MVJ4; B7MVJ5; B1LHB1; B7M0U2; B1LHD1; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B4TXF0; B6I437; B7NEU0; C4ZUE9; B7NLL7; B7L6I9; A8A5A4; P0C018; B4SUT9; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; P0A7Q6; B7MGC4; P0A7V5; A7MPH5; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; P02413; A9MN54; Q1C365; B7N102; B7M1C4; P60625; P0A7M6; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; A1AGJ7; C0Q0C4; B1IPY0; B1XHG2; B1IPY2; B1IPY5; A9MGD1; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; A6TG05; Q1R358; Q1R604; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; B7MJ76; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; B1LHD0; B1LHD3; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0AG65; B7NLP7; P0AG44; B5RFY6; P0AG66; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7NDS7; B7L847; Q0TCN6; B5YXA7; B7NGD6; B7LRT0; Q0THB3; B4SYA9; Q0THB2; B1X6F1; B7NDR8; A7ZSK4; B1X6F6; B7MCR9; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; B7N1A0; B7LQD9; B5XZP7; B7M092; B5BGY5; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B7UK21; P60438; A8AQJ1; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7T8; P0A7K6; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; C4ZUH1; C4ZUH2; Q1R632; Q32B24; P0A7T9; B6I228; P0AG51; B7MCT0; B1IPL2; B5BG21; A4WFC2; Q328J7; B1IPZ0; B4TKK1; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q0TCG7; Q2EEQ2; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0AG55; Q1R4V6; P0AG45; P0A7R0; A6THB3; Q1R616; B7MCV7; B1X6F8; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; Q5PK05; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B4TXC8; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5F7F9; A9MFK9; B5REG7; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7LRS4; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B7LX23; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; A1AGK6; A7MM78; B7UK35; B7UK32; B7UK30; B7L4K6; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; B7LRS7; A8APV6; B7L4K8; B6I218; Q57PV1; Q57PV0; B6I210; Q1R612; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; P0A7W6; B1LE15; A8ARM4; P0A7W3; B7N192; P0A7W1; P0A7W0; P0A7W9; P0A7W8; C0Q1W9; B4F277; C4ZR79; B5FN11; A8A5A2; B7M9G4; P0A7L8; B7MCS1; Q1CME3; P0A7W4; P0A7N1; B5YTM9; B5Y306; B1IPZ6; B4TXD1; B7M1M2; Q1RB79; B7M1M0; B5EXE1; B7M1M5; B7NLN0; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; B5QZ45; Q57IA6; B1IPZ3; B1X6E8; B1IT04; P0AG50; P02358; P02359; P0A7R9; P0A7X2; P0A7X3; Q5PGT9; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; B1LHC8; B5F3B9; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; P68919; B4T4N0; B5RBB1; B1LK73; B7UJ79; B1X6G3; Q1R6R5; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; P0C019; A8A501; Q1R620; A4WFD5; A9N240; A9N241; B7NDT2; B7NF20; B7NDT6; B7NDT5; A7ZSI8; B5R290; C0Q644; C4ZUH0; Q1R4N3; P61176; P0A7S9; P0A7S8; P0AG59; A8A5C2; P0A7S3; Q1RB78; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; P0A7J7; Q1R626; Q1R627; B7NDT7; P0A7J3; B7NDT8; P62399; B5R299
DB00561	Doxapram	approved; vet_approved	3156	-	"For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease."	P10635; P14324; Q9NPC2; O14649
DB00568	Cinnarizine	investigational; approved	2761	-	"For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins."	P35462; P18825; P28223; P35372; Q99250; O60840; O95180; P11229; Q99720; Q01959; Q9P0X4; P08912; P08913; O43497; Q01668; P23975; P08173; P14416; P41595; P21918; P18089; P35367; Q9NY46; P25100; Q13936; P20309; P08908; Q13698; P31645; P35498
DB00569	Fondaparinux sodium	investigational; approved	49852292	-	"Approved for: (1) prophylaxis of VTE for up to one month post surgery in patients undergoing orthopedic surgery of the lower limbs such as hip fracture, hip replacement and knee surgery, (2) prophylaxis of VTE patients undergoing abdominal surgery who are at high risk of thromboembolic complications (e.g. patients undergoing abdominal cancer surgery), (3) treatment of acute DVT and PE, (4) management of UA and NSTEMI for the prevention of death and subsequent myocardial infarction (MI), and (5) management of STEMI for the prevention of death and myocardial reinfarction in patients who are managed with thrombolytics or who are initially to receive no form of reperfusion therapy. Fondaparinux should not be used as the sole anticoagulant during percutaneous coronary intervention (PCI) due to an increased risk of guiding catheter thrombosis. "	P01008; P00742
DB01569	Formebolone	illicit; experimental	17150	-	"No approve indications. Studied experimentally as a treatment for non-pituitary growth retardation [1]."	P80365
DB01565	Dihydromorphine	illicit; experimental	5359421	-	"Dihydromorphine is an opioid analgesic used for moderate to severe pain relief."	P41145; O60858; P01189; P35372; P41143
DB01564	Calusterone	illicit; experimental	28204	-	"An anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was also investigated for use as a treatment for metastatic breast cancer."	P10275
DB01567	Fludiazepam	illicit; approved	3369	-	"Used for the short-term treatment of anxiety disorders."	P24046; P28472; P18507; P18505; A8MPY1; O00591; P28476; P14867; Q8N1C3; P31644; P47870; P47869; O14764; P34903; Q99928; P78334
DB11121	Chloroxylenol	approved	2723	-	"The predominant medical applications for which chloroxylenol is formally indicated for therapeutic use is as an application to the skin for use in cuts, bites, stings, abrasions, and for use as antiseptic hand cleaner [L1993]."	P21397; P41595
DB01616	Alverine	investigational; approved	3678	-	"Used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine citrate is also under investigation to increase the cytotoxic effects of the proteasome inhibitor MG132 on breast cancer cells. "	P41235; P08908
DB00968	Methyldopa	approved	38853	-	"For use in the treatment of hypertension."	P00533; P18825; P18089; P08913; P06241; P20711
DB01614	Acepromazine	approved; vet_approved	6077	-	"Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals."	P28223; P21918; P21728; P14416; P08908; P35348; P35368
DB01613	Erythrityl Tetranitrate	investigational; approved	5284553	-	"For the prevention of angina."	P16066; P20594
DB00219	Oxyphenonium	approved	5749	-	"For the treatment of visceral spasms"	P11229; P20309
DB01611	Hydroxychloroquine	approved	3652	-	"For the suppressive treatment and treatment of acute attacks of malaria due to <i>Plasmodium vivax</i>, <i>P. malariae</i>, <i>P. ovale</i>, and susceptible strains of <i>P. falciparum</i>. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis."	P08172; P25116; Q9NYK1; Q12809; Q9NR96; P25100
DB01610	Valganciclovir	investigational; approved	64147	-	"Valganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections."	P04293
DB00962	Zaleplon	illicit; investigational; approved	5719	-	"For the treatment of short-term treatment of insomnia in adults."	P28472; P18507; P18505; P30536; P47870; Q13304; P14867; P47869
DB00215	Citalopram	approved	2771	-	"For the treatment of depression. Off-label indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [FDA label]. "	P28335; P11229; P10635; Q99720; P28223; Q01959; P41595; P35348; P33261; P25100; P35367; P31645; P23975; Q12809
DB00960	Pindolol	investigational; approved	4828	-	"For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation."	P28335; P28221; P28222; P28223; P41595; P08588; P08908; P07550; P13945
DB00961	Mepivacaine	approved; vet_approved	4062	-	"For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks."	Q14524; Q9UQD0; Q9NY46; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q15858; Q9UI33
DB00966	Telmisartan	investigational; approved	65999	-	"Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure (only in patients who cannot tolerate ACE inhibitors)."	P23415; P12821; P37231; P30556
DB00743	Gadobenic acid	investigational; approved	131704172	-	"Gadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues."	Q9UNX9; P02768; P48050; P78348; Q9BX84; Q401N2; Q16515; Q8NER1; Q9NZQ8; O94759; Q9Y210; Q9UHC3; Q96QT4
DB00964	Apraclonidine	approved	2216	-	"For prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically. Also used as a short-term adjunctive therapy in patients with open-angle glaucoma who are on maximally tolerated medical therapy requiring additional IOP reduction."	P18825; P18089; P08913; P25100; P35368; P35348; P37288; P30518
DB00213	Pantoprazole	approved	4679	-	"Short-term (up to 16 weeks) treatment of erosive esophagitis."	P05023; P33261; P20648; P51164
DB01587	Ketazolam	approved	33746	-	"Ketazolam could be used for the treatment of anxiety. In approved countries, it is indicated for the treatment of anxiety, tension, irritability and similar stress related symptoms."	O14764; P18505; P30536; Q8N1C3; P14867; P78334
DB01586	Ursodeoxycholic acid	investigational; approved	31401	-	"The drug reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones in patients who want an alternative to surgery."	Q96RI1; Q9UGH3; P53004; P52895
DB01583	Liotrix	approved	71371	-	"May be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic lymphocytic thyroiditis multinodular goiter, and in the management of thyroid cancer. May be used in conjunction with other antithyroid agents to treat thyrotoxicosis to prevent goitrogenesis and hypothyroidism. May also be used for differential diagnosis of suspected mild hyperthyroidism or thyroid gland autonomy."	P10827; P10828
DB01582	Sulfamethazine	investigational; approved; vet_approved	5327	-	"For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections."	P0AC13
DB01581	Sulfamerazine	approved; vet_approved	5325	-	"A sulfanilamide that is used as an antibacterial agent. It can be used to treat bronchitis, prostatitis and urinary tract infections."	P0AC13
DB01580	Oxprenolol	approved	4631	-	"Used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety."	P07550; P08588; P13945
DB06825	Triptorelin	approved; vet_approved	25074470	-	"Triptorelin is indicated for the palliative treatment of advanced prostate cancer."	P30968
DB01008	Busulfan	investigational; approved	2478	-	"For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous  (myeloid, myelocytic, granulocytic) leukemia (FDA has designated busulfan as an orphan drug for this use). It is also used as a component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases."	P11274; P00519
DB01589	Quazepam	illicit; approved	4999	-	"Used to treat insomnia."	Q9UN88; P24046; P28472; P18507; P18505; A8MPY1; Q99928; O14764; P48169; P47870; P28476; Q8N1C3; P47869; P14867; P31644; P34903; Q16445; O00591; P78334
DB01588	Prazepam	illicit; approved	4890	-	"For the treatment of anxiety disorders."	Q9UN88; P24046; P28472; P18507; P28476; A8MPY1; O00591; O14764; P48169; P14867; Q8N1C3; P47869; P47870; P18505; Q16445; P31644; P34903; Q99928; P78334
DB00690	Flurazepam	illicit; investigational; approved	3393	-	"For short-term and intermittent use in patients with recurring insomnia and poor sleeping habits"	Q9UN88; P24046; P28472; P18507; P18505; A8MPY1; Q16445; P28476; P48169; P14867; Q8N1C3; P31644; P47870; P47869; O14764; P34903; Q99928; O00591; P78334
DB00691	Moexipril	approved	91270	-	"For the treatment of hypertension."	Q9BYF1; P12821
DB00692	Phentolamine	approved	5775	-	"Used as an aid for the diagnosis of pheochromocytoma, and may be administered immediately prior to or during pheochromocytomectomy to prevent or control paroxysmal hypertension resulting from anesthesia, stress, or operative manipulation of the tumor. Phentolamine has also been used to treat hypertensive crisis caused by sympathomimetic amines or catecholamine excess by certain foods or drugs in patients taking MAO inhibitors, or by clonidine withdrawal syndrome. Other indications include the prevention of dermal necrosis and sloughing following IV administration or extravasation of norepinephrine, decrease in impedance to left ventricular ejection and the infarct size in patients with MI associated with left ventricular failure, treatment of erectile dysfunction through self-injection of small doses combined with papaverine hydrochloride into the corpus cavernosum, and as an adjunct to the management of cocaine overdose to reverse coronary vasoconstriction following use of oxygen, benzodiazepines,and nitroglycerin. "	P28335; P41595; P18825; P10635; Q99720; P28223; P25100; P35348; Q12809; Q9Y2I1; P18089; Q99250; P08908; P35367; P35498; Q9NY46; P35368; P08913
DB00572	Atropine	approved; vet_approved	174174	-	"For the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides."	P08172; P08173; P23415; P11229; P28223; P28335; P25100; Q8TCU4; P08912; P20309; P35367; P17787; P43681
DB00694	Daunorubicin	approved	30323	-	"For remission induction in acute nonlymphocytic leukemia (myelogenous, monocytic, erythroid) of adults and for remission induction in acute lymphocytic leukemia of children and adults."	P11388; Q02880
DB00695	Furosemide	approved; vet_approved	3440	-	"For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents."	P00918; P22748; P55011; P43166; P05023; Q13621; P23280; Q9ULX7; P00915; Q16790; Q9Y2D0; O43570; P35218; Q9HC97; P28845
DB00696	Ergotamine	approved	8223	-	"For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called \"histaminic cephalalgia\"."	P28566; P28223; P41595; P21918; P18825; P28221; P28222; P28335; P18089; P30939; P50406; P08913; P25100; P14416; P08908; P47898; P23975; P35348; P35368
DB00697	Tizanidine	investigational; approved	5487	-	"For the management of increased muscle tone associated with spasticity"	P18825; P08913; P18089; Q9Y2I1
DB00698	Nitrofurantoin	approved; vet_approved	6604200	-	"May be used as an alternative in the treatment of urinary tract infections. May be used by females pericoitally for prophylaxis against recurrent cystitis related to coitus. "	P11413; P0A7R5; P17117; P52647
DB00699	Nicergoline	investigational; approved	34040	-	"For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration."	P35348
DB00360	Sapropterin	investigational; approved	44257	-	"For the treatment of tetrahydrobiopterin (BH4) deficiency."	P17752; P00439; P07101; P29474
DB00361	Vinorelbine	investigational; approved	44424639	-	"Vinorelbine tartrate is indicated in the treatment of advanced non-small cell lung cancer (NSCLC), as a single therapy or in combination with other chemotherapeutic drugs [L1998].
 
 Vinorelbine tartrate is also indicated for the treatment of patients with metastatic breast cancer who were unsuccessful with standard first-line chemotherapy for metastatic disease [L1998].
 "	Q9BVA1; P68371; Q9H4B7; Q5SU16; Q3ZCM7; P07437; P08684; Q13509; Q13885; Q9BUF5; P04350
DB00362	Anidulafungin	investigational; approved	166548	-	"For use in the treatment of the following fungal infections: Candidemia and other forms of <i>Candida</i> infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis."	A2QLK4
DB00363	Clozapine	approved	2818	-	"For use in patients with treatment-resistant schizophrenia."	P34969; P18825; P28221; P28222; P28223; P35462; P46098; P47898; P09211; Q03519; P28566; P11229; P07550; Q9H3N8; Q99720; Q12809; P08912; P30939; P21728; P08913; P14416; P10635; P23975; Q9Y5N1; P08172; P08173; P28335; P18089; P21918; P41595; P35368; P35367; Q9NYX4; P35348; P21917; P25021; P25100; P50406; Q16602; P20309; P08908; P31645; P08588; P01011
DB00364	Sucralfate	approved	70789197	-	"For the short-term treatment (up to 8 weeks) of active duodenal ulcer, as well as maintenance therapy for duodenal ulcer patients at reduced dosage (1 gram twice a day) after healing of acute ulcers. Also used for the short-term treatment of gastric ulcer."	P01133; P02671; P02675; P09038; P02679; P0DJD9
DB06802	Nepafenac	investigational; approved	151075	-	"For the treatment of pain and inflammation associated with cataract surgery."	P35354; P23219
DB00366	Doxylamine	approved; vet_approved	3162	-	"Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women."	P35367; P11229; Q14994
DB00367	Levonorgestrel	investigational; approved	13109	-	"For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive."	P04150; P06401; P04278; P18405; P03372; P10275; P31645
DB00368	Norepinephrine	approved	439260	-	"Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension."	P00439; P25100; P18825; P54219; Q01959; P18089; Q05940; P21728; P08588; P08913; P35368; P07550; P35348; P13945
DB00369	Cidofovir	approved	60613	-	"For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)"	P08546; P04293
DB06809	Plerixafor	approved	65015	-	"Used in combination with granulocyte-colony stimulating factor (G-CSF, filgrastim) to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin?s lymphoma (NHL) and multiple myeloma (MM)."	P25106; P61073; P51679
DB06209	Prasugrel	approved	6918456	-	"Indicated in combination with acetylsalicylic acid (ASA) to prevent atherothrombotic events in patients with acute coronary syndrome (ACS) who are to be managed with percutaneous coronary intervention (PCI). May be used in patients with unstable angina (UA), non-ST elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI) who are to be managed with PCI. Prasugrel is not recommended in patients 75 years of age or greater, those that weigh<60kg, and patients with a history of stroke or transient ischemic attack due to increased risk of fatal and intracranial bleeding. "	P20813; P33261; P11712; P20815; Q9H244
DB06757	Manganese	approved; nutraceutical	27854	-	"Indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms."	P05089; P50213; Q15750; P51553; P02787
DB06204	Tapentadol	approved	9838022	-	"The immediate-release formulation of tapentadol is indicated for the relief of moderate to severe acute pain. The long-acting formulation serves as a continuous, around-the-clock analgesic that is indicated for the relief of moderate to severe chronic pain or neuropathic pain associated with diabetic peripheral neuropathy. "	P41145; P41143; P35372; P46098; P31645; P23975
DB06207	Silodosin	approved	5312125	-	"Treatment for symptomatic relief of benign prostatic hyperplasia "	P35348; P25100; P35368
DB06201	Rufinamide	approved	129228	-	"Adjunct therapy for treatment of seizures associated with Lennox-Gastaut syndrome.   "	Q9Y5Y9; Q14524; Q9UQD0; P41594; Q01118; P35499; P35498; Q99250; Q9UI33; Q15858; Q9NY46
DB06200	Tedisamil	investigational	65825	-	"Investigated for use/treatment in arrhythmia, atrial fibrillation, and angina."	Q9BQ31; Q9H3M0; Q9NSA2; Q9UIX4; Q96KK3; Q9UJ96; Q9H252; Q03721; P17658; Q9NS40; P11308; Q16322; Q09470; O43525; Q8TAE7; Q9NR82; Q14003; Q96RP8; Q9UQ05; Q9ULD8; O43526; Q8NCM2; Q14721; Q9NZV8; Q96PR1; P16389; Q96L42; O95259; P22459; Q9UK17; P22460; Q8TDN2; Q6PIU1; P22001; P51787; P48547; Q92953; P56696; Q9ULS6
DB06751	Drotaverine	investigational; approved	1712095	-	"Used in the treatment of functional bowel disorders and alleviating pain in renal colic."	Q07343; Q13936; P27815
DB06202	Lasofoxifene	investigational; approved	216416	-	"Investigated for use/treatment in postmenopausal osteoporosis to reduce the risk of both vertebral and novertebral fractures, as well as address other postmenopausal conditions, including reduction in risk of breast cancer and treatment of vulvar and vaginal atrophy (VVA)"	Q92731; P34972; P03372
DB00486	Nabilone	investigational; approved	5284592	-	"Used for the control of nausea and vomiting, caused by chemotherapeutic agents used in the treatment of cancer, in patients who have failed to respond adequately to conventional antiemetic treatments."	P34972; P21554
DB00979	Cyclopentolate	approved	2905	-	"Used mainly to produce mydriasis and cycloplegia for diagnostic purposes."	O14842; Q9UBY5; P11229; Q99677; Q9HBW0; P20309; Q92633
DB01018	Guanfacine	investigational; approved	3519	-	"For use alone or in combination with other classes of antihypertensive agents in the management of hypertension. Has also been used for the treatment of attention deficit hyperactivity disorder (ADHD) in pediatric patients."	Q9Y2I1; P41595; P18825; P28223; P18089; P25101; P08913; P25100; P28335
DB00754	Ethotoin	approved	3292	-	"For the control of tonic-clonic (grand mal) and complex partial (psychomotor) seizures."	Q14524; Q9UQD0; O75469; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q9UI33; Q15858; Q9NY46
DB00209	Trospium	approved	5284632	-	"For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition."	P08172; P08912; P11229; P20309
DB00756	Hexachlorophene	approved; withdrawn	3598	-	"For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful."	P00533; P22303; P18825; Q92731; P28335; P00367; P41595; P03372; O14521; P35354; P08913; P04626; P06239; P31645; P06149; P0AEK4; P06241; P29274
DB04880	Enoximone	investigational; approved	53708	-	"For the treatment of congestive heart failure."	Q07343; Q14432; P27815; Q08499; Q08493
DB00759	Tetracycline	approved; vet_approved	54675776	-	"Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin."	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; B1LHB1; B5F3B9; P0A7T7; B7UPA5; Q57GI9; B1X6G8; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B7LS48; B7LRT1; B1X6G0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B7MTL9; B4TUF3; B7UMH0; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; A7MPH8; A9MN70; B7M1C4; P60625; P60626; C0Q0C4; B4SXD8; B7NDS9; B1IPL1; B7NDS5; B7NDS7; B5FJK8; B7UK28; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B4TKK9; P0A7T8; C4ZS29; P0A7T9; B1LE15; B1LQM1; B6I208; B7NJS8; A8ARM4; A8AQC0; C0Q2L0; B7N192; A8A5E9; C4ZUG9; P0A7W0; P0A7T3; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; A8A5B3; A7MNZ2; P0A7W9; B1LE14; A4THT0; B7N198; C4ZSS5; B4T4N1; B7M1L8; B7M1C5; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; B6I228; Q57J49; P62401; Q0T9J1; B4TAV0; B7MFJ7; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; B4TGH4; B4TGH3; B5QUQ1; P0A7R5; B5FN11; Q1R4V6; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; P0C020; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; Q0TCE2; P68686; B7MCV7; B1IPY8; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A1AGJ5; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; A1AGM9; P0AG67; B1IPY2; Q0TCN6; Q0THB3; Q32B54; Q32B57; A7ZSK5; B7N1A3; A7ZSK3; A7ZSK0; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; B7LHP9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; B7M1M3; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8A5A2; B5FJA5; B5F7T9; B5F7T1; B5F7T4; B7NR05; P68919; B7L6J0; A8AQL3; B7MST2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; B7N0V1; Q329M1; P60422; B1X6G3; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B7N554; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B7MJ76; F7VJQ1; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q9UM07; Q32BQ2; Q57IA6; A9MN66; B5BGX2; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; B7UK18; A1AGI8; A1AGI7; B7M1N1; A1AGI5; B7NDK8; B5R5G0; B4TKL4; B4TKL0; B5RAX1; P0A7M6; B1XG70; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; P0A7Q8; Q5PGT9; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; Q1RD68; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; A1AGK6; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; Q32FI2; B4TXC8; B1LHD1; A9MKN8; P0A7V9; B7LLY4; B1LHD3; B1LHB0; B6I437; B7NEU0; B7NLL4; B7NLL7; B7L6I9; P0C018; P0C019; B1LF57; P0A7N4; B4SUT4; B4SUT5; A7MPF5; A4W5T1; P0A7Q6; B7UK52; P0A7V5; Q0TCF8; A9MJT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; P02413; A9MN54; Q1C365; P60624; A9MN59; Q5PJ56; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; A1AGJ7; A6TE47; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; B7LR53; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; A7ZSK6; B4T679; A9N520; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; B1LHD0; B4TXF0; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; B7NLP7; B7MCR9; P0AG66; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; Q5PKU5; B7N0L5; B1LGQ0; B7L847; A7ZSK8; B7MCS6; B5YXA7; B7NGD6; B7LRT0; B1X6F8; B4SYA9; B7MCT2; B1X6F1; B7NDR8; B7MCT1; B1X6F6; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; B7N1A0; B7LQD9; B5YTM5; B7M092; B5YTM7; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; P60724; B1IT04; B5R286; B5FSA3; P60723; B5R280; B7N2E8; B7L4J5; P61179; B7LRS7; B6I3T6; A7ZTQ9; C4ZUH4; B1LGJ6; P61177; C4ZUH1; P61175; Q32B24; B4TUF2; B7NDH0; B1IPL2; B5BG21; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; C4ZUG3; P04156; Q5PC32; A8A539; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; B7N1C3; P60438; B7MLK7; B5BGY5; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; Q5PK05; B1X970; B7LRR3; B7LRR1; P60727; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; A8A5C2; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5RH21; B1X6H0; A9MFK9; A9MGD1; B5REG7; B5FM60; A9N241; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B1IV14; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; B1IPZ0; B1IPZ1; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; P68679; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; C0Q0A5; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; P0A7W4; P0A7W3; P0A7W2; P0A7W1; B7N190; B7N199; P0A7W8; C0Q1W9; B4F277; Q0THB2; C4ZR79; C5BF78; A8GJV2; B7M9G4; P0AG59; P0A7L8; B7MCS1; Q1CME3; B5RFY6; B1IPZ5; A8AQJ1; B5Y306; B7LX23; B4TXD1; B7M1M2; P0A7S3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B5QZ45; P0AG51; P0A7N7; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P60726; P0A7X2; P0A7X3; P0A7X0; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; A8A5A1; B5F8E7; B1LHC8; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; A8AQL8; B4T4N0; B5RBB1; B1LK73; B7UJ79; B7UK39; Q57JQ0; B1IPV7; P61178; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; Q1R620; B4SUT9; A8A501; B7LCR3; A4WFD5; A9N240; B5BKL1; P0A7J7; B7NF20; B7NDT5; B7L4K6; B5R290; C0Q644; C4ZUH0; Q1R4N3; P61176; P0A7S9; P0A7S8; P0AG55; C4ZUH2; Q1RB79; P0A7S2; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; Q1R626; Q1R627; B7NDT7; B7NDT6; B7NDT8; P62399; B5R299
DB00188	Bortezomib	investigational; approved	387447	-	"For treatment of multiple myeloma in patients who have not been successfully treated with at least two previous therapies."	O00487; P51665; O00232; P28066; Q53XL8; P28065; P28062; O14818; P20618; P48556; Q15008; Q16186; Q8TAA3; P25786; P25787; P25788; Q99460; P49721; Q6ZVN7; A5LHX3; P17980; Q6IAT9; P40306; A8K2M0; P00734; P28074; P55036; P28070; P28072; Q13200; P60896; O43242; Q99436; P49720; P62191; P62333; P62195; Q9UNM6; P60900; P35998; P25789; O00231; P43686
DB00189	Ethchlorvynol	illicit; approved; withdrawn	5281077	-	"Used for short-term hypnotic therapy in the management of insomnia for periods of up to one week in duration, however, this medication generally has been replaced by other sedative-hypnotic agents."	Q9UN88; P28472; P18507; P18505; Q99928; O14764; P48169; P14867; Q8N1C3; P31644; P47870; Q16445; P47869; P34903; O00591; P78334
DB00758	Clopidogrel	approved	60606	-	"For the reduction of atherosclerotic events (myocardial infarction, stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease."	P31645; Q9H244; P33261
DB00184	Nicotine	approved	89594	-	"For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation."	Q15825; P11230; P28329; P02708; Q9UGM1; Q9GZZ6; P30532; O95264; P46098; P17787; P32297; Q15822; A5X5Y0; Q05901; Q70Z44; O75762; Q9UK17; P30926; Q494W8; Q8WXA8; P07510; P36544; P43681; Q07001; P11511
DB00185	Cevimeline	approved	25137844	-	"For the treatment of symptoms of dry mouth in patients with Sj&ouml,gren's Syndrome."	P08172; P08173; P08912; P11229; P20309
DB00186	Lorazepam	approved	3958	-	"For the management of anxiety disorders, and for treatment of status epilepticus."	Q9UBU3; P30536; P24046; A8MPY1; Q92847; P47869; Q16445; P78334; P18507; P18505; Q15743; Q8N1C3; P14867; O00591; Q9UN88; P28472; P28476; O14764; P48169; P34903; P47870; P31644; Q99928
DB00187	Esmolol	approved	59768	-	"For the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventricular rate with a short-acting agent is desirable. Also used in noncompensatory sinus tachycardia where the rapid heart rate requires specific intervention."	P41145; P35372; P41143; P08588; P07550
DB00180	Flunisolide	investigational; approved	82153	-	"For the maintenance treatment of asthma as a prophylactic therapy."	P04150; P47712
DB00205	Pyrimethamine	investigational; approved; vet_approved	4993	-	"For the treatment of toxoplasmosis and acute malaria, For the prevention of malaria in areas non-resistant to pyrimethamine"	P0DPD6; Q9H1D0; B0YJ76; P11229; P35523; Q8IU57; P00374; Q16515; Q96FL8; Q15878; P0DPD8; P13922; P07686; Q9ULQ1; Q8IZF0; Q96D96; O75762; Q15858; O60344
DB00182	Amphetamine	illicit; investigational; approved	3007	-	"For treatment of Attention Deficit Disorder with Hyperactivity (ADDH), narcolepsy, and exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction for patients refractory to alternative therapy."	P18440; P18825; Q96RJ0; P27338; Q01959; Q05940; P08913; Q16568; P14416; P31645; Q07869; P23975; P35348; P13945
DB00183	Pentagastrin	approved	9853654	-	"Used as a diagnostic aid for evaluation of gastric acid secretory function"	P32238; P32239; Q99808
DB00204	Dofetilide	investigational; approved	71329	-	"For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm"	P11308; O95069; Q12809; O95259; Q14500
DB00970	Dactinomycin	investigational; approved	457193	-	"For the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen"	Q02880
DB00973	Ezetimibe	approved	150311	-	"For use as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia."	P35610; P15144; Q9UHC9
DB00200	Hydroxocobalamin	approved	70678542	-	"For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning."	O60494; P22033; Q99707; Q96EY8; Q9Y4U1; P20061; Q9UBK8; Q8IVH4; Q9BXJ7
DB00984	Nandrolone phenpropionate	illicit; investigational; approved	229455	-	"For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema."	P10275; P03372
DB00985	Dimenhydrinate	approved	441281	-	"Used for treating vertigo, motion sickness, and nausea associated with pregnancy."	P08172; P08173; P28335; P41595; P11229; P10635; Q99720; P28223; Q01959; P18089; P08912; P08913; P25100; P20309; P35367; P23975
DB00986	Glycopyrronium	investigational; approved; vet_approved	9933193	-	"For use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation. Also used to treat chronic obstructive pulmonary disease (COPD)."	P08172; P07550; P11229; P20309
DB00987	Cytarabine	investigational; approved	6253	-	"For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia."	Q07864; P49005; Q15054; P09884; P56282; Q14181; P06746; P49643; P49642; P28340; Q9HCU8; Q9NRF9
DB00980	Ramelteon	investigational; approved	208902	-	"For the treatment of insomnia characterized by difficulty with sleep onset."	P48039; P49286
DB00981	Physostigmine	investigational; approved	5983	-	"For the treatment of glaucoma, and in the treatment of severe anticholinergic toxicity."	P10635; P22303; P43681; P17787; P06276
DB00982	Isotretinoin	approved	5282379	-	"For the treatment of severe recalcitrant nodular acne"	P10276; P10826; P13631; P41595; P18089
DB00983	Formoterol	investigational; approved	3410	-	"For use as long-term maintenance treatment of asthma in patients 6 years of age and older with reversible obstructive airways disease, including patients with symptoms of nocturnal asthma, who are using optimal corticosteroid treatment and experiencing regular or frequent breakthrough symptoms requiring use of a short-acting bronchodilator. Not indicated for asthma that can be successfully managed with occasional use of an inhaled, short-acting beta2-adrenergic agonist. Also used for the prevention of exercise-induced bronchospasm, as well as long-term treatment of bronchospasm associated with COPD."	P07550; P08588; P35462; P13945
DB00988	Dopamine	approved	681	-	"For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure"	P34969; P35462; Q01959; Q96RJ0; P46098; P49286; Q05940; P21918; P21728; P08588; O95264; P14416; P08908; P07550; P48039; P31645; P23975; P21917; P00441
DB00989	Rivastigmine	investigational; approved	77991	-	"For the treatment of mild to moderate dementia associated with Parkinson's disease or of the Alzheimer's type."	P22303; P06276
DB06595	Midostaurin	investigational; approved	9829523	-	"Investigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML) who are FLT3 mutation-positive, agressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL). "	Q04759; P09619; Q05513; O94806; P24723; P41743; Q05655; P05129; P35968; P16234; Q02156; P06748; P17252; Q96GD4; P05771; P36888; Q15139; P10721
DB06594	Agomelatine	investigational; approved	82148	-	"Agomelatine is indicated for the treatment of major depressive episodes in adults."	P28223; P48039; P28335; P49286; P41595
DB06590	Ceftaroline fosamil	investigational; approved	9852981	-	"Ceftaroline fosamil is indicated for the treatment of patients with the following infections caused by susceptible isolates of the designated microorganisms."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB06370	Indisulam	investigational	216468	-	"Investigated for use/treatment in lung cancer."	O43570; P00915; P43166
DB00626	Bacitracin	approved; vet_approved	10909430	-	"For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. 
 However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question. "	P14735; P01023
DB06579	Adipiplon	investigational	11198924	-	"Investigated for use/treatment in insomnia and sleep disorders."	Q9UN88; P24046; P28472; P18507; P18505; A8MPY1; Q99928; O14764; P48169; P47870; P28476; Q8N1C3; P34903; P14867; P47869; P31644; Q16445; O00591; P78334
DB00115	Cyanocobalamin	approved; nutraceutical	70678590	-	"For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency."	P42898; P22033; Q99707; Q8IVH4; Q9Y4U1; Q9UBK8
DB00006	Bivalirudin	investigational; approved	16129704	-	"For treatment of heparin-induced thrombocytopenia and for the prevention of thrombosis. Bivalirudin is indicated for use in patients undergoing percutaneous coronary intervention (PCI), in patients at moderate to high risk acute coronary syndromes due to unstable angina or non-ST segment elevation in whom a PCI is planned."	P00734
DB05271	Rotigotine	approved	59227	-	"For use/treatment in neurologic disorders and parkinson's disease as well as moderate-to-severe primary Restless Legs Syndrome."	P35462; P18089; P21918; P21728; P14416; P08908; P21917
DB05479	CZEN 002	investigational	16129664	-	"Investigated for use/treatment in candidiasis and vaginitis."	Q01726; Q1JUL4
DB05478	Pradefovir Mesylate	investigational	9604653	-	"Investigated for use as a prodrug for Hepsera in treating hepatitis (viral, B)."	P08684
DB05476	WX-UK1	investigational	9939426	-	"Investigated for use/treatment in solid tumors."	Q03405
DB05475	Golotimod	investigational	6992140	-	"Investigated for use/treatment in hepatitis (viral, C), infectious and parasitic disease (unspecified), and tuberculosis."	O60603; O00206; Q9NR96; Q9NYK1
DB05470	VX-702	investigational	10341154	-	"Investigated for use/treatment in coronary artery disease, inflammatory disorders (unspecified), and rheumatoid arthritis."	Q15759; Q16539; P53778; P05231; P01584; P01375; O15264
DB03619	Deoxycholic Acid	approved	222528	-	"For improvement in appearance of moderate to severe fullness associated with submental fat in adults. "	P31224; P07445; P25553; Q7Z2Z2; P33517; Q96RI1; P54965; Q03736; P09211; P21462; Q8TDU6
DB05871	UC-781	investigational	3000926	-	"Investigated for use/treatment in HIV infection."	P03366
DB01397	Magnesium salicylate	approved	54684589	-	"Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain"	P35354; P23219
DB09352	Hydroxyamphetamine	approved	3651	-	"Mydriatic agent (eye pupil dilatation) for diagnosis of ophthalmic nerve lesions."	P18825; P18089; P08588; P13945; P25100; P35368; P07550; P35348; P08913
DB09351	Levobetaxolol	investigational; approved	60657	-	"Used in the treatment of open-angle glaucoma and ocular hypertension [FDA Label]."	P07550; P08588
DB09357	Dexpanthenol	approved	131204	-	"Injection: Prophylactic use immediately after major abdominal surgery to minimize the possibility of paralytic ileus. Intestinal atony causing abdominal distention, postoperative or postpartum retention of flatus, or postoperative delay in resumption of intestinal motility, paralytic ileus.
 
 Topical: This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). "	P20309
DB05010	SGS-742	investigational	130021	-	"Investigated for use/treatment in alzheimer's disease, attention deficit/hyperactivity disorder (ADHD), memory loss, and schizophrenia and schizoaffective disorders."	O75899; Q9UBS5
DB01202	Levetiracetam	investigational; approved	5284583	-	"Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy."	P00915; Q00975; P35498; O43497; P46098; Q7L0J3
DB00272	Betazole	approved	7741	-	"For use clinically to test gastric secretory function."	P25021
DB05057	Erdosteine	investigational	65632	-	"Fro the treatment of chronic bronchitis in adults."	P08246
DB05053	MB-07803	investigational	24770445	-	"Investigated for use/treatment in diabetes mellitus type 2."	P09467
DB01204	Mitoxantrone	investigational; approved	4212	-	"For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis"	P08172; P08173; Q9UNQ0; P28335; Q06187; P00533; Q12809; P11229; P06241; P04626; P11388; P23975; Q02880
DB05913	OSI-930	investigational	9868037	-	"Investigated for use/treatment in solid tumors."	P07333; P35968; P17948; P35916; P04049; P10721
DB00270	Isradipine	investigational; approved	3784	-	"For the management of mild to moderate essential hypertension. It may be used alone or concurrently with thiazide-type diuretics."	Q12809; O95180; P43220; P54289; Q08289; Q13936; Q13698; O60840; Q01668; Q9NY47
DB05297	Paclitaxel docosahexaenoic acid	investigational	6918473	-	"Investigated for use/treatment in breast cancer, colorectal cancer, gastric cancer, kidney cancer, lung cancer, pancreatic cancer, prostate cancer, and skin cancer."	P10415
DB05295	Eldecalcitol	investigational	6918141	-	"Investigated for use/treatment in osteoporosis."	P11473
DB05294	Vandetanib	approved	3081361	-	"Vandetanib is currently approved as an alternative to local therapies for both unresectable and disseminated disease. Because Vandetanib can prolong the Q-T interval, it is contraindicated for use in patients with serious cardiac complications such as congenital long QT syndrome and uncompensated heart failure. "	P21802; Q02750; P36507; P08631; P35968; P07947; Q13882; P04626; P21860; P54762; P54760; P22607; O15197; P07948; Q15303; P29317; P00533; P00519; P07333; Q9UM73; P21709; P16234; P17948; P35916; P54764; P06239; P08581; P07949; P11362; P54753; P54756; P09619; P12931; O75116; P22455; Q02763; P36888; P10721; P06241; Q06187; Q9UF33; Q15375; Q5JZY3; P15692; P29322; P29323; P29320
DB05298	Tetomilast	investigational	3025803	-	"Investigated for use/treatment in ulcerative colitis."	Q08499
DB05018	Migalastat	investigational; approved	176077	-	"Investigated for use/treatment in fabry disease."	P10253; O43451; P06280
DB09102	Daclatasvir	investigational; approved	25154714	-	"Indicated for use with sofosbuvir, with or without ribavirin, for the treatment of chronic HCV genotype 1a/b or 3 infection. The dosing regimen of 60mg daclatasvir 60 mg with 400mg sofosbuvir once a day is recommended for both genontypes. 
 
 Resistance: Reduced susceptibility to daclatasvir was associated with the polymorphisms at NS5A amino acid positions M28, Q30, L31, and Y93 in genotypes 1a, 1b, and 3a patients. NS5A Resistance Testing is recommended for HCV genotype 1a-infected patients with cirrhosis prior to the initiaition of the treatment, as the risk of resistance development is higher in genotype 1a patients. "	Q8IZI9; Q12809
DB01373	Calcium	approved; nutraceutical	5460341	-	"Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades."	P04271; P02585; P05109; Q99584; O75340; P98194; Q01082; P05187; P63316; B4DJ51; P00450; P0DP24; P0DP25; P0DP23; P20810; P29034; P49747; P06702; P19801; P12644; P62158; P08493; Q13936; Q8TAB3
DB05129	Elsamitrucin	investigational	5362259	-	"Investigated for use/treatment in lymphoma (non-hodgkin's)."	P11388; P11387
DB01118	Amiodarone	investigational; approved	2157	-	"Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia."	P10827; P41145; P28223; P10828; P35372; P04626; P08913; P35462; Q9Y3Q4; Q14524; O95180; P11229; Q99720; Q12809; Q01959; P21728; P08588; Q96RP8; P14416; P23975; P08172; P08173; P37231; P51679; P41143; P28335; P18089; P08684; P41595; Q9NY47; P35348; P13945; P25021; P25101; P30411; P20309; P08912; P31645; P06241
DB01119	Diazoxide	approved	3019	-	"Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma."	P00918; P51841; Q09428; P05023; P00915; Q14654; P55017; Q15842; Q12791
DB01110	Miconazole	investigational; approved; vet_approved	4189	-	"For topical application in the treatment of tinea pedis (athlete&rsquo,s foot), tinea cruris, and tinea corporis caused by <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, and <i>Epidermophyton floccosum</i>, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor."	P10613; Q12809; P08173; Q9UGI6; P10635; P28223; P25103; P35372; O75469; Q9NQA5; P35462; Q9H252; P00533; P11229; Q9Y691; Q01959; P21728; P08913; P13945; P14416; Q86W47; P29274; P30542; Q9H2S1; P08172; P41145; P22303; P20309; P41143; P28335; P41595; P08588; P08684; P18089; O15554; P23975; O94759; P31645; P35228; Q12791; P05093; P04626; P25021; P35354; P25100; Q16558; Q92952; Q9NS40; P29474; P08908; Q9NPA1; P06241; P21554; P11511
DB01112	Cefuroxime	approved	5479529	-	"For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections."	P00918; P0AEB2; P08506; P02918; P02919; Q8XJ01; P0AD68; P24228; P0AD65
DB01113	Papaverine	investigational; approved	4680	-	"For the treatment of impotence and vasospasms."	Q14123; Q9Y233; P22303; P27815; O00408; Q01064; Q14432; Q13370; P54750; O75676; Q07343; P49137; O76074; Q12809
DB01114	Chlorphenamine	approved	2725	-	"For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever."	P10635; Q12809; Q01959; P41595; P35498; Q99250; P35367; P31645; P23975; Q9NY46
DB01115	Nifedipine	approved	4485	-	"For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents). "	P54289; P28223; P02766; O75469; Q99250; O60840; P22460; O95180; Q09470; Q12809; Q08289; Q96RP8; B4DJ51; Q01668; P29274; P30542; Q9HCF6; P0DP24; P0DP25; P28335; P00390; P0DP23; P16389; O75311; P27815; P08684; P35498; Q9NY46; P48167; P23415; P62158; Q13936; Q13698
DB01116	Trimethaphan	investigational; approved	23576	-	"For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies."	P30926; P32297; Q9GZZ6; P43681
DB01117	Atovaquone	approved	74989	-	"For the treatment or prevention of <i>Pneumocystis carinii</i> pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX."	Q08210; Q02768; Q02127
DB00513	Aminocaproic Acid	investigational; approved	564	-	"For use in the treatment of excessive postoperative bleeding."	P00747; P08519; P00750
DB00512	Vancomycin	approved	14969	-	"A variety of dosage forms (for example, oral, injections, etc.) exist for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci [FDA Label].
 
 Additionally, a unique FDA approved oral liquid treatment is also available and indicated for the treatment of Clostridium difficile associated diarrhea and enterocolitis caused by _Staphylococcus aureus_, including methicillin-resistant strains [L1196]."	P08913
DB00511	Acetyldigitoxin	approved	5284512	-	"Used for fast digitalization in congestive heart failure."	P05023; P50993; P05026; P13637; Q13733; P14415; P54709; P54710
DB00517	Anisotropine Methylbromide	approved	21867154	-	"For use in conjunction with antacids or histamine H<sub>2</sub>-receptor antagonists in the treatment of peptic ulcer, to reduce further gastric acid secretion and delay gastric emptying."	P08172; P11229; P20309
DB00515	Cisplatin	approved	2767	-	"For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer."	P02787; P00533; P29372; P01023; P35462; O00244; P08912; P06239; P06241
DB00514	Dextromethorphan	approved	5360696	-	"For treatment and relief of dry cough."	P41145; Q494W8; P41143; P43681; Q99720; Q15822; Q12879; Q8TCU5; P15153; P35372; P30926; Q6IB11; P31645; P36544; P10635; Q14957; P17787; O00264; P23975; P32297
DB00519	Trandolapril	approved	5484727	-	"For the treatment of mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure (CHF), to improve survival following myocardial infarction (MI) in individuals who are hemodynamically stable and demonstrate symptoms of left ventricular systolic dysfunction or signs of CHF within a few days following acute MI, and to slow progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy. "	P12821
DB00518	Albendazole	approved; vet_approved	2082	-	"For the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, <i>Taenia solium</i> and for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, <i>Echinococcus granulosus</i>."	P68371; Q71U36; Q9H4B7; Q8TDU9; P83223; Q9NSD7
DB13872	Lormetazepam	approved	13314	-	"For the treatment of short-term insomnia [L927]"	P31644; P47869; P14867; P34903; P18507
DB13873	Fenofibric acid	approved	64929	-	"For use as an adjunctive therapy to diet to: (a) reduce triglyceride levels in adult patients with severe hypertriglyceridemia, and (b) reduce elevated total cholesterol, low-density-lipoprotein (LDL-C), triglycerides, and apolipoprotein B, and to increase high-density-lipoprotein (HDL-C) in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). [FDA Label]"	Q03181; O75469; P35523; P37231; Q07869
DB13874	Enasidenib	investigational; approved	89683805	-	"Indicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation."	P48735
DB01576	Dextroamphetamine	illicit; approved	5826	-	"Used to treat attention deficit hyperactivity disorder (ADHD)."	P21397; P18440; Q96RJ0; P08908; Q01959; Q05940; P08913; P14416; P35368; P31645; P23975; P35348
DB01577	Methamphetamine	illicit; approved	10836	-	"For the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity."	P21397; P27338; P18825; Q99720; P35368; Q01959; P18089; Q05940; P08913; P41595; P14416; P54219; P31645; P35348; P23975; Q96RJ0
DB00291	Chlorambucil	approved	2708	-	"For treatment of chronic lymphatic (lymphocytic) leukemia,  childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease,  non-Hodgkin's lymphomas, and Waldenstr?m?s Macroglobulinemia."	P41143
DB00229	Cefotiam	investigational; approved	43708	-	"For treatment of severe infections caused by susceptible bacteria."	P24228; P08506; P02918; P02919; Q8XJ01; P0AD68; P0AEB2; P0AD65
DB00228	Enflurane	investigational; approved; vet_approved	3226	-	"Used for the induction and maintenance of general anaesthesia during surgery and cesarean section and also used for analgesia during vaginal delivery."	P57789; Q9NPC2; P98194; Q09470; Q7Z418; Q9UN88; P47869; Q16445; P78334; P18507; P00390; P18505; P30049; P14867; P23415; O15554; O95069; O00591; O14649; Q12791; Q8N1C3; P48167; P28472; O14764; P48169; P34903; P47870; P31644; P03886; Q99928; P42261
DB04982	Talampanel	investigational	164509	-	"For the treatment of epilepsy."	P42263; P00390; P42261; P42262; P48058
DB00738	Pentamidine	investigational; approved	4735	-	"For the treatment of pneumonia due to <i>Pneumocystis carinii</i>."	P08172; P08173; P28335; Q05586; P28223; Q01959; Q12879; O14717; Q12809; P08912; P08913; P25100; P35462; P23975; P07477; P21397
DB01600	Tiaprofenic acid	approved	5468	-	"Tiaprofenic acid is used to treat pain, especially arthritic pain."	P35354; P23219
DB01601	Lopinavir	approved	92727	-	"Indicated in combination with other antiretroviral agents for the treatment of HIV-infection."	P21730; Q12809
DB01602	Bacampicillin	investigational; approved	441397	-	"For infections at the following sites: upper and lower respiratory tract, skin and soft tissue, urinary tract and acute uncomplicated gonococcal urethritis, when due to sensitive strains of the following organisms:  Gram-positive: streptococci (including <i>S. faecalis</i> and <i>S. pneumoniae</i>) and nonpenicillinase-producing staphylococci, Gram-negative: <i>H. influenzae</i>, <i>N. gonorrhoeae</i>, <i>E. coli</i>, <i>P. mirabilis</i>, <i>Salmonellae</i> and <i>Shigellae</i>."	P24228; P08506; P02918; P02919; Q8XJ01; P0AD68; P0AEB2; P0AD65
DB01603	Meticillin	investigational; approved	6087	-	"Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as <i>Staphylococcus aureus</i> that would otherwise be resistant to most penicillins."	O60755; Q8DR59; O43603; P0A3M6; P47211
DB00733	Pralidoxime	approved; vet_approved	5353894	-	"For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis."	P22303; P06276
DB00732	Atracurium besylate	approved	47320	-	"For use, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation."	Q15822; P11230; P07510; P02708; Q04844; Q07001
DB00223	Diflorasone	approved	71415	-	"For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses."	P04150; P04083; P04054; Q5TZZ9
DB00222	Glimepiride	approved	3476	-	"For concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus."	P11413; Q09428; Q14654; P48048; P32238; O60706
DB01608	Propericiazine	investigational; approved	4747	-	"For use as adjunctive medication in some psychotic patients. Propericiazine (Pericyazine)is used for the control of residual prevailing hostility, impulsiveness and aggressiveness. "	P25100; P10275; P21728; P08913; P35368; P35348
DB00736	Esomeprazole	investigational; approved	9568614	-	"For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use."	P33261; P20648; P51164
DB00227	Lovastatin	investigational; approved	53232	-	"For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia. For primary prevention of coronary heart disease and to slow progression of coronary atherosclerosis in patients with coronary heart disease. "	Q9UBN7; Q01959; Q13547; Q6IT96; Q92769; Q8TDS4; P04035; P20701; P23975; P30542
DB00734	Risperidone	investigational; approved	5073	-	"Risperidone belongs to the class of medications known as ?second generation atypical antipsychotics [A1114, A1115, L1213].  It is widely used in the treatment of schizophrenia and mood disorders, including bipolar disorder and depression with pyschosis [A1115, A1116, L1212, L1213]."	Q12809; P18825; P28221; P28222; P28223; P18089; P35462; P28566; P11229; Q99720; Q14209; P30939; P21728; P08913; P34969; P14416; P10635; P08172; P08173; P28335; P41595; P08588; O00716; P35368; P35367; P31645; P35348; P21917; P23415; P25021; P25100; P50406; P20309; P08908; P07550; P01011
DB01594	Cinolazepam	approved	3033621	-	"For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms."	P24046; O14764; P18507; P28476; A8MPY1; O00591; P18505; P14867; Q8N1C3; P31644; P47870; P28472; P30536; P47869; P34903; Q99928; P78334
DB01595	Nitrazepam	approved	4506	-	"Used to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening."	Q9UN88; P24046; P28472; P18507; P18505; P28476; A8MPY1; O00591; O14764; P48169; Q16445; Q8N1C3; P47869; P14867; P35498; P31644; P34903; Q99928; P47870; P78334
DB01597	Cilastatin	investigational; approved	6435415	-	"Combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect."	P16444
DB01590	Everolimus	approved	6442177	-	"Everolimus is indicated for the treatment of postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer (advanced HR+ BC) in combination with exemestane, after failure of treatment with letrozole or anastrozole.
 Indicated for the treatment of adult patients with progressive neuroendocrine tumors of pancreatic origin (PNET) with unresectable, locally advanced or metastatic disease.
 Indicated for the treatment of adult patients with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib.
 Indicated for the treatment of adult patients with renal angiomyolipoma and tuberous sclerosis complex (TSC), not requiring immediate surgery.
 Indicated in pediatric and adult patients with tuberous sclerosis complex (TSC) for the treatment of subependymal giant cell astrocytoma (SEGA) that requires therapeutic intervention but cannot be curatively resected."	P62942; P04626; P42345; P03372
DB01591	Solifenacin	approved	154059	-	"For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency."	P08172; P08173; P08912; P11229; P20309
DB01592	Iron	approved	23925	-	"Used in preventing and treating iron-deficiency anemia."	P02787; P02786; Q969S2; P06746; P02794; Q9GZT9; Q96FI4; Q9BY41; P39748; Q16595; D1MGQ2; P69905; Q9NZD4; P00450
DB01598	Imipenem	approved	104838	-	"For the treatment of bacterial infections caused by susceptible bacteria."	P0AEB2; P08506; P00807; P02918; P02919; P42971; P0AD68; P24228; P0AD65
DB01599	Probucol	investigational; approved	4912	-	"Used to lower LDL and HDL cholesterol."	O95342; Q12809; P23141; O95477
DB03255	Phenol	approved; experimental	996	-	"Phenol is primarily indicated for minor sore throat pain, sore mouth, minor mouth irritation, and pain associated with canker sores. Additionally, phenol is indicated in the treatment of focal spasticity. "	P00918; P02768; P00720; P07451; P22748; Q9ULX7; P00915; P43133; Q16790; O43570; Q05603
DB06815	Pyrithione zinc	approved	26041	-	"Indicated for the treatment of dandruff and seborrheic dermatitis [A27133]. "	P22748; P07451; P43166; P51787; P23280; Q9ULX7; Q9NR82; Q16790; O43570; P35218; Q8N1Q1; P56696; O43526; Q9Y2D0
DB00359	Sulfadiazine	investigational; approved; vet_approved	5215	-	"For the treatment of rheumatic fever and meningococcal meningitis"	P28223; P41595; P0AC13
DB00358	Mefloquine	investigational; approved	4046	-	"For the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of <i>Plasmodium falciparum</i> (both chloroquine-susceptible and resistant strains) or by <i>Plasmodium vivax</i>. Also for the prophylaxis of <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> malaria infections, including prophylaxis of chloroquine-resistant strains of <i>Plasmodium falciparum</i>."	P23415; D1MGQ2; Q12809; P46663; Q96G91; P69905; P29274; P30542
DB00429	Carboprost Tromethamine	approved	45266502	-	"For aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and in the following conditions related to second trimester abortion: 1. Failure of expulsion of the fetus during the course of treatment by another method, 2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity, 3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus, 4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion. Also for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management."	P34995; P43088; P43116
DB06813	Pralatrexate	investigational; approved	148121	-	"Treatment of relapsed or refractory peripheral T-cell lymphoma. "	P00374; P04818; B0YJ76; Q53Y97
DB00355	Aztreonam	approved	9568617	-	"For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections."	P0AEB2; P08506; P02918; P02919; P05193; P42971; P0AD68; P24228; P0AD65
DB00354	Buclizine	approved	6729	-	"For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness and vertigo (dizziness caused by other medical problems)."	P35367; P11229
DB00425	Zolpidem	approved	5732	-	"For the short-term treatment of insomnia."	P28472; P18507; P18505; P30536; P47870; P14867; P47869; P34903
DB00356	Chlorzoxazone	approved	2733	-	"For the relief of discomfort associated with acute painful musculoskeletal conditions."	O15554; Q12791
DB00351	Megestrol acetate	investigational; approved; vet_approved	11683	-	"For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries."	P04150; P06401; O95977; P03372; P21453
DB00422	Methylphenidate	investigational; approved	4158	-	"For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity."	Q09472; P18440; P18825; Q01959; P18089; P08913; P31645; P23975
DB00421	Spironolactone	approved	5833	-	"Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome."	P04150; P06401; P08235; Q92731; Q9H8P0; Q9P0X4; P10275; O75469; P21860; P19099; P04278; P30874
DB00420	Promazine	approved; vet_approved	4926	-	"Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly."	P35462; P18825; P10635; P28223; Q99250; P11229; Q99720; P21728; Q9NY46; P08912; P08913; P14416; P23975; P08172; P08173; P28335; P41595; P18089; P35368; P35367; P35348; P21917; P22001; P25021; P25100; P20309; P08908; P31645; P35498
DB07615	Tranilast	investigational; approved	5282230	-	"For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis."	P35367; O60760
DB00646	Nystatin	approved; vet_approved	11953884	-	"For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species"	Q6PCB7
DB00645	Dyclonine	approved	3180	-	"Used to provide topical anesthesia of accessible mucous membranes prior to examination, endoscopy or instrumentation, or other procedures involving the esophagus, larynx, mouth, pharynx or throat, respiratory tract or trachea, urinary tract, or vagina. Also used to suppress the gag reflex and/or other laryngeal and esophageal reflexes to facilitate dental examination or procedures (including oral surgery), endoscopy, or intubation. Also used for relief of canker sores, cold sores or fever blister."	Q9UI33; Q9UQD0; Q01118; Q14524; Q9Y5Y9; P35498; Q99250; P35499; Q15858; Q9NY46
DB06219	Dalbavancin	investigational; approved	23724878	-	"Dalbavancin is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by the following gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant strains), S. pyogenes, S. agalactiae, and S. anginosus group (including S. anginosus, S. intermedius, and S. constellatus). It is administered as a 30 minute IV infusion in a two-dose regimen of 1000 mg followed by 500 mg one week later."	P16233
DB00643	Mebendazole	approved; vet_approved	4030	-	"For the treatment of <i>Enterobius vermicularis</i> (pinworm), <i>Trichuris trichiura</i> (whipworm), <i>Ascaris lumbricoides</i> (common roundworm), <i>Ancylostoma duodenale</i> (common hookworm), <i>Necator americanus</i> (American hookworm) in single or mixed infections."	Q9H4B7; Q71U36; P35968; P68371; P00519
DB00642	Pemetrexed	investigational; approved	446556	-	"Used in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy"	B0YJ76; P00374; P04818; P22102; Q53Y97; P31939
DB00641	Simvastatin	approved	54454	-	"For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia. "	P20701; P04035; P05107
DB00640	Adenosine	investigational; approved	60961	-	"Used as an initial treatment for the termination of paroxysmal supraventricular tachycardia (PVST), including that associated with accessory bypass tracts, and is a drug of choice for terminating stable, narrow-complex supraventricular tachycardias (SVT). Also used as an adjunct to thallous chloride TI 201 myocardial perfusion scintigraphy (thallium stress test) in patients who are unable to exercise adequately, as well as an adjunct to vagal maneuvers and clinical assessment to establish a specific diagnosis of undefined, stable, narrow-complex SVT."	P33765; Q8TCG2; P00813; Q9BTU6; P0DMS8; Q8TD43; P29274; P29275; P30542
DB06212	Tolvaptan	approved	443894	-	"Treatment of symptomatic and resistant to fluid restriction euvolemic or hypervolemic hyponatremia associated with congestive heart failure, SIADH, and cirrhosis. "	P37288; P30518
DB06213	Regadenoson	investigational; approved	219024	-	"Diagnostic agent for radionuclide myocardial perfusion imaging (MPI) "	P0DMS8; P33765; P29274; P29275; P30542
DB06210	Eltrombopag	approved	9846180	-	"Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction. "	P06493; P01008; P40238; P12259
DB06211	Doripenem	investigational; approved	73303	-	"Doripenem is indicated in the treatment of complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis, caused by designated susceptible bacteria.
  "	P24228; P08506; P02918; P02919; P0AD68; P0AEB2; P0AD65
DB06216	Asenapine	approved	11954293	-	"Used for treatment in psychosis, schizophrenia and schizoaffective disorders, manic disorders, and bipolar disorders as monotherapy or in combination."	P18825; P28221; P28222; P28223; P08913; P35462; P46098; P47898; P11229; P34969; Q01959; P08912; P08588; P14416; P08172; P28335; P41595; P18089; P35368; P35367; P35348; P21917; P25021; P50406; P20309; P08908; P07550; P21728
DB06217	Vernakalant	investigational; approved	9930049	-	"Indicated for the rapid conversion of recent onset of atrial fibrillation to sinus rhythm in adults for non-surgery patients that lasts for less than 7 days of duration and post-cardiac surgery patients with atrial fibrillation lasting less than 3 days of duration."	P22460; Q14524; Q9UK17; Q12809
DB06742	Ambroxol	investigational; approved	2132	-	"Ambroxol is indicated as ?secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe freely and deeply. "	P31645; Q9Y5Y9; P10635
DB00648	Mitotane	approved	4211	-	"For treatment of inoperable adrenocortical tumours, Cushing's syndrome"	P06401; P10109; P23975; Q01959; P41595; P03372; P05108; P10275; P08913; P31645; P15538
DB03424	Ubenimex	investigational; experimental	72172	-	"An adjuvant therapy used  for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia."	Q01693; P09960
DB11921	Deflazacort	investigational; approved	189821	-	" is a corticosteroid indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients 5 years of age and older"	P04150
DB06589	Pazopanib	approved	10113978	-	"Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy) "	P21802; P52333; P08631; P35968; P07947; P29597; P01889; P22607; Q08881; P07948; P07949; P00519; P07333; Q9UM73; P16234; P17948; P30466; P35916; P06239; P08581; P11362; P22309; P09619; P12931; P22455; Q02763; P36888; P10721; O60674; P04049; Q9UQQ2; P15056; P06241; P05230
DB00498	Phenindione	investigational; approved	4760	-	"For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis."	P00734; Q9BQB6
DB06581	Bevirimat	investigational	457928	-	"Investigated for use/treatment in HIV infection."	P04591; P04585
DB06586	Cetilistat	investigational	9952916	-	"Investigated for use/treatment in obesity."	P16233
DB11691	Naldemedine	investigational; approved	54732242	-	"For the treatment of opioid-induced constipation [FDA Label]."	P41145; P35372; P41143
DB00528	Lercanidipine	investigational; approved	65866	-	"For the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome"	Q06432; Q01668; Q13936; P54289
DB11699	Tropisetron	investigational; approved	656665	-	"For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative. "	P32297; P48167; P23415; Q13639; P18440; P02708; Q8TCU4; P08912; P11230; P07510; P46098; P31645; P17787; P43681; Q07001; P08908
DB11156	Pyrantel	approved; vet_approved	708857	-	"For the treatment of enterobiasis including roundworm (ascariasis), pinworm (enterobius) and hookworm (strongyloides) and hookworm (ancylostoma) in the pyrantel pamoate form [L1893].
 
 Pyrantel is available in various formulations for humans, dogs, and cats as the pamoate (US Pharmacopeia nomenclature) or embonate (European Pharmacopoeia nomenclature) salt, which contains 34.7% pyrantel base combined with pamoic acid [L1893]. [L1900], [A32283].
 
 Pyrantel pamoate (embonate) ingested orally is effective for removal and control of ascarid and hookworm infections in puppies and dogs (adult Toxocara canis, Toxascaris leonina, Ancylostoma tubaeforme, An. braziliense, Uncinaria stenocephala), cats (adult Toxocara cati, Toxa. leonina, An. caninum, An. braziliense, U. stenocephala), horses and ponies (adult and immature Parascaris equorum, adult Strongylus vulgaris, S. edentatus, S. equinus, Cyathostomes (Triodontophorus spp., Cyathostomum spp., Cylicodontophorus spp., Cylicocyclus spp., Cylicostephanus spp., Poteriostomum spp.), Oxyuris equi, Anoplocephala perfoliata), swine (adult Ascaris suum, Oesophagostomum dentatum), and humans (adult A. lumbricoides, Enterobius vermicularis, An. duodenale, Necator americanus) [L1900]."	P11229; Q9HC97
DB03516	Eniluracil	investigational	43157	-	"For the treatment of cancer in combination with 5-fluorouracil."	Q06278; Q12882; P47989
DB09148	Florbetaben (18F)	approved	11501341	-	"Florbetaben is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the brain to estimate ?-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer?s Disease (AD) and other causes of cognitive decline."	P05067
DB09292	Sacubitril	approved	9811834	-	"Used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.  It is usually administered in conjunction with other heart failure therapies, in place of an ACE inhibitor or other ARB."	P08473
DB09291	Rolapitant	investigational; approved	10311306	-	"Rolapitant is indicated in combination with other antiemetic agents in adults for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including, but not limited to, highly emetogenic chemotherapy."	P25103
DB09290	Ramosetron	investigational; approved	108000	-	"For the treatment of nausea and vomiting and diarrhea-predominant irritable bowel syndrome in males."	P46098
DB09297	Paritaprevir	investigational; approved	68498031	-	"When used within the fixed-dose combination product with [DB09296], [DB09183], and [DB00503] as the FDA-approved product Viekira Pak, paritaprevir is indicated for the treatment of HCV genotype 1b without cirrhosis or with compensated cirrhosis, and when combined with [DB00811] for the treatment of HCV genotype 1a without cirrhosis or with compensated cirrhosis.
 
 When used within the fixed-dose combination product with [DB09296] and [DB00503] as the FDA- and Health Canada-approved product Technivie, paritaprevir is indicated in combination with [DB00811] for the treatment of patients with genotype 4 chronic hepatitis C virus (HCV) infection without cirrhosis or with compensated cirrhosis.
 
 When used within the fixed-dose combination product with [DB09296], [DB09183], and [DB00503] as the Health Canada-approved, commercially available product Holkira Pak, paritaprevir is indicated for the treatment of HCV genotype 1b with or without cirrhosis, and when combined with [DB00811] for the treatment of HCV genotype 1a with or without cirrhosis."	Q8IZI9
DB09296	Ombitasvir	investigational; approved	54767916	-	"When used in combination with [DB09297] and [DB00503] (as the fixed dose product Technivie), Ombitasvir is indicated in combination with [DB00811] for the treatment of patients with genotype 4 chronic hepatitis C virus (HCV) infection without cirrhosis [L866].
 
 When used in combination with [DB09297], [DB00503], and [DB09183] (as the fixed dose product Viekira Pak), Ombitasvir is indicated for the treatment of HCV genotype 1b and ,when combined with [DB00811], for the treatment of HCV genotype 1a [FDA Label]"	Q8IZI9
DB09295	Talniflumate	approved	48229	-	"Talnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis [L1409], and has also been studied for the management of cystic fibrosis [L1403]."	A8K7I4; P51800
DB05262	Oxypurinol	investigational	4644	-	"Intended for the treatment of congestive heart failure and hyperuricemia."	P47989
DB11090	Potassium nitrate	approved	24434	-	"For the relief of tooth sensitivity, and is also used as a pesticide, insecticide, as a food additive, and a rodenticide [L1751, L1754, L1757].
 "	Q12809
DB05260	Gallium nitrate	investigational; approved	61635	-	"For the treatment of hypercalcemia. Also intended for the treatment of non-hodgkin's lymphoma."	P21281; P01584; P02818; Q7LG56; P23921; P31350
DB05266	Ibudilast	investigational; approved	3671	-	"For the treatment of multiple sclerosis, asthma, and cerebrovascular disease."	Q14432; P27815; P05231; P01584; O76074; Q08493; Q07343; Q08499
DB05265	Ecabet	investigational; approved	65781	-	"For the treatment of reflux oesophagitis and peptic ulcer disease."	P0DJD8; P20142; Q8NFA2; P18314
DB05465	Tandutinib	investigational	3038522	-	"Investigated for use/treatment in leukemia (myeloid)."	P07333; P09619; P10721; Q96GD4; P36888; P40238; Q9GZP0
DB09140	Oxygen	approved; vet_approved	977	-	"Oxygen therapy in clinical settings is used across diverse specialties, including various types of anoxia, hypoxia or dyspnea and any other disease states and conditions that reduce the efficiency of gas exchange and oxygen consumption such as respiratory illnesses, trauma, poisonings and drug overdoses. Oxygen therapy tries to achieve hyperoxia [L745] to reduce the extent of hypoxia-induced tissue damage and malfunction. "	P68871; D1MGQ2; P00395; P69905; Q9Y5S8
DB05460	Ezatiostat	investigational	5310939	-	"Investigated for use/treatment in myelodysplastic syndrome."	P09211
DB05461	OPC-28326	investigational	15942713	-	"Investigated for use/treatment in peripheral vascular disease and raynaud's disease."	P18825; P41595; P18089
DB00737	Meclizine	approved	4034	-	"For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness."	P35367; Q14994
DB05861	Tasquinimod	investigational	54682876	-	"Investigated for use/treatment in prostate cancer."	P56524
DB05864	PPI-2458	investigational	6918653	-	"Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors."	P50579
DB05868	Ciluprevir	investigational	9853710	-	"Investigated for use/treatment in hepatitis (viral, C)."	P26664
DB05869	Ethyl pyruvate	investigational	12041	-	"Investigated for use/treatment in burns and burn infections, cardiac surgery, inflammatory disorders (unspecified), ischemic reperfusion injury, and sepsis and septicemia."	P09429; P01375
DB12865	Etelcalcetide	investigational; approved	71511839	-	"Etelcalcetide is a calcium-sensing receptor agonist indicated for: 
 Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis."	P41180
DB00499	Flutamide	investigational; approved	3397	-	"For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate"	P10275; Q9BYF1; O75469; P35869
DB11256	Levomefolic acid	investigational; approved	444412	-	"For the treatment and prevention of folate deficiency and for use as an antidote against folic acid antagonists. Contained in oral contraceptives to reduce the risk of neural tube defects arising from folic acid deficiency for pregnant women who conceived during use or shortly after the discontinuation of the product. Being studied for use as a treatment for cardiovascular diseases [A19273] and adjunct therapy for patients undergoing antidepressant pharmacotherapy [A19271, A19272]."	P04818; Q53Y97
DB01440	Gamma Hydroxybutyric Acid	illicit; investigational; approved	3037032	-	"Used as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance. "	Q9HAB3; P18505
DB01520	Tenocyclidine	illicit; investigational; experimental	62751	-	"Because of its high affinity for the phencyclidine binding site on the NMDA receptor, the 3H radiolabelled form of tenocyclidine is widely used in research into NMDA receptors."	O15399; O60391; Q13224; Q12879; Q8TCU5; Q14957
DB01444	Dimethylthiambutene	illicit; experimental	10668	-	"Dimethylthiambutene is an opioid analgesic previously used in moderate pain relief."	P35372; P41143
DB00319	Piperacillin	approved	43672	-	"For the treatment of polymicrobial infections."	P0AEB2; P08506; P0A3M6; P02918; P02919; P0AD68; P24228; P0AD65
DB01155	Gemifloxacin	investigational; approved	9571107	-	"For the treatment of bacterial infection caused by susceptible strains such as <i>S. pneumoniae</i>, <i>H. influenzae</i>, <i>H. parainfluenzae</i>, or <i>M. catarrhalis</i>, <i>S. pneumoniae</i> (including multi-drug resistant strains [MDRSP]), <i>M. pneumoniae</i>, <i>C. pneumoniae</i>, or <i>K. pneumoniae</i>."	P72524; P72525; Q59961; P0A4L9; P43700; P43702; Q02880
DB05737	Varespladib methyl	investigational	9886917	-	"Investigated for use/treatment in atherosclerosis and coronary artery disease."	P39877; O15496; P14555
DB05045	Obinepitide	investigational	131704295	-	"Investigated for use/treatment in obesity."	P49146; P50391
DB00771	Clidinium	approved	2784	-	"For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome."	P08172; P11229; P20309
DB05738	Vapitadine	investigational	9842252	-	"Investigated for use/treatment in atopic dermatitis."	P35367
DB01151	Desipramine	investigational; approved	2995	-	"For relief of symptoms in various depressive syndromes, especially endogenous depression. It has also been used to manage chronic peripheral neuropathic pain, as a second line agent for the management of anxiety disorders (e.g. panic disorder, generalized anxiety disorder), and as a second or third line agent in the ADHD management. "	Q7RTT9; P18825; P10635; P28222; P28223; Q99250; P11229; Q12809; Q01959; Q9NY46; P18089; P08912; P08913; P14416; P23975; P08172; P08173; P28335; P41595; P08588; P35498; P31645; P35367; P35348; P17405; P25100; P20309; P08908; P07550; P21728
DB11596	Levoleucovorin	investigational; approved	149436	-	"Levoleucovorin is indicated for use as rescue therapy following high-dose methotrexate in the treatment of osteosarcoma or for diminishing the toxicity associated with inadvertent overdosage of folic acid antagonists. Levoleucovorin, as the product Fusilev (FDA, dosed at one-half the usual dose of racemic d,l-leucovorin), has an additional indication for use in combination chemotherapy with 5-fluorouracil in the palliative treatment of patients with advanced metastatic colorectal cancer (although they should not be mixed in the same infusion as a precipitate may form)."	P0A827; P0ABQ4
DB11591	Bilastine	investigational; approved	185460	-	"For symptomatic relief of nasal and non-nasal symptoms of seasonal rhinitis in patients 12 years of age and older and for symptomatic relief in chronic spontaneous urticaria in patients 18 years of age and older [FDA Label]."	P35367
DB11590	Thimerosal	approved	16684434	-	"Used as preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes vaccines [L1671, L1672, L1673]."	P22748; P07451; P43166; P18825; P10635; P23280; Q9ULX7; Q9NR96; P18089; Q9UPY5; P08913; Q99707; O43570; P35218; Q8N1Q1; P31645; P54710; P23975; P35462; Q9Y2D0
DB05289	Tarenflurbil	investigational	92337	-	"Investigated for use/treatment in alzheimer's disease and prostate cancer."	Q96BI3; Q92542; Q9NZ42; Q8WW43; P49768; Q9Y6K9; P49810
DB01299	Sulfadoxine	investigational; approved	17134	-	"Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well.
 Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected. "	P13922
DB01298	Sulfacytine	approved	5322	-	"Used orally in the treatment of acute urinary tract infections."	P0AC13
DB12001	Abemaciclib	investigational; approved	46220502	-	"* Indicated in combination with fulvestrant for the treatment of women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer with disease progression following endocrine therapy. 
 
 * Inidicated as monotherapy for the treatment of adult patients with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting. "	Q00534; P11802
DB00315	Zolmitriptan	investigational; approved	60857	-	"For the acute treatment of adult migraine with or without auras."	P28566; Q13639; P28221; P28222; P30939; P08908
DB01291	Pirbuterol	approved	4845	-	"For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma."	P07550; O60479; P08588; P17342
DB01297	Practolol	approved	4883	-	"Used in the emergency treatment of cardiac arrhythmias."	Q9UDT6; P08588
DB01296	Glucosamine	investigational; approved	439213	-	"Glucosamine is usually used in the treatment of osteoarthritis, although its efficacy is still in question."	P01579; P33673; Q00653; P14780; P01375
DB01295	Bevantolol	approved	2372	-	"For the treatment of angina pectoris and hypertension."	P07550; P08588; P35348
DB01294	Bismuth Subsalicylate	approved; vet_approved	16682734	-	"Used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract."	P02768; P35354; P23219
DB09112	Nitrous acid	investigational; approved	23668193	-	"For sequential use with sodium thiosulfate for the treatment of acute cyanide poisoning that is judged to be life-threatening [FDA Label]."	P00918; D1MGQ2; P00915; P02144; P68871; P69905
DB09251	Phenoxypropazine	withdrawn	71467	-	"For the treatment of depression."	P21397; P27338
DB09115	Diiodohydroxyquinoline	approved	3728	-	"Used in the treatment of amoebiasis."	P00533; P06241; P04626; P06239
DB09116	Calcium carbimide	approved; withdrawn	56955933	-	"Calcium carbimide has not been approved by the FDA but the intended indication is for the treatment of alcoholism.[T74] This medication was marketed in Canada, United Kingdom and Europe under the trade name of Temposil for the sole use of alcoholism treatment.[L1114]"	P48448
DB09118	Stiripentol	approved	5311454	-	"Indicated for use in conjunction with clobazam and valproate as adjunctive therapy of refractory generalized tonic-clonic seizures in patients with severe myoclonic epilepsy in infancy (SMEI, Dravet?s syndrome) whose seizures are not adequately controlled with clobazam and valproate."	Q9UN88; P30531; P00338; P08684; Q5U077; P07195
DB09119	Eslicarbazepine acetate	approved	179344	-	"Eslicarbazepine acetate is indicated as adjunctive therapy in the treatment of partial-onset seizures that are not adequately controlled with conventional therapy in epileptic patients. "	Q9Y5Y9; Q14524; Q9UQD0; Q01118; Q99571; P35499; P35498; Q99250; Q9UI33; Q15858; Q9NY46
DB01349	Tasosartan	approved	60919	-	"Tasosartan is infrequently in the treatment of hypertension and heart failure."	P50052; P30556
DB01348	Spirapril	approved	5311447	-	"Spirapril is an ACE inhibitor class drug used to treat hypertension."	P12821
DB01345	Potassium	investigational; approved	5462222	-	"Potassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions. "	P05023
DB05137	Lobeline	investigational	101616	-	"Investigated for use/treatment in addictions."	Q9UGM1; Q494W8; Q9GZZ6; P36544
DB05134	Tanespimycin	investigational	6505803	-	"Investigated for use/treatment in leukemia (myeloid) and solid tumors."	P08238; P07900; K9JA46; P08581
DB01340	Cilazapril	approved	56330	-	"Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure."	Q9BYF1; P12821
DB01342	Forasartan	experimental	132706	-	"For the treatment of hypertension."	P30556
DB12483	Copanlisib	investigational; approved	24989044	-	"Indicated for the treatment of adult patients with relapsed follicular lymphoma (FL) who have received at least two prior systemic therapies."	P27986; P42338; P48736; P42336; Q92569; O00459; Q8WYR1; O00329
DB12267	Brigatinib	investigational; approved	68165256	-	"The anaplastic lymphoma kinase positive, metastatic non-small cell lung cancer (ALK+ NSCLC), represents only 3-5% of the NSCLC cancer cases, but the ALK mutation, overexpression and presence in several oncogenic fusion proteins in solid and hematologic tumors have pointed out the importance as well as its potential as a cancer therapy target.[A31311] The ALK-related cases of NSCLC are associated with the presence of the fusion gene EML4-ALK which fused the ALK protein with the echinoderm microtubule-associated protein like-4 whose original function is the correct formation of microtubules.[A31313] The presence of the aberrant fusion protein results in abnormal signaling that provokes increased cell growth, proliferation and survival.[A31316] Crizotinib is indicated for the treatment of such cases but the presence of ALK kinase domain mutations confer resistance to the treatment. Thus, brigatinib is indicated for the treatment of patients with ALK+ NSCLC with intolerance to Crizotinib.[A31314]"	P00533; P08069; Q9UM73; P04626; P06213; Q15303; P08581; P36888; P00519
DB00851	Dacarbazine	investigational; approved	5351166	-	"For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents."	Q14181; P52209; P07306
DB00500	Tolmetin	approved	5509	-	"For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis."	P35354; P23219; P15121
DB00501	Cimetidine	investigational; approved	2756	-	"For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion."	Q9BXB1; P28223; P25021; Q96FL8; O75473; Q7RTT9
DB00502	Haloperidol	approved	3559	-	"For the management of psychotic disorders (eg. schizophrenia) and delirium, as well as to control tics and vocal utterances of Tourette's syndrome (Gilles de la Tourette's syndrome). Also used for the treatment of severe behavioral problems in children with disruptive behavior disorder or ADHD (attention-deficit hyperactivity disorder). Haloperidol has been used in the prevention and control of non-retractable nausea and vomiting."	Q12809; Q99250; P18825; P28221; P28222; P28223; Q99705; P35372; P35462; P08908; P11229; Q99720; P34969; P21728; P35348; P18089; P08912; P08913; P14416; P23975; P35368; P28335; P41595; Q05940; P21918; O95259; P07550; P35367; Q9NY46; P21917; P25021; Q13224; P25100; P20309; P35498; P31645; P01011
DB00503	Ritonavir	investigational; approved	392622	-	"Indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection."	P41145; P10635; P35372; P20815; Q8IZI9; O75469; P08684; P37288
DB00504	Levallorphan	approved	5359371	-	"For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids."	P41145; P35372; Q15822
DB00505	Tridihexethyl	withdrawn	20299	-	"Used as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus"	P08172; P11229; P20309
DB00507	Nitazoxanide	investigational; approved; vet_approved	41684	-	"For the treatment of diarrhea in adults and children caused by the protozoa <i>Giardia lamblia</i>,  and for the treatment of diarrhea in children caused by the protozoan,  <i>Cryptosporidium parvum</i> [FDA label].
 
 Nitazoxanide has not been shown to be superior to placebo medication for the management of diarrhea caused by Cryptosporidium parvum in patients with HIV/immunodeficiency [FDA label, A31973, A31976]. "	Q968X7; P15121
DB00508	Triflupromazine	approved; vet_approved	5568	-	"Used mainly in the management of psychoses. Also used to control nausea and vomiting."	P08172; P11229; P28223; P41595; P21728; Q9Y2T6; P14416
DB00509	Dextrothyroxine	investigational; approved	8730	-	"Used to lower high cholesterol levels in the blood."	P10827; P07202; P10828
DB00728	Rocuronium	approved	441290	-	"For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation."	P08172; Q15822; P11230; P07510; P46098; P02708; Q04844; Q07001
DB00729	Diphemanil Methylsulfate	withdrawn; approved; vet_approved	6126	-	"Used in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration)."	O60755; O43603; P11229; P20309
DB13191	Phosphocreatine	nutraceutical	9548602	-	"Phosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates. Its primary utility within the body is to serve in the maintanence and recycling of adenosine triphosphate (ATP) for muscular activity like contractions.
 
 Given this utility of phosphocreatine to recycle ATP, the most plausible therapeutic potentials for its use involve conditions caused by energy shortage or by increased energy requirements - such as in ischemic stroke and other cerebrovascular diseases. It is important to note however that relatively little clinical research has been done to significantly further the evidence for any such indications, although it is administered intravenously for cardiovascular conditions in some countries.
 
 Additionally, because phosphocreatine is not regulated as a controlled substance it is taken as a supplement by some professional athletes as a means to perhaps increase short bursts of muscle strength or energy for professional athletics. "	V9HWH2; Q14353; P12277; P06732; P12532; P17540; P48029
DB00720	Clodronic Acid	investigational; approved; vet_approved	25419	-	"For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors."	P12236; P12235; P05141; Q9BYT1
DB00721	Procaine	investigational; approved; vet_approved	4914	-	"Used as a local anesthetic primarily in oral surgery"	Q9UGI6; P27338; Q9UQD0; Q92736; Q99250; P46098; Q15822; Q14524; P02708; Q01959; Q15858; P21817; Q9UHD2; Q01118; Q9UI33; P35498; Q9NY46; P11230; Q8TCU5; P35499; Q9Y5Y9; Q14164; Q07001
DB00722	Lisinopril	investigational; approved	5362119	-	"For the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or &beta,-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy. "	Q9BYF1; P12821
DB00723	Methoxamine	investigational; approved	6082	-	"Indicated for the treatment and management of hypotension."	P35368; P35348; P25100; P47211
DB00724	Imiquimod	investigational; approved	57469	-	"For the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above."	P25021; P29274; Q9NR97; P25100; Q9NYK1
DB00725	Homatropine Methylbromide	approved	6646	-	"Used in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcers, gastric ulcers and duodenal ulcers, to reduce further gastric acid secretion and delay gastric emptying."	P08172; P08173; P08912; P11229; P20309
DB00726	Trimipramine	approved	5584	-	"For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance"	P28223; P08909; P10635; P28335; P28221; Q01959; P18089; P21918; P08912; P08913; P13945; P25100; P14416; P46098; P35367; P31645; P23975; P35348; P35368; P08908
DB00727	Nitroglycerin	investigational; approved	4510	-	"For the prevention of angina"	P16066; O75343; P00533; Q02153; Q02108; P33402; P29400
DB00410	Mupirocin	investigational; approved; vet_approved	446596	-	"For the treatment of <i>Staphylococci</i> nasal carriers."	P41972; Q99YW3
DB01125	Anisindione	approved	2197	-	"For the prophylaxis and treatment of venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the prophylaxis and treatment of pulmonary embolism, and as an adjunct in the treatment of coronary occlusion."	P38435; P02774
DB01124	Tolbutamide	investigational; approved	5505	-	"For treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise."	Q09428; Q14654; P48048
DB01127	Econazole	approved	3198	-	"For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Trichophyton tonsurans</i>, <i>Microsporum canis</i>, <i>Microsporum audouini</i>, <i>Microsporum gypseum</i>, and <i>Epidermophyton floccosum</i>, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor."	P10613; P41145; P10635; P28223; P35372; O75469; Q9NQA5; P35462; P00533; P11229; Q99720; Q01959; P21728; P08913; P14416; P29274; P30542; P08172; P08173; P22303; P41143; P28335; P41595; P08588; P08684; P18089; O94759; P23975; P13945; P05093; P04626; P25021; P25103; P25100; P20309; P08908; P31645; P06241; P21554
DB01126	Dutasteride	investigational; approved	6918296	-	"For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for surgery."	P31213; P23415; Q9H8P0; P18405
DB01121	Phenacemide	approved	4753	-	"Used to control certain seizures in the treatment of epilepsy."	Q14524; Q15858; Q9UQD0; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q9UI33; Q9BXA5; Q9NY46
DB06824	Triethylenetetramine	investigational; approved	5565	-	"Trientine is a copper chelator used in the treatment of Wilson's disease as an alternative to D-penicillamine. It tends to be used in patients who are experiencing serious adverse effects from penicillamine therapy or intolerance of penicillamine. "	P00918; P22748; Q9Y2D0; P43166; P23280; Q9ULX7; P00915; Q16790; O43570; P35218; P07451
DB06827	Viomycin	approved	3037981	-	"Viomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis."	P9WH83; P9WH79; P9WH81; P9WH87; P9WH85; P9WH89; A5U0A0; C1AL48; P9WH25; P9WH27; P0A5X1; A1KGI1; P9WH29; P9WHC3; P9WH61; P9WHC1; P9WH63; P9WHC7; P9WH65; P9WHC5; P9WH41; P9WHC9; P9WH43; P9WH49; P9WHE5; P9WHE7; P9WH33; P9WHE3; P9WHA1; P9WHE1; P9WHA3; P9WH67; P9WHA5; P9WHA7; B2HSN0; P9WH91; P9WH93; P9WH95; P9WH94; P9WH97; P9WH47; P9WH99; A0QL02; P9WH31; P9WH45; P9WH37; A5U019; P9WH35; P9WH51; P9WH39; P9WH53; A1KGJ5; P66070; P9WH55; P9WHB5; P9WH57; P9WHB7; A1KGB4; P9WHB1; P9WHA9; Q73S98; P0A5W3; P9WHB3; P9WH59; P9WHB9; P9WH66; P9WHD7; P9WHD5; P9WHD3; A5U086; P9WHD1; C1AL34; P9WHD8; P9WHD9
DB01122	Ambenonium	approved	2131	-	"Ambenonium is used to treat muscle weakness due to muscle disease (myasthenia gravis)."	P22303
DB00342	Terfenadine	approved; withdrawn	5405	-	"For the treatment of allergic rhinitis, hay fever, and allergic skin disorders."	P51589; P18825; P28223; P35462; P00533; P11229; Q12809; Q01959; P21728; P14416; P23975; P08172; P08173; P28335; P41595; O95259; P35368; P35367; P35348; P51681; P25100; P20309; P08912; P06241
DB00435	Nitric Oxide	approved	145068	-	"For the treatment of term and near-term (&gt,34 weeks) neonates with hypoxic respiratory failure"	P04731; O75343; P16066; Q02153; Q02108; P21728; P33402; P14902
DB00340	Metixene	approved	4167	-	"Used for the symptomatic treatment of parkinsonism."	P08172; P08173; P11229; P28335; P08912; P20309
DB00437	Allopurinol	approved	2094	-	"For the treatment of hyperuricemia associated with primary or secondary gout. Also indicated for the treatment of primary or secondary uric acid nephropathy, with or without the symptoms of gout, as well as chemotherapy-induced hyperuricemia and recurrent renal calculi."	P47989
DB00430	Cefpiramide	approved	636405	-	"For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa."	P24228; P08506; P02918; P02919; Q07806; P10276; P0AD68; P0AEB2; P0AD65
DB00431	Lindane	approved; withdrawn	727	-	"For the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies."	P23416; P06401; P48167; P23415; P18507; P18505; P24046; P03372; O75311; P28472; O75469; P14867; Q16445
DB00344	Protriptyline	approved	4976	-	"For the treatment of depression. "	P08172; P08173; P28223; P11229; P14735; Q12809; Q01959; P41595; P08912; P20309; P10635; P35367; P31645; P28335; P23975; P21554
DB00433	Prochlorperazine	approved; vet_approved	4917	-	"For the symptomatic management of psychotic disorders, short term management of nonpsychotic anxiety in patients with generalized anxiety disorder, and for the control of severe nausea and vomiting of various causes."	P18825; P10635; P28223; P35462; P08908; P11229; Q99720; Q12809; Q01959; P21728; P08913; P14416; P23975; P08172; P08173; P28335; P41595; P18089; P35367; P35348; P21917; P25100; P20309; P08912; P31645; P06241
DB00654	Latanoprost	investigational; approved	5311221	-	"For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension."	P34995; P43088; P43115
DB00655	Estrone	approved	5870	-	"For management of perimenopausal and postmenopausal symptoms."	Q92731; P41595; P03372; P10275; P04278; P31645; P11511
DB00656	Trazodone	investigational; approved	5533	-	"For the treatment of depression."	Q12809; P18825; P28221; P28223; P35462; Q99720; P34969; Q01959; P21728; P08913; P14416; P23975; P28335; P18089; P41595; P35368; P35367; P35348; P25021; P25100; P08908; P31645
DB00657	Mecamylamine	investigational; approved	4032	-	"For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension"	Q15825; P32297; Q494W8; Q15822; P30926; P02708; Q05901; P36544; P17787; P43681
DB00650	Leucovorin	approved	6006	-	"For the treatment of osteosarcoma (after high dose methotrexate therapy). Used to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists, and to treat megaloblastic anemias due to folic acid deficiency. Also used in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer."	B0YJ76; Q02750; P00374; P04818; Q53Y97; P45985; P46734
DB00651	Dyphylline	approved	3182	-	"For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema."	Q13946; P27815; Q14432; Q9NP56; Q08493; Q07343; Q08499; P29274; P30542
DB00652	Pentazocine	approved; vet_approved	441278	-	"For the relief of moderate to severe pain."	P41145; P35372; Q99720; P55055; P41143
DB00653	Magnesium sulfate	investigational; approved; vet_approved	24083	-	"Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant."	Q06432; P54289; Q08289; Q13936; Q02641; Q13698
DB06771	Besifloxacin	approved	10178705	-	"Treatment of bacterial conjunctivitis. Bacterial isolates that are susceptible to besifloxacin include: CDC coryneform group G, Corynebacterium pseudodiphtheriticum, Corynebacterium striatum, Haemophilus influenzae, Moraxella lacunata, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis, Staphylococcus lugdunensis, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumoniae, Streptococcus salivarius* "	P72524; P72525; P0AFI2; P0AES4; P0AES6; P43700; P43702; P20083
DB09495	Avobenzone	investigational; approved	51040	-	"Sun protection factor, added in the sunscreen products for its wide spectrum ultraviolet absorption properties. "	P14679
DB06772	Cabazitaxel	approved	9854073	-	"For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen."	Q9BVA1; P68366; P68363; P68371; Q5SU16; Q9BQE3; Q6PEY2; Q3ZCM7; Q9H4B7; P07437; Q13885; Q13509; Q13748; Q71U36; Q9BUF5; P04350
DB06775	Carglumic Acid	approved	121396	-	"For the treatment of acute and chronic hyperammonaemia in patients with N-acetylglutamate synthase (NAGS) deficiency. This enzyme is an important component of the urea cycle to prevent build up of neurotoxic ammonium in the blood. "	P31327; Q8N159
DB00659	Acamprosate	investigational; approved	71158	-	"For the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation"	O60391; O15399; P47869; P34903; P78334; Q05586; P18507; P18505; Q16445; P41594; Q8N1C3; P14867; Q14957; O00591; Q9UN88; P28472; O14764; P48169; Q13224; Q12879; Q8TCU5; P47870; P31644; Q99928
DB06777	Chenodeoxycholic acid	approved	10133	-	"Chenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones."	Q8TDU6; Q96RI1; P21462; O75469; P52895
DB04889	Bicifadine	investigational	47953	-	"For the treatment of pain."	P31645; P23975; P00390; P14416
DB04888	Bifeprunox	investigational	208951	-	"Bifeprunox is being evaluated for the treatment of schizophrenia, psychosis, and Parkinson's disease."	P34969; P35462; P28223; P14416; P08908; P28335
DB04881	Elacridar	investigational	119373	-	"For the treatment of solid tumors."	P08183
DB04552	Niflumic Acid	approved	4488	-	"Used in the treatment of rheumatoid arthritis."	P04054; P35523; Q5XXA6; P51787; O60656; P23219; P35354; P51800; P51801; O60733; Q6UVM3; P02766; P47712
DB04883	Darusentan	investigational	177236	-	"For the treatment of congestive heart failure and hypertension."	P24530; P25101
DB04882	Edotecarin	investigational	9808998	-	"Clinical studies with edotecarin have shown activity in subjects with colorectal cancer, esophageal cancer and other solid tumors."	P11387
DB04885	Cilansetron	investigational	6918107	-	"For the treatment of symptoms associated with irritable bowel syndrome."	O95264; P46098
DB04884	Dapoxetine	investigational	71353	-	"For the treatment of premature ejaculation."	P31645; P28222; P28335; P08908
DB04886	Calanolide A	investigational	64972	-	"For use in combination treatment of HIV infection (AIDS)."	P03369
DB00237	Butabarbital	illicit; approved	2479	-	"For short-term treatment of insomnia and anxiety disorders"	Q9UN88; Q13002; P18507; P18505; P47869; Q99928; Q494W8; P34903; P14867; Q8N1C3; P43681; P47870; P28472; P36544; P31644; P48169; O14764; Q16445; O00591; P42262; P78334
DB00234	Reboxetine	investigational; approved	127151	-	"For the treatment of clinical depression."	P31645; P28335; P23975; Q01959
DB00235	Milrinone	approved	4197	-	"Indicated for the treatment of congestive heart failure."	P27815; O00408; Q14432; O76074; Q08493; Q07343; Q13370; Q08499
DB00232	Methyclothiazide	approved	4121	-	"For use in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension. Also used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy."	P00918; P22748; Q13621; P00915; P55017; Q99572
DB00233	Aminosalicylic Acid	approved	4649	-	"For the treatment of tuberculosis"	O15111; P09917; P9WNX1; P9WNC7; Q9NZK7; P35354; P23219
DB00230	Pregabalin	illicit; investigational; approved	5486971	-	"Pregabalin is used for the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and postherpetic neuralgia. It is not approved for the management of fibromyalgia or as adjuntive therapy for adult partial onset seizures.[FDA label] "	Q9UBN1; O00555; Q06432; Q9Y698; O60840; O60359; O95180; Q08289; Q9P0X4; Q7Z3S7; O43497; P62955; Q01668; Q9UF02; Q15878; Q8WXS5; P54284; Q02641; O00305; Q9BXT2; Q9NY47; Q8IZS8; P54289; Q00975; Q13936; Q13698
DB00231	Temazepam	investigational; approved	5391	-	"For the short-term treatment of insomnia (generally 7-10 days)."	O43603; P24046; A8MPY1; P47869; Q16445; P78334; P30536; P18507; P18505; Q8N1C3; P14867; O00591; P47211; Q9UN88; P28472; P28476; O14764; P48169; P34903; P47870; P31644; Q99928
DB01605	Pivmecillinam	approved	115163	-	"Used to treat infections due to mecillinam-sensitive organisms such as urinary tract infections, salmonellosis and typhoid fever."	Q8XJ01
DB00239	Oxiconazole	approved	5353853	-	"For treatment of dermal fungal infection."	Q8WUX1; P10613; Q8IY34; P18825; P10635; P28223; O75469; P35462; Q04782; P11229; Q8N697; Q01959; P21728; P08913; P23975; P22303; P41143; P18089; P08684; P41595; P13945; P20309; P08908; P31645
DB06176	Romidepsin	investigational; approved	57515973	-	"For the treatment of cutaneous T-cell lymphoma (CTCL) or/and peripheral T-cell lymphoma (PTCL) in patients who have received at least one prior systemic therapy. These indications are based on response rate. Clinical benefit such as improvement in overall survival has not been demonstrated. "	O75376; Q9UBN7; Q9Y618; P56524; Q8WUI4; Q9BY41; Q13547; Q6IT96; Q92769; Q969S8; Q96DB2; P33527; Q9UQL6; Q9UKV0; O15379
DB11915	Valbenazine	investigational; approved	24795069	-	"For the treatment of tardive dyskinesia in adults [FDA Label]."	P10635; Q05940
DB04957	Azimilide	investigational	9571004	-	"Investigated for use/treatment in arrhythmia and atrial fibrillation."	Q12809; P51787; P15382
DB04954	Tecadenoson	investigational	158795	-	"Investigated for use/treatment in arrhythmia and atrial fibrillation."	P30542
DB04953	Ezogabine	investigational; approved	121892	-	"Adjuvant treatment of partial-onset seizures. "	O43525; P56696; P51787; Q9NR82; O43526
DB04951	Pirfenidone	investigational; approved	40632	-	"For the treatment of idiopathic pulmonary fibrosis (IPF)."	Q15759; P53778; Q16539; P01375; P09958; O15264
DB00550	Propylthiouracil	investigational; approved	657298	-	"Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease)."	P07202; P49895
DB00953	Rizatriptan	approved	5078	-	"For treatment of acute migraine attacks with or without aura."	P28566; P28335; P10635; P25445; P28223; P30939; P28221; P28222; P08908
DB00776	Oxcarbazepine	approved	34312	-	"For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy."	Q9UI33; Q14524; Q9UQD0; Q01118; P30466; Q9Y5Y9; P35498; Q99250; P35499; P01889; Q15858; Q9NY46
DB05327	Ranirestat	investigational	153948	-	"Investigated for use/treatment in neuropathy (diabetic)."	P15121
DB00951	Isoniazid	investigational; approved	3767	-	"For the treatment of all forms of tuberculosis in which organisms are susceptible."	Q06187; P9WGR1; P20815; P08684; P9WIE5; Q01718; P9WNX1
DB00899	Remifentanil	approved	60815	-	"For use during the induction and maintenance of general anesthesia."	P41145; P35372; P41143
DB06554	Gaboxadol	investigational	3448	-	"Investigated for use/treatment in sleep disorders and insomnia."	P24046; P34903; P18505; A8MPY1; P28476; P48169; P14867; Q8N1C3; P31644; P47870; P28472; P47869; O14764; Q16445; O00591; P78334
DB00957	Norgestimate	investigational; approved	6540478	-	"For the prevention of pregnancy"	P10275; P06401; P03372
DB00956	Hydrocodone	illicit; approved	5284569	-	"For relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants."	P41145; P35372; P41143
DB00678	Losartan	approved	3961	-	"May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors."	P50052; P27815; Q14432; P12821; Q13370; Q08493; Q07343; Q08499; P30556
DB06480	Prucalopride	approved	3052762	-	"Investigated for use/treatment in constipation, ileus, and pediatric indications."	P46098; P18440; Q13639
DB00674	Galantamine	approved	9651	-	"For the treatment of mild to moderate dementia of the Alzheimer's type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer's disease."	Q15825; P32297; P22303; Q9GZZ6; P06276; Q15822; P43681; Q9UGM1; P11230; P30532; Q05901; P10635; P02708; P36544; Q494W8; P24530; Q04844; P17787; P30926; Q07001; P07510
DB09280	Lumacaftor	approved	16678941	-	"When given in combination with [DB08820] as the fixed dose combination product Orkambi, lumacaftor is indicated for the treatment of cystic fibrosis (CF) in patients age 6 years and older who are homozygous for the F508del mutation in the CFTR gene [FDA Label]."	P13569
DB05928	Dovitinib	investigational	9977819	-	"Investigated for use/treatment in multiple myeloma and solid tumors."	P00533; P36888; P07333; P21802; P22607; P09619; P16234; P35968; P35916; P11362; P06213; P17948; P10721
DB00675	Tamoxifen	approved	2733526	-	"Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ. "	P41145; P04278; P28223; Q01959; P10275; P35354; P62508; P04626; P35462; P35372; P00533; Q05513; P11229; Q99527; Q99720; Q12809; Q15125; P03372; P21728; P08913; P06239; Q92731; P23975; P12259; P30542; P08172; P08173; P14416; P41143; Q5S007; P28335; P18089; P08588; P41595; P31645; P06401; P23219; P13945; P00734; P08912; P29274; P25021; P25103; P25100; P30411; P20309; P08908; O75469; P06241
DB09285	Morniflumate	approved	72106	-	"
 Morniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for the treatment of pain associated with ear, nose, throat (ENT) and gastrointestinal inflammatory conditions in children.  Morniflumate is a well established NSAID that has been in use for over three decades in Italy (particularly for the treatment of upper respiratory tract infections in children), France, Belgium, Austria, Switzerland, Spain and Portugal, it has a generally favorable tolerability profile."	P21731; Q15722
DB09286	Pipamperone	investigational; approved	4830	-	"Treatment of chronic psychoses and states of aggressiveness of various origins [L1515]."	P28335; P14416; P18825; P28221; P28222; P28223; P41595; P18089; P35367; P21728; P08588; P25100; P35462; P08908; P21917; P07550; P08913
DB09288	Propacetamol	investigational; approved	68865	-	"Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy.[L1511]"	Q8NER1; P35354; P23219; P21554
DB09289	Tianeptine	investigational; approved	68870	-	"Used primarily in the treatment of major depressive disorder and anxiety [A31969]. It is currently being studied for fibromyalgia pain treatment [L1426]."	P31645; P35372; P42261; P21917; P08908
DB00897	Triazolam	investigational; approved	5556	-	"For the short-term treatment of insomnia."	Q9UN88; P24046; P28472; P18507; P28476; P18505; O00591; A8MPY1; O14764; P48169; Q16445; Q8N1C3; P31644; P14867; P08684; P30536; P47869; P34903; Q99928; P47870; P78334
DB05458	Pozanicline	investigational	178052	-	"Investigated for use/treatment in Alzheimer's disease, Attention Deficit/Hyperactivity Disorder (ADHD), and Schizophrenia and schizoaffective disorders."	Q15825; P17787; P43681; P30532
DB00894	Testolactone	investigational; approved	13769	-	"For palliative treatment of advanced breast cancer in postmenopausal women."	P11511
DB00895	Benzylpenicilloyl Polylysine	approved	45266800	-	"For use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G)."	P30273; P12319
DB05855	Rivanicline	investigational	5310967	-	"Investigated for use/treatment in ulcerative colitis."	P17787; P43681; P10145
DB05630	Sodium stibogluconate	investigational; approved	56927674	-	"For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment in cancer/tumors (unspecified) and solid tumors."	P29350; P11387
DB08887	Icosapent ethyl	investigational; approved; nutraceutical	9831415	-	"Icosapent ethyl is used as adjunct therapy to reduce triglyceride (TG) levels in adults with severe (>500 mg/dL) hypertriglyceridemia. "	Q03181; O75907; P35354; P23219; P37231
DB08881	Vemurafenib	approved	42611257	-	"Vemurafenib is approved since 2011 for the treatment of metastatic melanoma with a mutation on BRAF in the valine located in the exon 15 at codon 600, this mutation is denominated as V600E.[A31270] The V600E mutation, a substitution of glutamic acid for valine, accounts for 54% of the cases of cutaneous melanoma.[A31271] 
 Vemurafenib approval was extended in 2017, for its use as a treatment of adult patients with Erdheim-Chester Disease whose cancer cells present BRAF V600 mutation.[L1013] Erdheim-Chester disease is an extremely rare histiocyte cell disorder that affects large bones, large vessels, central nervous system, as well as, skin and lungs. It is reported an association of Erdheim-Chester disease and V600E mutation.[A31272]"	P15056; P35968; P04049
DB08880	Teriflunomide	approved	54684141	-	"Used in the treatment of relapsing forms of multiple sclerosis (MS)."	Q02127
DB08883	Perampanel	approved	9924495	-	"Used in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures."	P42261; P48058; P42262; P42263
DB08882	Linagliptin	approved	10096344	-	"Linagliptin is used for the management of type 2 diabetes mellitus. "	P11229; P27487
DB08889	Carfilzomib	investigational; approved	11556711	-	"Carfilzomib is indicated for the treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy. Approval is based on response rate. "	O00487; P51665; O00232; P28066; Q53XL8; P28065; P28062; O14818; P20618; P62191; P48556; Q15008; Q16186; P35998; P25786; P25787; P25788; P25789; Q6ZVN7; A5LHX3; P17980; Q6IAT9; P40306; A8K2M0; P28074; P55036; P28070; P28072; Q13200; P60896; O43242; Q8TAA3; Q99436; P49720; P49721; P62333; P62195; Q9UNM6; P60900; Q99460; O00231; P43686
DB02659	Cholic Acid	approved	221493	-	"Oral cholic acid is indicated for: treatment of bile acid synthesis disorders due to single enzyme defects, and as adjunctive treatment of peroxisomal disorders including Zellweger spectrum disorders in patients who exhibit manifestations of liver disease, steatorrhea or complications from decreased fat soluble vitamin absorption. "	Q02221; P23141; P20674; P14854; P09669; P04054; P00414; P22830; P24310; P24311; P00395; P10606; Q96RI1; P10176; P15954; P00403; P00326; P13073; P51161; P62508; P54965; Q8TDU6
DB12924	Ozenoxacin	investigational; approved	9863827	-	"Ozenoxacin cream is indicated for the topical treatment of impetigo caused by *Staphylococcus aureus* or *Streptococcus pyogenes* in patients aged 2 months of age and older [FDA Label]."	P43700; P0AFI2
DB11348	Calcium Phosphate	approved	24456	-	"For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste [FDA Label] [L851]."	P04271; Q99828; O14958; P80303; Q99653; P28676; P27797; Q15493; P13693; Q99584; P09486; O75340; O75838; Q96FQ6; P27824; P41180; B4DJ51; Q9ULB1; P62166; P0DP24; P0DP25; Q9UBV8; Q86UW7; P0DP23; Q9ULU8; P35556; P06703; P31415; P30626; Q02818; P22676; P62158; Q96L12; Q75N90; Q13938; P58400
DB05708	GTS-21	investigational	5310985	-	"Investigated for use/treatment in alzheimer's disease and schizophrenia and schizoaffective disorders."	Q494W8; P36544
DB11582	Thiocolchicoside	investigational; approved	9915886	-	"
 Thiocolchicoside is a  skeletal muscle-relaxant drug used in the treatment of orthopedic, traumatic and rheumatologic disorders [L1661]. It is indicated as an adjuvant drug in the treatment of painful muscle contractures and is indicated in acute spinal pathology, for adults and adolescents 16 years of age and older [L1658]. Recent studies have examined its effect on muscle tone, stiffness, contractures, and soreness experienced by athletes during sporting competitions [L1664]."	Q9UN88; P23415; P18507; P18505; O14788; P14867; P47870; P47869
DB11581	Venetoclax	investigational; approved	49846579	-	"For the treatment of patients with chronic lymphocytic leukemia (CLL) with 17p deletion, as detected by an FDA approved test, who have received at least one prior therapy."	P10415; Q07820; Q07817; Q92843
DB01288	Fenoterol	investigational; approved	3343	-	"Fenoterol is used for the treatment of asthma."	P07550; P08588; P13945
DB01289	Glisoxepide	investigational	32778	-	"For the treatment of diabetes mellitus type 2."	Q09428; Q15842; P78508; Q14654
DB01280	Nelarabine	investigational; approved	3011155	-	"For the treatment of pediatric and adult patients with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens."	P09884
DB01282	Carbetocin	investigational; approved	16681432	-	"Used to control postpartum hemorrhage and bleeding after giving birth."	P30559; P37288; P30518
DB01283	Lumiracoxib	investigational; approved	151166	-	"For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults."	P23786; P35354; P23219
DB01284	Tetracosactide	approved	16133751	-	"For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency."	Q01718
DB09129	Chromic chloride	approved	6452300	-	"For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN)."	P00533; P06241; P06213
DB09128	Brexpiprazole	investigational; approved	11978813	-	"As an adjunctive treatment of major depressive disorder (MDD) and for treatment of schizophrenia. "	P34969; P35462; P18825; P10635; P28223; P25100; P41595; P14416; P08908; P35367; P35368
DB09124	Medrogestone	approved	9949848	-	"Medrogestone is indicated as adjunct to treat endometial shedding in menopausal women, to treat secondary amenorrhea, to induce menses and to treat dysfunctional uterine bleeding in adult and adolescent women.[T76]"	P06401
DB09121	Aurothioglucose	approved; withdrawn	6104	-	"Aurothioglucose is indicated for the adjunctive treatment of early active adult and juvenile type rheumatoid arthritis that is not adequately controlled by other anti-inflammatory agents and conservative measures like salicylate, glucocorticoids, etc. [L1925, L1937]. In chronic, advanced cases of rheumatoid arthritis, such gold therapy is not demonstrated to be as valuable [L1937].
 
 Antirheumatic measures such as salicylate and other anti-inflammatory drugs (both steroidal and non steroidal) may be continued after initiation of gold therapy [L1937]. After improvement commences, these measures may be discontinued slowly as symptoms permit [L1937]."	O95622; Q08462; Q16881; Q08828; P46098
DB09120	Zucapsaicin	investigational; approved	1548942	-	"Indicated to be used in conjunction with oral COX-2 inhibitors or NSAIDs for the relief of severe pain in adult patients with osteoarthritis of the knee, not controlled with oral COX-2 inhibitors or NSAIDs alone, for a duration of no more than three months. "	Q8NER1
DB00221	Isoetarine	approved	3762	-	"For the treatment of asthma, wheezing, and chronic asthmatic bronchitis."	P07550; P08588
DB01359	Penbutolol	investigational; approved	37464	-	"Penbutolol is indicated in the treatment of mild to moderate arterial hypertension. It may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.Penbutolol is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity."	P07550; P28222; P08588; P08908
DB00251	Terconazole	approved	441383	-	"For the treatment of candidiasis (a yeast-like fungal infection) of the vulva and vagina."	P08172; P10613; P22303; P28335; P20309; P08173; P18825; Q99720; P28223; Q01959; P18089; P21728; P08912; P08913; P25100; P35462; P31645; P06241; P23975; P11229
DB01353	Butethal	illicit; approved	6473	-	"For the treatment of insomnia."	Q13002; Q494W8; P48169; Q16445; P31644; P14867; P36544; P47869; P34903; P43681; P42262
DB01356	Lithium	approved	28486	-	"Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment."	P29218; P49841; P49840; O14732; Q6FI27; P42263
DB01357	Mestranol	approved	6291	-	"Mestranol was used as one of the first oral contraceptives."	P31645; P23975; P21554; P03372
DB01354	Heptabarbital	approved	10518	-	"Used mainly for sedation and hypnosis."	Q16445; Q494W8; P48169; P47869; P14867; Q13002; P36544; P31644; P34903; P43681; P42262
DB01355	Hexobarbital	approved	3608	-	"For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli."	P28472; P18507; Q494W8; P48169; P34903; P14867; Q13002; P36544; P47869; Q16445; P43681; P31644; P42262
DB00701	Amprenavir	investigational; approved	65016	-	"For the treatment of HIV-1 infection in combination with other antiretroviral agents."	P21730; P08684
DB00706	Tamsulosin	investigational; approved	129211	-	"Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream...etc.)"	P34969; P14416; P18825; P35368; P25100; P08913; P35462; P08908; P35348
DB00220	Nelfinavir	approved	64143	-	"Used in combination with other antiviral drugs in the treatment of HIV in both adults and children."	P41145; P06239; P41143; Q01959; P21728; P08912; P08684; P35372; P06241; P23975; P00533; P13945
DB00704	Naltrexone	investigational; approved; vet_approved	5360515	-	"Used as an adjunct to a medically supervised behaviour modification program in the maintenance of opiate cessation in individuals who were formerly physically dependent on opiates and who have successfully undergone detoxification. Also used for the management of alcohol dependence in conjunction with a behavioural modification program."	P10635; P41145; P35372; Q99720; P41143
DB05339	MN-305	investigational	198746	-	"Investigated for use/treatment in anxiety disorders, depression, insomnia, and neurologic disorders."	P08908
DB09409	Magnesium acetate tetrahydrate	approved	134717	-	"Used as magnesium salf-containing laxatives to prevent constipation. It can bring synergistic effect to restore normal bowel function when using in combination with aluminum salts that induce bowel retention [T28]. Magnesium acetate tetrahydrate is used as a source of water and electrolytes when combined with dextrose and other salts to form intravenous infusions. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation or hypertension during pregnancy."	O60391
DB05034	Ularitide	investigational	16132416	-	"Investigated for use/treatment in congestive heart failure."	P16066
DB12107	Vaborbactam	investigational; approved	56649692	-	"- Indicated in combination with meropenem for the treatment of patients 18 years of age and older with complicated urinary tract infections (cUTI) including pyelonephritis caused by the following susceptible microorganisms: _Escherichia coli_, _Klebsiella pneumoniae_, and _Enterobacter cloacae_ species complex [FDA Label]."	Q9F663; Q848S6
DB01263	Posaconazole	investigational; approved; vet_approved	468595	-	"For prophylaxis of invasive <em>Aspergillus</em> and <em>Candida</em> infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD), or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis, including oropharyngeal candidiasis refractory to itraconazole and/or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis, <em>Fusarium</em> infections, and zygomycosis in patients who are intolerant of, or whose disease is refractory to, other antifungals."	P10613; P08684
DB00539	Toremifene	investigational; approved	3005573	-	"For the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer."	P04278; P03372; Q92731
DB00535	Cefdinir	approved	6915944	-	"For the treatment of the respiratory, skin, soft tissue, and ENT infections caused by <i>H. influenzae</i> (including b-lactamase producing strains), <i>H. parainfluenzae</i> (including b-lactamase producing strains), <i>S. pneumoniae</i> (penicillin-susceptible strains), <i>S. pyogenes</i>, <i>S. aureus</i> (including b-lactamase producing strains), and <i>M. catarrhalis</i>."	P08149; P0AEB2; P08506; P05164; P02918; P02919; P0AD68; P24228; P0AD65
DB00534	Chlormerodrin	approved; withdrawn	25210	-	"Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool."	Q13621; P51649
DB00537	Ciprofloxacin	investigational; approved	2764	-	"For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure)."	P20831; P05653; P0C1U9; Q12809; Q59192; P0AES4; P0AES6; P11388; P43700; P43702; Q02880
DB00536	Guanidine	approved	3520	-	"For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis."	P22001; Q03721; P51787; Q6PIU1; Q9UIX4; Q96KK3; Q9BQ31; Q9UJ96; Q9H252; O43525; P17658; Q9NS40; P00720; Q16322; Q09470; P48547; Q12809; Q8TAE7; Q9NR82; Q92953; Q96RP8; Q9UQ05; Q9ULD8; Q96L42; O43526; P0A6E4; Q8NCM2; Q14721; Q9NZV8; Q96PR1; Q9NSA2; P16389; Q9ULS6; P78352; O95259; P07998; P22459; Q9UK17; P22460; Q8TDN2; P53608; P05091; Q9H3M0; Q14003; P56696; Q14353; Q8TDN1
DB00531	Cyclophosphamide	investigational; approved	2907	-	"Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients. "	Q9BY21; P08684; Q9HBW0; O75469; Q9UBY5
DB00530	Erlotinib	investigational; approved	176870	-	"For the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Also for use, in combination with gemcitabine, as the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer."	P21802; P52333; P08631; P35968; P07947; P29597; P04626; P07948; Q15303; P00533; P00519; Q9UM73; P16234; P17948; P35916; P06239; P08581; P07949; P09619; P12931; P36888; P10721; O60674; O75469
DB00533	Rofecoxib	investigational; approved; withdrawn	5090	-	"For the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras."	P23786; P35354; P15502; P23219; P43116
DB00532	Mephenytoin	investigational; withdrawn	4060	-	"For the treatment of refractory partial epilepsy."	Q9UI33; Q14524; Q9UQD0; Q9Y5Y9; Q01118; P35499; P35498; Q99250; O75469; Q15858; Q9NY46
DB01347	Saprisartan	experimental	60921	-	"Saprisartan is used in the treatment of hypertension and heart failure."	P30556
DB01628	Etoricoxib	investigational; approved	123619	-	"For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout."	P23786; P35354; P23219; P43116
DB01626	Pargyline	approved	4688	-	"For the treatment of moderate to severe hypertension."	P21397; P27338
DB01627	Lincomycin	approved; vet_approved	3000540	-	"Lincomycin is an antibiotic used in the treatment of staphylococcal, streptococcal, and <i>Bacteroides fragilis</i> infections."	C1CNV7; C1C8L6; Q04MN1; A3CK67; B5E6G7; B5E6G6; B5E6G1; B5E6G0; B5E6G3; C1CAM8; B1I9N1; B8ZJX3; B2IS46; C1CSF7; B2IS44; B2IS45; B2IS42; B8ZKG1; Q04IH6; C1CA38; C1CC31; C1CC30; Q04I37; C1CP93; Q02W48; B8ZKG9; P66113; B2IS49; Q97QU4; C1CP99; P66096; C1CHZ1; C1CBQ4; B8ZKG2; P66257; P66256; B5E6U3; C1C8C8; B8ZNZ8; P66340; C1CPE4; C1CPE3; Q04MN2; Q04MN0; B1IB07; P66420; P0A496; B2IS48; P66136; P0A493; A8AZV4; B2IS51; Q04M37; P0A494; P0A495; B8ZKF9; Q97PI9; Q8CWV8; C1C6H2; B1ICV9; C1CAX9; Q8CWV1; Q8CWV0; Q8CWV3; B2IRD4; Q8CWV5; Q8CWV4; Q8CWV7; Q8CWV6; B8ZKQ6; P0A4B3; P66633; Q04MN4; B8ZKQ3; A8AZL6; P66201; A2RNN0; C1CC12; C1CC11; C1CC10; C1CC17; C1CC15; C1CC14; C1CC18; C1CAL8; B8ZLK5; P0A4B6; Q8CWU4; B8ZM28; Q8CWN3; Q04MM4; P0A484; B2IS66; B8ZKG5; P66445; Q8CWU8; P61363; C1CIA9; Q1JJF9; C1CFC0; C1CIA8; C1CIA5; P60629; P61361; C1CIA1; C1CIA3; C1CIA2; C1CP97; C1CPB5; B8ZKP6; C1CB45; C1CB44; P66359; B2IS65; B8ZKG6; A8AZM1; P66603; Q04ML0; Q04ML2; Q04ML3; P66051; C1CCK4; P66525; B2IN60; C1C5H5; Q04JE2; Q8CWV2; C1CIF2; C1CRK5; C1CC60; C1CC61; B8ZKG3; C1CFJ7; Q97SV1; C1CGS4; B1IBP2; Q3JYL4; B1I9V1; P66321; C1CIB3; A8AZD5; B4U0K8; P60630; B2IMG7; Q04I36; Q97SV3; Q04JL0; B8ZKG8; B8ZKQ4; B2IN61; P0A4A8; C1CIC1; C1CAL6; C1CAL7; C1CAL4; Q04MM8; Q04MM7; P0A474; Q04MM5; B2IS52; P61362; P0A4A7; P61360; Q04MM0; Q04L74; C1CIC4; C1CPB1; C1CIC2; C1CPB3; C1CIC0; B8ZPU9; C1CIA6; B1I8Z8; Q8CWS0; Q97SU6; C1CNB3; B1I8M2; A8AYZ9; B2ILY3; C1CP92; Q04KI4; C1CSP2; B1I8K3; A8AZK0; A8AZK2; B5E1Q0; B1I8K6; B1I8K4; C1CAM1; C1CAM0; C1CAM3; C1CIU2; B5E6G4; C1CAM4; Q8CWM8; Q04MH9; C1CI99; C1CPA0; A3CK72; B5E3E2; B5E3E3; B2IR58; C1CPA4; C1CJS7; P66582; Q8CWR5; P66392; P0A4B4; C1CAN9; Q8CWS9; Q8CWR9; Q8CWR8; C1CP94; P0A4C4; P0A472; B5E6U4; B8ZLD9; P0A476; P0A4C3; P66473; P66472; P66155; B1I700; P66474; C1CC08; P66393; B1I8U6; C1CLW8; C1CAN5; B1I8L4; C1CAN7; C1CAN6; B1I8L0; C1C9Y5; C1CC33; P61182; P61183; Q04MZ3; C1CE92; P0A7J6; C1C799; Q8CWQ0; B2IRG4; C1CTP8; B5E6H9; A3CL34; B1I8K2; P66279; Q8CWQ9; C1CP96; B5E6H1; B8ZKT9; B5E2I5; B1I8K0; P66565; C1CLN8; P0A4B5; P66566; B1I8K7; Q04MH8; Q8CWU6; B5E6F7; B2ISJ8; B1I9V0; P66156; B5E6Q4; B1I8M5; C1CPV0; B2ISJ7; B1I8M1; B1I8M3; B5E6F9; B5E5W8; C1CC29; C1CMU0; P0A483; C1CC22; B8ZPX5; C1CIF1; C1CU40; Q8CWN7; B1I7Y6; B2IS68; A3CQ97; A3CK89; P66360; B5E6I1; A3CK87; C1CP90
DB01624	Zuclopenthixol	investigational; approved	5311507	-	"Used in the management of acute psychoses such as mania or schizophrenia. However, the use of zuclopenthixol acetate in psychiatric emergencies as an alternative to standard treatments (haloperidol, clotiapine, etc.) should be cautioned, since well executed and documented trials of zuclopenthixol acetate for this use have yet to be conducted. Zuclopenthixol acetate is not intended for long-term use."	P28223; P21918; P21728; P08913; P14416; P35367; P35348
DB01625	Isopropamide	approved; vet_approved	3775	-	"For the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis, biliary dyskinesia and chronic cholelithiasis, duodenitis, gastrointestinal spasm, it may also be used to treat genitourinary spasm."	P08173; P22888; P11229; P20309
DB01622	Thioproperazine	approved	9429	-	"For the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics, manic syndromes."	P14416; P28223; P21728; P35462; P08908; P35348; P35368
DB01623	Thiothixene	approved	941651	-	"For the management of schizophrenia."	P18825; P28221; P28222; P28223; P35462; P46098; P11229; P34969; P08912; P21728; P08913; P14416; P08172; P08173; P28335; P18089; P35368; P35367; P35348; P25021; P20309; P08908; P31645
DB01620	Pheniramine	approved	4761	-	"Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria."	P35367; Q14994; P35498; Q99250; Q9NY46
DB01621	Pipotiazine	investigational; approved	62867	-	"For the maintenance treatment of chronic non-agitated schizophrenic patients."	P21728; P28223; P14416; P08908
DB01268	Sunitinib	investigational; approved	5329102	-	"For the treatment of advanced renal cell carcinoma as well as the treatment of gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate."	P21802; Q02750; P08069; P52333; P36507; P08631; P35968; P07947; P29597; P11802; P22607; Q08881; P07948; P07949; P00533; P00519; P07333; Q12809; Q9UM73; P16234; P17948; P35916; P06239; P08581; P10721; P11362; P06213; P09619; P12931; P22455; Q13464; Q96GD4; P36888; O00329; P23458; O75116; Q06187; O60674; P06241
DB04725	Licofelone	investigational	133021	-	"For the management of osteoarthritis."	P35354; P09917; Q9NZK7
DB00409	Remoxipride	approved; withdrawn	54477	-	"Remoxipride is an atypical antipsychotic once used for the treatment of schizophrenia."	P35462; Q99720; P28223; P14416; P08908; P21917
DB00408	Loxapine	approved	3964	-	"For the management of the manifestations of psychotic disorders such as schizophrenia"	P02708; P18825; P28221; P28222; Q9GZZ6; P35462; P46098; P47898; P28566; P11229; Q9H3N8; P34969; Q01959; P21728; P08913; P14416; P23975; Q9UGM1; P08172; P08173; P28223; P20309; P28335; P18089; P21918; P35368; P35367; P35348; P21917; Q5JUK3; P08912; Q494W8; P25021; P50406; Q92952; P36544; P08908; P31645; P08588
DB01130	Prednicarbate	investigational; approved	6714002	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses."	P04150; P04054; Q5TZZ9; P04083
DB01131	Proguanil	approved	4923	-	"For the causal prevention and suppression of malaria caused by susceptible strains of <i>P. falciparum</i> and other species of Plasmodium found in some geographical areas of the world."	P00374; B0YJ76; P13922
DB01136	Carvedilol	investigational; approved	2585	-	"For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin."	P17302; P18825; P10635; P28223; P08913; P35462; P19320; P48050; Q12809; Q01959; P21728; P08588; P14416; P23975; P35368; P16860; P28335; P41595; P18089; P31645; P35348; P13945; P16581; D0VY79; P25100; P08908; O95298; P07550; P15692; Q16665
DB01137	Levofloxacin	investigational; approved	149096	-	"For the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: <i>Corynebacterium</i> species, <i>Staphylococus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Streptococcus pneumoniae</i>, <i>Streptococcus</i> (Groups C/F/G), Viridans group streptococci, <i>Acinetobacter lwoffii</i>, <i>Haemophilus influenzae</i>, <i>Serratia marcescens</i>."	P72524; P72525; Q12809; Q59961; P0A4L9; P11388; P43700; P43702; Q02880
DB01134	Desoxycorticosterone Pivalate	vet_approved; experimental	11876263	-	"Examined for treatment of adrenocortical insufficiency especially in multiple sclerosis, congenital cerebral palsy, polyarteritis nodosa, and rheumatoid arthritis. Currently only approved in treating cats and dogs for the treatment of Addison's disease."	P08235
DB01135	Doxacurium chloride	approved	5284551	-	"Used to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation."	P08172; Q15822; P11230; P07510; P02708; Q04844; Q07001
DB00401	Nisoldipine	approved	4499	-	"For the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents."	O95180; P54289; Q16348; Q12809; O00555; Q08289; Q13936; P35498; Q99250; Q13698; O60840; Q01668; P29274; Q9NY46
DB00400	Griseofulvin	investigational; approved; vet_approved	441140	-	"For the treatment of ringworm infections of the skin, hair, and nails, namely: tinea corporis, tinea pedis, tinea cruris, tinea barbae, cradle cap or other conditions caused by <i>Trichophyton</i> or <i>Microsporum</i> fungi."	Q99456; P87066; P10875
DB01138	Sulfinpyrazone	approved	5342	-	"For the treatment of gout and gouty arthritis."	Q96S37; O75530; O75469; Q92887; P33527; P30968
DB01139	Cefapirin	approved; vet_approved	30699	-	"For treatment of infections caused by susceptible bacteria."	P20815; P18825; P10635; P02918; P02919; P03956; P35372; P35462; P16473; Q99720; P14416; P41145; Q9Y2I1; P0AEB2; P08506; P41143; P41595; P31391; P08684; Q8XJ01; P0AD68; P0AD65; P24228; P25021; P25103; P08908; P21554
DB00405	Dexbrompheniramine	approved	16960	-	"For treatment and relief of symptoms of allergies, hay fever, and colds"	P35367
DB00404	Alprazolam	illicit; investigational; approved	2118	-	"For the management of anxiety disorder or the short-term relief of symptoms of anxiety and for the treatment of panic disorder, with or without agoraphobia."	P32745; P30536; P30874; P24046; A8MPY1; P47869; P34903; P78334; P18507; P18505; Q8N1C3; P14867; P35346; P08684; O00591; Q9UN88; P28472; P21452; P28476; O14764; P48169; Q16445; P47870; P31644; Q99928
DB00406	Gentian Violet	approved	3468	-	"For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas' disease (as a blood additive)."	P41145; P18825; P10635; P28223; P35372; P35462; P00533; P11229; Q01959; P08912; P08913; P14416; P21728; P08172; P08173; P22303; P18089; P08684; P29274; P25021; P25100; P20309; P06241
DB04896	Milnacipran	investigational; approved	65833	-	"Milnacipran is used to treat moderate to severe clinical depression but this indication is not yet FDA-approved in the USA. Milnacipran is labelled for the treatment of fibromyalgia pain. "	P23975; O60391; Q01959; Q12879; P31645
DB04894	Vapreotide	investigational; approved	6918026	-	"For the treatment of esophageal variceal bleeding in patients with cirrhotic liver disease and has also shown efficacy in the treatment of patients with AIDS-related diarrhea."	P30874; P35346; P25103
DB04892	Phenserine	investigational	192706	-	"For the treatment of Alzheimer's disease (AD)."	P05067; P22303; P06276
DB00664	Sulfametopyrazine	approved; withdrawn	9047	-	"For the treatment of urinary tract infection and chronic bronchitis."	P0AC13
DB04890	Bepotastine	approved	2350	-	"For the symptomatic treatment of itchy eyes (caused by IgE-induced mast cell degranulation) due to allergic conjunctivitis."	P35367
DB00666	Nafarelin	approved	25077405	-	"For treatment of central precocious puberty (true precocious puberty, GnRH-dependent precocious precocity, complete isosexual precocity) in children of both sexes and for the treatment of endometriosis."	Q96P88; P30968
DB00669	Sumatriptan	investigational; approved	5358	-	"For the treatment of migraine attacks with or without aura."	P46098; P28566; P34969; P28223; P28221; P28222; P28335; P41595; P30939; P50406; P08908; P47898; P01011
DB00668	Epinephrine	approved; vet_approved	5816	-	"Used to treat anaphylaxis and sepsis. Also one of the body's main adrenergic neurotransmitters."	P00439; P18825; P18089; P08588; P21728; P08913; P25100; P01375; P35368; P07550; P23975; P35348; P13945; P00441
DB00887	Bumetanide	approved	2471	-	"For the treatment of edema associated with congestive heart failure, hepatic and renal disease including the nephrotic syndrome."	Q9H2X9; P05023; Q13621; Q9UP95; P13569; P55011; Q9HC97
DB00886	Omapatrilat	investigational	656629	-	"For the treatment of hypertension."	P08473; P12821
DB00881	Quinapril	investigational; approved	54892	-	"For the treatment of hypertension and as adjunct therapy in the treatment of congestive heart failure. May also be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy. "	P12821
DB00880	Chlorothiazide	approved; vet_approved	2720	-	"Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension."	P55017; P22748; P00918; P00915; Q12791
DB00883	Isosorbide Dinitrate	investigational; approved	6883	-	"For the prevention of angina pectoris due to coronary artery disease."	P23945; O75343; P16066; Q02153; Q02108; P33402; P29400
DB00882	Clomifene	investigational; approved	2800	-	"Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation. "	P18825; P10635; P28223; P04626; P35462; P00533; P11229; Q99720; Q12809; Q01959; P03372; P08912; P08913; P04278; P23975; P08172; P08173; P28335; P18089; P41595; P35367; P23219; P13945; P20309; P31645; P06241
DB00391	Sulpiride	investigational; approved	5355	-	"Sulpiride is indicated for the treatment of schizophrenia."	P00918; Q9Y2D0; P43166; P23280; P00915; P35462; O43570; Q16790; P08913; P14416; P35218; P21917; P07451
DB00390	Digoxin	approved	2724385	-	"For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure."	P05023; P50993; Q12809; P05026; P13637; Q13733; P14415; P54709; Q6ZQN7; P54710
DB00393	Nimodipine	investigational; approved	4497	-	"For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage (SAH) from ruptured intracranial berry aneurysms by reducing the incidence and severity of ischemic deficits."	P54284; P08684; P08235; O95180; P35869; Q06432; Q08289; Q96RI1; Q13936; Q02641; O00305; O60840; Q13698; P13569; Q01668; P21554
DB00392	Ethopropazine	approved	3290	-	"For use in the treatment of Parkinson's disease and also used to control severe reactions to certain medicines such as reserpine."	Q8TCU5; P08172; P22303; P11229; P06276
DB00395	Carisoprodol	approved	2576	-	"For the relief of discomfort associated with acute, painful, musculoskeletal conditions."	P33261; P47870; P14867; P18507
DB00394	Beclomethasone dipropionate	investigational; approved	21700	-	"Used in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older, and in treating symptoms for allergic rhinitis (seasonal or perennial) in patients 12 years of age and older. Also being investigated for oral treatment in mild-to-moderate Crohn's disease of ileal or ileal-right colonic localisation and for \"topical\" use mild-to-moderate graft versus host disease."	P04150; P05113; Q86Y34
DB00397	Phenylpropanolamine	withdrawn; approved; vet_approved	26934	-	"For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity."	P34969; P11229; P18825; Q12809; Q01959; P18089; P21728; P08588; P08913; P07550; P23975; P35348
DB00396	Progesterone	approved; vet_approved	5994	-	"For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer."	P04150; P41145; Q8NEC5; P08235; Q9UL62; P04278; Q99720; Q86XQ3; P06401; P03372; P10275; O75469; P05093; Q96P56; Q7RTX7; P02763
DB00399	Zoledronic acid	approved	68740	-	"For the treatment of hypercalcemia of malignancy. Also for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. In May of 2007, the drug was approved for treatment of Paget?s Disease."	P00918; P14324; Q9ULX7; P22894; O95749; Q16790; O43570
DB00398	Sorafenib	investigational; approved	216239	-	"Sorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma.  "	P21802; Q02224; P52333; P28223; P08631; P35968; Q16832; P22607; P07948; P07949; P29317; Q9BWU1; P00519; P07333; P34969; P16234; P17948; P35916; P06239; P11362; P06213; P28335; P09619; P41595; P12931; P49336; Q02763; P36888; P10721; P04049; P08908; P15056; P06241
DB01424	Aminophenazone	approved; withdrawn	6009	-	"Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water."	P35354; P23219
DB00715	Paroxetine	investigational; approved	43815	-	"Labeled indications include: major depressive disorder (MDD), panic disorder with or without agoraphobia, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Unlabeled indications include: eating disorders, impulse control disorders, vasomotor symptoms of menopause, obsessive-compulsive disorder (OCD) in children, and mild dementia-associated agitation in nonpsychotic individuals. Brisdelle, which consists of paroxetine mesylate is indicated for the treatment of moderate to severe vasomotor symptoms (like hot flashes) associated with menopause. "	P08172; P08173; P23458; Q12809; P11229; P52333; P20309; Q99720; P28223; P25103; Q01959; P08912; P08588; P10635; P35462; P08908; P31645; P29597; P23975; O60674
DB00242	Cladribine	investigational; approved	20279	-	"For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma."	Q07864; P27815; V9HWH6; P00491; Q9NR33; P56282; P00813; Q7LG56; P09884; P23921; P31350; Q9NRF9
DB00717	Norethisterone	approved	6230	-	"For the treatment of secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer."	P04150; P06401; P03372; P10275; P31645; Q14833
DB00716	Nedocromil	investigational; approved	50294	-	"For the treatment of mild to moderate asthma"	Q13258; Q9NS75; Q9Y271; K9JA46; P07900; P21462
DB00247	Methysergide	approved	6540428	-	"For the treatment of vascular headache"	P18825; P28221; P28222; P28223; P35462; P47898; P28566; P11229; Q99720; P34969; P30939; P21728; P08913; P14416; P08172; P28335; P18089; P41595; P35367; P50406; P20309; P08908; P01011
DB00246	Ziprasidone	approved	60854	-	"For the treatment of schizophrenia and related psychotic disorders."	P34969; P18825; P28221; P28222; P28223; P08913; P35462; P46098; P28566; P11229; Q12809; Q01959; P08912; P08588; P14416; P23975; P08172; P08173; P20309; P28335; P18089; P21918; P41595; P35368; P35367; P31645; P35348; P21917; Q494W8; P25021; P50406; P36544; P08908; P07550; P21728; P01011
DB00245	Benzatropine	approved	1201549	-	"For use as an adjunct in the therapy of all forms of parkinsonism and also for use in the control of extrapyramidal disorders due to neuroleptic drugs."	P08172; P08173; Q695T7; P28223; P11229; P18825; P20309; Q99720; P28335; P25021; P25100; P18089; Q01959; P08912; P08913; P41595; P35462; P35367; P31645; P23975
DB00244	Mesalazine	approved	4075	-	"For the treatment of active ulcerative proctitis."	O15111; Q13002; P09917; P05164; P23219; P43003; P35354; Q16099; P37231; P43004; P39086; P9WJI5; O14920
DB00249	Idoxuridine	investigational; approved	5905	-	"For use in keratoconjunctivitis and keratitis caused by herpes simplex virus."	Q9QNF7; Q9H244
DB00248	Cabergoline	approved	54746	-	"For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease. "	P34969; P41595; P35462; P18825; P28221; P28222; P08908; P18089; P21918; P21728; P08588; P25100; P14416; P35368; P21917; P07550; P28335; P35348; P08913; P28223
DB00719	Azatadine	approved	19861	-	"For the relief of the symptoms of upper respiratory mucosal congestion in perennial and allergic rhinitis, and for the relief of nasal congestion and eustachian t.b. congestion."	P35367
DB00718	Adefovir Dipivoxil	investigational; approved	60871	-	"For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease."	P24024
DB03843	Formaldehyde	approved; vet_approved	712	-	"Use for drying skin before or after surgical removal of warts or where dryness is required. "	P41180; P15555
DB00147	Pyridoxal	approved; nutraceutical	1050	-	"Pyridoxal is one of the natural forms available of vitamin B6, therefore, it is used for nutritional supplementation and for treating dietary shortage or imbalances."	O00764
DB11901	Apalutamide	investigational; approved	24872560	-	"Indicated for the treatment of patients with non-metastatic, castration-resistant prostate cancer (NM-CRPC) [FDA Label]."	Q9UN88; P10275
DB04946	Iloperidone	approved	71360	-	"Treatment of acute schizophrenia. "	P18825; P28221; P28222; P28223; P32239; P35462; P11229; Q99720; P34969; Q01959; P20292; P21728; P08913; P14416; P10635; P23975; P08172; P08173; P28335; P18089; P35367; P35348; P21917; P50406; P08908; P01011
DB04947	Altropane	investigational	6440180	-	"Investigated for use/treatment in attention deficit/hyperactivity disorder (ADHD), parkinson's disease, and pediatric indications."	Q01959
DB04942	Tamibarotene	investigational; approved	108143	-	"Investigated for use/treatment in leukemia (unspecified)."	P10276; P10826; P13631
DB04948	Lofexidine	investigational; approved	30668	-	"Investigated for use/treatment in addictions and substance abuse."	P18825; P08913; P18089; P08908
DB06766	Alcaftadine	approved	19371515	-	"For the prevention of itching associated with allergic conjunctivitis."	P35367
DB06764	Tetryzoline	approved	5419	-	"For temporary relief of discomfort and redness of the eye due to minor eye irritations."	P18825; P25100; P08913; P18089; P35368; P35348
DB01047	Fluocinonide	investigational; approved	9642	-	"A topical anti-inflammatory product for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses."	P04150; P08185; P47712; Q99835
DB06769	Bendamustine	investigational; approved	65628	-	"Bendamustine is indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen."	Q9UBN7; O15379; Q9BY41; Q13547; Q6IT96; Q92769; Q969S8
DB01511	Delorazepam	illicit; investigational; approved	17925	-	"Mainly used as an anti-anxiety agent. Studies have found delorazepam to be more effective in the first 4 weeks of use than antidepressants, however, after 4 weeks, antidepressants showed superior anti-anxiety effects. [Wikipedia] Anti-anxiety effects also appear to be weaker in elderly patients. [1]
 
 Effectiveness has also been observed in the treatment of alcohol withdrawal. Delorazapam was reported to be a manageable drug in that it did not exhibit severe side effects and did not require further therapies to control symptoms of withdrawal. [3]"	Q9UN88; P34903; P18507; P18505; Q99928; O14764; P48169; P47870; Q8N1C3; P47869; P14867; P28472; P31644; Q16445; O00591; P78334
DB13154	Parachlorophenol	approved	4684	-	"Used as an intermediate in organic synthesis of dyes and drugs.
 Local antibacterial agent in root canal therapy, as topical antiseptic in ointments
 "	P35499
DB06016	Cariprazine	investigational; approved	11154555	-	"Cariprazine is an atypical antipsychotic indicated for the treatment of schizophrenia and for the acute treatment of manic or mixed episodes associated with bipolar I
 disorder."	P34969; P14416; P28223; P25100; P21728; P41595; P35462; P08908; P35367; P28335
DB06543	Astaxanthin	investigational	5281224	-	"Investigated for use/treatment in eye disorders/infections, cancer/tumors (unspecified), and asthma."	P25963
DB00867	Ritodrine	investigational; approved	33572	-	"For the treatment and prophylaxis of premature labour"	P07550; P13945
DB00866	Alprenolol	approved; withdrawn	2119	-	"For the treatment of hypertension, angina, and arrhythmia"	P08908; P08588; P28223; P13945; P07550
DB00865	Benzphetamine	illicit; approved	5311017	-	"For the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction"	Q01959; P08913; P23975; P35348; Q05940
DB00864	Tacrolimus	investigational; approved	445643	-	"For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, and limb transplants. It has also been used in a topical preparation in the treatment of severe atopic dermatitis."	P08684; P62942; Q12809; P05113; P42345
DB00863	Ranitidine	approved	3001055	-	"Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD)."	P22303; P25021; P06276
DB00862	Vardenafil	approved	110634	-	"Used for the treatment of erectile dysfunction"	P54750; Q13956; Q9Y233; O00408; Q14432; Q13370; O76074; Q08493; P27815; P16499; Q07343; P18545; Q08499
DB00861	Diflunisal	investigational; approved	3059	-	"For symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis."	P00918; P00915; P35354; P23219; P02766
DB00860	Prednisolone	approved; vet_approved	5755	-	"For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders."	P04150; P04083; P08235; Q8TDV5; P08185; P05231; P10275; Q5TZZ9
DB00869	Dorzolamide	approved	5284549	-	"For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Also used prophylatically for the inhibition of perioperative IOP increase (before neodynium yttrium aluminum garnet laser posterior capsulotomy)."	P00918; P22748; P14324; P07451; P43166; P23280; Q9ULX7; P00915; Q16790; O43570; P35218; Q8N1Q1; O95477; Q9Y2D0
DB00868	Benzonatate	approved	7699	-	"For the symptomatic relief of cough. Has also been applied locally in the oral cavity in adults by releasing the drug from the liquid-filled capsules to provide oropharyngeal anesthesia for conscious intubation."	Q99572; Q14524; P42345
DB04872	Osanetant	investigational	219077	-	"Potential therapy for schizophrenia, depression and visceral pain."	P29371; P25103; P21452
DB05446	LJP 1082	investigational	1082	-	"Investigated for use/treatment in autoimmune diseases, strokes, and thrombosis."	P02749
DB05442	Etiprednol dicloacetate	investigational	9935073	-	"Investigated for use/treatment in asthma and crohn's disease."	P01584
DB05448	PX-12	investigational	219104	-	"Investigated for use/treatment in cancer/tumors (unspecified), gastric cancer, and pancreatic cancer."	P10599; Q16881
DB00426	Famciclovir	investigational; approved	3324	-	"For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients."	P04293; P09252
DB08892	Arbaclofen Placarbil	investigational	11281011	-	"Investigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD. "	O75899; Q9UBS5
DB08893	Mirabegron	approved	9865528	-	"Mirabegron is a beta-3 adrenergic agonist indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency."	P07550; P08588; P13945
DB08890	Linaclotide	approved	16158208	-	"Treatment of irritable bowel syndrome (IBS) with constipation and chronic idiopathic constipation. "	P25092
DB08891	Arbaclofen	investigational	44602	-	"Investigated in clinical trials as a potential treatment for spasticity in multiple sclerosis, autism spectrum disorder, and social withdrawal in fragile X syndrome."	O75899; Q9UBS5
DB08896	Regorafenib	approved	11167602	-	"Regorafenib is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. Regorafenib is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate."	P29317; P21802; Q15759; P04629; P00519; P42685; P10721; P35968; P16234; P17948; P11362; P35916; P23415; Q16832; Q02763; P15056; P09619; P04049; P07949
DB08897	Aclidinium	approved	11434515	-	"Aclidinium bromide inhalation powder is indicated for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema."	P08172; P08173; P08912; P11229; P20309
DB08895	Tofacitinib	investigational; approved	9926791	-	"For the treatment of moderate to severe rheumatoid arthritis which is resistant or intolerant to methotrexate therapy. It may also be used as an adjunct to methotrexate therapy, or other non-biologic disease-modifying antirheumatic drugs (DMARDS), when methotrexate alone is not sufficient.  
 
 Tofacitinib has also been investigated as a preventative therapy for kidney transplant rejections, and as a treatment for psoriasis, ulcerative colitis, and ankylosing spondylitis. 
 
 It is not to be initiated in patients with a history of chronic or recurrent infections, or in the presence of active infection, even if localized, due to reports of serious and sometimes fatal infections (commonly pneumonia, herpes zoster and urinary tract infections). Use of tofacitinib is also discouraged in those who have been, or are likely to be, exposed to TB. An increased likelihood of exposure may be encountered by traveling to certain areas. In addition, tofacitinib is not to be used in patients with severe hepatic impairment, or low hemoglobin (less than 9g/dL). Cautioned is advised when using tofacitinib in patients at risk of gastrointestinal perforation, and in the elderly who are more susceptible to infection.   "	P23458; O75116; P00519; P52333; Q05655; Q16512; P29597; P06239; Q13464; P06241; O60674; P07949
DB08899	Enzalutamide	approved	15951529	-	"Enzalutamide is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel."	P10275
DB05713	LY-517717	investigational	9939865	-	"Investigated for use/treatment in thrombosis and venous thromboembolism."	P00742
DB09257	Gimeracil	approved	54679224	-	"Gimeracil is used as an adjunct to antineoplastic therapy. When used within the product Teysuno, gimeracil is indicated for the treatment of adults with advanced gastric (stomach) cancer when given in combination with cisplatin."	Q12882
DB09256	Tegafur	investigational; approved	5386	-	"Indicated for the treatment of cancer usually in combination with other biochemically modulating drugs."	P04818; Q53Y97
DB02703	Fusidic Acid	investigational; approved	3000226	-	"For the treatment of bacterial infections."	P13551; P62580; P62579; P00484; P62577
DB09250	Pheniprazine	withdrawn	5929	-	"For the treatment of depression, schizophrenia, and angina pectoris."	P21397; P27338
DB11577	Indigotindisulfonic Acid	approved	5282430	-	"Used as a dye in renal function testing for the detection of nitrates and chlorates."	P35869
DB11575	Grazoprevir	approved	44603531	-	"Grazoprevir is indicated in combination with [DB11574] (as the fixed dose combination product Zepatier) with or without [DB00811] for treatment of chronic HCV genotypes 1a, 1b, or 4 infection in adults. "	Q8IZI9
DB11574	Elbasvir	approved	71661251	-	"Elbasvir, when used in combination with [DB11575] as the combination product Zepatier, is indicated for use with or without ribavirin for the treatment of chronic HCV genotypes 1 or 4 infection in adults [FDA Label]."	Q8IZI9
DB01086	Benzocaine	investigational; approved	2337	-	"For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex."	Q9Y5Y9
DB01551	Dihydrocodeine	illicit; approved	5284543	-	"Dihydrocodeine is used for the treatment of moderate to severe pain, including post-operative and dental pain [2]. It  can also be used to treat chronic pain [1], breathlessness and coughing. 
 
 In heroin addicts, dihydrocodeine has been used as a substitute drug, in doses up to 2500mg/day to treat addiction. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014322/]
  "	P35372
DB09130	Copper	investigational; approved	23978	-	"For use in the supplementation of total parenteral nutrition and in contraception with intrauterine devices [FDA Label] [L801]."	P01857; P51884; P30101; P27797; P15814; P10412; P68871; P07900; P31943; P31942; P35527; P01042; P31946; P14618; V9HWA0; P08185; P31948; Q0VD83; P06396; E9KL35; P01009; P10997; F7VJQ1; Q03154; P00390; Q15428; P02775; P05109; P30041; V9HWB8; P02787; P23415; P19823; P63244; P04003; P48723; P23560; P45973; P61987; P69905; Q6MZM0; P05067; P00387; Q96PD5; P02765; P02766; P04004; Q13748; P07358; P12814; P04264; P04156; P42858; P23246; P00558; P29401; Q969S2; P05156; P05155; P14625; P14866; P48637; P62807; Q99497; P00734; P08865; P17174; O00299; P68104; P05090; P00739; Q07021; P01019; P26447; Q06323; P10809; P56537; P09525; P07237; P22626; P18669; P36955; P05121; P51693; P04406; Q96FI4; P32119; Q08288; P00338; Q15185; P02750; P01008; P14550; P61769; P11142; Q9UHF0; Q06830; P13645; P43652; P30086; P29034; P29622; P06744; P23526; P23528; P09871; O75880; P50213; V9HWF5; P51858; P05543; P05546; P02743; P05787; O60701; P02747; P01031; P02749; P02748; P60842; P04217; P02649; P08758; Q07955; D1MGQ2; P02647; P10909; P58876; P06733; P01861; K9JA46; P15531; P08697; P62937; P25311; P37840; P01024; V9HWG0; P00747; P08603; P0C0L5; P0C0L4; P02652; P02655; P35858; P02656; P15880; P06727; P43487; P27169; P01619; P05452; Q5SU16; P07437; P11021; P63261; P35908
DB09131	Cupric Chloride	investigational; approved	24014	-	"For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN)."	P04080; P04070
DB05155	CR665	investigational	25030387	-	"Investigated for use/treatment in pain (acute or chronic)."	P41145
DB01084	Emedastine	approved	3219	-	"For the temporary relief of the signs and symptoms of allergic conjunctivitis."	P35367
DB01380	Cortisone acetate	investigational; approved	5745	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders."	P04150; Q8TDV5; Q09470
DB01382	Glycodiazine	investigational; approved	9565	-	"Glycodiazine is used concomitantly with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. "	P14902; Q09428; P78508; P48048
DB01384	Paramethasone	approved	5875	-	"For the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone."	P04150; P08185; Q96F46
DB01438	Phenazopyridine	approved	4756	-	"For the symptomatic relief of pain, burning, urgency, frequency, and other discomforts arising from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters."	Q9Y5Y9; Q14524; Q9UQD0; Q01118; Q9UI33; P35498; Q99250; P35499; Q15858; Q9NY46
DB01437	Glutethimide	illicit; approved	3487	-	"For the treatment of insomnia."	Q9UN88; P28472; P18507; P18505; Q99928; O14764; P48169; P14867; Q8N1C3; P34903; P47870; P47869; P10635; P31644; Q16445; O00591; P78334
DB01388	Mibefradil	investigational; withdrawn	60663	-	"For the treatment of angina and high blood pressure."	P54284; Q8NEC5; O95180; Q7RTX7; O60840; Q5XXA6; Q12809; P41597; Q08289; Q00975; Q9P0X4; Q13936; P08684; O00305; O43497; Q96P56; Q13698; Q02641; Q01668; Q86XQ3
DB01435	Antipyrine	investigational; approved	2206	-	"Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes.."	O75762; P35354; P23219; P37288
DB01433	Methadyl Acetate	illicit; approved	10517	-	"Used mainly in the treatment of narcotic dependence."	P35372; Q12809
DB01431	Allylestrenol	approved	235905	-	"Allylestrenol was designed to be used for miscarriage prevention, prevention of premature labour and has been investigated for possible use in men for treatment for benign prostatic hyperplasia."	P06401; P03372
DB01430	Almitrine	approved	33887	-	"For the treatment of chronic obstructive pulmonary disease."	P05023
DB12442	Alvespimycin	investigational	5288674	-	"Investigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia. "	P08238; P07900; K9JA46
DB11157	Anthralin	approved	2202	-	"Stable plaque psoriasis of the skin and scalp [L1933].
 
 It is also used topically in the management of psoriasis, dermatoses, and alopecia areata. Anthralin is also used in biomedical research due to its effect on EGFR autophosphorylation [L1936]."	Q99456; P35908; Q9UQF2
DB00529	Foscarnet	approved	3415	-	"For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients."	P08546; P04293
DB00339	Pyrazinamide	investigational; approved	1046	-	"For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents."	P9WH83; P9WH79; P9WH81; P9WH87; P9WH85; Q6L5J4; P9WH89; A5U0A0; C1AL48; P9WH25; P15169; P9WH27; P0A5X1; A1KGI1; P9WH29; P9WHB1; P9WHA3; P9WHC3; P9WH61; P9WHC1; P9WH63; P9WHC7; A5U086; P9WHC5; P9WH67; P21462; P9WHC9; P9WHE5; Q96IY4; P9WH49; P9WHA9; P9WHE7; P9WHE1; P25090; P9WHA1; P08581; P66070; P9WHA5; P9WHA7; B2HSN0; P9WH91; P9WH55; P9WH93; P9WH33; P9WH95; P9WHE3; P9WH97; P9WH47; P9WH99; P20815; A0QL02; P9WH65; P9WH31; P9WH45; P08684; A5U019; P9WH35; Q73S98; A1KGB4; P9WH39; A1KGJ5; P9WH43; P00918; P9WHB5; P9WH57; P9WHB7; P9WH51; P9WH66; P9WH53; C1AL34; P9WH41; P0A5W3; P9WHB3; P9WH59; P9WHB9; P9WHD7; P9WHD5; P9WHD3; P25089; P9WHD1; P9WH37; P9WH94; P9WHD8; P9WHD9
DB00522	Bentiromide	investigational; withdrawn	6957673	-	"Used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy."	P05981; O15554
DB00523	Alitretinoin	investigational; approved	449171	-	"For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma."	Q6V0L0; P10826; P17936; P48443; Q15238; P28702; P10276; P19793; P13631; Q9BQB6
DB00520	Caspofungin	approved	3035406	-	"For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies."	A2QLK4
DB00521	Carteolol	approved	2583	-	"For the treatment of intraocular hypertension and chronic open-angle glaucoma"	P08588; P15144; P09960; P07550; P08473; P13945
DB00527	Cinchocaine	approved; vet_approved	3025	-	"For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks."	P0DP24; P0DP25; Q14524; P0DP23; P62158; Q9Y5Y9; P35498; Q99250; B4DJ51; Q9NY46
DB00524	Metolazone	approved	4170	-	"For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class."	P55017; Q13621; P43166
DB00525	Tolnaftate	investigational; approved; vet_approved	5510	-	"Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot."	Q14534; P41595; Q92206
DB00489	Sotalol	approved	5253	-	"For the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias."	P07550; P08588; Q12809
DB01638	Sorbitol	approved	5780	-	"Used as a non-stimulant laxative via an oral suspension or enema."	P12851; P12070; P37330; P24300
DB12598	Nafamostat	investigational; approved	4413	-	"Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement therapy and extra corporeal membrane oxygenation. "	P00734; P00736; P07477; P78348; Q15661; Q16515; P05362; P00748; P00747; P01375; P00742; Q9UHC3; P06870; P20231; Q96QT4
DB00093	Felypressin	approved	14257662	-	"For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential."	P37288
DB00091	Cyclosporine	investigational; approved; vet_approved	5284373	-	"For treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis. "	Q9UNQ0; P21462; V9HWF5; Q99500; Q96LZ3; P62942; Q02127; P49069; Q9UBY5; P30405; Q9NPD5; P62937; P08684; Q14973; Q9Y6L6
DB00216	Eletriptan	investigational; approved	77993	-	"For the acute treatment of migraine with or without aura in adults."	P28566; P28221; P28222; P34969; P41595; P30939; P08908
DB00346	Alfuzosin	investigational; approved	2092	-	"For the reduction of urinary obstruction and relief of associated manifestations (eg. sensation of incomplete bladder emptying or straining, urgency, interrupted or weak stream) in patients with symptomatic beningn prostatic hyperplasia."	Q12809; P35348; P25100; P35368
DB01656	Roflumilast	approved	449193	-	"Roflumilast is indicated as a treatment to reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. Roflumilast is not a bronchodilator and is not indicated for the relief of acute bronchospasm."	Q07343; Q08493; P27815; Q08499
DB04711	Iodipamide	approved	3739	-	"Iodipamide is used as a contrast agent for cholecystography and intravenous cholangiography."	P02768; Q96RI0
DB01556	Chlorphentermine	illicit; withdrawn	10007	-	"Used as an appetite suppressant."	P31645; Q01959
DB00416	Metocurine Iodide	approved; withdrawn	24244	-	"For use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy."	Q15822; P11230; P07510; P02708; Q04844; Q07001
DB00417	Phenoxymethylpenicillin	approved; vet_approved	6869	-	"For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms."	P24228; P08506; P02918; P02919; P12256; Q8XJ01; P46059; P0AD68; P0AEB2; P0AD65
DB00414	Acetohexamide	investigational; approved; withdrawn	1989	-	"Used in the management of diabetes mellitus type 2 (adult-onset)."	P78508; Q09428; Q14654; P48048; Q9NYK1
DB00415	Ampicillin	approved; vet_approved	6249	-	"For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc"	P24228; P08506; P0A3M6; P0AEB2; Q02763; P02919; P25090; P0AD68; Q8DR59; P0AD65; P02918
DB00412	Rosiglitazone	investigational; approved	77999	-	"Rosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. "	P00918; O14842; P19793; P28702; O60488; P27338; Q9UL62; P48443; P13631; P37231; Q03181; Q07869; P21397; Q9HCF6
DB00413	Pramipexole	investigational; approved	119570	-	"For the treatment of signs and symptoms of idiopathic Parkinson's disease"	P34969; P35462; P18825; P28221; P28222; P28223; P25021; P18089; P21918; P21728; P14416; P41595; Q16769; P08908; P28335; P21917; P08913
DB00217	Bethanidine	approved	2368	-	"For the treatment of hypertension."	P18825; P48048; P18089; P08913; P25100; P35368; P23975; P35348; P13945
DB00411	Carbachol	approved	5831	-	"Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery."	P08172; P08173; P22303; P11229; Q15822; P08912; P20309; P17787; P43681
DB00418	Secobarbital	approved; vet_approved	5193	-	"For the Short-term treatment of intractable insomnia for patients habituated to barbiturates"	Q494W8; O60391; P47869; Q16445; P78334; Q13002; P18507; P18505; Q8N1C3; P14867; O00591; Q9UN88; P28472; Q99928; O14764; P48169; P34903; P47870; P36544; P31644; P43681; P42262
DB00419	Miglustat	approved	51634	-	"For the treatment of adult patients with mild to moderate type 1 (nonneuropathic) Gaucher's disease for whom enzyme replacement therapy is not a therapeutic option (e.g. due to constraints such as allergy, hypersensitivity, or poor venous access). Now approved in some countries for the treatment of progressive neurological symptoms in adult and pediatric patients with Niemann-Pick disease type C (NP-C). "	P10253; O43451; Q16739
DB04398	Lactic Acid	approved; vet_approved	612	-	"For use as an alkalinizing agent."	P09546
DB04575	Quinestrol	approved	9046	-	"Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer."	Q92731; P03372
DB04574	Estrone sulfate	approved	3001028	-	"Estropipate is used for the treatment of moderate to severe vasomotor symptoms associated with the monopause, and moderate to severe symptoms of vulval and vaginal atrophy associated with the menopause. It is also used to treat hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and prevent postmenopausal osteoporosis."	Q92731; P03372
DB00898	Ethanol	approved	702	-	"For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated."	Q15825; Q494W8; Q15822; Q9UGM1; Q9GZZ6; Q06432; Q9Y698; P30532; P48549; O95264; P46098; P19320; P17787; Q03519; P32297; Q14542; P48051; P32004; P48058; A5X5Y0; Q70Z44; Q05901; Q8WXA8; Q99928; P47869; Q01668; Q16445; Q92806; P47870; P78334; P18505; O60896; P23415; P48544; Q8N1C3; P31644; P14867; P28472; Q02641; O00591; P23416; Q9UN88; P34903; P30926; O14764; P48169; Q8TCU5; Q8TCU4; Q16602; Q13936; P36544; Q13698; Q99808; P43681; P42261; P42262; P42263
DB04576	Fleroxacin	approved	3357	-	"Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone."	P11388; P43700; P43702; Q02880
DB04571	Trioxsalen	approved	5585	-	"Trioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo."	P21397; P28335; P29274
DB04570	Latamoxef	investigational; approved	47499	-	"Latamoxef is an oxacephem antibiotic usually grouped with the cephalosporins. It is used to treat bacterial infections. Latamoxef  is primarily indicated in conditions like Bone and joint infection, GI infections, Gynecological infections, Meningitis, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, UTI. "	P0AEB2; P08506; P02918; P02919; P42971; P0AD68; P24228; P0AD65; P08246
DB04573	Estriol	investigational; approved; vet_approved	5756	-	"Used as a test to determine the general health of an unborn fetus."	P04150; Q92731; P03372; P31645; P04278
DB00679	Thioridazine	approved; withdrawn	5452	-	"For the treatment of schizophrenia and generalized anxiety disorder."	Q12809; P35462; P08173; P18825; P10635; P28222; P28223; Q99250; P00533; P41595; P11229; Q99720; P34969; Q01959; P35348; P21728; P08913; P14416; P28221; P23975; P08172; P41145; P28335; P18089; P21918; P35498; P35368; P35367; Q9NY46; P21917; P08912; P25021; P25100; P50406; P20309; P08908; P31645; P06241; P01011
DB00892	Oxybuprocaine	investigational; approved	4633	-	"Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed."	Q14524; Q9UQD0; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q9UI33; Q15858; Q9NY46
DB00677	Isoflurophate	investigational; approved; withdrawn	5936	-	"For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia."	P02787; P22303; P06276
DB00890	Dienestrol	investigational; approved	667476	-	"For use in the treatment of atrophic vaginitis and kraurosis vulvae."	P04278; P03372
DB00891	Sulfapyridine	approved	5336	-	"For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum"	P0AC13; Q49184
DB00672	Chlorpropamide	investigational; approved	2727	-	"For treatment of NIDDM in conjunction with diet and exercise. "	P11413; Q09428; P78508; Q14654; P48048
DB00673	Aprepitant	investigational; approved	6918365	-	"For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including high-dose cisplatin (in combination with other antiemetic agents)."	P35270; P27352; P08684; P25103
DB00670	Pirenzepine	approved	4848	-	"For the treatment of peptic ulcer, gastric ulcer, and duodenal ulcer."	P08172; P08173; P08912; P11229; P20309
DB00671	Cefixime	investigational; approved	5362065	-	"For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by <i>Escherichia coli</i> and <i>Proteus mirabilis</i>, (2) otitis media caused by <i>Haemophilus influenzae</i> (beta-lactamase positive and negative strains), <i>Moraxella catarrhalis</i> (most of which are beta-lactamase positive), and <i>S. pyogenes</i>, (3) pharyngitis and tonsillitis caused by <i>S. pyogenes</i>, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) caused by <i>Neisseria gonorrhoeae</i> (penicillinase- and non-penicillinase-producing strains)."	P17813; P0AEB2; P08506; P02918; P02919; P24228; P14416; P0AD68; P44469; P0AD65
DB00388	Phenylephrine	approved	6041	-	"Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs. "	P18825; P18089; P08913; P25100; P35368; Q9NYA1; P35348
DB00389	Carbimazole	investigational; approved	31072	-	"For the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy."	P07202
DB00387	Procyclidine	approved	4919	-	"For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents."	P08172; P08173; O15399; P11229; Q05586; P22001; O60391; Q13224; Q12879; Q8TCU5; P08912; P20309; Q14957
DB00384	Triamterene	approved	5546	-	"For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and the nephrotic syndrome, also in steroid-induced edema, idiopathic edema, and edema due to secondary hyperaldosteronism."	P07306; P10635; Q13621; P37088; P51170; P51172; P51168
DB00385	Valrubicin	approved	454216	-	"For the treatment of cancer of the bladder."	P11388; Q02880
DB00382	Tacrine	investigational; withdrawn	1935	-	"For the palliative treatment of mild to moderate dementia of the Alzheimer's type."	Q05586; P22303; P06276; P10635; Q13224; Q12879; P23141; P25100; Q04844; P23975
DB00383	Oxyphencyclimine	approved	4642	-	"For the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders."	P08172; P11229; P20309
DB00380	Dexrazoxane	approved; withdrawn	71384	-	"For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines."	P11388; Q02880
DB00381	Amlodipine	approved	2162	-	"For the treatment of hypertension and chronic stable angina."	Q8IZS8; O95180; P18825; P54289; P17405; Q06432; P00915; P25100; P35348; Q00975; Q01959; P08913; Q08289; P35368; Q13698; O60840; Q01668; O95069; Q13936
DB00250	Dapsone	investigational; approved	2955	-	"For the treatment and management of leprosy and dermatitis herpetiformis."	P08684; P0C0X2; P0C0X1
DB00703	Methazolamide	approved	4100	-	"For treatment of chronic open-angle glaucoma and acute angle-closure glaucoma"	P00918; P22748; Q9Y2D0; P43166; P23280; Q9ULX7; P00915; Q16790; O43570; P35218; Q8N1Q1; P07451
DB00700	Eplerenone	approved	443872	-	"For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction."	P04150; P08235
DB00253	Medrysone	approved	247839	-	"For the treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, and epinephrine sensitivity."	P04150; P41231; P47712
DB00254	Doxycycline	investigational; approved; vet_approved	54671203	-	"Doxycycline is indicated for use in respiratory tract infections caused by Mycoplasma pneumoniae, Haemophilus influenzae, Streptococcus pneumoniae, Legionella spp., or Klebsiella spp. It is also used for prophylaxis of malaria. Doxycycline is indicated for a variety of bacterial infections, from Mycobacterium fortuitum and M. marinum, to susceptible E. coli and Brucella spp. It can be used as an alternative to treating plague, tetanus, Campylobacter fetus 
 "	B7NDR8; A8AQJ1; P0A7W0; B6I1U8; B7LHZ8; B1IQ03; P09237; A1AGI7; P0A7V8; P0A7V9; Q0TCN6; B7M102; B7NDK8; B7UJW2; B1X6E8; B7N102; A7ZSC4; Q1R636; B6I210; P0A7X3; A1AGC3; P61769; B7N181; P0A7X4; P0A7X5; B7MBZ1; Q0TCG5; A7ZSI5; B7LRR3; B1LGJ6; P45452; B7MCR2; P22894; B5YT15; B1XHK3; A6TEN8; B1LHB0; P03956; B7UK20; Q1R6B0; C4ZUF1; B7NLL6; A8A539; Q9UM07; A8A5A1; Q32B55; B1IQP9; B7M0U2; A8AQC0; B7NKU2; C4ZSW8; B5YSV6; B7LHT8
DB00255	Diethylstilbestrol	investigational; approved	3054	-	"Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery."	P11474; Q15596; P18825; P04278; P28223; P10275; P35372; P62508; O75469; P08913; P35462; P04150; O95718; P11229; Q01959; P03372; Q9Y271; P21728; P08588; P14416; Q92731; P29274; P30542; P41145; P22303; P41143; P28335; P18089; P41595; P23219; P37288; P23975; P25100; P20309; P31645; P06241
DB00256	Lymecycline	investigational; approved	54707177	-	"For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by <i>Bacillus anthracis</i> (anthrax). It is also effective against <i>Yersinia pestis</i> and malaria and is also prescribed for the treatment of Lyme disease."	A8A539; A8AQJ1; B1XHK3; B6I1U8; B7LHZ8; B1IQ03; A1AGI7; P0A7V8; P0A7V9; Q0TCN6; B7M102; Q32B55; B7N181; B1X6E8; A7ZSI5; B7N102; A7ZSC4; B7LHT8; Q1R636; B6I210; P0A7X3; A1AGC3; P0A7X4; B7MCR2; B7MBZ1; Q0TCG5; B7LRR3; B1LGJ6; B7NKU2; B5YT15; P0A7W0; A6TEN8; B1LHB0; B7UK20; Q1R6B0; C4ZUF1; C4ZSW8; B7NLL6; B5YSV6; B7NDK8; B1IQP9; B7M0U2; A8AQC0; B7UJW2; P0A7X5; A8A5A1; B7NDR8
DB00257	Clotrimazole	approved; vet_approved	2812	-	"For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch."	P10613; P08173; P28223; P25103; P35354; O75469; Q14994; P35462; Q8TD43; P04150; P00533; Q7Z2W7; P11229; Q12809; Q01959; P30518; Q9Y271; P21728; P08913; P05093; P14416; P29274; P30542; P08172; P41145; P22303; P51679; P41143; P28335; P18089; P08588; Q96RI1; P08684; P41595; O15554; P35367; O94759; P31645; P13945; P00918; P23975; P22001; P25021; P35372; P25100; P20309; P08908; P04626; P06241; P11511
DB05095	Cimicoxib	investigational	213053	-	"Investigated for use/treatment in depression."	P35354
DB00259	Sulfanilamide	approved	5333	-	"For the treatment of vulvovaginitis caused by <i>Candida albicans</i>."	P00918; P22748; P0AC13; P43166; P23280; Q9ULX7; P00915; Q16790; Q9Y2D0; O43570; P35218; Q8N1Q1; P07451
DB00708	Sufentanil	investigational; approved	41693	-	"Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain."	P41145; P35372; P41143
DB00709	Lamivudine	investigational; approved	60825	-	"For the treatment of HIV infection and chronic hepatitis B (HBV)."	Q05486
DB00212	Remikiren	approved	6324659	-	"For the treatment of hypertension and heart failure"	P00797
DB06159	Rubitecan	investigational	11954380	-	"Investigated for use/treatment in pancreatic cancer, leukemia (unspecified), melanoma, ovarian cancer, and cancer/tumors (unspecified)."	P11387
DB06155	Rimonabant	investigational; approved	104850	-	"For use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m<sup>2</sup>, or patients wih a BMI greater than 27 kg/m<sup>2</sup> with associated risk factors, such as type 2 diabetes or dyslipidaemia."	P22303; Q12809; P21554; Q9Y2T6
DB06626	Axitinib	investigational; approved	6450551	-	"Used in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer."	P09603; P21802; Q02750; P52333; P36507; P35968; P07947; P29597; O00444; P22607; Q08881; P07949; P00533; P00519; P07333; P16234; P17948; P35916; P06239; P08581; P11362; P09619; Q02763; P36888; P10721; O60674
DB06151	Acetylcysteine	investigational; approved	12035	-	"Acetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose."	Q05586; O15111; O15399; V9HWA0; Q03154; Q13224; Q12879; Q9UPY5; Q8TCU5; P48637; P15692; O14920
DB06150	Sulfadimethoxine	approved; vet_approved	5323	-	"For use in the treatment of infections."	P0AC13
DB04970	Lesopitron	investigational	60813	-	"Intended for the treatment of anxiety disorders."	P08908
DB13155	Esculin	approved	5281417	-	"As medication, esculin is sometimes used as a vasoprotective agent.
 Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria). In fact, all strains of Group D Streptococci hydrolyze ?sculin in 40% bile."	P10275
DB04972	Canfosfamide	investigational	5312109	-	"Intended for the treatment of various forms of cancer."	P09211
DB04975	Banoxantrone	investigational	9955116	-	"For the treatment of various forms of cancer."	P11388
DB13158	Clobetasone	approved	71387	-	"In dermatology, topical clobestasone butyrate helps to reduce the itchiness and erythema associated with eczema and dermatitis.
 In ophthalmology, clobetasone butyrate 0.1% eye drops have been shown to be safe and effective in the treatment of dry eyes in Sj?gren's Syndrome."	P04150
DB06713	Norelgestromin	investigational; approved	62930	-	"Norelgestromin is used for contraception and menopausal hormonal therapy. Norelgestromin may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy. "	P02768; P10275; P06401; P03372
DB06712	Nilvadipine	investigational; approved	4494	-	"For the management of vasospastic angina, chronic stable angina and hypertension."	Q8IZS8; P54289; Q08289; Q13936; Q13698; Q01668
DB06711	Naphazoline	approved	4436	-	"Naphazoline is primarily indicated in conditions like Corneal vascularity, Hyperaemia, Itching, Nasal congestion, and can also be given in adjunctive therapy as an alternative drug of choice in Sinusitis"	Q9Y2I1; P18825; P18089; P08913; P25100; P35368; P35348
DB06710	Methyltestosterone	approved	6010	-	"Methyltestosterone is an anabolic steroid hormone used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause."	P04150; P10275; P03372
DB06717	Fosaprepitant	approved	219090	-	"For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy."	P25103
DB06716	Fospropofol	illicit; investigational; approved	3038498	-	"For monitored anaesthesia care sedation in patients undergoing diagnostic procedures like bronchoscopy and colonscopy or minor surgical procedures like arthroscopy and bunionectomy. "	Q16445; P18507; P18505; O14764; P48169; P47870; Q8N1C3; P31644; P14867; P28472; P35499; Q99250; P47869; P34903; Q99928
DB06715	Potassium Iodide	approved	4875	-	"Potassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution."	P22748
DB06714	Propylhexedrine	approved	7558	-	"It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis."	Q96RJ0; Q05940
DB06718	Stanozolol	approved; vet_approved	25249	-	"Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating C1-inhibitor deficient hereditary angioedema. C1-inhibitor is a protease that inhibits the complement system (part of the innate immune system), a biochemical chain of reactions which assists the body in removing pathogens from the body. Stanozolol may help control attacks of hereditary angioedema.  Stanozolol can be administered orally or intramuscularly. "	P10635; P10275; P03372
DB08819	Tafluprost	approved	9868491	-	"Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension."	P43088
DB03010	Patupilone	investigational; experimental	448013	-	"Investigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer."	P68366; P68363; P68371; Q5SU16; Q9BQE3; Q71U36; Q9H4B7; P07437; Q9NY65; Q13509; Q13748; P04350
DB06536	Tesaglitazar	investigational	208901	-	"Investigated for use/treatment in diabetes mellitus type 2."	P37231; Q07869
DB00875	Flupentixol	investigational; approved; withdrawn	5281881	-	"For use in the treatment of schizophrenia and depression"	P11229; Q99720; P28223; P21918; P21728; P14416; P08908; P35367; P35348; P35462
DB00876	Eprosartan	approved	5281037	-	"For the management of hypertension alone or in combination with other classes of antihypertensive agents. Also used as a first-line agent in the treatment of diabetic nephropathy, as well as a second-line agent in the treatment of congestive heart failure (only in those intolerant of ACE inhibitors)."	P30556
DB00877	Sirolimus	investigational; approved	5284616	-	"For the prophylaxis of organ rejection in patients receiving renal transplants."	P09038; P62942; P08684; P42345
DB00870	Suprofen	approved; withdrawn	5359	-	"Used as eye drops to inhibit the miosis (pupil constriction) that may occur during ocular surgery."	P23786; P35354; P23219
DB00871	Terbutaline	approved	5403	-	"For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial."	P07550; P08588; P13945
DB00872	Conivaptan	investigational; approved	151171	-	"For the treatment of euvolemic or hypervolemic hyponatremia (e.g. the syndrome of inappropriate secretion of antidiuretic hormone, or in the setting of hypothyroidism, adrenal insufficiency, pulmonary disorders, etc.) in hospitalized patients."	P37288; P30518
DB00873	Loteprednol	approved	9865442	-	"As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis."	P04150
DB00348	Nitisinone	investigational; approved	115355	-	"Used as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1."	P32754
DB00349	Clobazam	illicit; approved	2789	-	"For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy. "	Q9UN88; P24046; P28472; O14764; P18507; P28476; A8MPY1; O00591; P18505; P48169; P47870; Q8N1C3; P33261; P14867; P47869; P34903; Q16445; Q99928; P31644; P78334
DB00438	Ceftazidime	approved	5481173	-	"For the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis)."	P24228; P08506; P07333; P0AD68; P02918; P02919; P10276; P0AEB2; P72161; Q8DR59; P0AD65
DB01120	Gliclazide	approved	3475	-	"For the treatment of NIDDM in conjunction with diet and exercise. "	Q09428; P15692; O60706; Q14654; P48048
DB01123	Proflavine	approved	7099	-	"Topical antiseptic used mainly in wound dressings."	P00734; P0A0N4
DB05434	ABT-510	investigational	6918562	-	"Investigated for use/treatment in lymphoma (unspecified), melanoma, and solid tumors."	P09038; P14210; P15692; P10145
DB06446	Dotarizine	investigational	55285	-	"Investigated for use/treatment in migraine and cluster headaches."	P28223; P28335; O00555; P08908
DB06444	Dexanabinol	investigational	107778	-	"Investigated for use/treatment in traumatic brain injuries and neurologic disorders."	Q05586; O15399; O60391; Q13224; Q8TCU5; P01375
DB02709	Resveratrol	investigational; approved; experimental	445154	-	"Being investigated for the treatment of Herpes labialis infections (cold sores)."	P54577; P05067; P31749; P16152; P49286; B0LPE5; O75469; P48039; Q08499; P05106; P37840; P03372; P08648; P16050; P35869; Q92945; P68400; Q8TCG2; P23219; P09917; P16083; P35354; Q14994; Q07869; P23786; Q86T13; P37231; Q07343; P11166
DB06441	Cangrelor	approved	9854012	-	"For use as an adjunct to percutaneous coronary intervention (PCI) for reducing the risk of periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST) in patients in who have not been treated with a P2Y12 platelet inhibitor and are not being given a glycoprotein IIb/IIIa inhibitor."	Q9BPV8; Q9H244
DB00343	Diltiazem	investigational; approved	39186	-	"For the treatment of Hypertension"	P28223; O95180; P54289; Q12809; Q06432; Q13936; P08684; P35498; Q99250; P46098; Q13698; O60840; Q01668; P22460; Q9NY46
DB00436	Bendroflumethiazide	approved	2315	-	"For the treatment of high blood pressure and management of edema related to heart failure."	P00918; P22748; Q13621; P00915; P55017; Q92952; Q9H2S1; Q12791
DB03128	Acetylcholine	approved	187	-	"Used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required."	P08172; P08173; P22303; P11229; P20309; Q494W8; P08912; P36544; P17787; P43681
DB03496	Alvocidib	investigational; experimental	5287969	-	"Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified)."	P00533; P06493; P50613; P11217; P11216; Q00535; Q00534; Q00526; P06737; Q15131; P50750; P11802; P24941; P49336
DB00341	Cetirizine	approved	2678	-	"For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria"	P35367; Q02763; Q12809
DB11712	Tezacaftor	investigational; approved	46199646	-	"Tezacaftor, in combination with ivacaftor, is indicated for the treatment of cystic fibrosis in people aged 12 years or older who have two copies of the _F508del_ mutation or at least one mutation in the CFTR gene that is responsive to this treatment based on clinical evidence.[L1598]
 
 Cystic fibrosis is a rare, life-shortening disease caused by a defective or missing CFTR protein. This modification in the protein is caused by a mutation in the CFTR gene. The affected people carry two inherited defective copies of the CFTR gene. There are approximately 2000 known mutations in the CFTR gene. The presence of a defective or missing protein results in poor flow of salt and water into and out of the cell. This condition will cause the buildup of abnormally thick, sticky mucus in the lungs that will later potentially cause chronic lung infections and lung damage. In the patients with the _F508del_ mutation, the CFTR protein is not processed or folded normally within the cell and thus, it does not reach the cell surface.[L1599]"	P13569
DB01128	Bicalutamide	approved	2375	-	"For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer."	P10275
DB02383	Tolrestat	withdrawn	53359	-	"For the pharmacological control of certain diabetic complications."	O60218; P14550; Q99720; P15121
DB00432	Trifluridine	investigational; approved	6256	-	"Ophthalmic solution for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2."	P04818; Q53Y97
DB00345	Aminohippuric acid	investigational; approved	2148	-	"Used to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism."	Q4U2R8
DB09396	Propoxyphene napsylate	approved	33544	-	"Propoxyphene is a centrally acting opiate analgesic. It is indicated for the relief of mild to moderate pain"	P41145; P35372; P41143
DB00261	Anagrelide	approved	2182	-	"For the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events."	Q14432; O00408; Q13370
DB09395	Sodium acetate	approved	517045	-	"Injection, USP 40 mEq is indicated as a source of sodium, for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Sodium acetate and other bicarbonate precursors are alkalinising agents, and can be used to correct metabolic acidosis, or for alkalinisation of the urine."	P00915
DB05389	WF10	investigational; approved	3000391	-	"Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, cancer/tumors (unspecified), HIV infection, and inflammatory disorders (unspecified)."	Q86VB7; Q7L5Y9
DB05381	Histamine	investigational; approved	774	-	"Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function."	Q9H3N8; Q96RJ0; P25021; Q05940; P35367; Q9Y5N1
DB05383	Pimagedine	investigational	2146	-	"Investigated for use/treatment in diabetic kidney disease."	P15121; P35228; P35625
DB05382	Iodine	investigational; approved	807	-	"Investigated for use/treatment in breast disorders (unspecified) and pain (acute or chronic)."	P03915; P03372
DB08869	Tesamorelin	investigational; approved	56928011	-	"Tesamorelin acetate is a synthetic analogue of human hypothalamic Growth Hormone Releasing Factor (hGRF) indicated to induce and maintain a reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. "	Q02643
DB08868	Fingolimod	investigational; approved	107970	-	"Fingolimod is a sphingosine 1-phosphate receptor modulator indicated for the treatment of patients with relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability."	O95977; Q99500; P21453; Q13547; Q6IT96; O95136; Q9H228
DB08867	Ulipristal	approved	13559281	-	"As the product Ella (available in Canada and the US), ulipristal is indicated for use as emergency contraception after unprotected intercourse or possible contraceptive failure when administered within 120 hours (5 days) after unprotected intercourse or a known or suspected contraceptive failure. As the product Fibristal (available in Canada), ulipristal is indicated for treatment of the signs and symptoms of uterine fibroids in adult women."	P04150; P06401; P10275
DB08865	Crizotinib	approved	11626560	-	"Crizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test. "	P08069; P52333; P07947; P29597; P22607; Q08881; P07948; P07949; P29317; P00533; P00519; P07333; Q9UM73; P17948; P06239; P08581; P06748; P06213; P12931; Q13464; Q02763; P36888; P10721; P23458; O75116; Q06187; O60674; P06241
DB08864	Rilpivirine	approved	6451164	-	"Rilpivirine, in combination with other agents, is indicated for the treatment of HIV-1 infections in antiretroviral treatment-naive patients with HIV-1 RNA ?100,000 copies/mL and CD4+ cell count >200 cells/mm3.[L1030] The FDA combination therapy approval of rilpivirine and dolutegravir is indicated for adults with HIV-1 infections whose virus is currently suppressed (< 50 copies/ml) on a stable regimen for at least six months, without history of treatment failure and no known substitutions associated to resistance to any of the two components of the therapy.[L1031]"	O75469
DB05541	Brivaracetam	investigational; approved	9837243	-	"Used as adjunctive therapy for partial-onset seizures in patients 16 years of age or older."	P33261; Q7L0J3; Q8IWT1
DB05540	Alanosine	investigational	22128	-	"Investigated for use/treatment in brain cancer and cancer/tumors (unspecified)."	P0A786; Q8N142; P30520
DB02638	Terlipressin	investigational; approved	72081	-	"Commonly used to stop bleeding of varices in the food pipe (oesophagus)."	P30518; P37288; P47901
DB05944	Varlitinib	investigational	42642648	-	"Investigated for use/treatment in cancer/tumors (unspecified)."	P00533; P04626
DB06448	Lonafarnib	investigational	148195	-	"Investigated for use/treatment in solid tumors, leukemia (unspecified), and lung cancer."	P49354; P49356; P17936; P01112; P01111; P01116
DB06774	Capsaicin	approved	1548943	-	"The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain. "	Q99623; Q09470; Q8NER1; Q96RP8; P13569; P23219
DB11362	Selexipag	approved	9913767	-	"Selexipag is indicated for the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce risk of hospitalization."	P43119
DB11363	Alectinib	investigational; approved	49806720	-	"Alectinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials."	P08581; Q9UM73; P35968; P07949
DB05767	Andrographolide	investigational	5318517	-	"Investigated for use/treatment in ulcerative colitis."	Q00653; P05231; P01584; P19838; P01375
DB11367	Cefroxadine	withdrawn	5284529	-	"Was used for the treatment of bacterial infections."	P02919
DB09244	Pirlindole	approved	68802	-	"For the treatment of major depression.
 
 It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving a motor vehicle shows many similarities to that of placebo. The drug appears to stimulate the central nervous system, rather than exhibit a sedative effect, like many antidepressants.  Because of its selective, reversible inhibition of monoamine oxidase (MAO-A) and short half-life, unpleasant \"cheese effects\" are avoided. This refers to the effects of consuming tyramine-rich foods, such as cheese while medicated with monoamine oxidase inhibitors, leading to severe headaches and hypertension [L1395].  of The available evidence supports pirlindole as a safe and effective treatment option for the management of depression and fibromyalgia syndrome [L1394].
  
 
 "	P21397; P08913; P08908
DB09245	Toloxatone	approved	34521	-	"For the treatment of major depressive disorder. "	P21397; P27338
DB09241	Methylene blue	investigational; approved	6099	-	"Methylene blue has several indications in medicine:
 1. found to improve the hypotension associated with various clinical states.
 2. Antiseptic in urinary tract infections. 
 3. Improves hypoxia and hyper dynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome. 
 4. Results in transient and reproducible improvement in blood pressure and cardiac function in septic shock. 
 5. Investigated for the treatment of Alzheimer's disease.
 6. Treatment of ifofosamide induced neurotoxicity."	P21397; P00390; P27338; Q16881; P33402; P29475
DB09242	Moxonidine	investigational; approved	4810	-	"For the treatment of mild to moderate essential or primary hypertension [L1025]. Effective as most first-line antihypertensives when used as monotherapy [A27137]."	P18825; P08913; Q9Y2I1; P08908
DB09248	Mebanazine	withdrawn	6179	-	"For the treatment of depression."	P21397; P27338
DB00322	Floxuridine	approved	5790	-	"For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. Also for the palliative management of liver cancer (usually administered by hepatic intra-arterial infusion)."	P04818; Q53Y97; Q8TDS4
DB08916	Afatinib	approved	10184653	-	"Afatinib is a kinase inhibitor indicated for the first-line treatment of patient with metastatic non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test."	P00533; P00519; P08631; P12931; P04626; P06239; P08581; P36888; Q15303
DB08915	Aleglitazar	investigational	10274777	-	"Investigated for use in patients with type II diabetes to reduce their risks of cardiovascular mortality and morbidity."	Q15788; P37231; Q07869
DB00323	Tolcapone	approved; withdrawn	4659569	-	"Used as an adjunct to levodopa/carbidopa therapy for the symptomatic treatment of Parkinson's Disease. This drug is generally reserved for patients with parkinsonian syndrome receiving levodopa/carbidopa who are experiencing symptom fluctuations and are not responding adequately to or are not candidates for other adjunctive therapies."	P21964
DB08912	Dabrafenib	investigational; approved	44462760	-	"Dabrafenib is indicated for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA-approved test."	Q8NG66; P15056; P57059; P04049; P53667
DB08911	Trametinib	approved	11707110	-	"Trametinib is indicated for the treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, as detected by an FDA-approved test. "	P36507; P15056; Q02750; P11413; O14733
DB08910	Pomalidomide	approved	134780	-	"Pomalidomide is indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on or within 60 days of completion of the last therapy."	Q13619; Q16531; Q96SW2; P62877; P35354; P01375
DB05168	Vintafolide	investigational	122173811	-	"Investigated for use/treatment in solid tumors."	P41439; P15328; P14207
DB08918	Levomilnacipran	investigational; approved	6917779	-	"Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor and is indicated for the treatment of major depressive disorder (MDD). "	P31645; P23975; Q01959
DB01428	Oxybenzone	approved	4632	-	"Used as an ingredient in sunscreen and other cosmetics."	P06401; P03372; Q92731; P10275
DB01399	Salsalate	approved	5161	-	"For relief of the signs and symptoms of rheumatoid arthritis, osteoarthritis and related rheumatic disorders."	P35354; P23219; Q08289
DB01396	Digitoxin	investigational; approved	441207	-	"For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure."	P05023; P50993; Q12809; P05026; P13637; Q13733; P14415; P54709; P54710
DB01425	Alizapride	approved	43008	-	"Alizapride is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting. "	P18825; P14416
DB01394	Colchicine	approved	2833	-	"For treatment and relief of pain in attacks of acute gouty arthritis."	P23415; P07437; Q5SU16; P68371; Q9H4B7; P08684
DB01427	Amrinone	approved	3698	-	"Used in the treatment of congestive heart failure."	P27815; Q14432; Q13370; Q08493; P01375; Q07343; Q08499
DB01392	Yohimbine	investigational; approved; vet_approved	8969	-	"Indicated as a sympatholytic and mydriatic. Impotence has been successfully treated with yohimbine in male patients with vascular or diabetic origins and psychogenic origins."	P35462; P18825; P28221; P28222; P28223; P18089; Q99250; P47898; P28566; P48736; P34969; P35348; P30939; P08913; P11387; P14416; P10635; P42338; P42336; P28335; P41595; P35498; P35368; Q9NY46; O00329; P53634; P25100; Q15842; P08908; P42345; P01011
DB01421	Paromomycin	investigational; approved	165580	-	"For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy."	B5YVV7; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; B5F3B9; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; C4ZUG3; B1LHB0; P0A7T7; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; Q57PV0; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; B7UK52; P68680; Q1R612; B7LRT5; B1IPL2; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; P60423; B7NLN3; Q5SHN7; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B4TUF2; B7LHP9; B4TKM3; B6I1U8; B5R1G3; Q57J49; Q5PIU7; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; A7MPH8; A9MN70; P60624; P60625; P60626; C0Q0C4; B4SXD8; B7NDS9; B7NDS5; B7MTL9; B5FJK8; B5FJK9; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; P0A7T8; C4ZS29; B7NJS8; A8A539; B1LE15; B1LQM1; B6I208; P0A7N4; A8ARM4; B5BGY5; A8AQC0; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; P0A7W9; A4THT0; P0A7W8; B4T4N0; B4T4N1; Q2NWE7; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; A9MVN1; P62401; Q0T9J1; P0C020; C4ZSW8; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; A9MN59; P62400; A9MX79; B4TGH3; B5QUQ1; P0A7R5; B5FN11; P0AG44; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; B4TFD7; B6I2A8; A9N5Y8; B4TGH4; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; B5RAX1; P68686; B7MCV7; A1AGJ3; B6I242; B7MCS3; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; P68681; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; Q0TCN6; Q32B55; Q0THB2; Q32B57; B7MCT0; B7N1A3; A7ZSK3; A7ZSK0; A9MGD1; B5R285; P0A7K2; B5R286; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; B7MCS6; B5FJA6; A8A5A1; A8A5A2; B7MCS1; B5F7T9; A7ZSK6; P60727; B5F7T1; B7M1M5; B5F7T4; B7NR05; P68919; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; B7N0V1; Q329M1; P60422; B1X6G3; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; B6I228; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B5BGX2; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; P0A7S7; B7UK18; A1AGI8; A1AGI7; Q32BE7; A1AGI5; Q1R609; B7NDK8; B4TKL4; P68679; B4TKL0; Q0TCE2; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; Q1RD68; P0A7X0; P0A7X1; P0A7S4; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; Q57HZ9; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; A9MJT9; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; P0A7W4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; B1LHD1; Q5PJ56; A9MKN8; B1LHD0; B7LLY4; B1LHD3; Q0THB3; B6I437; B7MCT2; B7NEU0; B7NLL4; B7NLL7; B7NLL6; A8A5A4; P0C018; B4SUT9; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; P0A7Q6; B7MGC4; A7MPH5; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; B2K2I4; P02413; A9MN54; Q1C365; B1LL30; A1JQX1; B7M1C5; P0A7M6; P0A7M2; P0A7M9; B7MCR9; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; B7LR53; A1ABQ0; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B7MCT1; B6I229; A6TG05; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B4TXF0; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; B5RFY6; A1AGM9; P0A7J3; A6TE47; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7NDS7; B7L847; A7ZSK8; B5YXA7; B7NGD6; P60438; B4SYA9; Q32B54; B1X6F1; Q0TCS4; A7ZSK4; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; Q32B52; B7LQD9; B5XZP7; B7M092; C0Q0A5; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; B7LRS4; B1IT04; Q1R632; B5FSA3; P60723; B5R280; B7N2E8; A4WEK0; P61179; P61178; B6I3T6; P0AG55; B1LGJ6; P61177; P61176; P61175; B5QZ45; Q32B24; P0A7T9; B7NDH0; B7LS48; B1IPL1; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TKK9; A8A5C2; Q5PC32; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0AG47; Q1R4V6; P0AG45; P0A7R0; A6THB3; B2VGJ7; A8A5B3; B7N1C3; B1X6F8; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; P12235; Q5PK05; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; B7M1N1; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; C4ZUH4; A7ZS83; B5F7F9; B7LCR3; B5REG7; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B7LX23; B1IPZ0; B1IPZ1; P0A7N6; P0A7N7; P0A7N8; P0A7N9; B1X6F6; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B5BG21; B7UJW2; A7ZSI3; A7ZSI5; A7ZSI6; B6I218; Q57PV1; B1X6G8; B6I210; B6I211; A7ZRU7; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; B1LE14; P0A7W3; B7N192; P0A7W1; P0A7W0; B7N1A0; B7N199; B7N198; C0Q1W9; B4F277; C4ZR79; C5BF78; A8GJV2; B7M9G4; B5FJA5; Q1CME3; B1IPZ5; A8AQJ1; B5Y306; B1IPZ6; B7M1M2; B7M1M3; B7M1M0; B5EXE1; P0A7S2; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B7MJ76; P60724; Q57IA6; B1IPZ3; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P60726; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; Q1RB79; B1LHC8; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; A8AQL8; C4ZSS5; B5RBB1; B1LK73; B7UJ79; A1AGK6; Q57JQ0; P0A7Q8; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B7M1C4; P0C019; A8A501; A9MFK9; A4WFD5; A9N240; B5BKL1; B7NDT2; B7NF20; Q1R626; B7UMH0; B7L4K6; B7NDT7; C0Q644; C4ZUH0; B7NDT6; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0A7S3; Q1RB78; P0A7S1; P0A7S0; P0AG51; P0A7S6; P0A7S5; B7UPA5; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; P0A7J7; B7NDT5; Q1R627; B5R290; Q1R4N3; B7NDT8; B5R299; P62399
DB01390	Sodium bicarbonate	approved	516892	-	"Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments."	Q9NRG4; Q9UK17
DB12129	Tideglusib	investigational; withdrawn	11313622	-	"Tideglusib was initially formulated for the treatment of Alzheimer and progressive supranuclear palsy.[A31601] The raising interest for the use of tideglusib comes from the significant upregulation of GSK-3 in the brain in patients with Alzheimer disease. Its function as a degradant of ?-catenin, was also important, as it prevents the transcription of cell survival genes. All these factors have directed current research towards this kinase as a potential target.[A31603] Alzheimer disease is the most prevalent form of dementia. The most accepted hypothesis to explain this disease is related to the presence of amyloid ?, which triggers a cascade that will alter the Tau protein and provoke synaptic dysfunction and neuronal death.[A31605] 
 
 GSK-3 importance in the tissue repair pathway has also pointed out a novel application for tideglusib. Thus, it is also under the research for the natural repair treatment of deep caries lesions.[A31602] "	P49841; Q6FI27; P49840
DB09095	Difluocortolone	investigational; approved; withdrawn	11954369	-	"Difluocortolone is used as a topical treatment of the symptoms of inflammatory skin disorders like eczema, seborrheic eczema, lichen planus and psoriasis. All these disorders present as a common characteristic the occurrence of symptoms as itching, swelling, redness and scaling.[L1083]"	P04150; P12429
DB06243	Eflornithine	approved; withdrawn	3009	-	"Eflornithine is indicated in the treatment of facial hirsutism (excessive hair growth)."	P11926
DB09091	Tixocortol	approved; withdrawn	162955	-	"Tixocortol is indicated for the treatment of rhinitis as a nasal suspension or aerosol. It is also used in the form of lozenges for the treatment of pharyngitis and in the form of enemas or rectal solution for the treatment of ulcerative colitis. Tixocortol can be used orally in a suspension or powder for the treatment of inflammatory conditions.[L1077] It is also the substance used for the screening of contact allergies to class A steroids.[A31435]"	P04150; Q92769
DB09090	Pinaverium	approved	40704	-	"Indicated for the treatment and relief of symptoms associated with irritable bowel syndrome (IBS) associated with abdominal pain, bowel disturbances and intestinal discomfort, as well as the treatment of symptoms related to functional disorders of the biliary tract. "	Q13698
DB09093	Chlortetracycline	investigational; approved; vet_approved	54708735	-	"Used in the manufacuring of medicated animal feeds [FDA Label]."	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; A7ZSI6; C0PYY2; B5F3B9; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; B1LHB1; B1LHB0; P0A7T7; C0Q0A5; C4ZUG9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; P68686; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B7LS48; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B7UMH0; B7LHP9; B4TKM3; B6I1U8; B5R1G3; Q57J49; Q5PIU7; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; Q0TCF5; A9MN70; B7M1C4; B7M1C5; P60626; A6TE47; B4SXD8; B7NDS9; B1IPL1; P62401; B7NDS5; B7MTL9; B5FJK8; B7UK28; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; P0A7T8; C4ZS29; A8A539; P0A7W5; B1LQM1; B6I208; B7NJS8; P0A7W4; A8AQC0; C0Q2L0; B7N192; A8A5E9; Q57GI9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; P0A7W9; B1LE14; A4THT0; B7N198; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; A9MVN1; A9MX79; Q0T9J1; B4TAV0; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; A9MN59; B5R286; P62400; B4TGH4; B4TGH3; B5QUQ1; P0AG47; C5BF78; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; P0C020; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; Q0TCE2; Q0TD41; B7MCV7; B1IPY8; B6I242; B7MCS3; B7UK39; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; A1AGJ5; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; A7ZSK8; Q0THB3; Q32B54; A7ZSK4; B7MCT0; B7N1A3; A7ZSK3; A7ZSK0; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; B5R280; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; B7UK52; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; P60624; B7M1M3; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; P68679; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; A8A5A1; A8GJV2; B5FJA5; B5F7T9; A7ZSK6; Q32B57; B5F7T1; B5F7T4; B7NR05; A8AQL8; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; A1AGI5; Q329M1; P60422; B1X6G3; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; B6I228; B7LG22; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; B5R0S0; B5EYX3; A6TAI4; P0A7S7; B7UK18; A1AGI8; A1AGI7; B7M1N1; B7N0V1; Q1R609; B7NDK8; B4TKL4; B4TUF2; B5RAX1; B1XG70; B4TKL0; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; Q57HZ9; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; A9MJT9; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; Q1RD68; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B4TXC8; B1LHD1; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B4TXF0; B6I437; B7MCT2; B7NEU0; C4ZUE9; B7NLL7; B7L6I9; P0C018; B4SUT9; B1X6G0; B1LF57; P0A7N4; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7MGC4; P0A7V5; Q0TCF8; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; B1X6F8; P02413; A9MN54; Q1C365; B5RFY6; P60625; P0A7M6; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; P0A7L8; C0Q0C4; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; B7LR53; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; A6TG05; Q1R358; Q1R604; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; B7MJ76; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; B1LHD0; B1LHD3; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; A1JQX1; P0A7V6; P0A7V7; B7NLP7; P0AG44; B7MCR9; A1AGM9; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7NDS7; B7L847; Q0TCN6; B7MCS6; B5YXA7; B7NGD6; Q32B55; B4SYA9; Q0THB2; B1X6F1; Q0TCS4; B7MCT1; B1X6F6; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; B7MCT4; P0A7W8; B7LQD9; B5XZP7; B7M092; B5BGY5; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B5FJK0; A8AQJ1; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7K6; B7N2E8; B7L4J5; P61179; B7LRS7; B6I3T6; C4ZUH4; B1LGJ6; P61177; P61176; P61175; Q32B24; P0A7T9; B7NDH0; B1IPL2; B5BG21; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; A8A5C2; Q0TCG7; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0A7R5; Q1R4V6; P0AG45; P0A7R0; A6THB3; A8A5B3; B7N1C3; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; Q5PK05; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; Q32BE7; B7M1N0; Q1R5U1; A1AGJ7; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B1X6H0; B7LCR3; A9MGD1; A9N240; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7LRS4; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B1IV14; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B1IPZ6; B1IPZ0; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A8APV6; B7L4K8; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; P0A7W6; B1LE15; A8ARM4; P0A7W3; P0A7W2; P0A7W1; P0A7W0; B7N1A0; B7N199; Q5PKU5; C0Q1W9; B4F277; C4ZR79; B5FN11; A8A5A2; B7M9G4; P0AG59; B7MCS1; Q1CME3; P0A7N1; B5YTM9; B5Y306; B7LX23; B7M1M2; P0A7S3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; C4ZUG3; B5QZ45; Q57IA6; B1IPZ3; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; B1X6G8; A9MPV4; B5F8E7; B1LHC8; B7NLL4; B5YTN0; B5YTN2; P27815; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; P68919; C4ZSS5; B5RBB1; B1LK73; B7UJ79; A1AGK6; Q57JQ0; B1IPV7; P61178; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B1IT04; Q1R620; P0C019; A8A501; A9MFK9; A4WFD5; B5REG7; A9N241; B7NDT2; B7NF20; B7NDT5; B7L4K6; B7NDT7; C0Q644; C4ZUH0; B7NDT6; C4ZUH1; P0A7S9; P0A7S8; P0AG55; C4ZUH2; Q1RB79; P0A7S2; P0A7S1; P0A7S0; P0AG51; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; P0A7J7; Q1R626; Q1R627; B5R290; Q1R4N3; B7NDT8; P62399; B5R299
DB09092	Xanthinol	approved; withdrawn	9913	-	"Xanthinol is primarily used in diet supplements to increase the brain metabolism of glucose and obtain ATP. Xanthinol is also used as an agent to reduced cholesterol as it is a vasodilator.[L1080] Its action allows having an elevated rate of blood flow in the brain which helps improve memory function, concentration and awareness.[L1079] Thus, due to his actions, xanthinol is indicated to improve cerebrovascular and peripheral vascular disorders as well as hyperlipidaemias.[L1081]"	P50213; P39023; P04406; Q13423; P40926; Q02218
DB09099	Somatostatin	investigational; approved	16129681	-	"For the symptomatic treatment of acute bleeding from esophageal varices. Other treatment options for long-term management of the condition may be considered if necessary, once initial control has been established."	P30874; P32745; P35346; P30872; P31391
DB00207	Azithromycin	approved	447043	-	"For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: <i>H. influenzae</i>, <i>M. catarrhalis</i>, <i>S. pneumoniae</i>, <i>C. pneumoniae</i>, <i>M. pneumoniae</i>, <i>S. pyogenes</i>, <i>S. aureus</i>, <i>S. agal</i>"	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; A7ZSI6; C0PYY2; B5F3B9; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; C4ZUG3; B1LHB0; P0A7T7; C4ZUG9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; P68683; P68680; P68681; B7LRT5; B7LS48; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; B7NLN3; B5BG21; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5BIL5; B5YSV6; C4ZYY0; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; Q57J49; Q5PIU7; B1IQ03; B1IQ02; B1IQ00; B1IQ05; O43193; C4ZQY2; A6TEW0; Q0TCF5; A9MN70; P60624; P60625; P60626; Q1R4N3; A6TE47; B4SXD8; B7NDS9; B7NDS5; B7NDS7; B5FJK8; B7UK28; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B1LHB1; A8A539; B1LE15; B1LQM1; B6I208; B7NJS8; B1LE14; Q5PK05; C0Q2L0; P0A7W2; B5F8G0; A8A5E9; Q57GI9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; P0A7W9; A4THT0; Q32FI2; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; A9MVN1; B4TGH4; Q0T9J1; A9MN59; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; B5R286; P62400; P62401; B4TGH3; B5QUQ1; P0A7R5; C5BF78; Q1R4V6; B7NLM3; B7NLM7; B7NLM5; B7NLM8; Q12809; A9MFC1; P0C021; P0C020; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; A6TG05; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; B5RAX1; P68686; B7MCV7; B1IPY8; B6I242; B7UK39; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P0A7L6; P0A7L7; P0A7L4; B7MFJ7; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1XHG2; P0AG66; P0AG67; P0ADZ0; A7ZSK8; A7ZSK6; Q0THB2; Q32B57; A7ZSK5; B7N1A3; A7ZSK3; B7N1A1; B7MCT4; B5R285; P0A7K2; Q1R632; Q1R635; B5R280; B7LHP9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X970; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7UK52; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; Q32B54; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8GJV2; B5FJA5; B5F7T9; B7NLN0; B5F7T1; B7M1M5; B5F7T4; B7NR05; A8AQL8; P0A7S3; B6I3L3; A8AQL3; B7MST2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; B7N0V1; Q329M1; P60422; P60423; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; Q1R609; B7LG22; B1IPY4; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B7MJ76; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q9UM07; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; B5R0S0; B5EYX3; A6TAI4; P0A7S7; B7UK18; A1AGI8; C4ZUF2; A1AGI7; Q32BE7; A1AGI5; B7NDK8; B4TKL4; B4TKL0; P41587; Q0TCE2; Q57HZ9; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; B6I211; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; B7LVJ7; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B4TXC8; P0A7V8; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B4TXF0; Q0THB3; B6I437; B7NEU0; C4ZUE9; B7NLL7; B7L6I9; P0C018; B4SUT9; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; B1XHK3; Q2NWE7; A7MPH5; A9MJT9; P0A7L5; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; B1X6F8; P02413; A9MN54; Q1C365; B7N102; B7M1C4; B7M1C5; P32241; P0A7M6; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1IPY3; B1IPY2; B1IPY5; A9MGD1; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; B6I228; Q1R358; A9MSZ3; Q1R604; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; B1LHD1; B1LHD0; B1LHD3; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; B7MCR9; A1AGM9; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; Q5PKU5; B4TAV0; B7N0L5; B1LGQ0; B7L847; Q0TCN6; B7MCS6; B5YXA7; B7NGD6; P60438; B4SYA9; B7MCT2; B1X6F1; Q0TCS4; B7MCT1; B1X6F6; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; Q32B52; P0A7W8; B7LQD9; B5YTM5; B7M092; C0Q0A5; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7T8; P0A7K6; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; A7ZTQ9; C4ZUH4; B1LGJ6; P61177; C4ZUH1; C4ZUH2; Q32B24; P0A7T9; B7NDH0; B1IPL2; B1IPL1; A4WFC2; Q328J7; B4TKK1; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q0TCG7; Q2EEQ2; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; Q1R616; A8A5B3; B7N1C3; A1ABQ0; B7MLK7; B5BGY5; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; A8AQC0; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7M1N1; B7M1N0; Q1R5U1; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; A8A5C2; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; P0AG65; B1LHC5; A7ZS83; B5F7F9; A9MFK9; A9N240; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; P41586; B4T3F3; Q5PC32; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B7LX23; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; A1AGK6; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; B7LRS7; P68679; B7L4K8; B6I218; Q57PV1; Q57PV0; B6I210; Q1R612; Q1R610; B7LR53; B5FN11; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B7MTL9; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; A8ARM4; P0A7W3; B7N192; P0A7W1; P0A7W0; B7N1A0; B7N199; B7N198; C0Q1W9; B4F277; C4ZR79; A8A5A1; A8A5A2; B7M9G4; P0AG59; P0A7L8; B7MCS1; Q1CME3; B5RFY6; P0A7W4; B1IPZ5; A8AQJ1; B5Y306; B1IPZ6; B7M1M2; B7M1M3; B7M1M0; B5EXE1; P0A7S2; B1IPZ0; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; B5QZ45; Q57IA6; B1IPZ3; B1X6E8; B1X6E9; C0Q0C4; P0A7S6; P02358; P02359; P0A7R9; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; B1LHC8; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; P68919; C4ZSS5; B5RBB1; B1LK73; B7UJ79; B1X6G3; B7L6J0; Q57JQ0; B1IPV7; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; P0C019; A8A501; Q1R620; A4WFD5; B5REG7; A9N241; B7NDT2; B7NF20; B7NDT6; Q1R626; B7UMH0; B7L4K6; B7NDT7; C0Q644; C4ZUH0; B1IT04; P61176; P0A7S9; P0A7S8; P0AG55; P61175; Q1RB79; Q1RB78; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; P0A7J7; B7NDT5; Q1R627; B5R290; P0A7J3; B7NDT8; B5R299; P62399
DB01645	Genistein	investigational	5280961	-	"Currently Genistein is being studied in clinical trials as a treatment for prostate cancer.  "	P11474; Q14289; P31749; Q9UL62; Q15788; P04278; Q15596; Q92731; P13569; P03372; O95718; B0LPE5; O75469; Q16678; P37231; P02753; Q99527; P11388
DB00463	Metharbital	withdrawn	4099	-	"Metharbital is used for the treatment of epilepsy."	Q494W8; P24046; A8MPY1; P47869; P34903; P78334; Q13002; P18507; P18505; Q8N1C3; P14867; O00591; Q9UN88; P28472; P28476; Q99928; O14764; P48169; Q16445; P47870; P36544; P31644; P43681; P42262
DB00462	Methylscopolamine bromide	approved	23724781	-	"Used as adjunctive therapy for the treatment of peptic ulcer. Also used to treat nausea and vomiting due to motion sickness."	P08172; P11229; P20309
DB00461	Nabumetone	approved	4409	-	"For acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis."	P21397; P35354; P23975; P23219
DB00467	Enoxacin	investigational; approved	3229	-	"For the treatment of adults (&ge,18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to <i>Neisseria gonorrhoeae</i>, (2) uncomplicated urinary tract infections (cystitis) due to <i>Escherichia coli</i>, <i>Staphylococcus epidermidis</i>, or <i>Staphylococcus saprophyticus</i>, and (3) complicated urinary tract infections due to <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Proteus mirabilis</i>, <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus epidermidis</i>, or <i>Enterobacter cloacae</i>."	P48374; P43700; P16615; P48371; P11388; P22118; P43702; Q02880
DB00466	Picrotoxin	experimental	31304	-	"Used internally for relieving respiratory distress. Also for use as an antidote in poisoning by CNS depressants, especially barbiturates."	P23416; Q9UN88; P48167; P28472; P18505; A8MPY1; P24046; O14764; P48169; O75311; P28476; P34903; P47870; P23415; Q13508; P14867; P47869; Q16445; Q99928; P31644; P78334
DB00465	Ketorolac	approved	3826	-	"For the short-term (~5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting."	P23786; P35354; P23219; P46663
DB00464	Sodium Tetradecyl Sulfate	investigational; approved	23665772	-	"For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves."	P07225; P04070
DB00469	Tenoxicam	approved	54677971	-	"For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain."	P35354; P23219
DB00468	Quinine	approved	3034034	-	"For the treatment of malaria and leg cramps"	Q7RTT9; Q12809; Q92953; P14770; Q99250; O15554; Q9NY46; P35498
DB00609	Ethionamide	approved	2761171	-	"For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed."	P9WIE5; P9WGR1
DB00608	Chloroquine	investigational; approved; vet_approved	2719	-	"For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis"	Q8MU52; Q12809; Q9NR96; Q96LB2; P11413; P01375; P09210
DB13092	Meclocycline	investigational; approved	54676539	-	"Currently under investigation for the topical treatment of ulcerative oral mucositis [L797]"	P02359
DB00603	Medroxyprogesterone acetate	investigational; approved	6279	-	"Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens."	P06401; P48449; P03372
DB00602	Ivermectin	investigational; approved; vet_approved	46936176	-	"For the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite <i>Strongyloides stercoralis</i>. Also for the treatment of onchocerciasis (river blindness) due to the nematode parasite <i>Onchocerca volvulus</i>. Can be used to treat scabies caused by <i>Sarcoptes scabiei</i>."	P23416; P48167; P28472; P36544; Q99572; P18825; P20309; P23415; Q494W8; O75311; P91730; Q01959; Q8TCU4; Q96RI1; P08913; P35462; P08912; P21728; P23975; P11229
DB00601	Linezolid	investigational; approved	441401	-	"For the treatment of bacterial infections caused by susceptible strains of vancomycin resistant <i>Enterococcus faecium</i>, <i>Staphylococcal aureus</i> (methicillin resistant and susceptible strains), <i>Streptococcus pneumoniae</i>, <i>Streptococcus pyogenes</i>, <i>Streptococcus agalactiae</i>."	B5YVV7; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; C4ZUG3; B1LHB0; P0A7T7; C0Q0A5; C4ZUG9; B1X6G8; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; B7UK52; P68680; B6I211; B7LRT5; B7LS48; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B7UMH0; B4TKM3; B7MB01; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; A7MPH8; A9MN70; B1LL30; P60625; P60626; Q1R4N3; C0Q0C4; B4SXD8; B7NDS9; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; C4ZUG1; B5FJK0; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; B7NDH0; A8A539; B1LE15; B1LQM1; B6I208; Q5PK01; P0A7W4; B5BGY5; Q5PK05; C0Q2L0; B7N192; A8A5E9; Q57GI9; B7N190; P0A7T3; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; A7ZSC4; A7MNZ2; P0A7W9; B1LE14; A4THT0; B7N198; C4ZSS5; B4T4N1; Q2NWE7; B7M1L8; B7M1C5; C0Q6G0; Q57J46; Q57J43; B5RGF1; Q57J49; A9MX79; Q0T9J1; P0C020; B4TAV0; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; P62401; B4TGH3; B5QUQ1; P0A7R5; B5FN11; P0AG44; Q1R616; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; B4TFD7; B6I2A8; B4TUF2; B7NLM3; A9N5Y8; A7ZMI4; P60727; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; B5RAX1; P68686; B7MCV7; A1AGJ3; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; P68681; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1XHG2; P0AG66; P0AG67; B1IPY2; Q0TCN6; Q32B55; Q32B54; Q32B57; A7ZSK5; B7N1A3; A7ZSK3; B7N1A1; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; A8A5A1; A8A5A2; B7MCS1; B5F7T9; A7ZSK6; P27338; B5F7T1; B5F7T4; B7NR05; P68919; P0A7S3; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; B7N0V1; Q329M1; P60422; P60423; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; B6I228; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; P21397; Q6D9D4; B5EYX3; A6TAI4; P0A7S7; B7UK18; A1AGI8; A1AGI7; B7M1N1; A1AGI5; B7NDK8; B4TKL4; P68679; B4TKL0; Q0TCE2; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; Q5PGT9; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; Q57HZ9; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; B7LRS4; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B7M0U2; B1LHD1; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B1LHD3; Q0THB3; B6I437; B7NEU0; B7UPA5; B7NLL7; B7NLL6; P0C018; P0C019; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; B1XHK3; B7MGC4; Q0TCF8; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; P02413; A9MN54; Q1C365; P60624; A1JQX1; A9MN59; P0A7M6; P0A7M2; P0A7M9; B7MCR9; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A1ABQ0; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; B6I225; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; A6TG05; P0A7V8; B1LHD0; B4TXF0; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; B5RFY6; A1AGM9; A6TE47; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; Q5PKU5; B7N0L5; B1LGQ0; B7L847; A7ZSK8; B5YXA7; B7NGD6; P60438; B4SYA9; B7MCT2; B1X6F1; Q0TCS4; A7ZSK4; C5BF78; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; B7N1A0; B7LQD9; B5XZP7; B7M092; B5YTM7; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B7UK21; A8AQJ1; P60725; A9MJT9; B1IT04; B5R286; B5FSA3; P60723; P0A7T8; B5R280; A9MGD1; A4WEK0; P61179; B7MCT1; B6I3T6; C4ZUH4; B1LGJ6; P61177; P61176; P61175; B5QZ45; Q32B24; P0A7T9; B1IPL2; B1IPL1; A4WFC2; Q328J7; B1IPZ0; B4TKK1; B4TKK4; B7UQL1; B4TKK9; A8A5C2; Q5PC32; Q2EEQ2; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0AG47; Q1R4V6; P0AG45; P0A7R0; A6THB3; B2VGJ7; B7N1C3; B1X6F8; B7MLK7; B7MFJ7; B7NJS8; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B5BG21; A8AQC0; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B4TXC8; A8A5C4; B1LHC0; B1LHC2; B1LHC3; P0AG65; B1LHC5; A7ZS83; B1X6H0; A9MFK9; B5REG7; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B7LX23; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; B1X6F6; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; A7ZSI6; B6I218; A8APV6; Q57PV1; Q57PV0; B6I210; Q1R612; A7ZRU7; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B7MTL9; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; A8ARM4; P0A7W3; P0A7W2; P0A7W1; P0A7W0; Q1R626; B7N199; P0A7W8; C0Q1W9; B4F277; Q0THB2; C4ZR79; B7MCS3; A8GJV2; B7M9G4; B5FJA5; Q1CME3; B1IPZ5; B5YTM9; B5Y306; B1IPZ6; B4TXD1; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; B7MJ76; P60724; Q57IA6; B1IPZ3; B1X6E8; B1X6E9; P0A7S6; P02358; P02359; P0A7R9; P60726; P0A7X2; P0A7X3; P0A7X0; Q57J53; P0A7X4; P0A7X5; B7MBZ1; B7UK28; A9MPV4; B5F8E7; Q1RB79; B1LHC8; B5F3B9; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; Q1RB78; A8AQL8; B4T4N0; B5RBB1; Q32B47; B1LK73; B7N2E8; B7UJ79; B1X6G3; A1AGK6; Q57JQ0; B1IPV7; P61178; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B7M1C4; B4SUT9; A8A501; C4ZUF2; A4WFD5; A9N240; B5BKL1; B7NDT2; B7NF20; B4TGH4; B7L4K6; B5R290; C0Q644; C4ZUH0; B7NDT6; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0AG55; P0A7S2; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; B7MCS6; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; P0A7J7; B7NDT5; Q1R627; B7NDT7; P0A7J3; B7NDT8; B5R299; P62399
DB00600	Monobenzone	approved	7638	-	"Used topically to treat the loss of skin color (vitiligo)."	P35354; P23975; P14679; P23219
DB00607	Nafcillin	investigational; approved	8982	-	"Indicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug. "	P14091; P0A3M6; P25021; Q9H3N8; P07339; P20142; Q96RI0; P35367; Q8DR59; P0DJD9
DB00606	Cyclothiazide	approved	2910	-	"Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension."	P00918; P22748; Q6FHJ7; P00915; P48058; P55017; P54710; P42261; P42262; P42263
DB00605	Sulindac	investigational; approved	1548887	-	"For acute or long-term use in the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder (acute subacromial bursitis/supraspinatus tendinitis), and acute gouty arthritis."	P23415; Q03181; P35354; P19793; P27361; P15121; O60218; Q9Y5Y4; P23219
DB00604	Cisapride	investigational; approved; withdrawn	6917698	-	"For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease."	Q12809; P04035; P18825; P10635; P28223; O95264; P35462; P46098; Q99720; P34969; A5X5Y0; P21728; P08913; P14416; Q70Z44; P28335; P41595; P08684; P18089; Q13639; P25100; Q8WXA8; P31645
DB00350	Minoxidil	investigational; approved	4201	-	"For the treatment of severe hypertension and in the topical treatment (regrowth) of androgenic alopecia in males and females and stabilisation of hair loss in patients with androgenic alopecia."	P48167; P78508; Q14654; P48048; O60706; P00797; P23219
DB00269	Chlorotrianisene	investigational; withdrawn	11289	-	"Used to treat symptoms of menopause, deficiencies in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and in rare cases, prostate cancer. Chlorotrianisene may also be used to prevent breast engorgement following childbirth."	Q92731; O43613; P03372
DB00268	Ropinirole	investigational; approved	5095	-	"For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome."	P34969; P14416; P21918; P17752; P28221; P28222; P28223; P41595; P18089; P18825; P21728; P07101; P02746; P35462; P08908; P21917; P28335; P08913
DB01083	Orlistat	investigational; approved	3034010	-	"For obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. Also used to reduce the risk for weight regain after prior weight loss. Use of orlistat is pending revision due to reports of liver-related adverse events."	P16233; P49327; P07098; P21554; P06858
DB09472	Sodium sulfate	approved; vet_approved	24436	-	"indicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination."	P11413; P00918; P00915
DB00267	Cefmenoxime	approved	9570757	-	"Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria."	P24228; P08506; P02918; P02919; Q8XJ01; P0AD68; P0AEB2; P0AD65
DB00266	Dicoumarol	approved	54676038	-	"For decreasing blood clotting. Often used along with heparin for treatment of deep vein thrombosis."	Q9BQB6; Q08257; P15559
DB09477	Enalaprilat	approved	5462501	-	"Enalaprilat injection is indicated for the treatment of hypertension when oral therapy is not practical."	P12821; P46663
DB00260	Cycloserine	approved	6234	-	"Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB)."	P0A6J8; O15399; P9WQA9; Q05586; Q9L888; O60391; Q13224; Q12879; Q8TCU5; P08684; Q14957; P9WP31
DB00263	Sulfisoxazole	approved; vet_approved	5344	-	"For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections."	P11413; P24530; P0AC13; P25101
DB00262	Carmustine	investigational; approved	2578	-	"For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas."	P00390
DB00117	Histidine	approved; nutraceutical	6274	-	"The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol."	P19113; Q99624; P12081; P42357
DB00116	Tetrahydrofolic acid	nutraceutical	91443	-	"For nutritional supplementation, also for treating dietary shortage or imbalance."	P11586; P48728; O95954; P34896; P34897; O75891; Q99707; P13995; Q96DP5; P42898; P31939
DB06148	Mianserin	investigational; approved	4184	-	"For the treatment of depression."	P35462; P08173; P18825; P28221; P28222; P28223; P18089; Q99250; P46098; P11229; Q9H3N8; P34969; Q01959; P35408; P35348; P30939; P08912; P08913; P14416; P23975; P08172; P41145; P28335; P41595; P21918; P35498; P35368; P35367; Q9NY46; P25021; P25100; P50406; P20309; P08908; P31645; P21728; P01011
DB00114	Pyridoxal Phosphate	investigational; approved; nutraceutical	1051	-	"For nutritional supplementation and for treating dietary shortage or imbalance."	P32929; Q9HD40; Q96GA7; Q9GZT4; P34896; P34897; P80404; Q6P996; Q16773; Q96I15; O75600; O95470; Q9NUV7; Q9NVS9; P20711; Q99259; Q8N5Z0; Q96A70; Q8IUZ5; P35520; Q99527; Q9Y697; P20132; P0DN79; P19113; P21549; Q16719; O15270; Q6YP21; Q9Y600; P24298; P23378; Q6ZQY3; P04181; O95954; O94903; P11926; Q8TD30; Q96EN8; Q9BYV1; P22557; Q96GD0; P17174; Q6WRI0; P17735; P11217; Q8IYQ7; P11216; O15382; P00505; O15269; P54687; Q9Y617; P13196; P06737
DB06635	Otamixaban	investigational	5496659	-	"Investigated for use/treatment in thrombosis."	P00742
DB06637	Dalfampridine	approved	1727	-	"Dalfampridine is a neurofunctional modifier that helps improve walking speed in patients with multiple sclerosis (MS). "	Q9BQ31; P51787; Q6PIU1; Q9UIX4; Q96KK3; Q9UJ96; Q14721; Q9H252; P48547; P17658; Q9NS40; P11308; Q16322; Q09470; Q03721; Q12809; Q8TAE7; Q9NR82; Q92953; Q96RP8; Q96PR1; Q96L42; P48544; Q8NCM2; Q9UQ05; Q9NZV8; Q9NSA2; O60928; P16389; Q9ULS6; P47900; O95259; P22459; Q9ULD8; Q9UK17; P22460; O43526; Q8TDN2; Q8TDN1; P22001; Q9H3M0; Q14003; P56696; O43525
DB06147	Sulfathiazole	approved; vet_approved	5340	-	"Sulfathiazole is effective against a wide range of gram positive and gram negative pathogenic microorganisms. Although no longer used in humans, it is used in cattle."	P0AC13; P25101
DB00119	Pyruvic acid	investigational; approved; nutraceutical	1060	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	P11498; Q9BYV1; O15375; Q99500; O15374; P36021; O15403; P30613; P80404; O95907; P11177; P14618; V9HWB8; P21453
DB01087	Primaquine	approved	4908	-	"For the treatment of malaria."	P21397; P27338; P16083; Q12809; P11413; P08729; P31645; O95436
DB00287	Travoprost	approved	5282226	-	"Ophthalmic solution used for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication."	P43088; P43115
DB00285	Venlafaxine	approved	5656	-	"For the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), panic disorder with or without agoraphobia, vasomotor symptoms in women with breast cancer and in postmenopausal women, and neuropathic pain."	P28335; P10635; P28223; Q01959; P31645; P23975
DB00284	Acarbose	investigational; approved	9811704	-	"For treatment and management of diabetes type II (used in combination therapy as a second or third line agent)"	P10253; P04746; P14410; Q8IWI9; O43451; P14416
DB00283	Clemastine	investigational; approved	26987	-	"For the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold."	P18825; P10635; P28223; P35462; P11229; Q99720; Q12809; Q01959; P21728; P08913; P14416; P23975; P08172; P08173; P28335; P41595; P18089; P35367; P25021; P25100; P20309; P08912
DB00282	Pamidronate	approved	4674	-	"For the treatment of moderate or severe hypercalcemia associated with malignancy"	P41440; P14324
DB00281	Lidocaine	approved; vet_approved	3676	-	"For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks."	Q9UI33; Q01118; P19652; P00533; Q9UQD0; Q9NY46; P11413; Q14524; P35499; P35498; Q99250; Q9Y5Y9; O60353; Q15858; P02763
DB00280	Disopyramide	approved	3114	-	"For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug."	P08172; P35499; P19652; P20309; Q9NZV8; Q15858; Q9UQD0; Q12809; Q01118; Q14524; Q9Y5Y9; P35498; Q99250; P35367; Q9UI33; Q9Y3Q4; Q9UK17; Q9NY46; P11229
DB01085	Pilocarpine	investigational; approved	5910	-	"For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sj&ouml,grens syndrome."	P08172; P08173; P00519; P08912; Q15077; P20309; P11229
DB00289	Atomoxetine	approved	54841	-	"For the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) alone or in combination with behavioral treatment, as an adjunct to psychological, educational, social, and other remedial measures."	P10635; Q12809; O60391; Q01959; P31645; P23975
DB00288	Amcinonide	approved	443958	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses."	P29371; P04150; Q5TZZ9; P04083
DB13146	Fluciclovine (18F)	approved	450601	-	"Fluciclovine is indicated as a detection agent for positron emission tomography (PET) in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment.[A31388] The overexpression of L-type amino acid transporters such as LAT1 and LAT3 that mediate the uptake of essential amino acids has been extensively reported as a tumoral mechanism of cell growth.[A31389]"	Q15758; Q9UM01; O60391; P48058; Q8WY07; P42261; P42262; P42263
DB04967	Lucanthone	investigational; approved	10180	-	"Intended for use as a radiation sensitizer in the treatment of brain cancer."	P27695; P11388; P11387; Q02880
DB04960	Tipifarnib	investigational	159324	-	"Investigated for use/treatment in colorectal cancer, leukemia (myeloid), pancreatic cancer, and solid tumors."	P49354; P49356
DB04961	Troxacitabine	investigational	454194	-	"Investigated for use/treatment in leukemia (myeloid)."	Q07864; P49005; Q15054; P56282; Q14181; P09884; P49643; P49642; P28340; Q9HCU8; Q9NRF9
DB06700	Desvenlafaxine	investigational; approved	125017	-	"Desvenlafaxine is indicated for the treatment of major depressive disorder in adults."	P31645; P18440; P23975; Q01959; P42858
DB06701	Dexmethylphenidate	investigational; approved	154101	-	"Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment."	P31645; P23975; Q01959
DB06702	Fesoterodine	approved	6918558	-	"For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence)."	P08172; P08173; P11229; P10635; P08912; P20309
DB06706	Isometheptene	approved	22297	-	"Isometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches."	P35348; Q05940
DB06707	Levonordefrin	approved	164739	-	"Used as a topical nasal decongestant and vasoconstrictor in dentistry."	P18825; P08913; P18089; P25100
DB06708	Lumefantrine	approved	6437380	-	"Lumefantrine and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by <i>Plasmodium falciparum</i>, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the <i>Plasmodium</i> species has not been identified. Indicated for use in adults and children greater than 5 kg. "	P05023; Q12809
DB06709	Methacholine	investigational; approved	1993	-	"It is most commonly used for diagnosing bronchial hyperreactivity, using the bronchial challenge test."	P08172; P08173; P11229; P20309
DB08860	Pitavastatin	approved	5282452	-	"Pitavastatin is used to lower serum levels of total cholesterol, LDL-C, apolipoprotein B, and triglycerides, and raise levels of HDL-C for the treatment of dyslipidemia. "	P04035
DB01549	Rolicyclidine	illicit; experimental	62436	-	"Rolicyclidine has anesthetic properties and can induce a sedative effect. "	Q8TCU5; P14416
DB11817	Baricitinib	investigational; approved	44205240	-	"Indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs as monotherapy or in combination with methotrexate."	P52333; P23458; Q14289; O60674; P29597
DB00841	Dobutamine	approved	36811	-	"For inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures"	P43166; P18825; P23280; Q16790; P21964; P35462; P35218; Q8N1Q1; P00533; Q9Y2D0; Q99720; Q01959; P03372; P08588; P06239; P23975; P18089; O43570; P31645; P00918; P22748; P07451; Q9ULX7; P00915; P25100; P07550; P06241
DB00843	Donepezil	approved	3152	-	"For the palliative treatment of mild to moderate dementia of the Alzheimer's type."	P22303; Q12809; P06276; P27338; Q99720; P28223; P31645; Q9Y5N1
DB00842	Oxazepam	approved	4616	-	"For the treatment of anxiety disorders and alcohol withdrawal. "	P24046; P48736; A8MPY1; P47869; Q16445; P78334; P18507; P42338; P18505; P42336; Q8N1C3; P14867; O00591; O00329; Q9UN88; P28472; P28476; O14764; P48169; P34903; P47870; P31644; Q99928
DB00845	Clofazimine	investigational; approved	2794	-	"For the treatment of lepromatous leprosy, including dapsone-resistant lepromatous leprosy and lepromatous leprosy complicated by erythema nodosum leprosum."	Q5L2G3; Q8NHX9; Q9GZU1; Q9ULQ1
DB00844	Nalbuphine	approved	5311304	-	"For the relief of moderate to severe pain."	P41145; P35372; P55085; P41143
DB00847	Cysteamine	investigational; approved	6058	-	"Given intravenously or orally to treat radiation sickness. The bitartrate salts (Cystagon? and Procysbi) have been used for the oral treatment of nephropathic cystinosis and cystinurea. The hydrochloride salt (Cystaran?) is indicated for the treatment of corneal cystine crystal accumulation in cystinosis patients.
 "	P49146; P61278
DB00846	Flurandrenolide	approved	15209	-	"For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, particularly dry, scaling localized lesions"	P04150; P08185; P47712
DB00849	Methylphenobarbital	approved	8271	-	"For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy."	Q13002; P18507; Q494W8; P48169; P31644; P14867; P28472; O75469; P36544; P47869; P34903; Q16445; P43681; P42262
DB00848	Levamisole	investigational; withdrawn; approved; vet_approved	26879	-	"For adjuvant treatment in combination with fluorouracil after surgical resection in patients with Dukes' stage C colon cancer. Also used to treat malignant melanoma and head/neck cancer.
 Levamisole was originally used as an antihelminthic to treat worm infestations in both humans and animals."	P32297; Q23022; P05186; P48181; P10696; Q27218; Q9N587
DB05420	gallium maltolate	investigational	9846339	-	"Investigated for use/treatment in bladder cancer, lymphoma (unspecified), multiple myeloma, paget's disease, and prostate cancer."	P23921
DB05421	CP-122721	investigational	9821217	-	"Investigated for use/treatment in asthma, depression, and irritable bowel syndrome (IBS)."	P25103
DB05423	ORG-34517	investigational	9867361	-	"Investigated for use/treatment in depression."	P04150
DB05424	Canertinib	investigational	156414	-	"Investigated for use/treatment in breast cancer and lung cancer."	P00533; P04626; Q15303
DB05428	motexafin gadolinium	investigational	158385	-	"Investigated for use/treatment in brain cancer, cancer/tumors (unspecified), lung cancer, and lymphoma (non-hodgkin's)."	P31350; Q9NNW7; Q16881
DB00599	Thiopental	approved; vet_approved	3000715	-	"For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders."	Q494W8; P48169; Q03721; P18507; P47869; Q16445; P78334; Q13002; P20309; P18505; Q8N1C3; P14867; P28472; O00591; Q9UN88; P34903; Q99928; O14764; O00519; P47870; P36544; P31644; P43681; P42262
DB01067	Glipizide	investigational; approved	3478	-	"For use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM, type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory."	Q09428; P78508; Q14654; P48048; P11413; P37231
DB11703	Acalabrutinib	investigational; approved	71226662	-	"Acalabrutinib is currently indicated for the treatment of adult patients with Mantle Cell Lymphoma (MCL) who have received at least one prior therapy [FDA Label]."	P12931; P42680; P42681; Q06187; P00533; P52333; P51451; P51813; P04626; P06239; P06241; Q08881; P07948; Q15303
DB05398	C31G	investigational	456362	-	"Investigated for use/treatment in contraception, HIV infection, and prevention of stdis."	P03366; P21926
DB05399	Succinobucol	investigational	216325	-	"Investigated for use/treatment in atherosclerosis, coronary artery disease, diabetes mellitus type 2, and in-stent restenosis."	P19320
DB01069	Promethazine	investigational; approved	4927	-	"For the treatment of allergic disorders, and nausea/vomiting."	P0DP24; Q99250; P0DP25; P18825; P10635; P28223; P35462; P06276; Q99720; P62158; Q9NY46; P18089; P21728; P08913; B4DJ51; P14416; P23975; P08172; P08173; P0DP23; P28335; P41595; P35498; P35367; P35348; P11229; P08912; P25021; P25100; P20309; P08908; P31645
DB08878	Aminopterin	investigational; withdrawn	169371	-	"Prior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia, specifically to induce remissions. Later, aminopterin was used off-label in the United States to treat psoriasis, yielding dramatic lesion clearing. Aminopterin was later supplanted by methotrexate for treating cancer because of its better therapeutic index. Aminopterin (as well as methotrexate) has also been explored for use as an abortifacient. However, their association with severe congenital malformations and teratogenic effects have become known as fetal aminopterin syndrome. "	P00374; B0YJ76
DB08874	Fidaxomicin	approved	70678896	-	"Treatment of Clostridium difficile-associated diarrhea"	Q18CF1; Q182S6; Q18CF3; Q18CI5
DB08875	Cabozantinib	investigational; approved	25102847	-	"For the treatment of metastatic medullary thyroid cancer and for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy."	P35968; P07949; Q02763; P08581; P36888; P10721
DB08877	Ruxolitinib	approved	25126798	-	"Treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera (post-PV) myelofibrosis and post-essential thrombocythemia (post-ET) myelofibrosis. [Lexicomp] Myeolofibrosis is the proliferation of abnormal bone marrow stem cells which cause fibrosis (the excessive formation of connective tissue)."	P23458; Q02750; P00519; P52333; P36507; O60674; Q9UM73; P29597; O75116; Q13464; P15056; P07949; P10721
DB08871	Eribulin	investigational; approved	73425383	-	"For the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic cancer. "	Q9BVA1; P68366; P68363; P68371; Q9H4B7; Q5SU16; Q9BQE3; Q6PEY2; P10415; Q71U36; P07437; Q13885; Q13509; Q13748; Q3ZCM7; Q9BUF5; P04350
DB08872	Gabapentin Enacarbil	investigational; approved	9883933	-	"For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN)."	Q9UBN1; P62955; Q06432; Q9Y698; O60840; O00555; O95180; Q08289; Q9P0X4; Q7Z3S7; O43497; Q01668; Q9UF02; Q15878; Q8WXS5; Q8IZS8; Q02641; O00305; Q9BXT2; Q9NY47; P54284; P54289; Q00975; Q13936; Q13698; O60359
DB08873	Boceprevir	approved; withdrawn	10324367	-	"Boceprevir, when used in combination with [DB00811], [DB00008], and [DB00022] is indicated for use in the treatment of chronic HCV genotype 1 infection in adults [FDA Label]."	Q8IZI9; P10619
DB05087	Ganaxolone	investigational	6918305	-	"Investigated for use/treatment in pediatric indications and seizure disorders."	Q9UN88; P28472; P18507; P18505; O00591; O14764; P48169; P14867; Q8N1C3; P34903; P47870; P47869; Q16445; Q99928; P31644; P78334
DB05088	Tiomolibdate ion	investigational	25199766	-	"Investigated for use/treatment in liver disease and pulmonary fibrosis."	P05067
DB09270	Ubidecarenone	investigational; approved; nutraceutical	5281915	-	"The diet supplements containing ubidecarenone are indicated, as stated in the product label, to assist individuals with cardiovascular complaints including congestive heart failure and systolic hypertension. In the product, ubidecarenone is used to increase the cardiac input as well as for the prevention of several other diseases like Parkinson, fibromyalgia, migraine, periodontal disease and diabetes, based on preclinical studies.[L1064] It is important to highlight that these products are not FDA approved and it is recommended to use under discretion."	P31040; P56181
DB09273	Doxofylline	investigational; approved	50942	-	"Indicated for the treatment of chronic obstructive pulmonary disease (COPD), bronchial asthma and pulmonary disease with spastic bronchial component."	P07550; P29274
DB09272	Eluxadoline	investigational; approved	11250029	-	"For the treatment of irritable bowel syndrome with diarrhea (IBS-D)."	P41145; P35372; P41143
DB09275	Bismuth Subcitrate	investigational; approved	118987133	-	"For the treatment of peptic ulcer and gastro-oesophageal reflux disease (GORD).
 Treatment of inflammatory and erosive-ulcerous diseases of gastric and duodenal mucosa:  gastritis, ulcer disease of the stomach and duodenum, functional non-ulcerous dyspepsia, erosive duodenitis, post-operative inflammatory and erosive changes ? anastomositis, peptic ulcer of anastomosis"	O25926
DB09274	Artesunate	investigational; approved	6917864	-	"For the treatment of severe malaria caused by *Plasmodium falciparum* in adults and children [L891]"	P04926
DB09276	Sodium aurothiomalate	investigational; approved	16760302	-	"As anti-inflammatory agent for the treatment of arthritis. Disease-modifying antirheumatic drug, DMARD."	P00533; P06241; Q16881
DB09279	Fimasartan	investigational; approved	9870652	-	"Used for the treatment of hypertension and heart failure [A20319]."	P30556
DB08905	Formestane	investigational; approved; withdrawn	11273	-	"For the treatment of estrogen-receptor positive breast cancer in post-menopausal women."	P11511
DB08906	Fluticasone furoate	approved	9854489	-	"Fluticasone furoate nasal spray is indicated for the treatment of the symptoms of seasonal and perennial allergic rhinitis in patients aged 2 years and older. 
 
 Breo Ellipta, a mixture of fluticasone furoate and vilanterol is indicated for the long-term, once-daily maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema. It is also indicated for once-daily maintenance treatment of asthma in patients aged 18 or older with reversible obstructive airways disease. Breo Ellipta should not be used for the relief of acute symptoms of asthma or COPD."	P04150
DB08907	Canagliflozin	approved	24812758	-	"Canagliflozin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Use in type 1 diabetes mellitus patients or in treatment of diabetic ketoacidosis is not recommended. "	P13866; P31639
DB08901	Ponatinib	investigational; approved	24826799	-	"Ponatinib is indicated for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy."	P21802; Q9BWU1; P00519; P22607; P35968; P16234; P12931; P10721; P11274; P22455; P49336; P06239; Q02763; P36888; P07949; P07948; P11362
DB08903	Bedaquiline	approved	5388906	-	"Bedaquiline is indicated as part of combination therapy in adults (? 18 years) with pulmonary multi-drug resistant tuberculosis (MDR-TB). "	P9WPU9; P63692; P9WPU5; P9WPV1; P9WPU7; P9WPV3; A5U204; P9WPV5; P9WPS1; P9WPS0; A1KI93; C1AMU9; P9WPV7
DB12095	Telotristat ethyl	investigational; approved	25025298	-	"As a serotonin synthesis inhibitor, telotristat etiprate, has the potential to reduce serotonin levels and address the key elements of carcinoid syndrome. "	P17752; Q8IWU9
DB08908	Dimethyl fumarate	investigational; approved	637568	-	"Used in multiple sclerosis patients with relapsing forms."	Q14145; Q8TDS4; Q04206
DB05377	Chlorfenson	investigational	6635	-	"Investigated for use/treatment in fungal infections."	P29275
DB01419	Antrafenine	approved	68723	-	"Antrafenine is used as an anti-inflammatory and analgesic agent for the relief of mild to moderate pain."	P35354; P41222; P23219
DB01418	Acenocoumarol	investigational; approved	54676537	-	"For the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction."	Q9BQB6
DB01411	Pranlukast	investigational; approved	4887	-	"Used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. "	Q9UDT6; P05113; P12724; Q9NS75; P19838; Q02817; Q9Y271; P01375
DB13956	Estradiol valerate	investigational; approved; vet_approved	13791	-	"Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). 
 
 Estradiol valerate is also available in combination with [DB09123] as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding."	P04150; Q15596; Q14457; Q92731; Q99527; Q01959; P03372; P10275; P62508; O75469; P31645; P00846; P43681; P37059; Q12791
DB01413	Cefepime	investigational; approved	5479537	-	"For the treatment of pneumonia (moderate to severe) caused by <i>Streptococcus pneumoniae</i>, including cases associated with concurrent bacteremia, <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, or <i>Enterobacter</i> species. Also for empiric treatment of febrile neutropenic patients and uncomplicated and complicated urinary tract infections (including pyelonephritis) caused by <i>Escherichia coli</i> or <i>Klebsiella pneumoniae</i>, when the infection is severe, or caused by <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, or <i>Proteus mirabilis</i>, when the infection is mild to moderate, including cases associated with concurrent bacteremia with these microorganisms. Also for the treatment of uncomplicated skin and skin structure infections caused by <i>Staphylococcus aureus</i> (methicillin-susceptible strains only) or <i>Streptococcus pyogenes</i> and complicated intra-abdominal infections (used in combination with metronidazole) caused by <i>Escherichia coli</i>, viridans group streptococci, <i>Pseudomonas aeruginosa</i>, <i>Klebsiella pneumoniae</i>, <i>Enterobacter</i> species, or <i>Bacteroides fragilis</i>."	P24228; P08506; P02918; P02919; P0AD68; P0AEB2; P0AD65
DB01412	Theobromine	investigational; approved	5429	-	"theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension."	Q07343; P29274; P30542
DB13953	Estradiol benzoate	investigational; approved; vet_approved	222757	-	"Estradiol benzoate is not currently available in any FDA or Health Canada approved products."	P04150; P23975; Q99527; P18825; Q92731; Q15596; P41595; P03372; Q14457; P62508; P00846; P31645; O75469; P06241; P43681; P37059
DB01414	Cefacetrile	approved	91562	-	"Cefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections."	P02918; P02919
DB01416	Cefpodoxime	approved; vet_approved	6335986	-	"For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms."	P0AD68
DB09082	Vilanterol	approved	10184665	-	"Vilanterol is approved for use in several combination products such as with fluticasone furoate under the tradename Breo Ellipta and in combination with umeclidinium bromide as Anoro Ellipta. Approved by the FDA in 2013, use of Breo Ellipta is indicated for the long-term, once-daily maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema. It is also indicated for once-daily maintenance treatment of asthma in patients aged 18 or older with reversible obstructive airways disease."	P07550; P08588; P13945
DB09083	Ivabradine	approved	132999	-	"Ivabradine's indication by the FDA is to reduce the risk of hospitalization for worsening heart failure in patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction ?35%, who are in sinus rhythm with resting heart rate ?70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contraindication to beta-blocker use. "	Q9UL51; Q9Y3Q4; Q9P1Z3; O60741
DB09080	Olodaterol	approved	11504295	-	"Olodaterol is indicated for use in chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. It is not indicated for the treatment of acute exacerbations of COPD or for the treatment of asthma."	P07550; P08588; P13945
DB09081	Idebenone	investigational; approved	12881464	-	"Idebenone is indicated for use by the European Medicines Agency (EMA) for the treatment of visual impairment in adolescent and adult patients with
 Leber?s Hereditary Optic Neuropathy (LHON). It is not currently approved for use by either the Food and Drug Administration (USA) or Health Canada [L885]."	P10635; P08684
DB09086	Eugenol	approved	3314	-	"Eugenol is not currently available in any FDA-approved drug products. There are a number of unapproved OTC products that advertise it for the use of toothache.  Eugenol is is also commonly used in combination with zinc oxide in dental procedures for the cementation of temporary prostheses and the temporary restoration of teeth and cavities."	Q92731; Q8NET8; P03372; P23219; P10275
DB01098	Rosuvastatin	approved	446157	-	"Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. Furthermore, it is used to slow the progression of atherosclerosis and for primary prevention of cardiovascular disease. "	O43924; P04035; Q9Y6L6
DB09084	Benzydamine	approved	12555	-	"Available predominantly as a liquid mouthwash, oromucosal spray, or topical cream, benzydamine is most frequently employed as a locally acting analgesic and anti-inflammatory treatment for the relief of painful inflammatory conditions. 
 
 When formulated as a mouthwash or spray, benzydamine may be used to treat traumatic conditions like pharyngitis following tonsillectomy or the use of a naso-gastric tube, inflammatory conditions like pharyngitis, aphthous ulcers and oral ulceration due to radiation therapy, dentistry operations and procedures, or more general conditions like sore throat, sore tongue, sore gums, mouth ulcers, or discomfort caused by dentures. [L1121] 
 
 When used as a topical cream, benzydamine may be employed to relieve symptoms associated with painful inflammatory conditions of the muscolo-skeletal system including acute inflammatory disorders such as myalgia and bursitis or traumatic conditions like sprains, strains, bruises, sore muscles, stiff joints, or even the after-effects of fractures. [ L1123]"	O75343; Q02153; P33402; P35354; Q02108; P23219
DB09085	Tetracaine	approved; vet_approved	5411	-	"The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access.  The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.
 "	P21397; Q14524; P28223; Q9UQD0; P28335; Q99720; Q92736; Q9NY46; Q01118; P21817; P35499; P35498; Q99250; Q9Y5Y9; Q15858; Q9UI33
DB01095	Fluvastatin	approved	1548972	-	"To be used as an adjunct to dietary therapy to prevent cardiovascular events. May be used as secondary prevention in patients with coronary heart disease (CHD) to reduce the risk of requiring coronary revascularization procedures, for reducing progression of coronary atherosclerosis in hypercholesterolemic patients with CHD, and for the treatment of primary hypercholesterolemia and mixed dyslidipidemia. "	P04035
DB01094	Hesperetin	approved	72281	-	"For lowering cholesterol and, possibly, otherwise favorably affecting lipids. <i>In vitro</i> research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again."	P22748; O75908; P43166; P55157; P35610; P04278; O43570; O75907; P49841; Q6FI27
DB01097	Leflunomide	investigational; approved	3899	-	"For the management of the signs and symptoms of active rheumatoid arthritis (RA) to improve physical function and to slow the progression of structural damage associated with the disease. Has also been used for the prevention of acute and chronic rejection in recipients of solid organ trasnplants and is designated by the FDA as an orphan drug for this use."	P21397; Q14289; Q02127; P35869; Q01959; P23975
DB09089	Trimebutine	approved	5573	-	"Indicated for symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. "	Q9P0X4; Q9UGI6; P35372; O00305
DB01091	Butenafine	approved	2484	-	"For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to <i>M. furfur</i>, interdigital tinea pedis (athlete&rsquo,s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to <i>E. floccosum</i>, <i>T. mentagrophytes</i>, <i>T. rubrum</i>, and <i>T. tonsurans</i>."	P22303; Q14534; Q99720; P08913; P10635; P31645; P23975
DB01090	Pentolinium	approved	5850	-	"Used to produce controlled hypotension during surgical procedures and in hypertensive crises."	P32297; Q9GZZ6; P30926; P43681
DB01092	Ouabain	approved	439501	-	"For the treatment of atrial fibrillation and flutter and heart failure"	P05023; P50993; Q12809; P13637
DB01708	Prasterone	investigational; approved; nutraceutical	5881	-	"DHEA is taken as a supplement for a variety of unsubstantiated indications. The following indications have shown promise and are backed up by some scientific evidence: schizophrenia (DHEA may be more effective in women than men), improving the appearance of older people?s skin (taking DHEA by mouth seems to increase skin thickness and moisture, and decrease facial ?age spots? in elderly men and women), improving ability to achieve an erection in men with sexual dysfunction. Additionally, DHEA has shown promise in improving symptoms of lupus (SLE). Taking DHEA by mouth along with conventional treatment may help reduce the number of times symptoms flare up and may allow a reduction in the dose of prescription drugs needed. DHEA may also help SLE symptoms such as muscle ache and mouth ulcers. DHEA also seems to strengthen bones in SLE patients being treated with high-dose steroids (corticosteroids).
 DHEA also shows promise in the treatment of osteoporosis. Taking DHEA by mouth daily seems to improve bone mineral density (BMD) in older women and men with osteoporosis or osteopenia (pre-osteoporosis). DHEA may also increase BMD in young women with the eating disorder called anorexia nervosa. DHEA is often prescribed in India for the induction of ovulation to improve chances of pregnancy."	Q9UN88; P07445; Q06520; Q92731; Q99720; O60391; Q14994; P03372; P10275; O75469; P22637; Q07869; P14061; O00204
DB01259	Lapatinib	investigational; approved	208908	-	"Indicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma."	P00533; Q29974; P00519; P06401; P09619; P03372; P04626; P01909; P06213; P01912; P01911; P13761; Q15303
DB01256	Retapamulin	approved	6918462	-	"For use in adults and pediatric patients aged 9 months and older for the topical treatment of impetigo (up to 100 cm<sup>2</sup> in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes."	Q9A1X4
DB01255	Lisdexamfetamine	investigational; approved	11597698	-	"For the treatment of Attention Deficit/Hyperactivity Disorder (ADHD) in pediatric populations aged 6 to 12 years."	Q05940; P23975; Q01959; P35348; P35368
DB01254	Dasatinib	investigational; approved	3062316	-	"For the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy."	P21802; Q02750; P41240; P52333; P36507; P08631; P35968; P07947; P29597; P04626; P16234; Q15303; P09769; P54760; P22607; Q92570; P07948; P07949; P29317; P00533; P51692; P00519; P42684; P42685; P51451; Q9H3Y6; P17948; P57059; P06239; P10721; P11362; P54756; P09619; Q9Y2K2; P12931; P07333; P36888; O00329; Q9H0K1; Q06203; P11274; Q06187; Q9NYL2; O60674; Q16539; P04049; Q9H2G2; P11142; P15056; P06241; P42345
DB01253	Ergonovine	approved	443884	-	"Used to treat postpartum haemorrhage and postabortion haemorrhage in patients with uterine atony. "	P28566; P28223; P14416; P28221; P28335; P18089; P21728; P08913; P41595; P35462; P08908; P35348; P35368
DB01252	Mitiglinide	investigational; approved	121891	-	"For the treatment of type 2 diabetes."	P78508; Q09428; Q14654; P37231
DB01251	Gliquidone	investigational; approved	91610	-	"Used in the treatment of diabetes mellitus type 2."	Q15842; P78508; Q09428; Q14654
DB01250	Olsalazine	approved	6003770	-	"For the treatment of Inflammatory Bowel Disease and Ulcerative Colitis."	P09917; P51580; P01579; P35354; P37231; P23219
DB01077	Etidronic acid	approved	3305	-	"For the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury."	Q13332; P41586; P38606
DB01076	Atorvastatin	approved	60823	-	"May be used as primary prevention in individuals with multiple risk factors for coronary heart disease (CHD) and as secondary prevention in individuals with CHD to reduce the risk of myocardial infarction (MI), stroke, angina, and revascularization procedures. May be used to reduce the risk of cardiovascular events in patients with acute coronary syndrome (ACS). May be used in the treatment of primary hypercholesterolemia and mixed dyslipidemia, homozygous familial hypercholesterolemia, primary dysbetalipoproteinemia, and/or hypertriglyeridemia as an adjunct to dietary therapy to decrease serum total and low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and triglyceride concentrations, while increasing high-density lipoprotein cholesterol (HDL-C) levels."	Q9UBN7; P04035; P35869; Q13547; Q6IT96; Q92769; P08684; P27487
DB01075	Diphenhydramine	investigational; approved	3100	-	"For the treatment of symptoms associated with Vertigo/Meniere's disease, nausea and vomiting, motion sickness and insect bite."	P08172; P35367
DB01074	Perhexiline	investigational; approved	4746	-	"For the management of severe angina pectoris."	P08173; Q9P0X4; O95180; P11229; O43497; P10635; Q99720; Q12809; P50416; P20309; P23786; P08912; Q92523; P06241; P23975; P00533; P42345
DB01073	Fludarabine	approved	657237	-	"For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen"	P09884; P31350; P27707; P00813; P23921
DB01072	Atazanavir	investigational; approved	148192	-	"Used in combination with other antiretroviral agents for the treatment of HIV-1 infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission."	P08684
DB01071	Mequitazine	approved	4066	-	"For the treatment of Hay fever, urticaria (hives) and allergic rhinitis"	P08172; P08173; P11229; P08912; P20309; P35367
DB01070	Dihydrotachysterol	approved	5311071	-	"Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis)."	P11473
DB01079	Tegaserod	investigational; approved; withdrawn	5362436	-	"Provides relief from the symptoms of irritable bowel syndrome including chronic idiopathic constipation."	P28223; Q13639; P18440; P28221; P28335; P41595; P46098; P08908
DB01078	Deslanoside	approved	28620	-	"For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure."	P05023; P50993; P05026; P13637; Q13733; P14415; P54709; P54710
DB08604	Triclosan	investigational; approved	5564	-	"Triclosan is used in a variety of common household products, including soaps, mouthwashes, dish detergents, toothpastes, deodorants, and hand sanitizers.  It is also used in health care settings in surgical scrubs and personnel hand washes."	O24990; P9WGR1; P07202; Q14994; P10275; O75469; P37231; P0AEK4; Q6GI75
DB00470	Dronabinol	illicit; approved	16078	-	"For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments"	O75762; P11712; P23415; P21554; P34972
DB00471	Montelukast	approved	5281040	-	"For the treatment of asthma"	P00533; O95977; P09917; P11229; Q99500; P21453; P18825; P41143; Q01959; P41595; Q9Y271; P08913; P20309; P07550; P06241; P23975; P13945; P35462
DB00472	Fluoxetine	approved; vet_approved	3386	-	"Labeled indication include: major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and combination treatment with olanzapine for treatment-resistant or bipolar I depression. Unlabeled indications include: selective mutism, mild dementia-associated agitation in nonpsychotic patients, post-traumatic stress disorder (PTSD), social anxiety disorder, chronic neuropathic pain, fibromyalgia, and Raynaud's phenomenon. "	Q7RTT9; P10635; P28223; P08913; P35462; P61024; P48547; P11229; Q99720; Q12809; Q01959; P08912; P08588; Q5XXA6; P23975; Q9Y5N1; P08172; P08173; P22303; P28335; P18089; P41595; P35367; P35348; P43088; P20309; P31645
DB00473	Hexylcaine	approved; withdrawn	10770	-	"Used as a local anesthetic for surface application, infiltration or nerve block"	Q9Y5Y9; Q14524; Q9UQD0; Q01118; P35499; P35498; Q99250; Q9UI33; Q15858; Q9NY46
DB00474	Methohexital	approved	9034	-	"Methohexital is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation."	Q9UN88; P49662; Q16445; P18507; P18505; Q15822; O00591; P23415; O14764; P48169; P14867; Q8N1C3; P31644; P47870; P28472; P29466; P47869; P17787; P34903; Q99928; P78334
DB00475	Chlordiazepoxide	illicit; investigational; approved	2712	-	"For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety."	P32238; P32239; P24046; A8MPY1; P47869; Q16445; P78334; P34981; P18507; P18505; Q8N1C3; P14867; P35367; O00591; Q9UN88; P28472; P28476; O14764; P48169; P34903; P47870; P31644; Q99928
DB00476	Duloxetine	approved	60835	-	"For the acute and maintenance treatment of major depressive disorder (MDD), as well as acute management of generalized anxiety disorder. Also used for the management of neuropathic pain associated with diabetic peripheral neuropathy, and fibromyalgia. Has been used in the management of moderate to severe stress urinary incontinence (SUI) in women."	P28223; P10635; P28222; P34969; P28221; Q01959; P41595; P50406; P08908; P35367; P31645; P28335; P23975
DB00477	Chlorpromazine	investigational; approved; vet_approved	2726	-	"For the treatment of schizophrenia, to control nausea and vomiting, for relief of restlessness and apprehension before surgery, for acute intermittent porphyria, as an adjunct in the treatment of tetanus, to control the manifestations of the manic type of manic-depressive illness, for relief of intractable hiccups, for the treatment of severe behavioral problems in children (1 to 12 years of age) marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations), and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and poor frustration tolerance."	P0DP24; P34969; Q99250; P08173; Q05586; P18825; P10635; P28222; P28223; P35372; P19652; P04626; Q12879; P35462; P46098; P0DP23; P08908; P00533; O15399; P11229; Q9H3N8; Q99720; Q12809; Q01959; Q9NY46; P21728; P08913; B4DJ51; P14416; P28221; P23975; P08172; P41145; P21817; P41143; P28335; O60391; P18089; P21918; P41595; P35368; P35367; Q14957; P35348; P21917; P62158; Q9UL62; P0DP25; P17405; P25021; Q13224; P25100; P01011; Q8TCU5; P50406; P20309; P08912; P31645; P06241; P35498
DB00478	Rimantadine	investigational; approved	5071	-	"For the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults."	P0DOF8; P21430
DB00479	Amikacin	investigational; approved; vet_approved	37768	-	"For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin may also be used to treat Mycobacterium avium and Mycobacterium tuberculosis infections."	B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; P0A7T8; B5F3B9; P0A7T7; B7UPA5; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; B1X6G3; B7LRT5; B1IPL2; B7LRT1; B1X6G0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; Q57J49; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; Q0TCF5; A9MN70; P60624; P60625; P60626; Q1R4N3; C0Q0C4; B4SXD8; B7NDS9; B1IPL1; B7NDS5; B7MTL9; B5FJK8; B5FJK9; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; B4TKK9; B1LHB1; P0A7W6; C4ZS29; P0A7T9; B1LE15; B1LQM1; B6I208; B7NJS8; B1LE14; Q5PK05; B7LHT8; C0Q2L0; B7N192; A8A5E9; C4ZUG9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A7ZSC4; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; P0A7W9; A4THT0; P0A7W8; B4T4N0; B4T4N1; B7M1L8; B7M1C5; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; A9MVN1; P62401; Q0T9J1; P0C020; B4TAV0; P0ADY7; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; B4TGH4; B4TGH3; B5QUQ1; P0AG47; B5FN11; P0AG44; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; B4TFD7; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; A6TG05; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; Q0TCE2; P68686; B7N1C3; A1AGJ3; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; P68681; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; P0ADZ0; A7ZSK8; A7ZSK6; Q32B54; A7ZSK4; B7MCT0; B7N1A3; A7ZSK3; A7ZSK0; B7N1A0; B5R285; P0A7K2; B5R286; Q1R635; B5R280; B7LHP9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8A5A2; B5FJA5; B5F7T9; Q32B57; B5F7T1; B5F7T4; B7NR05; A8AQL8; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; A1AGI5; Q329M1; P60422; P60423; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; B6I228; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; Q6D9D4; P0AG55; A6TAI4; Q57QG6; B7UK18; A1AGI8; A1AGI7; Q32BE7; B7N0V1; B7NDK8; B4TKL4; B4TKL0; B5RAX1; Q57HZ9; P0A7M6; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; B7LRS4; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; Q1RD68; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B4TXC8; P0A7V8; A9MKN8; P0A7V9; B7LLY4; B1LHD3; B1LHB0; B6I437; B7NEU0; B7NLL4; B7NLL7; B7L6I9; P0C018; B4SUT9; B1LF57; P0A7N4; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7UK52; A7MPH5; A9MJT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; P02413; A9MN54; Q1C365; B7N102; B7M1C4; A9MN59; Q5PJ56; P0A7M2; A9N5Y8; A1AGJ2; B1IPY8; B7N0U4; P0A7L8; A6TE47; B1IPY0; B1IPY3; B1IPY2; B1IPY5; B1IPY4; Q329B5; P0ADZ4; B7LR53; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; B7MJ76; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; B1LHD1; B1LHD0; B4TXF0; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; B7MCR9; A1AGM9; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; Q5PKU5; B7N0L5; B1LGQ0; B7NDS7; B7L847; Q0TCN6; B5YXA7; B7NGD6; B7LRT0; P60438; B4SYA9; B7MCT2; B1X6F1; Q0TCS4; B7MCT1; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B5EYX3; B7N1A1; B5YRA5; B7LI05; Q32B52; B7LQD9; B5YTM5; B7M092; C0Q0A5; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; P60724; P60727; Q1R632; B5FSA3; P60723; P0A7K6; A9MGD1; A4WEK0; P61179; P61178; B6I3T6; A7ZTQ9; C4ZUH4; B1LGJ6; P61177; P61176; P61175; Q32B24; B7NDH0; P0AG51; B7LS48; B5BG21; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; C4ZUG3; A8A5C2; Q0TCG7; A8A539; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0A7R5; Q1R4V6; P0AG45; P0A7R0; A6THB3; B7MCV7; B1X6F8; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; A8AQC0; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; B7M1N1; B7M1N0; Q1R5U1; A1AGJ7; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5F7F9; A9MFK9; A1AGJ5; A9N240; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; B1IPZ0; B1IPZ1; P0A7N6; P0A7N7; P0A7N8; P0A7N9; B1X6F6; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; P68679; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; Q0THB3; B7LQ74; B7LQ73; B5BGY5; Q5PIV8; P0A7W7; B7MCS6; P0A7W5; A8ARM4; P0A7W3; P0A7W2; P0A7W1; P0A7W0; B7N199; B7N198; C0Q1W9; B4F277; Q0THB2; C4ZR79; C5BF78; A8GJV2; B7M9G4; B7MCS1; Q1CME3; B5RFY6; P0A7W4; B1IPZ5; A8AQJ1; B5Y306; B7LX23; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B5QZ45; Q57IA6; B1IPZ3; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P60726; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; A8A5A1; B5F8E7; Q1RB79; B1LHC8; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; P68919; C4ZSS5; B5RBB1; B1LK73; B7N2E8; B7UJ79; A1AGK6; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; Q1R620; P0C019; A8A501; B7LCR3; A4WFD5; B5REG7; B5BKL1; P0A7J7; B7NF20; B7NDT5; B7UMH0; B7L4K6; B7NDT7; C0Q644; C4ZUH0; B1IT04; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0A7S3; P0A7S2; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; Q1R626; Q1R627; B5R290; B7NDT6; B7NDT8; P62399; B5R299
DB01408	Bambuterol	investigational; approved	54766	-	"For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema."	P07550; P22303; P06276; P10635
DB00618	Demeclocycline	approved	54680690	-	"Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. "	B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; B1LHB1; B1LHB0; P0A7T7; C0Q0A5; C4ZUG9; B1X6G8; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; P68683; P68680; B1X6G3; B7LRT5; B7LS48; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; B7NLN3; B7NLN0; B7NLN6; B7NLN5; Q1R616; B1IQP9; B5YSV6; C4ZYY0; B7MTL9; B4TUF3; B7UMH0; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; Q0TCF5; A9MN70; B7M1C4; B7M1C5; P60626; Q1R4N3; A6TE47; B4SXD8; B7NDS9; B1IPL1; P62401; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B7NDH0; P0A7W6; C4ZS29; A8A539; P0A7W5; B1LQM1; B6I208; B7NJS8; A8ARM4; A8AQC0; C0Q2L0; B7N192; A8A5E9; Q57GI9; P0A7W0; P0A7T3; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; A8A5B3; P0AG55; A7MNZ2; P0A7W9; B1LE14; A4THT0; P0A7W8; C4ZSS5; B4T4N1; B7M1L8; C0Q6G0; Q57J46; B1IPY3; Q57J43; B5RGF1; Q57J49; B7NLN4; A9MX79; Q0T9J1; B4TAV0; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; A9MN59; P62400; B4TGH4; B4TGH3; B5QUQ1; P0AG47; C5BF78; P0AG44; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; P0C020; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; Q0TCE2; P68686; B7MCV7; A1AGJ3; B6I242; B7UK39; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; B7UPA5; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; P68681; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; P0ADZ0; Q0TCN6; A7ZSK6; Q32B54; A7ZSK4; B7MCT0; B7N1A3; A7ZSK3; A7ZSK0; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q92731; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7UK52; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; P60624; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; B7MCS6; B5FJA6; B7MCS3; A8A5A2; B5FJA5; B5F7T9; B5F7T1; B5F7T4; B7NR05; A8AQL8; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; A1AGI5; Q329M1; P60422; P60423; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B7MJ76; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; Q57IA6; A9MN66; B7NKQ3; B2VCV9; B5R0S0; B5EYX3; A6TAI4; B7UK18; A1AGI8; A1AGI7; B7M1N1; B7N0V1; Q1R609; B7NDK8; B4TKL4; P68679; B4TKL0; B5RAX1; B7M1M3; Q57HZ9; P0A7M6; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; Q5PGT9; P0A7X1; A9MSZ2; B6I211; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; A9MJT9; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; Q32FI2; B4TXC8; P0A7V8; P0A7T9; A9MKN8; B1LHD0; B7LLY4; B4TXF0; B6I437; B7NEU0; B1LHC3; B7NLL4; B7NLL7; B7L6I9; P0C018; P0C019; B1X6G0; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; B1XHK3; Q2NWE7; Q0TCF8; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; B1X6F8; P02413; A9MN54; Q1C365; B1LL30; P60625; Q5PJ56; P0A7M2; A9N5Y8; A1AGJ2; B1IPY8; B7N0U4; A7ZRU7; A1AGJ5; B1IPY0; B1XHG2; B1IPY2; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B7MCT1; B6I229; B6I228; Q1R358; A9MSZ3; B6I225; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; B1LHD1; P0A7V9; B1LHD3; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; B7NLP7; B7MCR9; A1AGM9; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7L847; A7ZSK8; B5YXA7; B7NGD6; Q0THB3; B4SYA9; B7MCT2; B1X6F1; B7NDR8; Q32B57; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; B7MCT4; B7LQD9; B5YTM5; B7M092; B5BGY5; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; P60724; P60727; B5R286; B5FSA3; P60723; P0A7T8; B5R280; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; Q1R636; P61177; P61176; C4ZUH2; Q32B24; B4TUF2; B1IPL2; B5BG21; A4WFC2; Q328J7; B1IPZ0; B4TKK1; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q0TCG7; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0A7R5; Q1R4V6; P0AG45; P0A7R0; A6THB3; B7N1C3; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; Q5PK05; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; Q32BE7; B7M1N0; Q1R5U1; A1AGJ7; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; A8A5C2; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1X6F6; B1LHC5; A7ZS83; B5F7F9; A9MFK9; A9MGD1; B5REG7; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7LRS4; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; P0A7N4; P0A7N5; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; B7L4K6; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A8APV6; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; Q1R612; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B5YTM7; Q5PIV8; P0A7W7; A8A5A4; B1LE15; P0A7W4; P0A7W3; P0A7W2; P0A7W1; B7N190; B7N1A0; B7N199; B7N198; C0Q1W9; B4F277; Q0THB2; C4ZR79; B5FN11; A8GJV2; B7M9G4; B7MCS1; Q1CME3; B5RFY6; B1IPZ5; A8AQJ1; B5Y306; B7LX23; B4TXD1; B7M1M2; P0A7S3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; C4ZUG3; B5QZ45; P0A7S7; P0A7N7; B1X6E8; B1X6E9; C0Q0C4; P0A7S6; P02358; P02359; P60726; P0A7X2; P0A7X3; P0A7X0; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; A8A5A1; B5F8E7; B1LHC8; B5F3B9; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; P68919; B4T4N0; B5RBB1; B1LK73; B7UJ79; A1AGK6; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B1IT04; Q1R620; B4SUT9; A8A501; Q1RD68; A4WFD5; A9N240; A9N241; B7NDT2; B7NF20; B7NDT5; A7ZSI8; B7NDT7; C0Q644; C4ZUH0; P0A7J3; C4ZUH1; P0A7S9; P0A7S8; P0AG59; P61175; Q1RB79; P0A7S2; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; P0A7J7; Q1R626; Q1R627; B5R290; B7NDT6; B7NDT8; P62399; B5R299
DB00619	Imatinib	approved	5291	-	"For the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST)."	P21802; P43166; Q9ULX7; P28223; P35968; P29597; Q16832; P35218; P04629; P07948; P07949; P00533; Q9Y2D0; P42684; P16234; P06213; P10721; P11362; Q6UN15; P23280; P06239; P09619; Q08345; P12931; P07333; O43570; P31645; P36888; P00519; P00918; P22748; P11274; P07451; Q16790; O60674; P25021; P00915; P04049; P15056; P06241
DB00610	Metaraminol	investigational; approved	5906	-	"For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage"	P53779; P23443; P35368; P25100; P80192; O43283; P35348; Q9H244; P45983
DB11560	Lesinurad	investigational; approved	53465279	-	"For use, in combination with a xanthine oxidase inhibitor, for the treatment of hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone."	P11712; Q9NSA0; Q96S37
DB00612	Bisoprolol	approved	2405	-	"For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI). "	P07550; P08588; P13945
DB00613	Amodiaquine	investigational; approved	2165	-	"For treatment of acute malarial attacks in non-immune subjects."	Q12809; P50135
DB00615	Rifabutin	investigational; approved	6323490	-	"For the prevention of disseminated <i>Mycobacterium avium</i> complex (MAC) disease in patients with advanced HIV infection."	B5QTY1; B4T9Z3; B1X982; P0A8V2; A7ZSI4; P0A7Z9; C4ZXP1; Q5PK10; B7NEV3; A7MQB3; P07900; B7NQ13; A1AGI6; P0A7Z4; P0A7Z5; P0A7Z6; Q329K7; A8A6B1; A8ARN6; P0A7Z8; A8AQJ0; B1IYV1; P0A8T7; Q1R637; A9MKM3; A1AHI0; P0A7Z7; B7MFL0; P0A800; Q0TCG6; A9MVP7; B1LK86; B7UM71; Q5PC39; B6I3M8; A6TFP8; P14625; Q1R4U2; Q57I91; B7M4D4; B5BI24; Q0TBG0; B5XTE8; B5FM73; P0A801; B7N2X2; A8A5A0; B4U000; B7L773; B7LVL1; P0A804; K9JA46; B5EY10; B4SXF1; P0A803; P0A802; B5RG73; C0Q1Y1; A7ZTK1; B5YWE9
DB00617	Paramethadione	approved	8280	-	"Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications."	Q9P0X4; O95180; Q92949; O43497
DB00969	Alosetron	approved; withdrawn	2099	-	"Only for the treatment of symptoms of severe diarrhea-predominant irritable bowel syndrome (IBS) in women with chronic symptoms (generally lasting greater than 6 months) who does not present with anatomic or biochemical GI abnormalities and have not responded to conventional therapy."	Q12809; P41595; P46098
DB06558	Tezosentan	investigational	151174	-	"Investigated for use/treatment in congestive heart failure, liver disease, and heart disease."	P24530; P25101
DB00218	Moxifloxacin	investigational; approved	152946	-	"For the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye)."	P0AFI2; Q02880; P0AES4; P0AES6; P11388; P43700; P43702; P20083
DB01612	Amyl Nitrite	approved	10026	-	"For the rapid relief of angina pectoris."	P16066
DB00748	Carbinoxamine	approved	2564	-	"For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis, as well as allergic conjunctivitis caused by foods and inhaled allergens. Also for the relief of allergic reactions to blood or plasma, and the symptomatic management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema."	P35367; P11229
DB00749	Etodolac	investigational; approved; vet_approved	3308	-	"For acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain."	P23786; P35354; P19793; P23219
DB00214	Torasemide	approved	41781	-	"For the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Also for the treatment of hypertension alone or in combination with other antihypertensive agents."	Q13621
DB00278	Argatroban	investigational; approved	152951	-	"Argatroban is indicated for prevention and treatment of thrombosis caused by heparin induced thrombocytopenia (HIT). It is also indicated for use in patients with, or at risk for, HIT who are undergoing percutaneous coronary intervention."	P00734; P00750; P00742
DB00279	Liothyronine	approved; vet_approved	5920	-	"Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis."	Q9UN88; P10827; P28472; P18507; P18505; Q99928; O14764; P48169; P10828; Q8N1C3; P47869; P47870; P14867; Q16445; P31644; P12004; P34903; O00591; P30542; P78334
DB00747	Scopolamine	investigational; approved	3000322	-	"For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness."	P08172; P08173; P11229; P14410; P08912; P20309; P17787; P43681
DB09460	Sodium carbonate	approved	10340	-	"Used topically for dermatitides, mouthwash, vaginal douche, veterinary use as emergency emetic.Occasionally, for dermatitides topically as a lotion. Medication (Vet): In solution to cleanse skin, in eczema, to soften scabs of ringworm."	P00918; P22748; Q16790; P00915
DB00273	Topiramate	approved	5284627	-	"Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Qsymia? is indicated for the treatment and management of obesity."	P43166; Q9ULX7; Q9UQD0; P23280; Q16790; Q99250; P35218; Q8N1Q1; Q14524; Q9Y2D0; P48058; Q9UN88; P39086; P35499; Q16445; Q15858; Q01118; P78334; Q13003; Q13002; P18507; P18505; Q8N1C3; P47869; P14867; P28472; Q9Y5Y9; P35498; O43570; O00591; Q9NY46; P00918; P22748; P34903; P07451; O14764; P48169; P00915; Q16478; P47870; Q16099; P31644; Q9UI33; Q99928; P42261; P42262; P42263
DB09462	Glycerin	investigational; approved	753	-	"It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent."	Q93PP9; O43252; P52477; P09211; P17802; P23367; O60760; O14717; P84077; P37700; P13632; P0A6E4; P06988; P32246; Q14643; P37173; Q9NPH2; Q52369; Q03181; P00325; P51681; P17050; Q9NZK7; P09466; Q8GR70; P0AER0; P69924
DB00276	Amsacrine	investigational; approved	2179	-	"For treatment of acute myeloid leukaemia."	P02768; Q9BXC0; P10635; P02763; Q12809; P30559; P11387; Q969P6; P11388; P37288; Q02880
DB00277	Theophylline	approved	2153	-	"For the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, such as emphysema and chronic bronchitis."	Q99829; Q9Y4R7; P27815; P33765; O76074; Q7Z5B4; Q14432; P0DMS8; Q13370; Q08493; Q92769; Q15155; Q8TCT9; Q07343; P09874; Q08499; P29274; P29275; P30542; O00329
DB00274	Cefmetazole	investigational; approved	42008	-	"For the treatment of infections caused by susceptible organisms."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB00275	Olmesartan	investigational; approved	158781	-	"For the treatment of hypertension."	P30556
DB00104	Octreotide	investigational; approved	448601	-	"For treatment of acromegaly and reduction of side effects from cancer chemotherapy"	P32745; P31391; P35372; P35346; P30874; P30872
DB00106	Abarelix	investigational; approved; withdrawn	16131215	-	"For palliative treatment of advanced prostate cancer."	P01148; P30968
DB00745	Modafinil	investigational; approved	4236	-	"To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy."	P10635; Q01959; Q12879; Q13224; P14416; P35368; Q14957; P51575
DB00210	Adapalene	approved	60164	-	"For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back."	P10826; P48443; P23415; P28702; P10276; P19793; P13631
DB06603	Panobinostat	investigational; approved	6918837	-	"Panobinostat is indicated in the treatment of multiple myeloma in combination with dexamethasone and bortezomib in patients who have received 2 previous treatment regimens including bortezomib and an immunomodulatory agent. This indication is approved by accelerated approval based on progression free survival as of February 23, 2015. "	Q969S8; Q9UQL6; Q8WUI4; O15379; Q9BY41; Q13547; Q6IT96; Q92769; Q9UKV0; Q96DB2; Q9UBN7; P56524
DB06605	Apixaban	approved	10182969	-	"Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures. "	P00734; P00742
DB00211	Midodrine	approved	4195	-	"For the treatment of symptomatic orthostatic hypotension (OH)."	P35348; P25100; P35368
DB00294	Etonogestrel	investigational; approved	6917715	-	"For use as a female contraceptive (depot)."	P06401; P03372
DB00295	Morphine	investigational; approved	5288826	-	"For the relief and treatment of severe pain."	P41145; P35372; P41143; Q9Y6Y9
DB00296	Ropivacaine	approved	175805	-	"Used in obstetric anesthesia and regional anesthesia for surgery."	Q14524; Q9UQD0; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q9UI33; Q15858; Q9NY46
DB00297	Bupivacaine	investigational; approved	2474	-	"For the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures, for diagnostic and therapeutic procedures, and for obstetrical procedures."	Q9UK17; P10635; P34995; Q12809; P35499; P35498; P46098; Q9Y5Y9; P22460
DB00290	Bleomycin	investigational; approved	5360373	-	"For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas."	P49916; P18858
DB00740	Riluzole	investigational; approved	5070	-	"For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)"	Q01118; Q14524; Q9UQD0; P23975; P57789; Q9UPY5; Q8TCU5; Q92952; Q9NYG8; Q9UI33; P35498; Q99250; O15554; P35499; Q9Y5Y9; Q15858; Q9NY46
DB00292	Etomidate	approved	667484	-	"Used in the induction of general anesthesia."	Q9UN88; P28472; P18507; P18505; O00591; O14764; P48169; Q16445; P18089; Q8N1C3; P31644; P14867; Q99928; P47869; P34903; P15538; P47870; P78334
DB00293	Raltitrexed	investigational; approved	104758	-	"For the treatment of malignant neoplasm of colon and rectum"	P00374; P04818; B0YJ76; Q53Y97; Q05932
DB00741	Hydrocortisone	approved; vet_approved	5754	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease."	P04150; P04083; P08235; P14060; P25103; P80365; Q5TZZ9; P35228
DB00298	Dapiprazole	approved	3033538	-	"Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations."	P28335; P28223; P25100; P18089; P41595; P35368; P35348; P08908
DB00299	Penciclovir	approved	4725	-	"Used to treat recurrent cold sores on the lips and face from various herpesvirus invections."	P06478; P04293
DB13170	Plecanatide	investigational; approved	70693500	-	"Plecanatide stimulates intestinal fluid secretions in the gastrointestinal tract to support regular bowel function. Plecanatide, taken orally once daily, works locally in the upper GI tract to stimulate secretion of intestinal fluid and support regular bowel function."	P25092; P33402
DB04918	Ceftobiprole	investigational; approved	12993649	-	"For the treatment of serious bacterial infections in hospitalised patients."	P14677; P0AD68
DB13174	Rhein	experimental	10168	-	"No approved indication."	P09917; P55055; Q13133
DB13179	Troleandomycin	approved	202225	-	"For the treatment of bacterial infection."	C1CNV7; C1C8L6; P66113; Q04MN1; Q04L74; B5E6G4; B5E6G7; B5E6G6; B5E6G1; B5E6G0; B5E6G3; C1CAM8; B1IB07; B1I9N1; A7MPH8; A3CK87; B2IS46; C1CSF7; B8ZKG6; B2IS45; B1I8M5; B8ZKG1; B8ZKG2; B8ZKG3; C1CC31; C1CC30; Q04I37; C1CP93; C1CP94; B8ZKG9; B2IS48; C1CP97; C1CA38; Q97QU4; B2ILY3; C1CAL6; P66096; C1CIA9; C1CBQ4; C1CP90; P66257; B6I233; C1CPA0; B5E6U3; C1C8C8; B7UK43; O75469; B8ZNZ8; C1CPE4; C1CPE3; Q04MN2; Q04MN0; A3CK72; B7LRT5; B1IPY0; Q1JJF9; P66136; P0A493; B7NLN8; B2IS51; P0A494; Q04M37; Q97PI9; B8ZKF9; B2IS52; A8AZV4; Q8CWV8; C1C6H2; B1ICV9; C1CAX9; Q1R604; Q8CWV0; Q8CWV3; B2IRD4; Q8CWV5; A9MN48; Q8CWV7; Q8CWV6; B8ZKQ6; B8ZKT9; P66633; Q04MN4; B8ZKQ3; A8AZL6; A8A5C4; B1X6H0; A2RNN0; B2IS66; C1CC12; C1CC11; A8AQL8; C1CC17; C1CC15; A1AGK6; Q5PIV3; B2IN61; C1CC18; Q04MM5; B8ZLK5; B1LHD3; Q8CWU4; B8ZM28; Q8CWU6; Q04MM4; B2IS65; Q8CWN7; B8ZKG5; B8ZJX3; Q8CWU8; P0A484; B7L4K8; P61363; C1CFC0; C1CIA8; C1CIA5; C1CIF2; C1CIA6; C1CIA1; C1CIA3; C1CIA2; Q04MM0; Q3JYL4; B8ZKP6; C1CB45; C1CB44; C1CP99; B2IS68; P49228; B2IS44; A8AZM1; Q04MH9; Q04ML0; Q8CWV1; Q04ML2; Q04ML3; P66051; C1CCK4; P66525; B2IN60; P66603; B8ZKQ4; Q04JE2; C0Q0B5; Q8CWM8; A7ZSK8; C1CC60; C1CC61; B5E6U4; C1CFJ7; Q8CWV4; C1CGS4; B1IBP2; P66566; P60629; P66321; C1CIB3; A8AZD5; P66445; B8ZLD9; B2IMG7; Q04I36; Q97SV3; Q04JL0; P66420; B7N1A3; Q02W48; B5F8F1; P66340; B7M1N3; P0A4A8; B2IRG4; C1CAL7; C1CAL4; Q04MM8; Q04MM7; C1CAL8; B2IS49; P61362; P0A4A7; P61360; B8ZKG8; C1CPB5; B8ZPU9; B5BGY5; C1CIC4; C1CPB1; C1CIC2; C1CIC1; Q8CWR8; A8AZK2; B2IS42; P60725; P60724; P60727; B4TKL4; B1I8Z8; P60723; P66201; C1CNB3; P0A4B6; Q0TCE2; A8AYZ9; Q8CWS9; C1CPB3; C1CP92; Q8CWS0; C1CSP2; B1I8K3; B1I8K2; Q97SU6; B1I8K7; B1I8K6; B1I8K4; C1CAM1; C1CAM0; C1CAM3; C1CIU2; C1CAM4; B5RH16; C1CPV0; C1CI99; C1CRK5; B7MCT4; B5E3E2; B5E3E3; B5E6F9; C1C799; B2IR58; C1CPA4; B4TXE1; C1CJS7; P66582; Q8CWV2; P66256; Q8CWR5; C1CC10; Q04IH6; Q8CWR9; Q97SV1; C1CAN9; P0A4C4; P0A472; P0A495; P0A474; P0A476; P0A4C3; P66473; P66472; P66155; C1CC14; B1I700; P66474; C1CC08; C1CC33; B1I8U6; C1CU40; C1CAN5; Q32B32; C1CAN6; C1CAN7; B1I8L4; B1I8L0; Q04KI4; C1C9Y5; Q57J33; C1CHZ1; P61182; P61183; Q04MZ3; C1CE92; A3CQ97; B5FJL3; P0A496; Q8CWQ0; C4ZUH4; B7NDU0; C1CTP8; A3CK67; B5E6H9; A3CL34; A8AZK0; P66279; Q8CWQ9; C1CP96; B1I9V1; B5E6H1; P66359; P0A4B3; B5E2I5; B1I8K0; P66565; C1CLN8; P0A4B5; P0A4B4; B5E1Q0; C1CIC0; Q04MH8; Q8CWN3; B5E6F7; B2ISJ8; B1I9V0; P66156; B5E6Q4; P66392; P66393; B2ISJ7; B1I8M1; B1I8M3; B1I8M2; C1C5H5; B5E5W8; C1CC29; C1CMU0; P61361; P0A483; C1CC22; P60726; B4U0K8; B8ZPX5; C1CIF1; C1CLW8; B1I7Y6; B4SUT9; B5YTP0; A3CK89; B5R290; P66360; B5E6I1; P60630
DB04912	Stannsoporfin	investigational	15978579	-	"Investigated for use/treatment in liver disease, metabolic disease, and pediatric indications."	P09601; P30519
DB04910	Oxibendazole	investigational; vet_approved	4622	-	"Investigated for use/treatment in infectious and parasitic disease (unspecified) and pediatric indications."	P68371
DB04917	Renzapride	investigational	3052778	-	"For the treatment of constipation-predominant irritable bowel syndrome (IBS-C)."	P46098; Q13639
DB04915	Idronoxil	investigational	219100	-	"Intended for the treatment of various forms of cancer."	O94907; Q9NYA1; Q16206; Q9NRA0
DB09517	Sodium ferric gluconate complex	approved	76968835	-	"Used to replete the total body content of iron during iron deficiency anemia in patients age 6 years and older with chronic kidney disease receiving hemodialysis and receiving supplemental epoetin therapy."	P68871; P02792; P69905; D1MGQ2
DB06738	Ketobemidone	investigational; approved	10101	-	"For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures."	Q8TCU5; P41145; P35372; O60391; P41143
DB03925	Freselestat	investigational; experimental	46936829	-	"Investigated for use/treatment in chronic obstructive pulmonary disease (COPD)."	Q9UNI1; P08246
DB06736	Aceclofenac	investigational; approved	71771	-	" Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. "	P35354; P23219; P02766
DB06515	Resiniferatoxin	investigational	104826	-	"Investigated for use/treatment in interstitial cystitis and urinary incontinence."	Q8NER1
DB06512	Deramciclane	investigational	119590	-	"Investigated for use/treatment in anxiety disorders."	P28223; P28335
DB11828	Neratinib	investigational; approved	9915743	-	"For use as an extended adjuvant treatment in adult patients with early stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy [FDA Label]."	P00533; P04626; P21860; Q15303
DB06287	Temsirolimus	approved	23724530	-	"For the treatment of renal cell carcinoma (RCC). Also investigated for use/treatment in breast cancer, lymphoma (unspecified), rheumatoid arthritis, and multiple myeloma."	P62942; P42345
DB06281	Torcetrapib	investigational	159325	-	"Investigated for use/treatment in peripheral vascular disease and hyperlipidemia."	P11597
DB06282	Levocetirizine	approved	1549000	-	"Levocetirizine is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older. "	P35367
DB06288	Amisulpride	investigational; approved	2159	-	"Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression."	P28566; P28335; P14416; Q13639; P18825; P28221; P28222; P46098; O95264; A5X5Y0; P34969; P30939; P50406; P08913; P41595; P35462; P08908; P47898; P28223; Q70Z44; Q8WXA8
DB11827	Ertugliflozin	investigational; approved	44814423	-	"Ertugliflozin as a monotherapy is indicated to improve the glycemic control in adult patients with type 2 diabetes.[FDA label] Ertugliflozin, in combination with metformin hydrochloride, is indicated to improve glycemic control in patients with diabetes type 2 who are not controlled on a regimen of ertugliflozin or metformin or in patients who are already treated with both ertugliflozin and metformin.[L1134] The administration of ertugliflozin in combination with sitagliptin is indicated to improve glycemic control in adult patients with type 2 diabetes when treatment with ertugliflozin and sitagliptin is appropriate.[L1135] It is pointed out that the use of ertugliflozin has to be an adjunct therapy to the use of diet and exercise.
 The type 2 diabetes mellitus is characterized by insulin resistance in muscle and liver, which results in the elevation of glucose levels in blood, or by presence of insulin deficiency. The insulin resistance is related to genetic factors, obesity, sedentary lifestyle or/and aging. This increase in the blood glucose can cause severe damage to kidney, eyes and vascular system.[A31582]"	P13866; P31639
DB04824	Phenolphthalein	approved; withdrawn	4764	-	"Used for over a century as a laxative."	P04818; O60656; Q05940; O75469; Q14994; P04278; Q53Y97; P03372
DB00858	Drostanolone	illicit; approved	6011	-	"For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal."	P10275
DB00857	Terbinafine	investigational; approved; vet_approved	1549008	-	"For the treatment of dermatophyte infections of the toenail or fingernail caused by susceptible fungi. Also for the treatment of tinea capitis (scalp ringworm) and tinea corporis (body ringworm) or tinea cruris (jock itch)."	P23975; P10635; Q99720; P08913; Q14534
DB00854	Levorphanol	approved	5359272	-	"For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate."	P41145; O15399; P41143; O60391; Q13224; Q12879; Q8TCU5; P35372; P35498; Q99250; Q14957; Q9NY46; Q05586
DB00855	Aminolevulinic acid	approved	137	-	"Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp."	P28221; P28222; P13716
DB00852	Pseudoephedrine	approved	7028	-	"For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism."	P05412; Q99873; O95644; Q01959; P08588; P60568; P08913; P01375; P31645; P07550; P23975; P35348
DB00850	Perphenazine	approved	4748	-	"For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults."	Q12809; P18825; P10635; P28223; P35462; P34969; P21728; P08913; B4DJ51; P14416; P0DP24; P0DP25; P0DP23; P28335; P18089; P35367; P35348; P62158; P50406; P20309; P08908; P01011
DB04828	Zomepirac	withdrawn	5733	-	"Zomepirac was indicated for the management of mild to severe pain."	Q9Y5Y4; P35354; P23219
DB05416	GW-501516	investigational	9803963	-	"Investigated for use/treatment in hyperlipidemia."	Q03181; P37231; Q07869
DB05413	Tifuvirtide	investigational	16130644	-	"Investigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections and HIV infection."	P05154
DB05412	Talmapimod	investigational	9871074	-	"Investigated for use/treatment in pain (acute or chronic) and rheumatoid arthritis."	P00403; Q15759; P53778; Q16539; P01584; P01375
DB11737	Icotinib	investigational; approved	22024915	-	"Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR)?tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC) who failed previous chemotherapy."	P00533
DB00252	Phenytoin	approved; vet_approved	1775	-	"For the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery."	Q01118; P11712; Q14524; O75469; P30466; Q07699; Q9UQD0; P01889; Q9UI33; P33261; P35499; P35498; Q99250; Q9Y5Y9; Q15858; Q9NY46
DB11731	Depatuxizumab mafodotin	investigational	71300933	-	"No approved indication."	P00533; Q5SU16; P07437
DB11730	Ribociclib	investigational; approved	44631912	-	"Kisqali (ribociclib) is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably."	P06401; P11802; Q00534; P03372
DB06191	Zosuquidar	investigational	153997	-	"Investigated for use/treatment in leukemia (myeloid) and myelodysplastic syndrome."	P08183
DB06190	Solabegron	investigational	9887812	-	"Investigated for use/treatment in diabetes mellitus type 2, irritable bowel syndrome (IBS), and urinary incontinence."	P07550; P13945
DB06195	Seliciclib	investigational	160355	-	"Investigated for use/treatment in breast cancer, lung cancer, lymphoma (unspecified), multiple myeloma, leukemia (lymphoid), and cancer/tumors (unspecified)."	Q5U045; P06493; P50613; Q00535; P28482; P27361; P49674; P50750; P24941
DB06194	Elocalcitol	investigational	11396600	-	"Investigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility."	P11473
DB06196	Icatibant	investigational; approved	71364	-	"Approved for use in acute attacks of hereditary angioedema (HAE). Investigated for use/treatment in angioedema, liver disease, and burns and burn infections."	P30411; P15144; P46663
DB06199	Atrasentan	investigational	159594	-	"Investigated for use/treatment in prostate cancer and cancer/tumors (unspecified)."	P24530; P25101
DB08848	Guvacine	experimental	3532	-	"There is no approved indication for guvacine."	Q9NSD5; P30531; P48065; P48066
DB09283	Trapidil	approved	5531	-	"Used in the treatment of chronic stable angina [A19770]."	P35913
DB02342	2-Methoxyestradiol	investigational	16760554	-	"For the treatment of breast cancer and inflammatory diseases such as rheumatoid arthritis."	D0VY79; Q16678; Q9H4B7; P21964; P04798; Q16665; P11511
DB08844	Uric Acid	investigational; experimental	1175	-	"At present (August 2013), there is no approved indication for uric acid.  The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke."	P06737
DB08846	Ellagic Acid	investigational	5281855	-	"Ellagic acid is being investigated for use in follicular lymphoma, brain injury in intrauterine growth restricted babies, obese adolescents, and solar lentigines."	P00918; P22748; P07451; P43166; P35218; Q14534; P23280; Q9ULX7; P43405; P00915; Q16790; O43570; P17252; P17612; P05771; P68400; Q9Y2D0
DB09075	Edoxaban	approved	10280735	-	"Edoxaban is indicated to reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF). However, it should not be used in patients with creatinine clearance (CrCL) > 95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg). It is also indicated for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5-10 days of initial therapy with a parenteral anticoagulant."	P00742
DB06803	Niclosamide	investigational; approved; vet_approved	4477	-	"For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis."	P00533; Q5JUK3; O60674; P35968; P50391; P12931; P49841; Q02763; P10721; Q6FI27; P07948; P11362
DB00365	Grepafloxacin	investigational; approved; withdrawn	72474	-	"For treatment of adults with mild to moderate infections caused by susceptible strains of <i>Haemophilus influenzae</i>, <i>Streptococcus pneumoniae</i>, or <i>Moraxella catarrhalis</i>."	P0A4L9; P72525; Q12809; Q59961; P72524; P43700; P43702
DB06800	Methylnaltrexone	approved	16089915	-	"Treatment of opioids induced constipation in palliative patients that are inadequately responding to laxative therapy. "	P10635; P35372; P41145; P41143
DB09269	Phenylacetic acid	approved	999	-	"For use as adjunctive therapy for the treatment of acute hyperammonemia and associated encephalopathy in patients with deficiencies in enzymes of the urea cycle."	P15121
DB09267	Strontium ranelate	approved; withdrawn	6918182	-	"Strontium ranelate is therapeutically indicated for the treatement of severe osteoperosis in: a) postmenopasual women, and b) adult men, who are at high risk of fractures, for whom treatment with other medical products approved for the treatment of osteoperosis is not possible due to, for example, contraindications or intolerance. [L1127]
 
 In postmenopausal women, strontium ranelate can also reduce the risk of vertebral and hip fractures [L1127]."	P41180
DB09265	Lixisenatide	approved	131704317	-	"For use as an antihyperglycemic agent in the treatment of T2DM [FDA Label]."	P43220
DB09262	Imidafenacin	investigational; approved	6433090	-	"Used in the treatment of overactive bladder [FDA Label]."	P08172; P11229; P20309
DB01230	Pemoline	illicit; investigational; withdrawn	4723	-	"For treatment of Attention Deficit Hyperactivity Disorder (ADHD)"	Q01959
DB08931	Riociguat	approved	11304743	-	"Riociguat is indicated for the treatment of adults with persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH), (WHO Group 4) after surgical treatment, or inoperable CTEPH, to improve exercise capacity and WHO functional class.
 Riociguat is indicated for the treatment of adults with pulmonary arterial hypertension (PAH), (WHO Group 1), to improve exercise capacity, WHO functional class and to delay clinical worsening. Efficacy was shown in patients on Riociguat monotherapy or in combination with endothelin receptor antagonists or prostanoids. Studies establishing effectiveness included predominately patients with WHO functional class II?III and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (25%)."	O75343; Q02153; Q02108; Q9NP56; P33402; P29400
DB08930	Dolutegravir	approved	54726191	-	"Dolutegravir is indicated in combination with other antiretroviral agents for the treatment of patients with HIV-1 infection that comply with the characteristics of being adults or children aged 12 years and older and present at least a weight of 40 kg.[A7520] The FDA combination therapy approval of dolutegravir and rilpivirine is indicated for adults with HIV-1 infections whose virus is currently suppressed (< 50 copies/ml) on a stable regimen for at least six months, without history of treatment failure and no known substitutions associated to resistance to any of the two components of the therapy.[L1031]"	P22309
DB08933	Luliconazole	approved	3003141	-	"Luliconazole is indicated in adults aged 18 years and older for the topical treatment of fungal infections caused by Trichophyton rubrum and Epidermophyton floccosum, specifically tinea pedis, cruris, and corporis.
  "	P10613
DB08932	Macitentan	approved	16004692	-	"Macitentan is indicated for patients with pulmonary arterial hypertension."	P24530; P25101
DB08934	Sofosbuvir	approved	45375808	-	"Sofosbuvir is used in combination therapy with other antiviral medications to treat chronic hepatitis C virus (HCV) infected patients with HCV genoptypes 1-6, and to treat HCV and HIV co-infected patients. Depending on the level of cirrhosis or decompensation, combination therapy can also include either ribavirin alone or ribavirin and peg-interferon alfa.
 
 When used in combination with [DB09027] as the combination product Harvoni, sofosbuvir has the following indications: treatment of genotypes 1, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis, in combination with [DB00811] for genotype 1 infection with decompensated cirrhosis, or in combination with [DB00811] for the treatment of genotype 1 or 4 infection who are liver transplant recipients without cirrhosis or with compensated cirrhosis.
 
 When used in combination with [DB11613] as the combination product Epclusa, sofosbuvir is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotypes 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis, or in combination with [DB00811] if associated with decompensated cirrhosis.
 
 Resistance: Reduced susceptibility to sofosbuvir has been associated with the NS5B substitution mutation S282T [A19634]."	Q8IZI9
DB05187	Elafibranor	investigational	9864881	-	"Investigated for use/treatment in atherosclerosis and diabetes mellitus type 2."	Q03181; P37231; Q07869
DB05343	Arundic acid	investigational	208925	-	"Investigated for use/treatment in cerebral ischemia."	P04271
DB00138	Cystine	approved; nutraceutical	67678	-	"It has been claimed that L-cysteine has anti-inflammatory properties, that it can protect against various toxins, and that it might be helpful in osteoarthritis and rheumatoid arthritis. More research will have to be done before L-cysteine can be indicated for any of these conditions. Research to date has mostly been in animal models."	O60931; P82251; Q9UPY5; Q07837
DB12140	Dilmapimod	investigational	10297982	-	"Dilmapimod has been used in trials studying the treatment and diagnostic of Nerve Trauma, Inflammation, Pain, Neuropathic, Arthritis, Rheumatoid, and Coronary Heart Disease, among others."	P05231; Q16539; P01584; P01375
DB06203	Alogliptin	approved	11450633	-	"Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. "	P27487
DB01088	Iloprost	investigational; approved	5311181	-	"Used for the treatment of pulmonary arterial hypertension."	P43119; P27815; Q08493; Q13258; P34995; P43115; P35408; P43116; Q07343; P43088; P00750; P21731; Q9Y5Y4; Q08499
DB01089	Deserpidine	approved	8550	-	"For the treatment of hypertension."	Q86TI2; P27487; Q6V1X1; P12821; Q05940
DB09079	Nintedanib	approved	9809715	-	"Nintedanib is indicated for the treatment of idiopathic pulmonary fibrosis (IPF)."	P21802; Q02750; P08069; P52333; P36507; P08631; P35968; P07947; P29597; P11802; P22607; Q08881; P07948; P07949; P29317; P00519; P07333; Q9UM73; P16234; P17948; P35916; P06239; P08581; Q6FI27; P11362; P06213; P09619; P12931; P22455; Q02763; P36888; P10721; P23458; Q06187; O60674; P49841; P49840; P06241
DB09078	Lenvatinib	investigational; approved	9823820	-	"Lenvatinib is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer."	P21802; P00533; P35968; P16234; P09619; P07949; P35916; P22455; P11362; P22607; P17948; P10721
DB01082	Streptomycin	approved; vet_approved	19649	-	"For the treatment of tuberculosis. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium)."	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; C4ZUG3; B1LHB0; P0A7T7; C0Q0A5; C4ZUG9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; Q1R4V6; Q57PV0; B5FHU4; B1IRQ1; P68686; B7US99; P68684; P68685; P68682; P68683; P68680; P68681; B7LRT5; B1IPL2; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; P60423; B7NLN3; B5BG21; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B4TUF2; B7LHP9; B4TKM3; B6I1U8; B5R1G3; Q57J49; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; Q0TCF5; A9MN70; P60624; B7M1C5; P60626; A6TE47; B4SXD8; B7NDS9; B7NDS5; B1X9T1; B5FJK8; B7UK28; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B1LHB1; P0A7W6; C4ZS29; A8A539; B1LE15; B1LQM1; B6I208; B7NJS8; A8ARM4; A8AQC0; B7LHT8; C0Q2L0; P0A7W2; A8A5E9; Q57GI9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; B6I3L3; A7ZSC4; P0AG55; A7MNZ2; P0A7W9; A4THT0; P0A7W8; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; A9MVN1; A9MX79; Q0T9J1; A9MN59; P0ADY7; B6I1Q9; B5QVW5; B4TN08; B5QVW6; B5R286; P62400; P62401; B4TGH3; B5QUQ1; P0A7R5; C5BF78; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; P0C020; B6I2A8; P0A7M9; B4TGH4; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; Q0TCE2; Q0TD41; B7N1C3; B1IPY8; B6I242; B7UK39; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; A1AGJ7; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A1AGJ5; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; A1AGM9; P0AG67; P0ADZ0; A7ZSK8; Q32B55; Q0THB2; B7MCT1; A7ZSK5; B7N1A3; A7ZSK3; A7ZSK0; B7N1A0; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8A5A2; B7MCS1; B5F7T9; A7ZSK6; B7NLN0; B5F7T1; B7M1M5; B5F7T4; B7NR05; P68919; P61175; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; B7N0V1; Q329M1; P60422; B1X6G3; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q9UM07; Q32BQ2; A9MN66; B5BGX2; B2VCV9; B5R0S0; B5EYX3; A6TAI4; B7UK18; A1AGI8; A1AGI7; Q32BE7; A1AGI5; B7NDK8; B4TKL4; B7UMH0; B5RAX1; B4EW58; B4TKL0; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B4TXC8; B1LHD1; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B4TXF0; Q0THB3; B6I437; B7MCT2; B7NEU0; B7NDH0; C4ZUE9; B7NLL7; B7NLL6; P0C018; P0C019; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; P0A7Q6; B7UK52; P0A7V5; A7MPH5; A9MJT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; P02413; A9MN54; Q1C365; B1LL30; P60625; P0A7M6; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; A7ZRU7; C0Q0C4; B1IPY0; B1IPY3; B1IPY2; B1IPY5; A9MGD1; Q329B5; P0ADZ4; B7LR53; A1ABQ0; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; Q1R604; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; P0A7V8; B1LHD0; B1LHD3; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; B7NLP7; B7MCR9; P0AG66; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; B4TAV0; B7N0L5; B1LGQ0; B7NDS7; B7L847; Q0TCN6; B5YXA7; B7NGD6; P60438; B4SYA9; Q32B54; B1X6F1; Q0TCS4; Q32B57; B1X6F6; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; Q32B52; B7LQD9; B5YTM5; B7M092; B5BGY5; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7T8; B5R280; B7N2E8; B7L4J5; P61179; B7LRS7; B6I3T6; C4ZUH4; B1LGJ6; P61177; C4ZUH1; C4ZUH2; B5QZ45; Q32B24; P0A7T9; B6I228; P0AG51; B7LS48; B1IPL1; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q5PC32; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; B7MCV7; B1X6F8; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B7UK41; Q5PK05; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; B7M1N1; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5F7F9; A9MFK9; A9N240; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; Q2NWE7; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B7LX23; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; P68679; A7ZSI6; B6I218; Q57PV1; B1X6G8; B6I210; B6I211; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B7MTL9; Q5PIV8; P0A7W7; B7MCS6; P0A7W5; B1LE14; P0A7W3; B7N192; P0A7W1; P0A7W0; B7N199; B7N198; C0Q1W9; B4F277; C4ZR79; B5FN11; A8GJV2; B7M9G4; B5FJA5; Q1CME3; B5RFY6; P0A7W4; P0A7N1; A8AQJ1; B5Y306; B1IPZ6; B4TXD1; B7M1M2; B7M1M3; B7M1M0; B5EXE1; Q1RB78; B1IPZ0; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; B7MJ76; Q57IA6; B1IPZ3; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; A8A5A1; B5F8E7; Q1RB79; B1LHC8; B5F3B9; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; A8AQL8; C4ZSS5; B5RBB1; B1LK73; B7UJ79; A1AGK6; Q57JQ0; B1IPV7; P61178; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B1IT04; Q1R620; B7M1C4; B4SUT9; A8A501; Q1RD68; A4WFD5; B5REG7; A9N241; P0A7J7; B7NF20; B7NDT6; B7NDT5; B7L4K6; B7NDT7; B1IPY4; C4ZUH0; Q1R4N3; P61176; P0A7S9; P0A7S8; P0AG59; A8A5C2; P0A7S3; P0A7S2; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; Q1R626; Q1R627; B5R290; P0A7J3; C0Q644; B7NDT8; P62399; B5R299
DB09076	Umeclidinium	approved	11519070	-	"Indicated for the long-term, once-daily, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD)."	P08172; P08173; P08912; P11229; P20309
DB01080	Vigabatrin	approved	5665	-	"For use as an adjunct in treatment resistant epilepsy, refractory complex partial seizures, and secondary generalized seizures. It is also used as monotherapy in infantile spasms in West syndrome."	Q9H598; Q9UBS5; P80404
DB01081	Diphenoxylate	illicit; approved	13505	-	"For as adjunctive therapy in the management of diarrhea"	P35372; P22001; P41143
DB09073	Palbociclib	investigational; approved	5330286	-	"Palbociclib is indicated in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy for their metastatic disease. This indication is approved under accelerated approval based on progression-free survival (PFS). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial. "	P24385; P52333; Q00534; P03372; P04626; P14416; P11802; P36888; P21917
DB09072	Sodium oxybate	approved	23663870	-	"For the treatment of cataplexy in narcolepsy and excessive daytime sleepiness (EDS) in narcolepsy."	O75899; Q9HAB3; Q9UBS5
DB09071	Tasimelteon	investigational; approved	10220503	-	"Tasimelteon is indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD)."	P48039; P49286
DB09070	Tibolone	investigational; approved	444008	-	"For the relief of post-menopausal symptoms and for the prevention of osteoporosis [L1724]."	P10275; P31645; P06401; P03372
DB01248	Docetaxel	investigational; approved	148124	-	"For the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Also used as a single agent in the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of prior platinum-based chemotherapy. It is also used in combination with prednisone, in the treatment of patients with androgen independent (hormone refractory) metastatic prostate cancer. Furthermore, docetaxel has uses in the treatment of gastric adenocarinoma and head and neck cancer. "	P68366; P68363; Q6PEY2; P10636; Q3ZCM7; P10415; O75469; Q13509; Q13748; P04350; P00533; P11137; Q9BUF5; P68371; P08684; Q02643; Q71U36; P27816; Q9BVA1; Q9H4B7; Q5SU16; Q9BQE3; P07437; Q13885
DB01244	Bepridil	approved; withdrawn	2351	-	"For the treatment of hypertension, and chronic stable angina (classic effort-associated angina)."	P0DP24; Q9UBN1; P54289; P0DP25; P05023; P62955; P41586; P41587; Q06432; Q9Y698; O00257; Q99250; O60840; Q9Y3Q4; O60359; Q14524; O95180; Q8IZS8; Q12809; P62158; Q08289; Q9P0X4; Q7Z3S7; P63316; B4DJ51; O43497; Q01668; Q9UF02; P32241; P51787; Q15878; P54750; Q8WXS5; Q01064; P0DP23; Q15746; Q9H1R3; P35498; Q9BXT2; Q9NY47; Q9NY46; Q14123; P54284; O00555; Q00975; Q13936; Q13698; Q02641; P56696; O00305
DB01245	Decamethonium	approved	2968	-	"For use as a skeletal muscle relaxant"	P08172; P22303; P11230; P02708; Q15822; Q9Y5N1; P07510; Q04844; P17787; P43681; Q07001
DB01246	Alimemazine	approved; vet_approved	5574	-	"Used to prevent and relieve allergic conditions which cause pruritus (itching) and urticaria (some allergic skin reactions)."	P35367
DB01247	Isocarboxazid	approved	3759	-	"Isocarboxazid is indicated for the treatment of the enduring and debilitating symptoms of depression that have not responded to other antidepressant drugs.[L1372] Depression is a common but serious mood disorder. The patient will present changes in its feelings, thoughts, and ability to handle everyday activities. For a mood disorder to be considered as depression, the symptoms should be present for at least two weeks.[L1375]"	P21397; P27338
DB01240	Epoprostenol	approved	5280427	-	"For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy."	P43119; Q16647; P34995; P28223; P35408; Q9H244
DB01241	Gemfibrozil	approved	3463	-	"For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet."	Q07869; Q9NPD5; P06858; P02766; P13945; Q9Y6L6
DB01242	Clomipramine	investigational; approved; vet_approved	2801	-	"May be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette?s disorder).
 Unlabeled indications include: depression, panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy (limited evidence), autistic disorder (limited evidence), trichotillomania (limited evidence), onchophagia (limited evidence), stuttering (limited evidence), premature ejaculation, and premenstrual syndrome. "	P18825; P10635; P28223; P35462; P09211; P11229; Q99720; Q01959; P08912; P08913; P14416; P23975; P08172; P08173; P28335; P41595; P18089; P35367; P35348; P25021; P25100; P20309; P31645; P21728
DB01243	Chloroxine	approved	2722	-	"Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp."	P09917
DB01064	Isoprenaline	investigational; approved	3779	-	"For the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis"	P28482; Q9Y463; P27986; Q92569; P08588; P07550; O00459; P13945; P00441
DB01065	Melatonin	vet_approved; approved; nutraceutical	896	-	"Used orally for jet lag, insomnia, shift-work disorder, circadian rhythm disorders in the blind (evidence for efficacy), and benzodiazepine and nicotine withdrawal. Evidence indicates that melatonin is likely effective for treating circadian rhythm sleep disorders in blind children and adults. It has received FDA orphan drug status as an oral medication for this use. A number of studies have shown that melatonin may be effective for treating sleep-wake cycle disturbances in children and adolescents with mental retardation, autism, and other central nervous system disorders. It appears to decrease the time to fall asleep in children with developmental disabilities, such as cerebral palsy, autism, and mental retardation. It may also improve secondary insomnia associated with various sleep-wake cycle disturbances. Other possible uses for which there is some evidence for include: benzodiazepine withdrawal, cluster headache, delayed sleep phase syndrome (DSPS), primary insomnia, jet lag, nicotine withdrawal, preoperative anxiety and sedation, prostate cancer, solid tumors (when combined with IL-2 therapy in certain cancers), sunburn prevention (topical use), tardive dyskinesia, thrombocytopenia associated with cancer, chemotherapy and other disorders. "	P0DP24; P0DP25; P0DP23; P16083; P62158; P49286; P27797; P03372; Q92753; B4DJ51; P41595; P48039; P11678
DB01066	Cefditoren	investigational; approved	9870843	-	"For the treatment of mild to moderate infections in adults and adolescents (12 years of age or older) which are caused by susceptible strains of microorganisms in acute bacterial exacerbation of chronic bronchitis, community-acquired pneumonia, pharyngitis/tonsillitis, and uncomplicated skin and skin-structure infections."	P24228; P08506; P0A3M6; P02918; P02919; Q8XJ01; P0AD68; P0AEB2; P0AD65
DB00598	Labetalol	approved	3869	-	"For the management of hypertension (alone or in combination with other classes of antihypertensive agents), as well as chronic stable angina pectoris and sympathetic overactivity syndrome associated with severe tetanus. Labetalol is used parenterally for immediate reduction in blood pressure in severe hypertension or in hypertensive crises when considered an emergency, for the control of blood pressure in patients with pheochromocytoma and pregnant women with preeclampsia, and to produce controlled hypotension during anesthesia to reduce bleeding resulting from surgical procedures."	P25100; P18825; P10635; Q99720; P08908; Q01959; P41595; P18089; P08588; P08913; P35368; P07550; P23975; P35348; P13945; P30518
DB01060	Amoxicillin	approved; vet_approved	33613	-	"For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of <i>Streptococcus</i> spp. (a- and b-hemolytic strains only), <i>S. pneumoniae</i>, <i>Staphylococcus</i> spp., <i>H. influenzae</i>, <i>E. coli</i>, <i>P. mirabilis</i>, or <i>E. faecalis</i>. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to <i>N. gonorrhoeae</i> (males and females)."	P28335; P0AEB2; P08506; P02918; P28223; Q8XJ01; P02919; P41595; P0AD68; P24228; P0AD65; P08581
DB01061	Azlocillin	approved	6479523	-	"For the treatment of infections caused by <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Haemophilus influenzae</i>."	Q07806; Q8XJ01
DB01062	Oxybutynin	investigational; approved	4634	-	"For the treatment of overactive bladder."	P08172; P08173; P11229; Q99720; Q01959; P41595; P08912; P20309; P23975; P35462
DB01063	Acetophenazine	approved	17676	-	"For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)"	P10275; P21728; P14416
DB00593	Ethosuximide	approved	3291	-	"For the treatment of petit mal epilepsy."	Q9P0X4; O95180; O43497
DB00592	Piperazine	approved; vet_approved	4837	-	"Used as alternative treatment for ascariasis caused by <i>Ascaris lumbricoides</i> (roundworm) and enterobiasis (oxyuriasis) caused by <i>Enterobius vermicularis</i> (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children."	P28472
DB00591	Fluocinolone Acetonide	investigational; approved; vet_approved	6215	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also for the treatment of chronic non-infectious uveitis affecting the posterior segment of the eye (Retisert)."	P04150; P08185; P47712; Q13255
DB00590	Doxazosin	approved	3157	-	"For treatment and management of mild to moderate hypertension and urinary obstruction symptoms caused by BPH."	Q9NS40; Q12809; P18825; P28335; Q01959; P25100; P03956; P08913; P41595; P07550; P31645; Q9H252; P35348; P35368
DB01068	Clonazepam	illicit; approved	2802	-	"Clonazepam is used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. It can also be used for the treatment of panic disorders. "	Q9UN88; P24046; P30536; P18507; P28476; P18505; Q99928; A8MPY1; O14764; P48169; P14867; Q8N1C3; P31644; P47870; P28472; O75469; Q16445; P47869; P34903; O00591; P78334
DB00596	Ulobetasol	approved	5311167	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses."	P04150
DB00595	Oxytetracycline	investigational; approved; vet_approved	54675779	-	"Oxytetracycline is indicated for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including <i>Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae</i> (respiratory infections), and <i>Diplococcus pneumoniae</i>."	B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; B1LHB1; B5F3B9; P0A7T7; C0Q0A5; Q57GI9; B1X6G8; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; P68683; P68680; A8A5C2; B7LRT5; B7LS48; B7LRT1; B1X6G0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; B7NLN3; B1IPL1; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; Q57J49; B7UMH0; B1IQ02; B1IQ00; B1IQ05; B7NLN0; C4ZQY2; Q57QG6; A7MPH8; A9MN70; B7M1C4; P60625; P60626; A6TE47; B4SXD8; B7NDS9; Q1R616; B7NDS5; B7NDS7; B5FJK8; B7UK28; B7N0W8; B1LHB3; B5FJK0; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; C4ZUG3; C4ZS29; A8A539; P0A7W5; B1LQM1; B6I208; B7NJS8; B1LE14; B5BGY5; A8AQC0; B7LHT8; C0Q2L0; P0A7W2; B5F8G0; A8A5E9; C4ZUG9; P0A7W0; P0A7T3; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; A8A5B3; A7MNZ2; P0A7W9; A4THT0; Q32FI2; C4ZSS5; B4T4N1; B7M1L8; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; B6I228; A9MVN1; B4TGH4; Q0T9J1; B4TAV0; P0A7R9; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; P62401; B4TGH3; B5QUQ1; P0A7R5; B5FN11; P0AG44; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; P0C020; B6I2A8; A9N5Y8; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; Q0TCE2; P68686; B7MCV7; B1IPY8; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; P68681; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1XHG2; A1AGM9; P0AG67; P0ADZ0; Q0TCN6; Q0THB3; B7MCT2; B7MCT1; A7ZSK5; B7N1A3; A7ZSK3; B7N1A1; B7N1A0; B5R285; P0A7K2; B5R286; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7UK52; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8A5A2; B5FJA5; B5F7T9; Q32B57; B5F7T1; B7M1M5; B5F7T4; B7NR05; P68919; P0A7S3; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; B7N0V1; Q329M1; P60422; P60423; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B7N554; B1IPY4; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B5QZ45; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B5BGX2; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; P0A7S7; B7UK18; A1AGI8; Q32B52; A1AGI7; Q32BE7; A1AGI5; B7NDK8; B4TKL4; P68679; B4TKL0; B5RAX1; B7M1M3; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; B1XHK3; P0A7Q9; Q1RD68; Q5PGT9; Q57J53; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B7M0U2; P0A7V8; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B4TXF0; B1LHB0; B6I437; B7NEU0; B1LHC3; C4ZUE9; B7NLL7; B7L6I9; P0C018; P0C019; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; P0A7Q6; Q2NWE7; P0A7V5; A7MPH5; A9MJT9; P0A7Q8; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; B7N198; Q0TCF7; B1X6F8; P02413; A9MN54; Q1C365; P60624; A9MN59; P0A7M6; P0A7M2; P0A7M9; A1AGJ2; A1AGJ3; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1IPY3; B1IPY2; B1IPY5; A9MGD1; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; Q1R604; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; B1LHD1; B1LHD0; B1LHD3; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; B7MCR9; P0AG66; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7L847; A7ZSK8; B7MCS6; B5YXA7; B7NGD6; B7LRT0; A7ZSK6; B4SYA9; Q32B54; B1X6F1; B7NDR8; A7ZSK4; B5FJK9; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; B7MCT4; B7LQD9; B5YTM5; B7M092; B5YTM7; A8AQJ9; Q5PKU5; B5BGY1; A7ZSI8; B7UK21; B5YTM9; P60725; P60724; B1IT04; P60726; B5FSA3; P60723; P0A7T8; B5R280; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; C4ZUH1; C4ZUH2; Q1R632; Q32B24; P0A7T9; B7NDH0; B1IPL2; B5BG21; A4WFC2; Q328J7; B1IPZ0; B4TKK1; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q0TCG7; Q2EEQ2; Q0TBH3; P0ADY3; P0ADY7; P0AG48; P0AG49; P0AG46; P0AG47; Q1R4V6; P0AG45; P0A7R0; A6THB3; B2VGJ7; B7N1C3; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; Q5PK05; Q57J33; B7LRR3; B7LRR1; P60727; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7M1N1; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B4TXC8; A8A5C4; B1LHC0; B1LHC2; B1X6F6; P0AG65; B1LHC5; A7ZS83; B1X6H0; B7LCR3; B5REG7; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B1IQ03; B7M555; Q665U4; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B7LX23; P0A7N4; P0A7N5; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; B7L4K6; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; B7LRS7; A8APV6; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B7MTL9; Q5PIV8; P0A7W7; P0A7W6; B1LE15; A8ARM4; P0A7W3; B7N192; P0A7W1; B7N190; B7N199; P0A7W8; C0Q1W9; B4F277; Q0THB2; C4ZR79; B5BGY0; C5BF78; A8GJV2; B7M9G4; P0A7L8; B7MCS1; Q1CME3; B5RFY6; P0A7W4; P0A7N1; A8AQJ1; B5Y306; B1IPZ6; B4TXD1; B7M1M2; P0AG55; B7M1M0; B5EXE1; Q1RB78; A7MPH2; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; B7MJ76; Q57IA6; P0A7N7; B1X6E8; B1X6E9; P0A7S6; P02358; P02359; P0A7X2; P0A7X3; P0A7X0; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; A8A5A1; B5F8E7; B1LHC8; B7NDT5; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; A8AQL8; B4T4N0; B5RBB1; B1LK73; B7UJ79; B1X6G3; A1AGK6; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B4SUT9; A8A501; A9MFK9; A4WFD5; A9N240; B5BKL1; B7NDT2; B7NF20; C0Q0C4; B7M1C5; B5R290; C0Q644; C4ZUH0; Q1R4N3; P61176; P0A7S9; P0A7S8; P0AG59; P61175; Q1RB79; P0A7S2; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; P0A7J7; Q1R626; Q1R627; B7NDT7; B7NDT6; B7NDT8; B5R299; P62399
DB00594	Amiloride	approved	16231	-	"For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension."	P21397; Q9HCX4; P78348; P07306; Q16515; P00749; P37088; Q9Y5S1; Q9UHC3; P19634; P51170; P51172; Q9P0L9; P51168; P29274; Q14940
DB00449	Dipivefrin	approved	3105	-	"Dipivefrin is a prodrug which is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma."	P22303; P06276; P18825; P18089; P08588; P08913; P25100; P35368; P07550; P30043; P35348; P13945
DB00448	Lansoprazole	investigational; approved	3883	-	"For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use."	P20648; P10635; P10636; P33261; Q96RI0; P51164
DB00445	Epirubicin	approved	41867	-	"For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer."	P06241; O14646; P11388; Q02880
DB00444	Teniposide	approved	452548	-	"Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia"	P11388; Q02880
DB00447	Loracarbef	investigational; withdrawn	5284585	-	"Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by <i>E. coli</i>, <i>S. pyogenes</i>, <i>S. aureus</i>, <i>S. saprphyticus</i>, <i>S. penumoniae</i>, <i>H. influenzae</i> and <i>M. catarrhalis</i>."	P0AEB2; P08506; P02918; P02919; Q8XJ01; P0AD68; P24228; P0AD65
DB00446	Chloramphenicol	approved; vet_approved	5959	-	"Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis."	B5YVV7; B5RH07; B1XG23; B1XG24; A7ZSI6; C0PYY2; B5F3B9; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; P0A7T8; P0A7T9; P0A7T7; Q57GI9; B7N102; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P60423; B7LRT5; B7LS48; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B7UMH0; B4TKM3; B6I1U8; B5R1G3; Q57J49; Q5PIU7; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; Q0TCF5; A9MN70; B1LL30; B7M1C5; P60626; A6TE47; B4SXD8; B7NDS9; B7NDS5; B7MTL9; B5FJK8; B5FJK9; B7N0W8; C4ZUG1; B5FJK0; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; C4ZUG3; P0A7W6; B1LHB0; P0A7W5; B1LQM1; B6I208; B7NJS8; B1LE14; B5BGY5; Q5PK05; B7LHT8; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; B7N190; P0A7T3; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; A7ZSC4; A7MNZ2; P0A7S2; P0A7W9; A4THT0; P0A7W8; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; A9MVN1; P62401; Q0T9J1; C4ZSW8; P0ADY7; B6I1Q9; B5QVW5; B4TN08; B5QVW6; A9MN59; P62400; A9MX79; B4TGH3; B5QUQ1; P0AG47; C5BF78; Q1R4V6; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; P0C020; B6I2A8; A9N5Y8; B4TGH4; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; B5RAX1; P68686; B7MCV7; A1AGJ3; B6I242; B7MCS3; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; P68681; A9MGD1; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; P0ADZ0; Q0TCN6; A7ZSK6; B7MCT2; A7ZSK4; B7MCT0; B7N1A3; A7ZSK3; B7N1A1; B7N1A0; B5R285; P0A7K2; B5R286; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; B7UK52; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; P60624; Q32B54; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; B7MCS6; B5FJA6; A8A5A1; A8GJV2; B7MCS1; B5F7T9; Q32B57; B5F7T1; B5F7T4; B7NR05; A8AQL8; P0A7S3; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; A1AGI5; Q329M1; P60422; B1X6G3; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; Q1R609; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B6I211; Q32FI2; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; P0A7S7; B1X6E9; B7UK18; A1AGI8; C4ZUF2; A1AGI7; Q32BE7; B7N0V1; B7NDK8; B4TKL4; P68679; B4TKL0; B7NDH0; Q0TCE2; P0A7M6; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P08684; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; P0A7S4; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; Q57HZ9; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; A9MJT9; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; B1LHD1; A9MKN8; P0A7V9; B7LLY4; B4TXF0; Q0THB3; B6I437; B7NEU0; B1LHC3; B7NLL4; B7NLL7; B7NLL6; P0C018; P0C019; B1LF57; P0A7Q5; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7MGC4; A7MPH5; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; B1X6F8; P02413; A9MN54; Q1C365; B5RFY6; A1JQX1; P60625; Q5PJ56; P08174; P0A7M2; P0A7M9; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1IPY3; B1IPY2; B1IPY5; B1IPY4; Q329B5; P0ADZ4; B7LR53; A1ABQ0; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; A6TG05; Q1R358; B6I225; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; P0A7V8; B1LHD0; B1LHD3; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; B7MCR9; A1AGM9; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7NDS7; B7L847; A7ZSK8; B5YXA7; B7NGD6; Q32B55; B4SYA9; Q0THB2; B1X6F1; Q0TCS4; B7MCT1; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; Q32B52; B7LQD9; B5YTM5; B7M092; C0Q0A5; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B7UK21; A8AQJ1; P60725; B7LRS4; B1IT04; Q1R632; B5FSA3; P60723; B5R280; B7N2E8; A4WEK0; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; P61176; P61175; P24093; B5QZ45; Q32B24; B4TUF2; B6I228; B1IPL2; B1IPL1; A4WFC2; Q7BG35; Q328J7; B1IPZ0; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; A8A5C2; Q0TCG7; A8A539; Q2EEQ2; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0A7R5; P0AG44; P0AG45; P0A7R0; A6THB3; B2VGJ7; B7N1C3; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B5BG21; A8AQC0; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; B7M1N1; B7M1N0; Q1R5U1; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1X6F6; B1LHC5; A7ZS83; B5F7F9; B7LCR3; A9N240; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B7LX23; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; B7L4K6; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; B7L4K8; B6I218; A8APV6; Q57PV1; Q57PV0; B6I210; Q1R612; A7ZRU7; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; A8A5A4; B1LE15; A8ARM4; P0A7W3; B7N192; P0A7W1; P0A7W0; B7N199; B7N198; C0Q1W9; B4F277; C4ZR79; B5FN11; A8A5A2; B7M9G4; P0A7L8; B5FJA5; Q1CME3; P0A7W4; P0A7N1; B5YTM9; B5Y306; B1IPZ6; B4TXD1; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; B7MJ76; P60724; Q57IA6; B1IPZ3; B1X6E8; P60727; C0Q0C4; P0A7S6; P02358; P02359; P0A7R9; P60726; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; Q1RB79; B1LHC8; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; P68919; C4ZSS5; B5RBB1; B1LK73; B7UJ79; A1AGK6; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B7M1C4; B4SUT9; A8A501; A9MFK9; A4WFD5; B5REG7; B5BKL1; P0A7J7; B7NF20; B7NDT5; A7ZSI8; B5R290; C0Q644; C4ZUH0; B7NDT6; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0AG55; Q1RB78; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; B7UPA5; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; B7NDT2; Q1R626; Q1R627; B7NDT7; Q1R4N3; B7NDT8; B5R299; P62399
DB00441	Gemcitabine	approved	60750	-	"Gemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy, metastatic ovarian cancer, inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer, and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas. "	Q14181; Q07864; P49005; P09884; P30085; P04818; P56282; Q7LG56; P49643; Q53Y97; P23921; Q15054; P49642; P31350; P28340; Q9HCU8; Q9NRF9
DB00440	Trimethoprim	approved; vet_approved	5578	-	"For the treatment of urinary tract infections, uncomplicated pyelonephritis (with sulfamethoxazole) and mild acute prostatitis. May be used as pericoital (with sulfamethoxazole) or continuous prophylaxis in females with recurrent cystitis. May be used as an alternative to treat asymptomatic bacteriuria during pregnancy (only before the last 6 weeks of pregnancy). Other uses include: alternative agent in respiratory tract infections (otitis, sinusitus, bronchitis and pneumonia), treatment of Pneumocystis jirovecii pneumonia (acute or prophylaxis), Nocardia infections, and traveller's diarrhea."	B0YJ76; P0ABQ4; P00374; P04818; P11413; Q53Y97
DB00443	Betamethasone	approved; vet_approved	9782	-	"Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
 Topical use (foam): relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp.
 Systemic use: for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis."	P04150; P04083; Q5TZZ9
DB01406	Danazol	approved	28417	-	"For the treatment of endometriosis and fibrocystic breast disease (in patients unresponsive to simple measures). Also used for the prophylactic treatment of all types of hereditary angioedema in males and females."	P04150; P41145; P13500; P35462; P06401; P18825; Q96P88; P28223; Q01959; P18089; P03372; P10275; P35372; P08913; P13945; P20309; P31645; P21728; P23975; P30968
DB01407	Clenbuterol	investigational; approved; vet_approved	2783	-	"Used as a bronchodilator in the treatment of asthma patients. "	P01138; P08588; P01375; P08908; P07550; P13945
DB01405	Temafloxacin	withdrawn	60021	-	"For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections."	P0AES4; P0AES6; P43700; P43702
DB01403	Methotrimeprazine	investigational; approved	72287	-	"For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder."	P08172; P08173; P28223; P11229; P18825; P20309; P28335; P25100; P18089; P21918; P21728; P08913; P41595; P14416; P35368; P35367; P08912; P35348; P21917; P35462
DB01400	Neostigmine	approved; vet_approved	4456	-	"Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone."	P22303; P06276
DB01401	Choline magnesium trisalicylate	approved	54682045	-	"Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults."	P35354; P23219
DB09183	Dasabuvir	approved	56640146	-	"Dasabuvir, in combination with [DB09296], [DB09297], and [DB00503] (as Viekira Pak) is indicated for the treatment of patients with HCV genotype 1a with [DB00811] or genotype 1b without [DB00811] including those with compensated cirrhosis [FDA Label]."	Q8IZI9
DB01426	Ajmaline	investigational; approved	441080	-	"For use as an antiarrhythmic agent."	P10635; Q14524
DB09185	Viloxazine	investigational; approved; withdrawn	5666	-	"Indicated for the treatment of clinical depression."	P31645; P23975; Q01959
DB01409	Tiotropium	approved	5487427	-	"Used in the management of chronic obstructive pulmonary disease (COPD)."	P08172; P08173; P08912; P11229; P20309
DB01395	Drospirenone	approved	68873	-	"For the prevention of pregnancy in women who elect an oral contraceptive."	P33261; P08235; P06401; P10275
DB01420	Testosterone propionate	investigational; withdrawn; approved; vet_approved	5995	-	"Testosterone propionate is often used for muscle mass building. The original medical indication is for the treatment of androgen deficiency in male adults either in hypogonadism or andropause.[L1161] Nowadays testosterone propionate is indicated for its use in heifers in order to stimulate maximal growth.[L1160]"	P05093; P10275
DB01393	Bezafibrate	investigational; approved	39042	-	"For the treatment of primary hyperlipidaemia types IIa, IIb, III, IV and V (Fredrickson classification) corresponding to groups I, II and III of the European Atherosclerosis Society guidelines - when diet alone or improvements in lifestyle such as increased exercise or weight reduction do not lead to an adequate response. Also for the treatment of secondary hyperlipidaemias, e.g. severe hypertriglyceridemias, when sufficient improvement does not occur after correction of the underlying disorder (e.g. diabetes mellitus)."	P19793; P04035; P28702; Q07869; P48443; O75469; P37231; Q03181
DB01422	Nitroxoline	approved	19910	-	"Nitroxoline is an antibiotic agent."	P50579; P35354
DB00950	Fexofenadine	investigational; approved	3348	-	"For management of Seasonal allergic rhinitis"	P35367; Q12809
DB01669	Virginiamycin M1	experimental	5459319	-	"For the treatment of bacterial infections."	P50870
DB00131	Adenosine monophosphate	investigational; approved; nutraceutical	6083	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	P09467; P11309; P49773; Q08828; O60755; P16220; O43603; O43741; Q9Y478; P12931; Q9NUB1; P55263; P06737; Q07343; Q9NR19; Q08499; Q13131; P33121; P47211
DB00130	L-Glutamine	investigational; approved; nutraceutical	5961	-	"Used for nutritional supplementation, also for treating dietary shortage or imbalance.
 
 Used to reduce the acute complications of sickle cell disease in adult and pediatric patients 5 years of age and older [FDA Label]."	P15104; Q06203; Q99624; P17812; Q5T6X5
DB00133	Serine	approved; nutraceutical	5951	-	"Used as a natural moisturizing agent in some cosmetics and skin care products."	P49591; P35520; Q9GZT4; P20132; P0DN79; Q5T6X5; O15269; P21549; O15270
DB00132	Alpha-Linolenic Acid	approved; nutraceutical	5280934	-	"For nutritional supplementation and for treating dietary shortage or imbalance."	O14842; P19793; P32418; Q8NER1; Q07869; Q9GZR5; Q03181; Q96RI1; O60427; P37231; Q5NUL3; O95864; P23219; P11511
DB00135	L-Tyrosine	investigational; approved; nutraceutical	6057	-	"Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies."	P54577; P07101; P17735; Q9Y2Z4
DB00134	Methionine	approved; nutraceutical	6137	-	"Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate."	Q9H2M3; Q93088; O43603; V9HWA4; P50579; Q99707; Q9UBK8
DB00136	Calcitriol	approved; nutraceutical	5280453	-	"Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis."	P11473; P31260; P02774
DB00139	Succinic acid	approved; nutraceutical	1110	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	Q96I99; Q99643; P51649; O14521; Q9BYC2; Q9BXA5; Q32P28; O14756; O15460; E5KS60; Q9NVH6; P13674; Q02809; Q9P2R7; P31040; Q9BZW2; Q8IVL6; Q12797; P21912; P53597; Q8IVL5; O60568; Q13183; Q9UBX3; P55809; O75936; Q8WWT9
DB11943	Delafloxacin	investigational; approved	487101	-	"Delafloxacin is indicated for the treatment of acute bacterial skin and skin structure infections caused by the Gram-positive organisms Staphylococcus aureus (including methicillin-resistant and methicillin-susceptible isolates), Staphylococcus haemolyticus, Staphylococcus lugdunensis, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), Streptococcus pyogenes, and Enterococcus faecalis as well as the Gram-negative organisms Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeruginosa [FDA Label]."	P0AES4; P0AES6; P0AFI2; P20083
DB00710	Ibandronate	investigational; approved	60852	-	"For the treatment and prevention of osteoporosis in postmenopausal women."	P14324
DB00919	Spectinomycin	investigational; approved; vet_approved	15541	-	"For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of <i>Neisseria gonorrhoeae</i>."	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; B1LHB1; B5F3B9; P0A7T7; B7UPA5; C0Q0A5; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; Q1R4V6; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; B1X6G3; B7LRT5; B7LS48; B7LRT1; A1ABQ0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7LR53; B1IQP9; B5YSV6; C4ZYY0; B7MTL9; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; Q0TCF5; A9MN70; B1LL30; B7M1C5; P60626; A6TE47; B4SXD8; B7NDS9; B7NDS5; B7NDS7; B5FJK8; B7UK28; B7N0W8; B1LHB3; B5FJK0; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; C4ZUG3; C4ZS29; P0A7T9; B1LE15; B1LQM1; B6I208; Q5PK01; P0A7W4; Q5PK05; B7LHT8; C0Q2L0; B7N192; A8A5E9; C4ZUG9; P0A7W0; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A7ZSC4; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; B6I3L3; B4TXD1; P0A7N6; A7MNZ2; B7N199; A4THT0; B7N198; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; Q57J43; C4ZSW8; B5RGF1; B6I228; Q57J49; P62401; Q0T9J1; A9MN59; B7MFJ7; P0A7R9; B6I1Q9; B5QVW5; B4TN08; B5QVW6; B5R286; P62400; A9MX79; B4TGH3; B5QUQ1; P0AG47; C5BF78; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; P0C020; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; B5RAX1; P68686; B7MCV7; B1IPY8; Q1CME3; B7UK39; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; P68681; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; A7ZSK8; A7ZSK6; B7MCT2; B7MCT1; A7ZSK5; B7N1A3; A7ZSK3; A7ZSK0; B7MCT4; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7UK52; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; P60624; Q32B54; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8A5A2; B7MCS1; B5F7T9; B5F7T1; B5F7T4; B7NR05; A8AQL8; P0A7S3; B7L6J0; A8AQL3; B7MST2; B7LH01; B7NLN4; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; A1AGI5; Q329M1; P60422; P60423; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; Q1R609; B7LG22; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; Q57IA6; A9MN66; B5BGX2; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; B7UK18; A1AGI8; Q32B52; A1AGI7; Q32BE7; B7N0V1; B7NDK8; B4TKL4; P68679; B7UMH0; Q0TCE2; B4EW58; B4TKL0; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; Q5PGT9; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; Q57HZ9; B5F6A5; B6I242; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; A9MJT9; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; Q1RD68; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B7M0U2; P0A7V8; Q5PJ56; A9MKN8; P0A7V9; B7LLY4; B4TXF0; Q0THB3; B1LHB0; B6I437; B7NEU0; B7NLL4; B7NLL7; B7L6I9; P0C018; P0C019; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7MGC4; P0A7V5; Q0TCF8; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; P02413; A9MN54; Q1C365; B7N102; B5RFY6; P60625; P0A7M6; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; A6TG05; Q1R358; Q1R604; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; B7MJ76; B1IT04; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; B1LHD1; B1LHD0; B1LHD3; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; A1JQX1; P0A7V6; P0A7V7; B7NLP7; B7MCR9; A1AGM9; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; A8AQL0; A8ARM4; B7N0L5; B1LGQ0; B7L847; Q0TCN6; B5YXA7; B7NGD6; B7LRT0; B1X6F8; B4SYA9; Q0THB2; B1X6F1; B7NDR8; Q32B57; B1X6F6; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; B7N1A0; B7LQD9; B5XZP7; B7M092; B5YTM7; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B7UK21; B5YTM9; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7T8; B5R280; B7N2E8; A4WEK0; P61179; C6DKG8; B6I3T6; C4ZUH4; B1LGJ6; P61177; C4ZUH1; C4ZUH2; Q32B24; B7NDH0; B1IPL2; B1IPL1; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q5PC32; A8A539; Q2EEQ2; Q0TBH3; P0ADY3; P0ADY7; P0AG48; P0AG49; P0AG46; P0A7R5; P0AG44; P0AG45; P0A7R0; A6THB3; B2VGJ7; B7N1C3; P60438; B7MLK7; B5BGY5; B7NJS8; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B5BG21; A8AQC0; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7M1N1; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; A8A5C2; B1LHC9; A8A5C0; A8A5C1; B4TXC8; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5F7F9; B7LCR3; A9MGD1; A9N240; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7LRS4; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; B1IPZ0; B1IPZ1; A8A4M2; B1IPZ3; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; A1AGK6; A7MM78; B7UK35; B7UK32; B7UK30; B7L4K6; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A8APV6; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; A7ZRU7; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; B1LE14; P0A7W3; P0A7W2; P0A7W1; B7N190; P0A7W9; P0A7W8; C0Q1W9; B4F277; C4ZR79; B5FN11; A8GJV2; B7M9G4; B5FJA5; B7MCS6; B1IPZ5; A8AQJ1; B5Y306; B7LX23; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; P0A7N4; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B5QZ45; P0A7S7; P0A7N7; B1X6E8; B1X6E9; C0Q0C4; P0A7S6; P02358; P02359; P0A7X2; P0A7X3; P0A7X0; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; A8A5A1; B5F8E7; Q1RB79; B1LHC8; B7NDT5; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; P68919; C4ZSS5; B5RBB1; B1LK73; B7UJ79; Q1R6R5; Q57JQ0; B1IPV7; P61178; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B7M1C4; B4SUT9; A8A501; A9MFK9; A4WFD5; B5REG7; A9N241; B7NDT2; B7NF20; B7NDT6; B4TGH4; A7ZSI8; B5R290; C0Q644; C4ZUH0; Q1R4N3; P61176; P0A7S9; P0A7S8; P0AG59; P61175; P0AG55; P0A7S2; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; P0A7J7; Q1R626; Q1R627; B7NDT7; P0A7J3; B7NDT8; B5R299; P62399
DB00918	Almotriptan	investigational; approved	123606	-	"For the treatment of acute migraine headache in adults"	P30939; P28221; P28222
DB00917	Dinoprostone	approved	5280360	-	"For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical \"ripening\") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage."	P43119; Q8NEC5; P43088; Q7RTX7; Q13258; P34995; Q86XQ3; P43115; P35408; P43116; Q96P56; P21731; Q9Y5Y4; Q92959
DB00916	Metronidazole	approved	4173	-	"For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, Clostridium difficile-associated diarrhea and colitis, Helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, Giardia lamblia gastro-enteritis, amebiasis caused by Entamoeba histolytica, acne rosacea (topical treatment), and Trichomonas infections."	O25608; Q16850; P29166; Q5XXA6
DB00915	Amantadine	approved	2130	-	"For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions."	Q05586; P06821; O15399; P14416; Q99720; O60391; Q13224; Q12879; Q8TCU5; P21430; Q14957
DB00914	Phenformin	investigational; approved; withdrawn	8249	-	"For the reatment of type II diabetes mellitus."	Q15842; Q13131
DB00913	Anileridine	illicit; approved	8944	-	"For treatment and management of pain (systemic) and for use as an anesthesia adjunct."	P41145; P35372
DB00912	Repaglinide	investigational; approved	65981	-	"As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. "	O60706; P37231; Q09428; Q14654; P48048
DB00910	Paricalcitol	investigational; approved	5281104	-	"For treatment of secondary hyperparathyroidism associated with chronic kidney disease (CKD) Stage 3 and 4"	P11473
DB04908	Flibanserin	investigational; approved	6918248	-	"For the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. "	P11712; P28335; P35462; P10635; P28223; P41595; P33261; P14416; P08908; P21917
DB13167	Alclofenac	approved; withdrawn	30951	-	"Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies."	P35354; P23219
DB13164	Olmutinib	investigational; approved	54758501	-	"For use in treatment of metastatic T790M mutation positive non-small cell lung cancer [A19196]."	P00533
DB04903	Pagoclone	investigational	131664	-	"For the potential treatment of panic and anxiety disorders."	Q9UN88; P28472; P18507; P18505; O00591; O14764; P48169; P14867; Q8N1C3; P34903; P47870; P47869; Q16445; Q99928; P31644; P78334
DB04905	Tesmilifene	investigational	108092	-	"Intended for the treatment of various forms of cancer."	P35367; P08183; P24462; P08684; P20815
DB00625	Efavirenz	investigational; approved	64139	-	"For use in combination treatment of HIV infection (AIDS)"	P20813
DB00624	Testosterone	investigational; approved	6013	-	"To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast  in women who are 1-5 years postmenopausal, testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone."	P04150; P08235; Q99720; P03372; P10275; P11511
DB00627	Niacin	investigational; approved; nutraceutical	938	-	"For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy."	Q9BXC0; Q96PD7; P49019; Q15274; P21918; P21728; Q8TDS4; P40261
DB06729	Sulfaphenazole	approved	5335	-	"For the treatment bacterial infections."	P0AC13
DB00621	Oxandrolone	investigational; approved	5878	-	"Use to promote weight gain after weight loss following extensive surgery."	P10275; P14778
DB00620	Triamcinolone	approved; vet_approved	31307	-	"For the treatment of perennial and seasonal allergic rhinitis."	P04150; P06401; P08185; Q5TZZ9; P04083
DB00623	Fluphenazine	approved	3372	-	"For management of manifestations of psychotic disorders."	P0DP24; Q12809; Q99250; P08173; P18825; P25021; P28222; P28223; P10275; P35372; P04626; P35462; P00533; P11229; Q99720; P0DP23; Q01959; P35348; P21728; P08913; B4DJ51; P34969; P14416; P28221; P23975; P08172; P41145; P28335; P41143; P08908; P18089; P21918; P41595; P35368; P35367; Q9NY46; P13945; P0DP25; P62158; P25100; P01011; P50406; P20309; P08912; P31645; P06241; P35498
DB00622	Nicardipine	investigational; approved	4474	-	"Used for the management of patients with chronic stable angina and for the treatment of hypertension."	P0DP24; P08173; Q01064; P62158; O60840; O95180; P11229; Q08289; P08912; B4DJ51; Q01668; P08172; P0DP25; P54750; P33765; P0DP23; P0DMS8; P08684; P35368; P22459; P35348; P54289; P25100; Q13936; P20309; Q13698
DB00629	Guanabenz	investigational; approved	3517	-	"For management of High blood pressure"	P21397; P28223; P18825; P28335; P25100; P41595; Q9Y2I1; P18089; P08908; P08913
DB00628	Clorazepate	illicit; approved	2809	-	"For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal."	Q9UN88; P24046; P30536; P18507; P28476; A8MPY1; Q99928; O14764; P48169; P47870; Q8N1C3; P31644; P14867; P28472; P18505; P47869; P34903; Q16445; O00591; P78334
DB06725	Lornoxicam	investigational; approved	54690031	-	"For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases."	P35354; P23219
DB09526	Hydroquinone	investigational; approved	785	-	"Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles. "	P00918; P22748; P07451; Q9ULX7; P00915; Q16790; P14679; O43570; P35218; Q9Y2D0
DB09097	Quinagolide	investigational; approved	3086401	-	"Indicated for the treatment of hyperprolactinemia (idiopathic or originating from a prolactin-secreting pituitary microadenoma or macroadenoma)."	P21918; P14416
DB06292	Dapagliflozin	approved	9887712	-	"Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise. "	P13866; P31639
DB06290	Simeprevir	approved	24873435	-	"Indicated for the treatment of adults with chronic hepatitis C virus (HCV) infection: typically in combination with sofosbuvir in patients with HCV genotype 1 without cirrhosis or with compensated cirrhosis and in combination with peginterferon alfa (Peg-IFN-alfa) and ribavirin (RBV) in patients with HCV genotype 1 or 4 without cirrhosis or with compensated cirrhosis. 
 
 Resistance: Reduced susceptibility to simeprevir was most commonly associated with the viral NS3 Q80K polymorphism. Amino acid substitutions at NS3 positions S122, R155 and/or D168 are also shown to reduce susceptibility to simeprevir in genotype 1a/b patients. 
 "	Q8IZI9
DB04834	Rapacuronium	withdrawn	5311399	-	"Used in anaesthesia, to aid and enable endotracheal intubation."	Q04844; P11230; P07510; Q07001; P02708
DB04835	Maraviroc	investigational; approved	3002977	-	"For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents."	P51681
DB04836	Amineptine	illicit; withdrawn	34869	-	"For the treatment of depression."	P31645; P23975
DB04837	Clofedanol	approved; withdrawn	2795	-	"Used in the treatment of dry cough."	P35367
DB00693	Fluorescein	approved	16850	-	"For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature."	P06310
DB04832	Zimelidine	withdrawn	41987	-	"For the treatment of depression."	P21397; P27338; P28221; P28222; P28223; O95264; P46098; P47898; P28566; P34969; A5X5Y0; P30939; P14416; P23975; Q70Z44; P28335; P41595; Q13639; P50406; Q8WXA8; P08908; P31645
DB04833	Methaqualone	illicit; withdrawn	6292	-	"For the treatment of insomnia, and as a sedative and muscle relaxant."	Q9UN88; P28472; P18507; P18505; Q99928; O14764; P48169; Q16445; Q8N1C3; P47869; P47870; P14867; P31644; P34903; O00591; P78334
DB00823	Ethynodiol diacetate	approved	9270	-	"For the prevention of pregnancy in women who elect to use this product as a method of contraception."	P06401; Q9NR97; P03372
DB00822	Disulfiram	approved	3117	-	"For the treatment and management of chronic alcoholism"	P21397; P41145; P51681; P14416; P51679; P05091; Q01959; P41595; P21728; P35372; P08913; P18089; P35462; P27815; P23975; P09172
DB00821	Carprofen	withdrawn; approved; vet_approved	2581	-	"For use as a pain reliever in the treatment of joint pain and post-surgical pain."	P23786; P35354; P23219
DB00820	Tadalafil	investigational; approved	110635	-	"Used for the treatment of erectile dysfunction."	P27815; P16499; Q13956; Q12809; Q9HCR9; O76074; O43924; P51160; P35913; P18545
DB04838	Cyclandelate	approved	2893	-	"Used in the treatment of various blood vessel diseases (e.g., claudication, arteriosclerosis and Raynaud's disease) and nighttime leg cramps."	P54289; P23141
DB04839	Cyproterone acetate	investigational; approved	9880	-	"For the palliative treatment of patients with advanced prostatic carcinoma."	P04150; P10275; P35372; P07288; P06401
DB00825	Menthol	approved	16666	-	"Used to treat occasional minor irritation, pain, sore mouth, and sore throat as well as cough associated with a cold or inhaled irritants."	O75762; P41145; Q8NET8; Q7Z2W7
DB00824	Enprofylline	investigational; approved	1676	-	"Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy."	P27815; P33765; P0DMS8; Q07343; P29274; P29275; P30542
DB06616	Bosutinib	approved	5328940	-	"Treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients. "	Q02750; P57059; P36507; Q9Y4K4; P08631; Q8IU85; P07949; P07947; P29597; Q9Y2U5; P04626; Q07912; P07948; Q15303; P29317; P00533; P42681; P00519; P42684; P42685; Q08881; Q05655; Q9UM73; P16234; P52333; P06239; P08581; P10721; P07333; O94804; P09619; Q9Y2K2; P12931; Q13555; O75116; Q13464; Q02763; P36888; P24941; Q13043; P06748; Q9H0K1; P11274; Q06187; O60674; Q9Y6E0; P06241
DB06614	Peramivir	investigational; approved	154234	-	"Investigated for use/treatment in influenza."	P03474; P06818; P03472; P03468; P27815; P27907
DB05408	Emricasan	investigational	12000240	-	"Investigated for use/treatment in hepatitis (viral, C), liver disease, and transplantation (organ or tissue)."	P31944; Q6UXS9; P51878; P55211; P49662; Q92851; P29466; Q14790; P55210; P55212; P42574; P42575
DB05403	CEP-1347	investigational	133005	-	"Investigated for use/treatment in asthma and parkinson's disease."	P53778
DB06470	clomethiazole	investigational	10783	-	"Investigated for use/treatment in strokes."	Q9UN88; P28472; P18507; P18505; O00591; O14764; P48169; P14867; Q8N1C3; P34903; P47870; P47869; Q16445; Q99928; P31644; P78334
DB06471	Naxifylline	investigational	70691449	-	"Investigated for use/treatment in congestive heart failure."	P30542
DB06185	Forodesine	investigational	444499	-	"Investigated for use/treatment in lymphoma (non-hodgkin's) and leukemia (lymphoid)."	P00491; P27930; V9HWH6
DB05119	Rilapladib	investigational	9918381	-	"Investigated for use/treatment in atherosclerosis and cardiovascular disorders."	Q13093
DB11619	Gestrinone	approved	27812	-	"Endometriosis with or without accompanying sterility. Treatment is limited to a single course of 6 months duration per lifetime [L1699, L1700]."	P04150; P06401; P04278; P03372; P10275; P30968
DB11614	Rupatadine	approved	133017	-	"For the symptomatic relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and perennial allergic rhinitis in patients 2 years of age and older [FDA Label]. Also used for the symptomatic relief of chronic spontaneous urticaria in patients 2 years of age and older."	P35367; P25105
DB03754	Tromethamine	approved	6503	-	"For the prevention and correction of metabolic acidosis."	P44160; P17707; P07585; P01556; Q9X0N8; Q96FI4; Q8UCK6; P06653; Q8WVQ1; Q52369; P0AFB1; P15692; P12996
DB11613	Velpatasvir	investigational; approved	67683363	-	"Velpatasvir is used in combination therapy with other antiviral medications to treat chronic hepatitis C virus (HCV) infected patients with HCV genoptypes 1-6, and to treat HCV and HIV co-infected patients. Depending on the level of cirrhosis or decompensation, combination therapy can also include therapy with [DB00811].
 
 When used in combination with [DB08934] as the combination product Epclusa, Velpatasvir is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis, or in combination with [DB00811] if associated with decompensated cirrhosis [FDA Label]."	Q8IZI9
DB03756	Doconexent	investigational; approved	445580	-	"Used as a high-docosahexaenoic acid (DHA) oral supplement. "	P19793; P48443; Q07869; P28702; P37231; P36956; P11511
DB11611	Lifitegrast	approved	11965427	-	"For the treatment of signs and symptoms of keratoconjunctivitis sicca (dry eye syndrome)."	P05362; P20701; P05107
DB05990	Obeticholic acid	approved	447715	-	"Investigated for use/treatment in liver disease.
 Obeticholic acid was approved as an orphan drug based on its reduction in the level of the biomarker alkaline phosphatase as a surrogate endpoint for clinical benefit. It is indicated for the treatment of primary biliary cholangitis in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA, or as monotherapy in adults unable to tolerate UDCA. Additional studies are being required to prove its clinical benefit."	Q96RI1
DB09213	Dexibuprofen	investigational; approved	39912	-	"Similar indications as ibuprofen, to be used as a symptomatic treatment for pain and inflammation in rheumatic disease such as osteoarthritis and rheumatoid arthritis, as well as other musculoskeletal disorders.  It is also used to reduce oral postoperative pain and alleviate fever."	P37231; P07204; P12104; P10415; P35354; P13569; P00750; P23219
DB09212	Loxoprofen	investigational; approved	3965	-	"Loxoprofen is non-steroidal anti-inflammatory medication (NSAID) indicated for pain and inflammation related to musculoskeletal and joint disorders [L1226].   In addition to its effects on pain, it is an antipyretic and anti-inflammatory medication [L1227]."	P35354; P23219
DB09211	Limaprost	investigational; approved	6438378	-	"Limaprost is used for the improvement of various ischemic symptoms such as ulcer, pain and feeling of coldness associated with thromboangiitis obliterans as well as improvement of subjective symptoms (pain and numbness of lower legs) and gait ability associated with acquired lumbar spinal canal stenosis (in patients with bilateral intermittent claudication showing normal SLR test result)."	P34995; P43115; P35408; P43116
DB09217	Firocoxib	vet_approved; experimental	208910	-	"Used for the treatment of pain inflammation and fever in horses and dogs."	P35354
DB09216	Tolfenamic Acid	investigational; approved	610479	-	"In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults.[L1293]"	P10275; P35354; P23219; P42330; P02766
DB09215	Droxicam	withdrawn	65679	-	"Droxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis [L1119]."	P35354; P23219
DB09214	Dexketoprofen	investigational; approved	667550	-	"For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache [L1302]. "	P35354; P23219
DB00712	Flurbiprofen	investigational; approved	3394	-	"Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis. "	P23786; P35354; P11712; P23219
DB00829	Diazepam	illicit; investigational; approved; vet_approved	3016	-	"Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome."	P30536; P33261; P24046; A8MPY1; P47869; Q16445; P78334; P18507; P18505; Q8N1C3; P14867; P08684; O00591; P35348; Q9UN88; P28472; P28476; O14764; P48169; P34903; P47870; P31644; Q99928
DB00828	Fosfomycin	approved	446987	-	"For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of <i>Escherichia coli</i> and <i>Enterococcus faecalis</i>."	P0A749
DB08922	Perospirone	approved	115368	-	"For the treatment of schizophrenia and acute cases of bipolar mania."	P35462; P28223; P25100; P14416; P08908; P35367; P21917
DB09327	Tegafur-uracil	investigational; approved	104747	-	"Tegafur-uracil is indicated for the first line treatment of metastatic colorectal cancer with concomitant administration of calcium folinate.[L934] Colorectal cancer is the third most diagnosed cancer and 30% of the cases can present the metastatic state.[A32077]"	P04818; Q53Y97
DB09324	Sulbactam	approved	130313	-	"Sulbactam is currently available in combination products with ampicillin. Within this formulation it is indicated  for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below.
 Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli, Klebsiella spp. (including K. pneumoniae), Proteus mirabilis, Bacteroides fragilis, Enterobacter spp., and Acinetobacter calcoaceticus.
 Intra-Abdominal Infections caused by beta-lactamase producing strains of Escherichia coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp.
 Gynecological Infections caused by beta-lactamase producing strains of Escherichia coli, and Bacteroides spp. (including B. fragilis)."	P62594; P00807; P62593
DB09323	Benzathine benzylpenicillin	approved; vet_approved	25137901	-	"For the treatment of several infections include: acute glomerulonephritis, respiratory tract infections, rheumatic fever and chorea, rheumatic heart disease, rheumatic heart disease, syphilis and other venereal diseases."	P07944; P08149
DB05351	Dexlansoprazole	investigational; approved	9578005	-	"Indicated for healing all grades of erosive esophagitis (EE), maintaining and healing of EE and relief of heartburn, and treating heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD). "	P33261; P20648; P51164
DB00827	Cinoxacin	investigational; approved; withdrawn	2762	-	"For the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, <i>Proteus vulgaris</i>, <i>Klebsiella</i> species (including <i>K. pneumoniae</i>), and <i>Enterobacter</i> species."	P00918; P0AES4; P0AES6; P43700; Q02880
DB04468	Afimoxifene	investigational	449459	-	"For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring."	P11474; P04155; P04278; P03372; P62508; O75469; Q92731
DB09068	Vortioxetine	investigational; approved	71768094	-	"Vortioxetine is indicated for the treatment of major depressive disorder (MDD)."	P46098; P28221; P28223; P10635; P28222; P28335; P25021; P50406; P08588; P34969; P08908; P47898; P07550; P31645; P35367; P01011
DB09069	Trimetazidine	investigational; approved	21109	-	"Trimetazidine is indicated for use in angina pectoris."	P09110
DB09065	Cobicistat	approved	25151504	-	"Cobicistat is a CYP3A inhibitor indicated to increase systemic exposure of atazanavir or darunavir (once daily dosing regimen) in combination with other antiretroviral agents in the treatment of HIV-1 infection. It is not interchangeable with ritonavir to increase systemic exposure of darunavir 600 mg twice daily, fosamprenavir, saquinavir, or tipranavir due to lack of exposure data. The use of cobicistat is not recommended with darunavir 600 mg twice daily, fosamprenavir, saquinavir or tipranavir. Complex or unknown mechanisms of drug interactions preclude extrapolation of ritonavir drug interactions to certain cobicistat interactions. Cobicistat and ritonavir when administered with either atazanavir or darunavir may result in different drug interactions when used with concomitant medications."	O95992; P24462; Q9HB55; P08684; P20815
DB09067	Corticorelin ovine triflutate	approved	16132344	-	"Corticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome."	P34998
DB09060	Avibactam	approved	9835049	-	"AVYCAZ (ceftazidime-avibactam), in combination with metronidazole, is indicated for the treatment of complicated intra-abdominal infections caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Providencia stuartii, Enterobacter cloacae, Klebsiella oxytoca, and Pseudomonas aeruginosa in patients 18 years or older.
 AVYCAZ is also indicated for the treatment of complicated urinary tract infections including pyelonephritis caused by the following susceptible microorganisms: Escherichia coli, Klebsiella pneumoniae, Citrobacter koseri, Enterobacter aerogenes, Enterobacter cloacae, Citrobacter freundii, Proteus spp., and Pseudomonas aeruginosa in patients 18 years or older."	P62594; Q848S6; P62593; P37321; P0A9Z7; Q9F663; P0AD64; P0AD63
DB09061	Cannabidiol	investigational; approved	644019	-	"When used in combination with delta-9-tetrahydrocannabinol as the product Sativex, cannabidiol was given a standard marketing authorization (ie. a Notice of Compliance (NOC)) by Health Canada for the following indications: 
 1) as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS) who have not responded adequately to other therapy and who demonstrate meaningful improvement during an initial trial of therapy [L886],
 
 Due to the need for confirmatory studies to verify the clinical benefit coupled with the promising nature of the clinical evidence, Sativex was also given a Notice of Compliance with Conditions (NOC/c) by Health Canada for the following indications: 
 1) as adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis, 
 2) as adjunctive analgesic treatment in adult patients with advanced cancer who experience moderate to severe pain during the highest tolerated dose of strong opioid therapy for persistent background pain [L886]."	P28223; P35372; P47775; Q7Z2W7; Q9P0X4; O43497; P37231; P41143; P23415; P48167; O75311; Q9Y2T6; O75762; O95180; Q8NET8; P21796; Q14330; P34972; Q8NER1; Q494W8; Q9Y5S1; Q9HBA0; P36544; P08908; P21554
DB09063	Ceritinib	approved	57379345	-	"Ceritinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This indication is approved under accelerated approval based on tumor response rate and duration of response. An improvement in survival or disease-related symptoms has not been established. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials."	P21802; P08069; P52333; P35968; P11802; P22607; Q9BXA7; P07949; P00533; P00519; Q12809; Q9UM73; P16234; P07948; P06239; P08581; P06213; P12931; P22455; P36888; P10721; P23458; O75116; Q06187; O60674
DB01273	Varenicline	investigational; approved	5310966	-	"For use as an aid in smoking cessation."	Q15825; P32297; Q494W8; P02708; P43681; P11230; P07510; P36544; P17787; P30926; Q07001
DB01275	Hydralazine	approved	3637	-	"For the treatment of essential hypertension, alone or as an adjunct. Also for the management of severe hypertension when the drug cannot be given orally or when blood pressure must be lowered immediately, congestive heart failure (in combination with cardiac glycosides and diuretics and/or with isosorbide dinitrate), and hypertension secondary to pre-eclampsia/eclampsia."	P51686; P26358; Q92736; Q9Y6K1; Q16853; Q13936; P13674
DB01274	Arformoterol	investigational; approved	3083544	-	"A bronchodilator used for the long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. "	P22309; P10635; P08588; P13945; P07550
DB01051	Novobiocin	investigational; approved; vet_approved	54675769	-	"For the treatment of infections due to staphylococci and other susceptible organisms"	P0A0K8; Q06AK7; Q5HK04; Q5HK03; Q16853; Q02880
DB01050	Ibuprofen	approved	3672	-	"For symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates. 
 "	P12104; P07204; P09917; P37231; P78348; Q8N695; P35354; Q07869; P23786; P10415; P46059; P13569; P00750; P23219
DB01053	Benzylpenicillin	approved; vet_approved	5904	-	"For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia."	P62594; P0AEB2; P08506; P62593; P02918; P02919; P0AD68; P24228; P0AD65
DB01054	Nitrendipine	investigational; approved	4507	-	"For the treatment of mild to moderate hypertension"	O95180; P32249; Q06432; Q12809; P54289; Q08289; P02766; Q13936; P35498; Q99250; O15554; Q13698; O60840; Q01668; Q9NY47; Q9NY46
DB01057	Echothiophate	approved	10548	-	"For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated."	P22303; P06276
DB01056	Tocainide	approved	38945	-	"For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening."	Q14524; Q9UQD0; Q01118; Q9UI33; P35498; Q99250; P35499; Q9Y5Y9; Q15858; Q9NY46
DB01059	Norfloxacin	approved	4539	-	"For the treatment of urinary tract infection"	P11388; P0AFI2; P48169; Q16445; Q02880; P0AES4; P14867; P0AES6; P47869; P34903; P43700; P31644; P43702; P20083
DB00581	Lactulose	approved	11333	-	"For the treatment of constipation and hepatic encephalopathy."	P06864
DB00582	Voriconazole	investigational; approved	71616	-	"For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by <i>Scedosporium apiospermum</i> and <i>Fusarium</i> spp."	P10613; P08684; P33261
DB00583	L-Carnitine	investigational; approved	10917	-	"For treatment of primary systemic carnitine deficiency, a genetic impairment of normal biosynthesis or utilization of levocarnitine from dietary sources, or for the treatment of secondary carnitine deficiency resulting from an inborn error of metabolism such as glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency. Used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. Parenteral levocarnitine is indicated for the prevention and treatment of carnitine deficiency in patients with end-stage renal disease."	P43155; P05164; O43772; P23141; P50416; P23786; Q8N8R3; Q9UKG9; Q92523; P47989
DB00584	Enalapril	approved; vet_approved	5388962	-	"For the treatment of essential or renovascular hypertension and symptomatic congestive heart failure. It may be used alone or in combination with thiazide diuretics."	P12821
DB00585	Nizatidine	approved	3033637	-	"For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer."	P22303; P25021
DB00586	Diclofenac	approved; vet_approved	3033	-	"For the acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis."	P09917; P78348; P14555; P02766; P23786; P35354; P35499; P37231; Q9UHC3; O43525; P23219; O43526
DB00587	Cinalukast	approved	6436135	-	"For Protection against second- phase inflamation in exercise-induced bronchoconstriction and Asthma."	Q9Y271
DB01873	Epothilone D	investigational; experimental	447865	-	"Investigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer."	P68366; P68363; P68371; Q9H4B7; Q5SU16; Q9BQE3; Q71U36; P07437; Q9NY65; Q13509; Q13748; P04350
DB01183	Naloxone	approved; vet_approved	5284596	-	"For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol. It is also indicated for the diagnosis of suspected acute opioid overdose. It may also be used as an adjunctive agent to increase blood pressure in the management of septic shock."	P41145; P41143; P10635; P23141; P03372; P25103; P35372; P16220; O00206
DB01182	Propafenone	approved	4932	-	"Used to prolong the time to recurrence of paroxysmal atrial fibrillation/flutter (PAF) associated with disabling symptoms in patients without structural heart disease. Also used for the treatment of life-threatening documented ventricular arrhythmias, such as sustained ventricular tachycardia."	P10635; Q9UQD0; P28223; Q14654; O60706; Q99250; Q9Y3Q4; P22460; Q14524; Q99720; Q12809; Q01959; Q9UI33; P08588; P23975; P28335; P41595; Q01118; Q9Y5Y9; P35498; P36888; Q9NY46; P13945; Q15858; P25100; P08908; P35499; P07550
DB00458	Imipramine	approved	3696	-	"For the relief of symptoms of depression and as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older [FDA Label]. 
 
 May also be used off-label to manage panic disorders with or without agoraphobia, as a second line agent for ADHD in children and adolescents, to manage bulimia nervosa, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy [L1349,L1348,A31900,L1351,L1352,L1353,A31904]. "	P19652; P35462; P10635; P28223; Q99250; P11229; Q99720; P34969; Q01959; P35348; P08912; P14416; P23975; P08172; P08173; Q9NZV8; P28335; P18089; P21918; O95259; P35368; P35367; Q9UK17; Q9NY46; P25100; Q12809; P50406; P20309; P08908; P31645; P35498
DB00459	Acitretin	approved	5284513	-	"For the treatment of severe psoriasis in adults."	P10826; P28702; P40763; P09455; P48443; P10276; P19793; P13631
DB01186	Pergolide	investigational; withdrawn; approved; vet_approved	47811	-	"Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson's disease. It was withdrawn from the US and Canadian markets in 2007 due to an increased risk of cardiac valvulopathy. "	P28335; P14416; P18825; P10635; P28222; Q12809; P25100; P41595; P18089; P21918; P21728; P08913; P35368; P34969; P35462; P28221; P28223; P35348; P21917; P08908
DB01185	Fluoxymesterone	illicit; approved	6446	-	"In males, used as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone. In females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal."	P04150; P10275; P16471; P80365; P03372
DB01184	Domperidone	investigational; approved; vet_approved	3151	-	"For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting."	P41145; P28223; P41595; P14416; P18825; P10635; Q12809; P25100; P35372; P08913; P18089; P35462; P35368; P35367; P31645; P28335; P23975; P35348
DB00452	Framycetin	approved	8378	-	"For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal"	A8A5E9; B4TKM3; B7UK52; B1IPV7; B5RH07; P0A7S3; Q5PIW1; B4SUU8; A1AGM9; B4TXF0; B7N1C3; B7MCV7; A7ZSL7; A4WFD5; B7NLP7; C0Q0C4; P61073; B7M1P3; P41180; B5F8G0; P0A7S8; B7L4L7; Q32B24; Q1R5U1; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B1LHE2; B7NDV0; B7LS48; Q57J24; B6I242; B5FJM2; Q8NER1; B5BGZ4; B5YTP9; B5R299
DB00453	Clomocycline	approved	54680675	-	"For the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection,Chronic bronchitis"	B7NDR8; A8AQJ1; P0A7W0; B6I1U8; B7LHZ8; B1IQ03; A1AGI7; P0A7V8; P0A7V9; Q0TCN6; B7M102; B7NDK8; B7UJW2; B1X6E8; A7ZSC4; B7N102; Q1R636; B6I210; P0A7X3; A1AGC3; B7N181; P0A7X4; C4ZSW8; B7MBZ1; Q0TCG5; A7ZSI5; B7LRR3; B1LGJ6; B7MCR2; B5YT15; B1XHK3; A6TEN8; B1LHB0; B7UK20; Q1R6B0; C4ZUF1; B7NLL6; A8A539; A8A5A1; Q32B55; B1IQP9; B7M0U2; A8AQC0; B7NKU2; P0A7X5; B5YSV6; B7LHT8
DB00450	Droperidol	approved; vet_approved	3168	-	"Droperidol is ssed to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures."	Q99250; P18825; P28223; P35462; P14324; Q12809; P21728; P35348; P08912; P08913; P14416; P08173; P28335; P41595; P18089; P35367; Q9NY46; P21917; P25100; P08908; P21554; P35498
DB00451	Levothyroxine	approved	5819	-	"For use alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor."	Q96RI1; P02766; P10827; P10828
DB00456	Cefalotin	investigational; approved; vet_approved	6024	-	"Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract."	P15555; P24228; P08506; P0A3M6; P0AEB2; P02918; P02919; P00811; Q9NSA0; P31391; P35354; Q8TCC7; Q8XJ01; P0AD68; Q8DR59; P0AD65
DB00457	Prazosin	approved	4893	-	"For treatment of hypertension, symptomatic benign prostatic hyperplasia, and severe congestive heart failure. May also be used alone or in combination with &beta,-blockers in the preoperative management of signs and symptoms of pheochromocytoma. "	Q9NS40; P28223; P35498; P28221; Q12809; P25100; P03956; P18089; P18825; P08913; P41595; Q99250; P35368; P35348; Q9H252; Q9NY46; P16471
DB00454	Pethidine	approved	4058	-	"Used to control moderate to severe pain."	Q05586; O15399; P41143; P41145; Q12809; P23141; Q01959; Q12879; Q13224; Q8TCU5; P08912; P35372; P31645; Q14957; P23975
DB00455	Loratadine	investigational; approved	3957	-	"A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian)."	P35367; Q96RI1; Q12809; P41595; Q9H2J7
DB09198	Lobeglitazone	investigational; approved	9826451	-	"Lobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use by either the Food and Drug Administration (USA), Health Canada, or by the European Medicines Agency for use in the management of diabetes."	P37231; Q07869
DB09194	Etoperidone	withdrawn	40589	-	"Etoperidone has been studied for the treatment of depression[T47], tremors in Parkinson, extrapyramidal symptoms[L1041] and male impotence[L1042]. It is not certain if it was ever approved and marketed but its current status is withdrawn."	P28335; P18825; P28223; P25100; P08912; P14416; P08908; P35367; P31645
DB09195	Lorpiprazole	approved	20055414	-	"In 2016, lorpiprazole was classified in the \"Chemical structure-related drug-like criteria of global approved drugs\" as an antipsychotic and anxiolytic.[L1167] An antipsychotic is a medication used to treat a state of delusion, hallucination, paranoia or disordered thought. On the other hand, an anxiolytic is a medication used for the treatment of severe, chronic or debilitating anxiety. The anxiety state can be defined as an unpleasant state of tension, apprehension or uneasiness.[T77]"	P28223; P18825; P28335; P25100; P35367; P31645
DB04339	Carbocisteine	investigational; approved	193653	-	"Used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis."	P09211
DB04335	Inosine	investigational; approved	6021	-	"The primary popular claim made for inosine, that it enhances exercise and athletic performance, is refuted by the available research data. There is some preliminary evidence that inosine may have some neurorestorative, anti-inflammatory, immunomodulatory and cardioprotective effects."	P09874; P00491; V9HWH6; P0ABP8
DB11136	Chromium	approved	23976	-	"Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN), to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms [FDA Label]."	P00167
DB09449	Sodium phosphate	approved	23672064	-	"Used to treat constipation or to clean the bowel before a colonoscopy [FDA Label]."	P22748
DB00050	Cetrorelix	investigational; approved	25074887	-	"For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation"	P22888; P30968
DB00548	Azelaic Acid	approved	2266	-	"For the topical treatment of mild-to-moderate inflammatory acne vulgaris."	P32241; P51857; P31213; P41586; P41587; P00582; P14679; P66010
DB00549	Zafirlukast	investigational; approved	5717	-	"For the prophylaxis and chronic treatment of asthma."	Q9Y271; P08684; P00533; Q9NS75
DB00128	L-Aspartic Acid	approved; nutraceutical	5960	-	"There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids."	Q03154; Q14957; Q7L266; Q12879; P00966; P22234; P08243; V9HWA0; P27708; P07998; P61626; Q9UJS0; O75746; Q96HD9; P30520; Q12797; P14868; P17174; Q6PI48; P45381; Q13224; P00505; Q8N142; P43005
DB00129	Ornithine	approved; nutraceutical	6262	-	"Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing."	Q9UMX2; P05089; O95190; Q9Y3Q4; P04181; Q8WY07; P54368; Q5T6X5; P78540; P30825; Q9BXI2; Q9Y619; P52569; P50440; P00480; O43246
DB00126	Vitamin C	approved; nutraceutical	54670067	-	"Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent."	O14832; Q9GZT9; Q8IVL6; P19021; P14679; P09848; Q9NVH6; P09172; O00469; Q8N543; Q96KS0; Q32P28; P13674; Q02809; Q9BY66; Q9NXG6; Q54873; Q8IVL5; O60568; P24300; Q9H6Z9; P11413; O75936; Q6NS38; Q6N063; Q96Q83
DB00127	Spermine	approved; nutraceutical	1103	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	P48050; P41180; P11926; P08588; Q9NZQ8; P52788; P07550; Q8TD43; Q9NWM0
DB01544	Flunitrazepam	illicit; approved	3380	-	"For short-term treatment of severe insomnias, that are not responsive to other hypnotics."	Q9UN88; P34903; P18507; P18505; Q99928; O14764; P48169; P47870; Q8N1C3; P31644; P14867; P28472; P30536; P47869; Q16445; O00591; P78334
DB00122	Choline	approved; nutraceutical	305	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	P49585; Q13393; P06276; Q8TCT1; Q494W8; P22303; Q9Y5K3; P36544; O14939
DB00123	L-Lysine	approved; nutraceutical	5962	-	"Supplemental L-lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity."	P00390; Q8WY07; P52569; P30825; Q15046; O43246
DB00120	L-Phenylalanine	investigational; approved; nutraceutical	6140	-	"L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs."	Q9UHI5; P00439; P17735; Q6DWJ6; O43603; P07101; Q9Y285; Q9NSD9; O95363
DB00121	Biotin	investigational; approved; nutraceutical	171548	-	"For nutritional supplementation, also for treating dietary shortage or imbalance."	P11498; P05166; O00763; P05165; Q13085; P50747; Q9Y289; B2ZZ90; Q9HCC0; Q96RQ3
DB06623	Flupirtine	investigational; approved	53276	-	"Investigated for use/treatment in fibromyalgia."	P48051; O43525; P48549; P08913; O43526; Q92806; P48544
DB04934	Rifalazil	investigational	6540558	-	"Investigated for use/treatment in atherosclerosis, bacterial infection, and peripheral vascular disease."	P0A8V2
DB00908	Quinidine	investigational; approved	441074	-	"For the treatment of ventricular pre-excitation and cardiac dysrhythmias"	P10635; Q9UQD0; P57789; Q99250; Q9Y3Q4; P22460; Q9Y5Y9; Q14524; P06276; O00180; Q12809; Q9NY46; Q9Y257; Q96RP8; Q15858; P08172; Q9NZV8; Q7Z418; Q01118; P35499; P35498; P35368; P35348; P25100; Q9UI33; O95259
DB00909	Zonisamide	investigational; approved	5734	-	"For use as adjunctive treatment of partial seizures in adults with epilepsy."	P21397; Q99250; P43166; P27338; O60939; Q9UQD0; P23280; Q9NY72; Q16790; P35219; P35218; Q8N1Q1; Q9Y5Y9; Q14524; O95180; Q9Y2D0; Q9P0X4; O43497; Q15858; Q9NS85; Q01118; P35499; P35498; O43570; O75493; Q9NY46; P00918; P22748; P07451; Q07699; Q8IWT1; Q9ULX7; P00915; Q9UI33
DB04933	Eritoran	investigational	6912404	-	"Investigated for use/treatment in sepsis and septicemia."	O00206; Q9Y6Y9
DB00904	Ondansetron	approved	4595	-	"For the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, postoperation, and radiation. Also used for the treatment of postoperative nausea and vomiting."	Q12809; Q13639; P10635; P28222; P46098; P41595; P35372; O95264; P08908; P17787; P43681
DB00905	Bimatoprost	investigational; approved	5311027	-	"For the reduction of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication."	P34995; P43088; P43115; P42330
DB00906	Tiagabine	investigational; approved	60648	-	"For the treatment of partial seizures"	P30531; P80404
DB00907	Cocaine	illicit; approved	446220	-	"For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities."	Q99250; P28222; P30531; P23141; O95264; P35462; P46098; Q14524; P11229; Q99720; Q12809; Q01959; Q9NY46; P21728; P23975; P08172; P41145; Q9UI33; P35498; P31645; P35367; P35348; Q9Y5Y9
DB00900	Didanosine	approved	50599	-	"For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults."	P00491; V9HWH6
DB04938	Ospemifene	investigational; approved	3036505	-	"Ospemifene is used for the treatment of moderate to dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause."	Q92731; P03372
DB00902	Methdilazine	approved	14677	-	"Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders"	P35367; Q9P296
DB00903	Etacrynic acid	investigational; approved	3278	-	"For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure."	P05023; Q9UJU2; Q13621; P11229; P09211
DB00547	Desoximetasone	approved	5311067	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses."	P04150; P04054; Q5TZZ9; P04083
DB00540	Nortriptyline	approved	4543	-	"Primarily indicated for the relief of symptoms of depression."	P08908; P18825; P10635; P28223; P78508; P35462; P07949; P11229; Q99720; Q01959; P21728; P08913; P14416; P23975; P08172; P08173; P08909; P28335; P41595; P18089; P35368; P35367; P35348; P13945; P25021; P25100; P50406; P20309; P08912; P31645
DB00541	Vincristine	investigational; approved	5978	-	"Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL). "	Q9BVA1; P68366; P68363; P68371; Q9H4B7; Q5SU16; Q9BQE3; Q6PEY2; Q3ZCM7; P07437; Q13885; Q13509; Q13748; Q71U36; Q9BUF5; P04350
DB00632	Docosanol	investigational; approved	12620	-	"For the topical treatment of recurrent oral-facial herpes simplex episodes (cold sores or fever blisters)."	P68331; O09800; P03200; P10211; P68332; P68333; P10228; P68344; P06477; P04288; P10185; P06480; Q9NYK1; Q69091; P06484; P04488; P06487
DB00633	Dexmedetomidine	approved; vet_approved	5311068	-	"For sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting, also used in pain relief, anxiety reduction and analgesia"	P04150; P18825; P25100; P08913; P18089; P35368; P35348
DB00630	Alendronic acid	approved	2088	-	"For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women."	P32745; P29074; P14324; P31391; Q13332; P35346; P30874; P23469; P38606; P30872
DB00631	Clofarabine	investigational; approved	119182	-	"For the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphocytic (lymphoblastic) leukemia after at least two prior regimens. It is designated as an orphan drug by the FDA for this use."	Q7LG56; Q07864; P49005; P49643; P56282; Q14181; P09884; P23921; Q15054; P49642; P31350; P28340; Q9HCU8; Q9NRF9
DB00636	Clofibrate	investigational; approved	2796	-	"For Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet. This helps control high cholesterol and high triglyceride levels. "	P08581; P06858; P35968; Q07869
DB00637	Astemizole	approved; withdrawn	2247	-	"Astemizole was indicated for use in the relieving allergy symptoms, particularly rhinitis and conjunctivitis. It has been withdrawn from the market however due to concerns of arrhythmias."	P41145; P18825; P10636; P28223; Q01959; P35372; P04626; P35462; P46098; P00533; P11229; Q99720; Q12809; P08912; P18089; P21728; P08913; P14416; P23975; P08172; P08173; P06239; P41143; P28335; P41595; P08588; P35346; P08684; O95259; P35367; P13945; P23415; P25021; P25103; P25100; P30559; P20309; P08908; P31645; P06241
DB00634	Sulfacetamide	approved	5320	-	"For the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis."	B0YJ76; P0C004; P0C003; P34949; P0AC13; P00374; P53848; P0C002
DB00635	Prednisone	approved; vet_approved	5865	-	"For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn's disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin's or non-Hodgkin's lynphomas, Waldenstrom's macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler's syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis."	P04150; P04083; P28845; Q5TZZ9
DB09536	Titanium dioxide	approved	26042	-	"In the pharmaceutical industry, titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups."	Q9UEW3
DB00639	Butoconazole	approved	47472	-	"For the local treatment of vulvovaginal candidiasis (infections caused by Candida)"	P10613
DB03904	Urea	investigational; approved	1176	-	"<ul>
 <li>10% hydrate skin</li>
 <li>15% accelerate fibrin degradation</li>
 <li>20-30% are antipruritic, break down keratin, decrease the thickness of the stratum corneum and are used in scaling conditions such as ichthysosis</li>
 <li>40% are proteolytic and may be used to dissolve and peel dystrophic nails</li>
 </ul>
 <br>[Patient Self Care, 2010]</br>"	P05089; P00918; P0ABQ4; P35222; Q8XB74; P09592
DB11842	Angiotensin II	investigational; approved	172198	-	"Angiotensin II is a vasoconstrictor indicated for increasing blood pressure in adults with septic or other distributive shock [FDA Label]."	P50052; P30556
DB00765	Metyrosine	approved	441350	-	"For use in the treatment of patients with pheochromocytoma, for preoperative preparation of patients for surgery, management of patients when surgery is contraindicated, and chronic treatment of patients with malignant pheochromocytoma."	P07101
DB06061	AZD-8330	investigational	16666708	-	"Investigated for use/treatment in cancer/tumors (unspecified)."	P36507; Q02750; Q13233; O14733
DB00942	Cycrimine	approved	2911	-	"For treatment and management of Parkinson's disease."	P11229
DB06268	Sitaxentan	investigational; approved; withdrawn	216235	-	"Investigated for use/treatment in pulmonary hypertension, connective tissue diseases, hypertension, and congestive heart failure."	P24530; P35557; P25101
DB06267	Udenafil	investigational; approved	6918523	-	"Investigated for use/treatment in erectile dysfunction and hypertension."	O76074
DB06266	Lonidamine	investigational	39562	-	"Investigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified)."	P19367; P35557; P13569
DB06263	Amrubicin	investigational; approved	3035016	-	"Investigated for use/treatment in lung cancer [A4138]."	P11388
DB06262	Droxidopa	investigational; approved	92974	-	"For treatment of neurogenic orthostatic hypotension (NOH) associated with various disorders including Multiple System Atrophy, Familial Amyloid Polyneuropathy, hemodialysis induced hypotension and Parkinson's Disease. Also investigated for use/treatment in neurologic disorders, nephropathy, blood (blood forming organ disorders, unspecified), and dizzy/fainting spells."	P00439; P18825; P25100; P18089; P08588; P08913; P35368; P07550; P35348; P13945
DB00945	Acetylsalicylic acid	approved; vet_approved	2244	-	"For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris."	P25090; Q04828; P04637; P11021; P19838; P41595; P23219; P23786; P51812; P35354; Q9UGI9; P04035; P25963; P25101; Q9UHC3; O14920
DB00838	Clocortolone	approved	5311052	-	"For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp."	P04150
DB00839	Tolazamide	investigational; approved	5503	-	"For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone."	P78508; Q09428; Q14654; P48048
DB13025	Tiapride	investigational; approved	5467	-	"Tiapride is indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly."	P14416; P18825; P34969; P25100; P08913; Q9Y5Y9; P35462; P35367
DB00946	Phenprocoumon	investigational; approved	54680692	-	"Used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation (AF)."	Q9BQB6
DB00830	Phenmetrazine	illicit; approved	4762	-	"Used as an anorectic in the treatment of obesity."	P21397; P42338; P48736; P42336; Q01959; P23975; O00329
DB00831	Trifluoperazine	investigational; approved	5566	-	"For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation."	Q12809; Q99250; P18825; P28223; P08913; P35462; Q99720; P34969; Q9NY46; P63316; B4DJ51; P14416; P0DP24; P0DP25; P0DP23; P28335; P18089; P35498; P35367; Q9NYX4; P35348; P21917; P62158; P20309; P08908; P26447
DB00832	Phensuximide	approved	6839	-	"For the treatment of epilepsy."	Q9P0X4; O95180; O43497
DB00833	Cefaclor	approved	51039	-	"For the treatment of certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections."	P0AEB2; P08506; P02918; P02919; Q8XJ01; P0AD68; P24228; P0AD65
DB00834	Mifepristone	investigational; approved	55245	-	"For the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery."	P04150; P41145; P08235; P06401; P07288; Q99720; P18089; P03372; P10275; P35372; O75469; Q92731; P08684; P06241
DB00835	Brompheniramine	approved	6834	-	"For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing."	P08172; P08173; P11229; P20309; Q12809; P08912; P35498; Q99250; P35367; Q9NY46
DB00836	Loperamide	approved	3955	-	"For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies."	Q99250; P41145; P62158; P35372; P25100; P35462; Q14957; O00555; O15399; P01189; Q99720; P41143; B4DJ51; P10635; P0DP24; P0DP25; P0DP23; P41595; P35346; P35498; P31645; P35367; Q02763; Q9NY46; P25021; Q13224; Q12879; P07550; Q14994
DB00837	Progabide	investigational; approved	5361323	-	"Indicated for the treatment of epilepsy."	Q9UN88; P28472; P18507; P18505; O00591; O14764; P48169; P14867; Q8N1C3; P31644; P47870; P47869; P34903; Q16445; Q99928; Q9UBS5; P78334
DB06663	Pasireotide	approved	9941444	-	"For the treatment of Cushing?s disease, specifically for those patients whom pituitary surgery has not been curative or is not an option."	P30874; P32745; P35346; P30872
DB02187	Equilin	approved	223368	-	"For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)"	P14061; P03372
DB06403	Ambrisentan	investigational; approved	6918493	-	"Ambrisentan is indicated for treatment of idiopathic (?primary?) pulmonary arterial hypertension (IPAH) and pulmonary arterial hypertension (PAH) associated with connective tissue disease in patients with WHO functional class II or III symptoms. In the United States of America, ambrisentan is also indicated in combination with tadalafil to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability."	P24530; P25101
DB06401	Bazedoxifene	investigational; approved	154257	-	"Investigated for use/treatment in osteoporosis and menopause."	Q92731; P03372
DB03166	Acetic acid	approved	176	-	"Used to treat infections in the ear canal."	P28335; O15552; P28223; P41595; Q9NS39; P06239; P06241
DB11994	Diacerein	investigational; approved	26248	-	"For the treatment of osteoarthritis affecting the hip or knee [L780]."	P05181; P11712; P24462; P05177; P18510; P10635; P01584; Q13133; P09917; P55055
DB08822	Azilsartan medoxomil	investigational; approved	11238823	-	"Treatment of hypertension (alone or as an adjunct)."	P50052; P30556
DB05501	AMD-070	investigational	11256587	-	"Investigated for use/treatment in HIV infection."	P61073; P51681
DB08820	Ivacaftor	approved	16220172	-	"When used as monotherapy as the product Kalydeco, ivacaftor is indicated for the managmenet of CF in patients age 2 years and older who have a mutation in the CFTR gene that is responsive to ivacaftor potentiation. Ivacaftor received expanded approval in May 2017 for the following 33 CFTR mutations: E56K, P67L, R74W, D110E, D110H, R117C, R117H, G178R, E193K, L206W, R347H, R352Q, A455E, S549N, S549R, G551D, G551S, D579G, S945L, S977F, F1052V, K1060T, A1067T, G1069R, R1070Q, R1070W, F1074L, D1152H, G1244E, S1251N, S1255P, D1270N, and G1349D [L768, FDA Label].
 
 When used in combination with the drug [DB09280] as the product Orkambi, ivacaftor is indicated for the management of CF patients age 6 years and older who are homozygous for the F508del mutation in the CFTR gene."	P13569
DB08827	Lomitapide	investigational; approved	9853053	-	"Used in homozygous familial hypercholesterolemia (HoFH) patients to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C)."	P55157; P48039; P07237; P49286
DB08828	Vismodegib	investigational; approved	24776445	-	"Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation."	Q99835
DB11660	Latanoprostene Bunod	investigational; approved	11156438	-	"Latanoprostene bunod opthalmic solution is indicated for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension [FDA Label]."	P43088; P29400
DB06756	Glycine betaine	approved; nutraceutical	247	-	"Betaine is indicated for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Included within the category of homocystinuria are deficiencies or defects in: 1. cystathionine beta-synthase (CBS), 2. 5,10-methylenetetrahydrofolate reductase (MTHFR), 3. cobalamin cofactor metabolism (cbl). "	P78540; P10415; P05089
DB05219	Crisaborole	investigational; approved	44591583	-	"Intended for the topical treatment of mild to moderate atopic dermatitis in patients 2 years of age and older."	Q13946; P54750; Q08493; P27815; Q07343; Q08499
DB05212	HE3286	investigational	16739648	-	"For the treatment of rheumatoid arthritis and type 2 diabetes."	Q00653; P19838
DB09209	Pholcodine	illicit; approved	5311356	-	"Pholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of \"temporary relief of dry cough.\"[L1200] Cough is the respiratory movement that occurs after an irritation signal is transmitted to the central nervous system and further stimulates the medulla oblongata. This stimulation causes a motor output that is sent through motoneurons to the respiratory muscles. A non-productive cough is a type of cough characterized by the absence of sputum, and it has a large inspiration that will cause continuous coughing."	P41145; P35372; P41143
DB09204	Arotinolol	investigational	2239	-	"Artinolol was introduced to be used as an antihypertensive agent since 1986.[T88] It has been studied for other functions like tremor control for patients with Parkinson disease and it is currently in clinical trials for its use in the control of blood pressure and heart rate.[L1168]"	P07550; P08588; P25100
DB09205	Moxisylyte	investigational; approved	4260	-	"By the WHO, moxisylyte is indicated for the symptomatic management of sequelae of cerebral infarction or hemorrhage.[T91] The cerebral infarction is characterized by the blockage of the artery either by the formation of a thrombus or an embolus.[A31644] 
 
 On the other hand, the FDA classified moxisylyte for the reversal of phenylephrine-induced mydriasis in patients who have narrow anterior angles and are at risk of developing an acute attack of angle-closure glaucoma.[L1172]  Closed-angle glaucoma is caused by the contact between the iris and the trabecular meshwork. This contact will damage the aqueous outflow by the meshwork thus, increasing eye pressure and producing the symptoms of glaucoma.[A31645] Mydriasis is referred to the dilatation of the pupils and this standard body function is known to be a trigger factor for the development of acute closed-angle glaucoma.This risk is explained by the generation of a pupillary block, which is the contact between the pupillary margins and the lens, thus preventing flow from the aqueous humor to the anterior chamber and followed by an increased pressure gradient.[L1173] 
 
 Moxisylyte is also approved in France as the first drug for the treatment of impotence.[A31647]"	P18825; P18089; P08913; P25100; P35368; P35348
DB09330	Osimertinib	approved	71496458	-	"Osimertinib is indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA- approved test, who have progressed on or after EGFR-TKI therapy."	P00533; Q12809; P04626; P21860; P06213; Q15303
DB09332	Kappadione	approved	8555	-	"Anticoagulant-induced prothrombin deficiency caused by coumadin or indanedione derivatives,
 prophylaxis and therapy of hemorrhagic disease of the newborn, hypoprothrombinemia due to antibacterial therapy,
 hypoprothrombinemia secondary to factors limiting absorption or synthesis of vitamin K (for example, obstructive jaundice, biliary fistula, sprue, ulcerative colitis, celiac disease, intestinal resection, cystic fibrosis of the pancreas, and regional enteritis, other drug-induced hypoprothrombinemia where it is definitely shown that the result is due to interference with vitamin K metabolism) [L1545, L1546]."	P00734; P38435; P04070; P00740; P07225; P00742; P08709
DB09333	Iopodic acid	investigational; approved; withdrawn	5241	-	"Iopodic acid is available as a cholecystographic agent. This denomination indicates the iopodic acid is a radiopaque substance that can be used to visualize the gallbladder and biliary channels in abdominal X-ray.[L1587, A32087] An abdominal X-ray uses a minimal amount of ionizing radiation to produce pictures of the inside of the abdominal cavity. It is commonly used to evaluate the stomach, liver, intestines, and spleen.[L1589]
 
 Iopodic acid has also been indicated for the treatment of hyperthyroidism such as Graves disease.[A32085, A32086] Hyperthyroidism refers to any condition where there is too much thyroid hormone produced in the body (overactive thyroid). When the overactivity involves the entire thyroid gland, it is known as Grave's disease.[L1590]"	P55073
DB09338	Mersalyl	approved	443130	-	"Elevated blood pressure, edema [L1577, L1585]."	P53985; P29972; P05186
DB09123	Dienogest	approved	68861	-	"Indicated for use as the treatment of endometriosis alone and as a contraceptive in combination with ethinylestradiol. "	P10275; P03372; P06401
DB05025	Arimoclomol	investigational	208924	-	"Investigated for use/treatment in amyotrophic lateral sclerosis (ALS), diabetes mellitus type 2, neurologic disorders, and neuropathy (diabetic)."	P00441
DB12161	Deutetrabenazine	investigational; approved	73442840	-	"Indicated for the treatment of chorea associated with Huntington?s disease [FDA Label]. "	Q05940
DB00896	Rimexolone	approved	5311412	-	"For the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis."	P04150; P04083; P08185; Q5TZZ9
DB00264	Metoprolol	investigational; approved	4171	-	"For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches."	P10635; P08588; P07550
DB12364	Betrixaban	investigational; approved	10275777	-	"Betrixaban is indicated for prophylaxis of venous thromboembolism (VTE) in conditions of moderate to severe restricted mobility or in patients that qualify as in risk of VTE. "	P00742
DB01267	Paliperidone	approved	115237	-	"For the treatment of schizophrenia."	P20815; Q12809; P18825; P10635; P28222; P28223; P08913; P35462; P28566; P34969; P21728; P08588; P14416; P28221; P35368; P28335; P43115; P18089; P08684; P41595; P07550; P35367; P35348; P21917; P25021; P08908; P31645
DB05035	Eprotirome	investigational	10299876	-	"Investigated for use/treatment in hyperlipidemia, metabolic disease, and obesity."	P10827; P10828
DB01265	Telbivudine	investigational; approved	159269	-	"For the treatment of chronic hepatitis B in adult and adolescent patients ?16 years of age with evidence of viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease."	Q05486
DB01262	Decitabine	investigational; approved	451668	-	"For treatment of patients with myelodysplastic syndromes (MDS) including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups (scores ?0.5)."	Q9Y6K1; P26358
DB05022	Amonafide	investigational	50515	-	"Investigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer."	P11388; Q02880
DB01260	Desonide	investigational; approved	5311066	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose."	P04150; P04083; P04054; Q5TZZ9
DB01261	Sitagliptin	investigational; approved	4369359	-	"For use as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Also for use in patients with type 2 diabetes mellitus to improve glycemic control in combination with metformin or a PPAR? agonist (e.g., thiazolidinediones) when the single agent alone, with diet and exercise, does not provide adequate glycemic control."	P27487
DB09050	Ceftolozane	investigational; approved	53234134	-	"-Complicated Intra-abdominal Infections, used in combination with metronidazole.
 -Complicated Urinary Tract Infections, including Pyelonephritis."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB09053	Ibrutinib	approved	24821094	-	"Ibrutinib acquired an accelerated approval for the treatment of mantle cell lymphoma who have received at least one prior therapy.[FDA label] Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma that develops in the outer edge of a lymph node. MCL is usually diagnosed at late stages and it is easily spread into bone marrow, spleen, liver and gastrointestinal tract.[L1929]
 
 Ibrutinib is indicated for the treatment of chronic lymphocytic leukemia (CLL) who have at least one prior therapy.[FDA label] CLL is a type of cancer caused by an overproduction of lymphocytes by the bone marrow. Some of the symptoms include swollen lymph nodes and tiredness.[L1931]
 
 Ibrutinib is indicated for the treatment of chronic lymphocytic leukemia (CLL) with 17p deletion.[FDA label] CLL with 17p is a type of leukemia in which a deletion in 17p disrupts the tumor suppressor p53 by deleting one allele of the TP53 gene. The remaining allele is mainly inactivated and thus, this type of leukemia is unresponsive to p53-dependent treatments.[A32305]
 
 Ibrutinib is indicated for the treatment of patients with Waldenstrom's Macroglobulinemia (WM).[FDA label] WM, also called lymphoplasmacytic lymphoma, is a type of non-Hodgkin lymphoma in which the cancer cells make large amounts of macroglobulin. The macroglobulin is a monoclonal protein that corresponds to the type of IgM antibodies and the unrestricted formation of this protein causes typical symptoms such as excessive bleeding and effects in vision and nervous system.[L1934]"	P00533; P42680; P42681; P12931; Q06187; P21802; P52333; P51451; P08631; P06241; P51813; P07947; P04626; P06239; P07949; Q08881; P07948; Q15303
DB09055	Acipimox	investigational; approved	5310993	-	"Used in the treatment of hyperlipidemias (abnormally elevated levels of any or all lipids and/or lipoproteins in the blood)."	Q8TDS4
DB09054	Idelalisib	approved	11625818	-	"Idelalisib is indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies."	P42336; P42338; P48736; O00329
DB05039	Indacaterol	approved	6918554	-	"For the long term, once-daily-dosing maintenance of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
 "	P11229; P22309; P08588; P14416; P07550; P35462
DB05038	Anatibant	investigational	9831652	-	"Investigated for use/treatment in traumatic brain injuries."	P30411
DB01048	Abacavir	investigational; approved	441300	-	"For the treatment of HIV-1 infection, in combination with other antiretroviral agents."	P21731; P30466; P18465; P01889
DB01046	Lubiprostone	investigational; approved	157920	-	"For the treatment of chronic idiopathic constipation in the adult population. Also used for the treatment of irritable bowel syndrome with constipation in women who are 18 years of age or older."	P51788; P10909
DB04743	Nimesulide	investigational; approved; withdrawn	4495	-	"For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old."	P27815; Q01959; Q9NZK7; P03956; P23786; P35354; P02788; P23219; P11511
DB01044	Gatifloxacin	investigational; approved	5379	-	"For the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenes"	P0A4L9; Q02880; P72524; P72525; Q59961
DB01045	Rifampicin	approved	5381226	-	"For the treatment of Tuberculosis and Tuberculosis-related mycobacterial infections."	B5QTY1; B4T9Z3; B1X982; P0A8V2; A7ZSI4; Q9NPD5; P0A7Z9; C4ZXP1; Q16850; Q5PK10; O75469; B7NEV3; P02768; A7MQB3; B7NQ13; A1AGI6; P0A7Z4; P0A7Z5; P0A7Z6; Q329K7; A8A6B1; A8ARN6; P46721; P0A7Z8; A8AQJ0; B1IYV1; Q0TBG0; Q1R637; A9MKM3; Q9Y6L6; A1AHI0; P0A7Z7; B7MFL0; P0A800; Q0TCG6; A9MVP7; B1LK86; B7UM71; Q5PC39; B6I3M8; A6TFP8; Q1R4U2; Q57I91; B7M4D4; B5BI24; P0A8T7; B5XTE8; B5FM73; P0A801; B7N2X2; A8A5A0; B4U000; B7L773; B7LVL1; P0A804; B5EY10; B4SXF1; P0A803; P0A802; B5RG73; C0Q1Y1; A7ZTK1; B5YWE9
DB01043	Memantine	investigational; approved	4054	-	"For the treatment of moderate to severe dementia of the Alzheimer's type."	Q05586; O15399; O60391; Q13224; Q12879; Q8TCU5; P14416; P46098; Q14957
DB01041	Thalidomide	investigational; approved; withdrawn	5426	-	"For the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). Also for use as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence."	P21802; P19652; P01375; Q13619; P62877; P19838; P35354; Q16531; Q96SW2; P23219
DB01190	Clindamycin	approved; vet_approved	446598	-	"For the treatment of serious infections caused by susceptible anaerobic bacteria, including Bacteroides spp., Peptostreptococcus, anaerobic streptococci, Clostridium spp., and microaerophilic streptococci. May be useful in polymicrobic infections such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, aspiration pneumonia and dental infections. May also be used to treat MSSA and respiratory infections caused by S. pneumoniae and S. pyogenes in patients who are intolerant to other indicated antibiotics or who are infected with resistant organism. May be used vaginally to treat vaginosis caused by Gardnerella vaginosa. Clindamycin reduces the toxin producing effects of S. aureus and S. pyogenes and as such, may be particularly useful for treating necrotizing fasciitis. May be used topically to treat acne."	B5FJK9; B5YVV7; B5RH07; B1XG23; B1XG24; A7ZSI6; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; C4ZUG3; B1LHB0; P0A7T7; C0Q0A5; C4ZUG9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; Q1R4V6; B5FHU4; B1IRQ1; P68686; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B7LS48; B7LRT1; B1X6G0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B7UMH0; B7LHP9; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; Q0TCF5; A9MN70; B1LL30; P60625; P60626; A6TE47; B4SXD8; B7NDS9; B1IPL1; B7NDS5; B7MTL9; B5FJK8; B7UK28; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B1LHB1; A8A539; B1LE15; B1LQM1; B6I208; B7NJS8; B1LE14; Q5PK05; B7LHT8; C0Q2L0; B7N192; B5F8G0; A8A5E9; Q57GI9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A7ZSC4; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; B6I3L3; B4TXD1; A7MNZ2; P0A7W9; A4THT0; B7N198; C4ZSS5; B4T4N1; B7M1L8; B7M1C5; C0Q6G0; Q57J46; Q57J43; B5RGF1; Q57J49; P62401; Q0T9J1; C4ZSW8; C4ZS29; B6I1Q9; B5QVW5; B4TN08; B5QVW6; B5R286; P62400; B4TGH4; B4TGH3; B5QUQ1; P0A7R5; C5BF78; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; P0C020; B6I2A8; A9N5Y8; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; Q0TCE2; Q0TD41; B7MCV7; A1AGJ3; B6I242; B7MCS3; B7UK39; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; A1AGJ5; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; P0ADZ0; A7ZSK8; Q32B55; Q32B54; Q32B57; A7ZSK5; B7N1A3; A7ZSK3; A7ZSK0; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; B7UK52; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; P60624; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; A8A5A1; A8GJV2; B5FJA5; B5F7T9; B5F7T1; B5F7T4; B7NR05; A8AQL8; P61175; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; A1AGI5; Q329M1; P60422; B1X6G3; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; B6I228; B7LG22; B1IPY4; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B5QZ45; Q1R6B0; B7NDV0; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; B5R0S0; P11473; B5EYX3; A6TAI4; P0A7S7; B7UK18; A1AGI8; C4ZUF2; A1AGI7; Q32BE7; B7N0V1; Q1R609; B7NDK8; B5R5G0; B4TKL4; P0A7S3; P68679; B4TKL0; B5RAX1; B7M1M3; B1XG70; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; A9MX79; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; P0A7V0; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; Q32FI2; B4TXC8; B1LHD1; Q5PJ56; P0A7T9; A9MKN8; B1LHD0; B7LLY4; B4TXF0; B6I437; B7NEU0; C4ZUE9; B7NLL7; B7L6I9; P0C018; B4SUT9; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; B1XHK3; B7MGC4; P0A7V5; Q0TCF8; A9MJT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; P0A7J6; B1X6F8; P02413; A9MN54; Q1C365; B7N102; B7M1C4; A9MN59; P0A7M6; P0A7M2; P0A7M9; A1AGJ2; B1IPY8; B7N0U4; P0A7L8; C0Q0C4; B1IPY0; B1IPY3; B1IPY2; B1IPY5; A9MGD1; Q329B5; P0ADZ4; B7LR53; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; A6TG05; Q1R358; Q1R604; B7NTQ7; Q1R607; B6I220; B6I223; B6I222; A7ZSK6; B4T679; A9N520; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B1LHD3; B7UPA5; P0A7R9; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; B7NLP7; B5RFY6; A1AGM9; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; A8ARM4; B7N0L5; B1LGQ0; B7NDS7; B7L847; Q0TCN6; B5YXA7; B7NGD6; B7LRT0; Q0THB3; B4SYA9; B7MCT2; B1X6F1; Q0TCS4; B7MCT1; B1X6F6; B7MCR9; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; B7MCT4; P0A7W8; B7LQD9; B5XZP7; B7M092; B5BGY5; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; P60724; P60727; P60726; B5FSA3; P60723; P0A7T8; B5R280; B7N2E8; B7L4J5; P61179; B7LRS7; B6I3T6; C4ZUH4; B7LRS0; B1LGJ6; P61177; C4ZUH1; C4ZUH2; Q32B24; B4TUF2; B7NDH0; B7MCT0; B1IPL2; B5BG21; A4WFC2; Q328J7; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; Q5PC32; Q2EEQ2; Q0TBH3; P0ADY3; P0ADY7; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; B7N1C3; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; A8AQC0; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7M1N1; B7M1N0; Q1R5U1; A1AGJ7; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B1LHC8; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5F7F9; A9MFK9; B5REG7; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; A1AGK6; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; B7L4K8; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B1X9T1; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; P0A7W4; P0A7W3; P0A7W2; P0A7W1; P0A7W0; B7N1A0; B7N199; Q5PKU5; C0Q1W9; B4F277; Q0THB2; C4ZR79; B5FN11; A8A5A2; B7M9G4; B7MCS1; Q1CME3; B1IPZ5; A8AQJ1; B5Y306; B7LX23; B7M1M2; P0AG55; B7M1M0; B5EXE1; B7M1M5; B1IPZ0; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; B7MJ76; Q57IA6; B1IPZ3; B1X6E8; B1X6E9; P0A7S6; P02358; P02359; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; B5F3B9; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; P68919; B4T4N0; B5RBB1; Q32B47; B1LK73; B7UJ79; Q1R6R5; Q57JQ0; B1IPV7; P61178; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B1IT04; P0C019; A8A501; Q1R620; A4WFD5; A9N240; A9N241; P0A7J7; B7NF20; B7NDT6; Q1R626; B7L4K6; B7NDT7; C0Q644; C4ZUH0; P0A7J3; P61176; P0A7S9; P0A7S8; P0AG59; A8A5C2; Q1RB79; P0A7S2; P0A7S1; P0A7S0; P0AG51; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; B7MCS6; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; B7NDT5; Q1R627; B5R290; Q1R4N3; B7NDT8; B5R299; P62399
DB01191	Dexfenfluramine	illicit; investigational; approved; withdrawn	66265	-	"For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet"	P18825; P28221; P28222; P28223; O95264; P46098; P47898; P28566; P11229; Q99720; P34969; A5X5Y0; P30939; P08913; P08172; P08173; Q70Z44; P28335; P41595; P08588; P18089; P35368; P35348; Q13639; P50406; Q8WXA8; P20309; P08908; P31645
DB01192	Oxymorphone	investigational; approved; vet_approved	5284604	-	"For the treatment of moderate-to-severe pain."	P41145; P35372; P41143
DB01193	Acebutolol	investigational; approved	1978	-	"For the management of hypertension and ventricular premature beats in adults."	P07550; P08588; Q99572
DB01194	Brinzolamide	approved	68844	-	"For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma."	P00918; P22748; P07451; P43166; P23280; Q9ULX7; P00915; Q16790; O43570; P35218; Q8N1Q1; Q9Y2D0
DB01195	Flecainide	approved; withdrawn	3356	-	"Flecainide is is a class Ic antiarrhythmic agent and as such, it is used for the prevention of paroxysmal supraventricular tachycardias (PSVT), including atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and other supraventricular tachycardias of unspecified mechanism associated with disablin."	Q14524; P22460; Q12809; Q96RP8; P35499; Q9Y3Q4; P48547
DB01196	Estramustine	investigational; approved	259331	-	"For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate"	Q92731; P11137; P78559; P03372
DB01197	Captopril	approved	44093	-	"For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, &beta,-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy. "	P00734; P08253; P12821; P46663; P35354; P00797; P09960; P14780; P23219
DB01198	Zopiclone	approved	5735	-	"For the short-term treatment of insomnia."	P28472; P18507; Q8TDV5; P30536; P14867; P31644; P47870; P47869; P34903; Q99928
DB01199	Tubocurarine	approved	6000	-	"Used as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure"	O14764; Q15822; O95264; P46098; P17787; P32297; P02708; P47870; P47869; Q16445; Q9H2S1; P78334; P08172; P22303; P18507; P18505; Q401N2; Q8N1C3; P30926; P14867; P11230; O00591; Q9UN88; P28472; Q99928; Q494W8; P48169; P34903; Q92952; P07510; P36544; P31644; Q04844; P43681; Q07001
DB11079	Trolamine salicylate	approved	25213	-	"Indicated for the temporary relief of aches, and pains of muscles and joints associated with backache, lumbago, strains, bruises, sprains and arthritic or rheumatic pain, pain of tendons and ligaments [L1791]."	P35354; P23219
DB01463	Fencamfamine	illicit; approved; withdrawn	14584	-	"For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy."	Q01959
DB01466	Ethylmorphine	illicit; approved	5359271	-	"Ethylmorphine is an analgesic used for pain relief."	P35372
DB00481	Raloxifene	investigational; approved	5035	-	"For the prevention and treatment of osteoporosis in post-menopausal women, as well as prevention and treatment of corticosteroid-induced bone loss. Also for the reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis or have a high risk for developing breast cancer."	P18825; P28221; P28223; P35372; P35462; P04155; Q99527; Q99720; Q01959; P03372; P21728; P08913; P14416; Q92731; P23975; P50453; P41145; P22303; Q8NI17; P41143; P28335; P18089; Q96RI1; P41595; P29274; P05231; P25100; P26992; P31645; P06241
DB00480	Lenalidomide	approved	216326	-	"Lenalidomide is indicated for the treatment of multiple myeloma in combination with dexamethasone. It is also indicated for the treatment of patients with transfusion-dependent anemia due to low- or intermediate- risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities."	Q13619; Q16531; P01375; O14788; P62877; P33151; P35354; Q96SW2
DB00483	Gallamine Triethiodide	approved	6172	-	"For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation"	P08172; P22303; P11229; Q15822; P28336; P11230; P08912; P07510; P02708; Q04844; P30550; Q07001
DB00482	Celecoxib	investigational; approved	2662	-	"For relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis"	P11712; P43166; P10635; P23280; Q16790; P35218; Q8N1Q1; Q9Y2D0; Q01959; P21728; P23975; P18089; O43570; P23219; P13945; O15530; P00918; P22748; P27815; P07451; Q9ULX7; P00915; P23786; P35354; P31645
DB00485	Dicloxacillin	investigational; approved; vet_approved	18381	-	"Used to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug."	P08172; P51841; P11229; O00408; P0A3M6; P25021; Q01959; P20309; Q8DR59; Q99808
DB00484	Brimonidine	approved	2435	-	"The ophthalmic solution is indicated for patients with open-angle glaucoma or ocular hypertension to lower intraocular pressure. The topical gel is indicated for the treatment of persistent (nontransient) facial erythema of rosacea in adults 18 years or older. "	P18825; P08908; P25100; P08913; P18089; P35368; P35348
DB00487	Pefloxacin	approved	51081	-	"For the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract."	Q06AK7; P11388; P43700; P43702; Q02880
DB00338	Omeprazole	investigational; approved; vet_approved	4594	-	"Omeprazole is indicated for the treatment of duodenal ulcers, benign gastric ulcers, gastroesophageal reflux disease (GERD), heartburn and other symptoms associated with GERD, erosive esophagitis, and long-term treatment of pathological hypersecretory conditions like Zollinger-Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis. "	P33261; P35869; P08684; P20648; P51164
DB00337	Pimecrolimus	investigational; approved	6509979	-	"For treatment of mild to moderate atopic dermatitis."	P62942; P05113; P42345
DB00336	Nitrofural	investigational; approved; vet_approved	5447130	-	"For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms."	P07003; P06715; P77390; P61889
DB00335	Atenolol	approved	2249	-	"For the management of hypertention and long-term management of patients with angina pectoris"	P07550; P30559; P20393; P08588
DB00334	Olanzapine	investigational; approved	4585	-	"For the acute and maintenance treatment of schizophrenia and related psychotic disorders, as well as acute treatment of manic or mixed episodes of bipolar 1 disorder. Intramuscular olanzapine is indicated for the rapid control of agitated patients."	P34969; P18825; P28221; P28222; P28223; P08913; P35462; P46098; P47898; P28566; P11229; P07550; Q9H3N8; Q12809; P21728; P30939; P08912; P08588; P21917; P14416; P08172; P08173; P28335; P18089; P21918; P41595; P35368; P35367; P35348; P13945; Q9UN88; P25021; P25100; P50406; P20309; P08908; P31645; P01011
DB00333	Methadone	approved	4095	-	"For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain."	P41145; P19652; P41143; Q9GZZ6; P35372; Q9Y6Y9; Q8TCU5; P31644; P14867; P46098; P47869; P34903; Q12809
DB00332	Ipratropium bromide	approved	657308	-	"For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema."	P08172; P08173; P08912; P11229; P20309
DB00331	Metformin	approved	4091	-	"For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS). Jentadueto is for the treatment of patients when both linagliptin and metformin is appropriate."	P03915; Q9Y478; O00483; Q9UI09; O75380; Q9NRX3; O75306; Q9Y6M9; P56181; Q16795; O96000; O75489; O00217; P03886; O95182; O00763; O95168; O75251; O95167; O14561; Q9P032; Q16718; O43920; O43677; O43676; O43678; Q9Y375; O75438; O15239; P03905; P03901; P19404; Q86Y39; P51970; P28331; Q8N183; P27487; P03891; O95139; P17568; Q96FL8; P49821; O95178; P03923; Q9BU61; O95169; O43181; O43674; Q9NX14; O95298; O95299; Q9P0J0; P43304; P56556; P42345; P03897
DB00330	Ethambutol	approved	14052	-	"For use, as an adjunct, in the treatment of pulmonary tuberculosis."	P28223; P9WNL5; P9WNL7; P9WNL9; P28335; P41595; P08684; P20815
DB00148	Creatine	investigational; approved; nutraceutical	586	-	"For nutritional supplementation, also for treating dietary shortage or imbalance."	V9HWH2; Q14353; P12277; P06732; P12532; P17540; P48029
DB06144	Sertindole	investigational; approved; withdrawn	60149	-	"Used in the treatment of schizophrenia."	Q12809; P18825; P28221; P28222; P28223; P08913; P35462; P28566; P34969; P30939; P21728; P08588; O43613; P14416; P28335; P18089; P35368; P35367; P35348; P21917; P25100; P50406; P20309; P08908; P07550
DB00118	Ademetionine	investigational; approved; nutraceutical	34755	-	"S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being."	P17707; P35520; Q00266; P0DN79; Q8N1G2; P31153; V9HW60; P21964; Q14749; Q9HBK9
DB00149	L-Leucine	approved; nutraceutical	6106	-	"Indicated to assist in the prevention of the breakdown of muscle proteins that sometimes occur after trauma or severe stress."	O60294; O43603; O15382; Q9UIC8; Q9P2J5; P54687; Q15031; P47211
DB00027	Gramicidin D	approved	45267103	-	"For treatment of skin lesions, surface wounds and eye infections."	P06241; P06239; P25101
DB01685	Topiroxostat	investigational; approved	5288320	-	"Indicated for the treatment of gout and hyperurcemia in Japan."	P47989
DB00159	Icosapent	approved; nutraceutical	446284	-	"EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy."	O14842; O95573; P32418; Q8NER1; Q07869; P35354; O60427; P37231; O60488; Q03181; P23219; P11511
DB00158	Folic Acid	vet_approved; approved; nutraceutical	6037	-	"For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood."	O14757; P41440; P04818; P14207; P41439; Q53Y97; P15328
DB00153	Ergocalciferol	approved; nutraceutical	5280793	-	"For use in the management of hypocalcemia and its clinical manifestations in patients with hypoparathyroidism, as well as for the treatment of familial hypophosphatemia (vitamin D resistant rickets). This drug has also been used in the treatment of nutritional rickets or osteomalacia, vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis)."	P28223; O43194; P11473
DB00152	Thiamine	vet_approved; investigational; approved; nutraceutical	1130	-	"For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis."	Q9H3S4; O60779
DB00151	L-Cysteine	approved; nutraceutical	5862	-	"For the prevention of liver damage and kidney damage associated with overdoses of acetaminophen"	Q9BZV2; Q9Y697; P17174; P35520; P32929; Q96RJ0; Q9HA77; P0DN79; P49589; P16455; P48507; P48506; Q16878; P48637; Q9Y600
DB00150	L-Tryptophan	withdrawn; approved; nutraceutical	6305	-	"Tryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight."	P14902; Q6DWJ6; P41180; Q7Z2H8
DB00157	NADH	approved; nutraceutical	439153	-	"Some evidence suggests that NADH might be useful in treating Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease."	P09601; P40939; P07864; Q16878; Q5U077; Q86YI5; P00374; O14561; P13995; Q00796; P51553; P56937; Q9UDR5; P00390; P50213; P20839; P40925; P40926; Q9NY65; O43920; P30043; Q9UBM7; Q02338; Q08426; P48728; P00367; O14556; Q13630; P31937; P03891; P30519; P03897; E9KL44; P00387; O00483; P53004; P29803; Q15800; Q9Y6M9; P47895; P15121; Q16795; O96000; P08559; Q16798; P16219; P30838; P03886; P26439; P43353; P49189; P30837; Q16718; Q02252; P03905; Q96C36; P03901; P19404; O75438; P51970; P42330; Q92781; Q99714; O95139; Q04828; P28845; P05093; P05091; O95479; O43181; P21695; O43837; P56556; P03915; P12268; O43175; O75380; Q9NRX3; Q16836; O75306; Q15738; P04035; Q92506; P48448; O00217; P49448; O95182; P04406; P10515; P17516; P00338; O43674; O43677; O43676; O43678; P09417; O75251; Q86Y39; P11177; P28331; P52895; P00326; P49821; P48163; P32322; P15428; O60701; P80365; O95298; O95299; Q9P0J0; O15239; P07195; P14679; Q9BYZ2; Q13423; P51648; P51649; P03923; P56181; P30038; O75489; P09622; P00352; O94788; O95168; Q9UI09; P23368; O95167; A4D0W4; Q02928; P11586; P51659; Q02218; P17568; B0YJ76; O95178; P16083; O95169; P14061; P14060; P49419; Q6ZMR3; P37059; P37058
DB00156	L-Threonine	approved; nutraceutical	6288	-	"L-Threonine makes up collagen, elastin, and enamel protein. It aids proper fat metabolism in the liver, helps the digestive and intestinal tracts function more smoothly, and assists in metabolism and assimilation."	Q9BW92; P26639; Q8IYQ7
DB00155	L-Citrulline	investigational; approved; nutraceutical	9750	-	"Used for nutritional supplementation, also for treating dietary shortage or imbalance."	Q9Y2J8; P29474; O94760; P00480; P00966; Q9UM07; O95865; Q5T6X5; Q6TGC4; Q9ULW8; V9HW53; P29475; Q9ULC6; P35228
DB00154	Dihomo-gamma-linolenic acid	investigational; approved; nutraceutical	5280581	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	P35354; P23219
DB00939	Meclofenamic acid	approved; vet_approved	4037	-	"For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis."	P09917; P02766; P23786; P10275; P35354; O43525; P23219; O43526
DB00938	Salmeterol	approved	5152	-	"For the treatment of asthma and chronic obstructive pulmonary disease (COPD)."	P07550; P08588; P15260; P35462; P13945
DB04920	Clevidipine	investigational; approved	153994	-	"For the treatment of hypertension."	Q06432; Q00975; Q13936; Q13698; O60840; Q01668
DB01038	Carphenazine	withdrawn	18104	-	"Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients."	P28223; P21918; P21728; P28335; P14416
DB04926	Neramexane	investigational	6433106	-	"Investigated for use/treatment in alzheimer's disease, hearing loss, and pain (acute or chronic)."	Q05586; O15399; Q9UGM1; Q9GZZ6; O60391; Q13224; Q12879; Q8TCU5; Q14957
DB04924	Itopride	investigational	3792	-	"Investigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous)."	P22303; P14416; P20309
DB00931	Methacycline	investigational; approved	54675785	-	"For the treatment of acute bacterial exacerbations of chronic bronchitis"	B5YVV7; B5RH07; B1XG23; B1XG24; A7ZSI6; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; P0A7T8; B5F3B9; P0A7T7; B7UPA5; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B1IPL2; B7LRT1; A1ABQ0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7LR53; B1IQP9; B5YSV6; C4ZYY0; B7MTL9; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; Q57J49; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; Q0TCF5; A9MN70; P60624; P60625; P60626; Q1R4N3; C0Q0C4; B4SXD8; B7NDS9; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; B1LHB3; B5FJK0; B7UK20; B5FJK3; B7L4J5; B7L4J4; B7L4J7; B4TKK9; B7NDH0; P0A7W6; C4ZS29; P0A7T9; P0A7W5; B1LQM1; B6I208; B7NJS8; A8ARM4; Q5PK05; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; P0A7W0; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A7ZSC4; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; B7N199; A4THT0; B7N198; C4ZSS5; B4T4N1; P0A7N7; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; A9MVN1; P62401; Q0T9J1; P0C020; C4ZSW8; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; Q5PJ56; B4TGH3; B5QUQ1; P0A7R5; B5FN11; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; B4TFD7; B6I2A8; A9N5Y8; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; B5RAX1; P68686; B7N1C3; A1AGJ3; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; A8A5A8; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; A7ZSK8; Q32B55; Q0THB2; A7ZSK4; B7MCT0; B7N1A3; A7ZSK3; A7ZSK0; B7MCT4; B5R285; B5EYX3; B5R286; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; B7LK45; B1X6H0; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; B1IPY3; A8A5A9; B7MCS9; B7MCS6; B5FJA6; B7MCS3; A8A5A2; B7MCS1; B5F7T9; A7ZSK6; Q32B57; B5F7T1; B5F7T4; B7NR05; A8AQL8; B7L6J0; A8AQL3; B7MST2; B7LH01; B7NLN4; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; P0A7S2; P60429; A1AGI5; Q329M1; P60422; B1X6G3; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; Q1R609; B7LG22; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B5BGX2; B2VCV9; Q6D9D4; P0AG55; A6TAI4; B1X6E9; B7UK18; A1AGI8; A1AGI7; B7M1N1; B7N0V1; B7NDK8; B4TKL4; P68679; B4TKL0; Q0TCE2; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; Q5PGT9; Q57J53; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; B7LRS4; B7LRS5; B7LRS7; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; Q1RD68; B7LHZ6; Q57J33; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B7M0U2; B1LHD1; A9MKN8; B1LHD0; B7LLY4; B4TXF0; Q0THB3; B1LHB0; B6I437; B7MCT2; B7NEU0; B1LHC3; B7NLL4; B7NLL7; B7NLL6; P0C018; P0C019; B1LF57; P0A7N4; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7UK52; P0A7V5; A7MPH5; A9MJT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; Q0TCF7; P02413; A9MN54; Q1C365; B7N102; B1LL30; B7L4K6; A9MN59; P0A7M6; P0A7M2; P0A7M9; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1XHG2; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; A6TG05; Q1R358; Q1R604; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; B7MJ76; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B1LHD3; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; Q1R6R5; B7NLP7; P0AG44; B7MCR9; A1AGM9; A6TE47; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A8AQL0; B7N0L5; B1LGQ0; B7L847; Q0TCN6; B5YXA7; B7NGD6; B7LRT0; B1X6F8; B4SYA9; Q32B54; B1X6F1; B7NDR8; B7MCT1; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; Q32B52; B7LQD9; B5YTM5; B7M092; B5BGY5; A8AQJ9; Q5PKU5; B5BGY1; P0A7K2; B7UK21; B5YTM9; P60725; P60724; B1IT04; P60726; B5FSA3; P60723; B5R280; B7N2E8; A4WEK0; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; P61177; P61176; P61175; Q1R632; Q32B24; B6I228; P0AG51; B7LS48; B1IPL1; A4WFC2; Q328J7; B4TKK1; B4TKK4; B7UQL1; C4ZUG3; A8A5C2; Q0TCG7; A8A539; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0AG47; Q1R4V6; P0AG45; P0A7R0; A6THB3; B2VGJ7; B7MCV7; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; B5BG21; A8AQC0; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B4TXC8; A8A5C4; B1LHC0; B1LHC2; B1X6F6; B1LHC5; A7ZS83; B5F7F9; B7LCR3; A9MGD1; A9N240; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; C6DKG8; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B1IPZ6; B1IPZ0; B1IPZ1; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; A1AGK6; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; B7L4K8; B6I218; A8APV6; Q57PV1; Q57PV0; B6I210; B6I211; A7ZRU7; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; C0Q0A5; Q5PIV8; P0A7W7; A8A5A4; B1LE15; B1LE14; P0A7W3; B7N192; P0A7W1; B7N190; B7N1A0; P0A7W9; P0A7W8; C0Q1W9; B4F277; C4ZR79; B5BGY0; C5BF78; A8GJV2; B7M9G4; B5FJA5; Q1CME3; B5RFY6; P0A7W4; P0A7N1; A8AQJ1; B5Y306; B7LX23; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B5QZ45; Q57IA6; B5YTM7; B1X6E8; P60727; P0AG50; P02358; P02359; P0A7X2; P0A7X3; P0A7X0; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; B1X6G8; A9MPV4; A8A5A1; B5F8E7; Q1RB79; B1LHC8; B7NDT5; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B6IBD4; B1IQT7; P68919; B4T4N0; B5RBB1; B1LK73; B7UJ79; B7UK39; Q57JQ0; B1IPV7; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B7M1C4; B4SUT9; A8A501; A9MFK9; A4WFD5; B5REG7; B5BKL1; P0A7J7; B7NF20; B4TGH4; B7UMH0; B7M1C5; B7NDT7; C0Q644; C4ZUH0; B7NDT6; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0A7S3; Q1RB78; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; B7NDT2; Q1R626; Q1R627; B5R290; P0A7J3; B7NDT8; P62399; B5R299
DB00933	Mesoridazine	investigational; approved	4078	-	"Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses."	P08172; P08173; P28335; P35462; P20309; P28223; P21728; Q12879; Q13224; P08912; P14416; P08908; P35367; Q14957; Q12809; P11229
DB00932	Tipranavir	investigational; approved	54682461	-	"For combination antiretroviral treatment of HIV-1 infected adult patients with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors."	P0DJD9
DB00935	Oxymetazoline	investigational; approved	4636	-	"For treatment of nasal congestion and redness associated with minor irritations of the eye"	P10635; P08173; P28335; P18825; P28221; P28222; P28223; P25100; P18089; P08912; P08913; P41595; P35368; P35348; Q9Y2I1; P08908
DB00934	Maprotiline	investigational; approved	4011	-	"For treatment of depression, including the depressed phase of bipolar depression, psychotic depression, and involutional melancholia, and may also be helpful in treating certain patients suffering severe depressive neurosis."	P18825; P28223; P30532; P35462; P11229; P34969; Q01959; P08912; P08913; P14416; P23975; P08172; P08173; P28336; P28335; P41595; P08684; P18089; O15554; P35367; P35348; P25021; P25100; P03971; P20309; P31645; P21728
DB00937	Diethylpropion	illicit; approved	7029	-	"Used in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction."	P33981; P23975; Q01959
DB00936	Salicylic acid	investigational; approved; vet_approved	338	-	"Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts."	P00918; P22748; Q04828; P11229; P43166; P08172; P23280; Q9ULX7; P00915; Q9UHC3; Q16790; P35354; O43570; P23219
DB00963	Bromfenac	approved	60726	-	"For the treatment of postoperative inflammation in patients who have undergone cataract extraction."	P35354; P23219
DB01032	Probenecid	investigational; approved	4911	-	"For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics. "	P00918; O43570; Q96S37; Q16790; Q9NSA0; Q4U2R8; Q8TCC7; Q9NYV7; Q9NYB5; Q96RD7
DB06070	SNX-5422	investigational	44195571	-	"Investigated for use/treatment in cancer/tumors (unspecified)."	P08238; P07900; K9JA46
DB06077	Lumateperone	investigational	21302490	-	"Investigated for use/treatment in schizophrenia and schizoaffective disorders."	P31645; P28223; P14416
DB00805	Minaprine	approved	4199	-	"For the treatment of depression"	P21397; P22303; P28223; P11229; P28335; P41595; P21728; P14416; P08909; P31645; P14842; P30994
DB00804	Dicyclomine	approved	3042	-	"For the treatment of functional bowel/irritable bowel syndrome
 including Colicky abdominal pain, diverticulitis"	P08172; P08173; P28223; P20309; Q99720; Q12809; P25021; P41595; P08912; P35498; Q99250; P28335; Q9NY46; P35462; P11229
DB00807	Proparacaine	approved; vet_approved	4935	-	"Used as a local (ophthalmic) anesthetic."	Q06418; P21397; Q14524; Q9Y5Y9; Q99720; P30530; Q9NY46; Q01118; Q9UI33; P35498; Q99250; P35499; Q15858; Q9UQD0; Q12866
DB00806	Pentoxifylline	investigational; approved	4740	-	"For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs."	Q01064; Q14432; Q9NP56; Q08493; O95263; P16499; Q08499; O00408; Q13946; O76083; P21589; Q13370; O43924; P35913; P29274; P29275; P30542; O60658; P22303; P54750; P18089; O76074; P18545; Q14123; P27815; Q13956; Q9Y233; P51160; P01375; Q07343
DB00801	Halazepam	illicit; approved; withdrawn	31640	-	"Used to relieve anxiety, nervousness, and tension associated with anxiety disorders."	Q9UN88; P24046; P28472; P18507; P18505; A8MPY1; Q99928; P28476; P48169; Q16445; Q8N1C3; P47869; P14867; P31644; O14764; P34903; O00591; P47870; P78334
DB00800	Fenoldopam	approved	3341	-	"For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function."	P18825; P25100; P21918; P21728; P08913; P18089; P14416; P35368; P35348; P21917
DB00803	Colistin	approved	131704173	-	"For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly <i>Pseudomonas aeruginosa</i>."	P00533; P06241; P04626
DB00802	Alfentanil	illicit; approved	51263	-	"For the management of postoperative pain and the maintenance of general anesthesia."	P35372
DB06274	Alvimopan	investigational; approved	5488548	-	"Used to accelerate the time to upper and lower gastrointestinal recovery following partial large or small bowel resection surgery with primary anastomosis. Also investigated for use in the treatment of pain (acute or chronic)."	P41145; P35372; P41143
DB01034	Cerulenin	approved	28517	-	"For use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animals"	P0A6R0; P49327; P0A953; P0AAI5
DB00809	Tropicamide	investigational; approved	5593	-	"Indicated to induce mydriasis (dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) in diagnostic procedures, such as measurement of refractive errors and examination of the fundus of the eye."	P08172; P08173; P08912; P11229; P20309
DB00808	Indapamide	approved	3702	-	"For the treatment of hypertension, alone or in combination with other antihypertensive drugs, as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy (appropriate only in the management of edema of pathologic origin during pregnancy when clearly needed). Also used for the management of edema as a result of various causes."	P00918; P22748; Q9Y2D0; P43166; Q9ULX7; P23280; P51787; P00915; P55017; Q16790; P15382; O43570; P35218; Q8N1Q1
DB04818	Iproniazid	withdrawn	3748	-	"For the treatment of depression (originally intended to treat tuberculosis)."	P21397; P27338
DB04817	Metamizole	investigational; approved; withdrawn	522325	-	"Used in the past as a powerful painkiller and fever reducer."	O75762; P23219
DB06670	Odanacatib	investigational	10152654	-	"Investigated for use/treatment in osteoporosis [A19388]."	P43234; P43235; Q9UBR2; P25774
DB06678	Esmirtazapine	investigational	3085218	-	"Investigated for use/treatment in insomnia and sleep disorders."	P28223; P18825; P28335; P18089; P08913; P46098; P35367
DB02959	Oxitriptan	investigational; approved; nutraceutical	439280	-	"For use as an antidepressant, appetite suppressant, and sleep aid."	P28223; P34969; Q9RVD6; P08908
DB06410	Doxercalciferol	approved	46705423	-	"Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, as well as for the treatment of secondary hyperparathyroidism in patients with Stage 3 or Stage 4 chronic kidney disease. "	P11473
DB06412	Oxymetholone	illicit; approved	5281034	-	"Indicated in the treatment of anemias caused by deficient red cell production. Acquired aplastic anemia, congenital aplastic anemia, myelofibrosis and the hypoplastic anemias due to the administration of myelotoxic drugs often respond. Oxymetholone should not replace other supportive measures such as transfusion, correction of iron, folic acid, vitamin B12 or pyridoxine deficiency, antibacterial therapy and the appropriate use of corticosteroids. "	P10275; P16860; P03372
DB06413	Armodafinil	investigational; approved	9690109	-	"Investigated for use/treatment in sleep disorders, obstructive sleep apnea, schizophrenia and schizoaffective disorders, depression, and bipolar disorders."	Q01959; P14416; P35368
DB06414	Etravirine	approved	193962	-	"Indicated as an adjunct therapy in the treatment of adult HIV-1 infections resistant to therapy with other NNRTIs and antiretroviral agents. "	P03366; P04591; P04585
DB00967	Desloratadine	investigational; approved	124087	-	"For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria."	P08172; P08173; P28335; P20309; P28223; P25021; Q01959; P41595; P08912; P18089; P35462; P35367; P31645; P23975; P11229
DB05511	Piclidenoson	investigational	123683	-	"Investigated for use/treatment in cancer/tumors (unspecified), eye disorders/infections, psoriasis and psoriatic disorders, and rheumatoid arthritis.
 Can-Fite BioPharma has reported that by targeting the adenosine A3-receptor, CF101 may also be used to treat Crohn's disease, a serious gastrointestinal disorder."	P36955; P33765; P0DMS8
DB08835	Spaglumic Acid	approved	210320	-	"Used in patients with allergic conjunctivitis."	Q04609
DB08836	Temocapril	investigational; experimental	443874	-	"Temocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction). "	P12821
DB08837	Tetraethylammonium	investigational; experimental	5413	-	"Tetraethylammonium is an experimental drug with no approved indication."	Q9UGM1; P0A334; Q96FL8; Q08460; Q09470
DB08838	Agmatine	investigational; experimental	199	-	"Agmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety, schizophrenia, and cognition). As an investigational drug, agamatine is being studied in a non-blinded prospective case study in the United States looking at patients who have been diagnosed with small fiber peripheral neuropathy."	Q05586; Q9Y2I1; P02708; P18825; P48048; Q00975; Q9UHC3
DB00889	Granisetron	investigational; approved	5284566	-	"For the prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer therapy (including high dose cisplatin), postoperation, and radiation (including total body irradiation and daily fractionated abdominal radiation)."	P32297; P17787; Q12809; P43681; P46098
DB06094	Apatorsen	investigational	131704298	-	"Investigated for use/treatment in cancer/tumors (unspecified)."	P04792
DB06090	Bradanicline	investigational	25147644	-	"Investigated for use/treatment in neurologic disorders."	Q494W8; P43681; P36544
DB09235	Efonidipine	investigational; approved	119171	-	"For the treatment of hypertension."	Q9P0X4; Q01668; Q13936; O95180
DB09237	Levamlodipine	investigational; approved	9822750	-	"For the treatment of hypertension and angina [L1483]. "	Q01668; Q13936
DB09236	Lacidipine	investigational; approved	5311217	-	"Indicated for the treatment of hypertension either alone or in combination with other antihypertensive agents, including ?-adrenoceptor antagonists, diuretics, and ACE-inhibitors [L1126]."	Q13936; P08684; O00305; P35462; Q01668; P23975
DB09231	Benidipine	investigational; approved	656668	-	"Benidipine is a potent and long-lasting drug indicated for the treatment of cardiovascular diseases such as hypertension, renoparenchymal hypertension and angina pectoris.[A31950]"	Q00975; O95180; Q9P0X4; Q13936; O00305; Q01668
DB09230	Azelnidipine	investigational; approved	65948	-	"For the treatment of hypertension."	Q01668; Q13936; Q02641
DB09232	Cilnidipine	investigational; approved	5282138	-	"Cilnidipine is indicated for the management of hypertension for end-organ protection.[L1436] It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cilnidipine has been increasingly used in patients with chronic kidney disease 
 
 Hypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel.[L1438]"	Q00975; Q01668; Q13936; O00305
DB09238	Manidipine	investigational; approved	4008	-	"For the treatment of hypertension."	Q9P0X4; Q01668; Q13936; O00305
DB13914	Volixibat	investigational; experimental	24987688	-	"Volixibat is an investigational drug that has not been approved for use in any conditions."	Q12908
DB08949	Inositol nicotinate	approved; withdrawn	3720	-	"Indicated as a dietary supplement for the source of niacin. Has been investigated for potential beneficial effects on serum lipids. In Europe, inositol hexanicotinate is indicated as a patented drug known as Hexopal, which is therapeutically indicated for the symptomatic relief of severe intermittent claudication and Raynaud?s phenomenon. "	P49019; Q8TDS4
DB01326	Cefamandole	investigational; approved	456255	-	"For the treatment of serious infections caused by susceptible strains of  microorganisms."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB09300	Butylscopolamine	investigational; approved; vet_approved	6852391	-	"Used to treat abdmoninal cramping and pain [FDA Label]."	P08172; P20309
DB09304	Setiptiline	approved	5205	-	"For the treatment of depression [A19792]."	P18825; P34969
DB00146	Calcidiol	approved; nutraceutical	5283731	-	"Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis."	P11473
DB01320	Fosphenytoin	investigational; approved	56339	-	"For the control of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. It can also be substituted, short-term, for oral phenytoin."	Q14524; Q9UQD0; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q9UI33; Q15858; Q9NY46
DB09047	Finafloxacin	investigational; approved	11567473	-	"Finafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of <i>Pseudomonas aeruginosa</i> and <i>Staphylococcus aureus</i> in patients age 1 year and older. "	P0C1S7; P20831; P0A0K8; Q9I7C2; P0C1U9; Q9HUJ8; P48372; P11388; P43700; Q9HUK1; P43702
DB09042	Tedizolid Phosphate	approved	11476460	-	"Tedizolid Phosphate is an oxazolidinone antibacterial drug indicated in adults for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), and Enterococcus faecalis."	B5FJK9; B5YVV7; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; P0A7T8; B5F3B9; P0A7T7; C0Q0A5; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; B4TAV0; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; P68683; P68680; P68681; B7LRT5; B1IPL2; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7LR53; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B7UMH0; B7LHP9; B4TKM3; B6I1U8; B5R1G3; Q57J49; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; A7MPH8; A9MN70; P60624; P60625; P60626; A6TE47; B4SXD8; B7NDS9; B1IPL1; P62401; B7NDS5; B7NDS7; B5FJK8; B7UK28; B7N0W8; B1LHB3; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B1LHB1; P0A7W6; P0A7T9; B1LE15; B1LQM1; B6I208; B7NJS8; P0A7W4; B5BGY5; Q5PK05; B7LHT8; C0Q2L0; B7N192; A8A5E9; C4ZUG9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; B4TXD1; A7MNZ2; B7N199; B1LE14; A4THT0; Q32FI2; C4ZSS5; B4T4N1; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; B6I228; A9MVN1; A9MX79; Q0T9J1; C4ZSW8; C4ZS29; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; P0A7M6; B4TGH3; B5QUQ1; P0A7R5; B5FN11; P0AG44; B7NLM3; B7NLM7; B7NLM5; B7NLM8; A9MFC1; P0C021; P0C020; B6I2A8; P0A7M9; B4TGH4; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B7NKQ3; B5RAX0; B5RAX1; P68686; B7MCV7; B1IPY8; B6I242; B7MCS3; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; A1AGJ7; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; Q0TCN6; Q32B55; Q32B54; B7MCT1; A7ZSK5; B7N1A3; A7ZSK3; A7ZSK0; B7N1A0; B5R285; P0A7K2; Q1R632; Q1R635; B5R280; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; B7UK52; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; A8A5A1; A8GJV2; B7MCS1; B5F7T9; A7ZSK6; P60727; B5F7T1; B5F7T4; B7NR05; P68919; P0A7S3; B7L6J0; A8AQL3; B7MST2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; A1AGI5; Q329M1; P60422; B1X6G3; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B5QZ45; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B5BGX2; B2VCV9; B5R0S0; B5EYX3; A6TAI4; B7UK18; A1AGI8; A1AGI7; B7M1N1; B7N0V1; B7NDK8; B4TKL4; P68679; B4TUF2; Q0TCE2; B1XG70; B4TKL0; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; Q5PGT9; Q57J53; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; A9MJT9; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; Q1RD68; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B7M0U2; B1LHD1; A9MKN8; P0A7V9; B7LLY4; B1LHD3; Q0THB3; B1LHB0; B6I437; B7MCT2; B7NEU0; C4ZUE9; B7NLL7; B7NLL6; P0C018; P0C019; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7NLN4; Q2NWE7; P0A7V5; A7MPH5; B4SUT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; B7N198; Q0TCF7; P02413; A9MN54; Q1C365; B7N102; B1LL30; B7L4K6; A9MN59; Q5PJ56; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; P0A7L8; A1AGJ5; B1IPY0; B1IPY3; P0ADZ0; B1IPY5; A9MGD1; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; P0A7V8; B1LHD0; B4TXF0; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; B7NLP7; B7MCR9; A1AGM9; P0A7J3; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; B7N0L5; B1LGQ0; B7L847; A7ZSK8; B5YXA7; B7NGD6; B1XHK3; B1X6F8; B4SYA9; Q0THB2; B1X6F1; Q0TCS4; Q32B57; B1X6F6; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; Q32B52; B7LQD9; B5YTM5; B7M092; B5YTM7; A8AQJ9; Q5PKU5; B5BGY1; B5BGY0; B5FJK0; A8AQJ1; P60725; B7LRS4; B1IT04; B5R286; B5FSA3; P60723; P0A7K6; B7N2E8; B7L4J5; P61179; B7LRS7; B6I3T6; C4ZUH4; B1LGJ6; P61177; C4ZUH1; P61175; Q32B24; B7NDH0; P0AG51; B7LS48; B5BG21; A4WFC2; Q328J7; B1IPZ0; B4TKK1; B1XHG2; B4TKK4; B7UQL1; B4TFD7; B4TKK9; A8A5C2; Q0TCG7; A8A539; Q2EEQ2; A1AGK6; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0AG47; Q1R4V6; P0AG45; P0A7R0; A6THB3; A8A5B3; B7N1C3; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; A8AQC0; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B4TXC8; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B1X6H0; B7LCR3; A9N240; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B7LX23; P0A7N4; P0A7N5; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A7ZSI5; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; Q1R616; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B7MTL9; Q5PIV8; P0A7W7; B7MCS6; P0A7W5; A8ARM4; P0A7W3; P0A7W2; P0A7W1; P0A7W0; P0A7W9; P0A7W8; C0Q1W9; B4F277; C4ZR79; C5BF78; A8A5A2; B7M9G4; B5FJA5; Q1CME3; B5RFY6; P0A7N1; B5YTM9; B5Y306; B1IPZ6; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; C4ZUG3; B7MJ76; P60724; Q57IA6; P0A7N7; B1X6E8; B1X6E9; P0A7S6; P02358; P02359; P60726; P0A7X2; P0A7X3; P0A7X0; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; Q1RB79; B1LHC8; B7NDT5; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; Q1RB78; A8AQL8; B4T4N0; B5RBB1; B1LK73; B7UJ79; B7UK39; Q57JQ0; B1IPV7; P61178; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; Q1R620; B7M1C4; B1X6G0; A8A501; A9MFK9; A4WFD5; B5REG7; B5BKL1; P0A7J7; B7NF20; C0Q0C4; B7M1C5; B5R290; B1IPY4; C4ZUH0; B7NDT6; P61176; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0AG55; P0A7S2; P0A7S1; P0A7S0; P0A7S7; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; Q1R626; Q1R627; B7NDT7; Q1R4N3; C0Q644; B7NDT8; P62399; B5R299
DB09040	Efinaconazole	approved	489181	-	"Indicated in the treatment of fungal infection of the nail, known as onychomycosis."	P50859
DB01143	Amifostine	investigational; approved	2141	-	"For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer."	P10696; P22413; P35462
DB09048	Netupitant	investigational; approved	6451149	-	"Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy."	P35270; P25103
DB09049	Naloxegol	approved	56959087	-	"Indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain."	P35372
DB01213	Fomepizole	approved; vet_approved	3406	-	"Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis"	P00326; P07327; P00325; P04040; P14550
DB01212	Ceftriaxone	approved	5479530	-	"For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph"	P0AEB2; P08506; P0A3M6; P02918; P02919; P0AD68; P24228; P0AD65
DB01211	Clarithromycin	approved	84029	-	"An alternative medication for the treatment of acute otitis media caused by <i>H. influenzae, M. catarrhalis, or S. pneumoniae</i> in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible <i>Streptococcus pyogenes</i>, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Other indications include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by <i>Toxoplasma gondii</i> (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of ?-hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention for <i>Mycobacterium avium</i> complex (MAC) bacteremia or disseminated infections (in adults, adolescents, and children with advanced HIV infection)."	B5YVV7; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; P0A7T8; B1LHB0; P0A7T7; C4ZUG9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; Q1R4V6; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B1IPL2; B7LRT1; B7LRT0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; B7NLN8; B7NLN3; B1IPL1; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; B7MCS3; Q57J33; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; A6TEW0; A7MPH8; A9MN70; B7M1C4; B7M1C5; P60626; Q1R4N3; C0Q0C4; B4SXD8; B7NDS9; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; C4ZUG1; B5FJK0; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B7NDH0; P0A7W6; B5F3B9; P0A7W5; B1LQM1; B6I208; B7NJS8; P0A7W4; B5BGY5; Q5PK05; C0Q2L0; B7N192; A8A5E9; Q57GI9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; B4TXD6; B4TXD7; B6I3L3; B4TXD1; A7MNZ2; P0A7S2; P0A7W9; A4THT0; Q32FI2; B4T4N0; B4T4N1; B7M1L8; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; Q57J49; P62401; Q0T9J1; P0C020; A9MN59; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; B4TGH4; B4TGH3; B5QUQ1; P0A7R5; B5FN11; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; Q12809; P0C021; B4TFD7; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; A6TG05; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; B5RAX1; P68686; B7N1C3; B1IPY8; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A1AGJ5; A9MGD1; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1XHG2; A1AGM9; P0AG67; P0ADZ0; Q0TCN6; Q0THB3; B7MCT2; Q32B57; B7MCT0; B7N1A3; A7ZSK3; B7N1A1; B7N1A0; B5R285; P0A7K2; B5R286; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; Q32B55; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; Q32B54; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; A8APV6; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; A8A5A1; A8GJV2; B5FJA5; B5F7T9; B7NLN0; P60727; B5F7T1; B5F7T4; B7NR05; P68919; B7L6J0; A8AQL3; B7MST2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B1X6G8; P60429; B7N0V1; Q329M1; P60422; P60423; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; Q1R609; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B6I211; B5QZ45; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; Q57IA6; A9MN66; B7NKQ3; C4ZYY0; B2VCV9; Q6D9D4; B5EYX3; A6TAI4; B7UK18; A1AGI8; C4ZUF2; A1AGI7; Q32BE7; A1AGI5; B7NDK8; B4TKL4; P68679; B4TKL0; Q0TCE2; B7M1M3; Q57HZ9; P0A7M6; B4EW58; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A8A5A2; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; B7NDR8; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B1XG70; B7LHZ6; B1LHC8; B5RH29; B7M100; B7M103; B7M102; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; B1LHD1; A9MKN8; B1LHD0; B7LLY4; B1LHD3; B6I437; B7NEU0; B1LHC3; B7UPA5; B7NLL7; B7NLL6; P0C018; P0C019; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7UK52; A7MPH5; B4SUT9; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; P0A7J6; B1X6F8; P02413; A9MN54; Q1C365; B7N102; P60624; P60625; Q5PJ56; P0A7M2; A9N5Y8; A1AGJ2; A1AGJ3; B7N0U4; A7ZRU7; A6TE47; B1IPY0; B1IPY3; B1IPY2; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; B6I228; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B6IBD4; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B4TXF0; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; P0A7V5; P0A7V6; P0A7V7; B7NLP7; B7MCR9; P0AG66; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; A7ZSK4; A8ARM4; B4TAV0; B7N0L5; B1LGQ0; Q9NPD5; B7L847; A7ZSK8; B5YXA7; B7NGD6; Q5PKU5; A7ZSK6; B4SYA9; Q0THB2; B1X6F1; Q0TCS4; B7MCT1; B7UK28; A7ZSK5; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; A7ZSK0; B5YRA5; B7LI05; Q32B52; P0A7W8; B7LQD9; B5YTM5; B7M092; C0Q0A5; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B7UK21; A8AQJ1; P60725; A9MJT9; B1IT04; Q1R632; B5FSA3; P60723; Q9Y6L6; B5R280; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; C4ZUH4; B1LGJ6; C4ZUH0; P61176; P61175; Q32B24; P0A7T9; B7LS48; B5BG21; A4WFC2; Q328J7; B4TKK1; B4TKK4; B7UQL1; B4TKK9; Q5PC32; A8A539; Q2EEQ2; A1AGK6; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; Q1R616; A8A5B3; B7MCV7; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; A8AQC0; B1X970; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; B7M1N1; B7M1N0; Q1R5U1; A1AGJ7; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B4TI60; A8A0Q9; B5RH16; C4ZUF9; A8A5C2; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1X6F6; P0AG65; B1LHC5; A7ZS83; B1X6H0; A9MFK9; B5REG7; B5FM60; A9N241; B7M4C0; B4SUU8; B7LVJ7; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; B1IPZ5; B7LX23; P0A7N4; P0A7N5; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; B7UK39; A7MM78; B7UK35; B7UK32; B7UK30; B7L4K6; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; B7LRS7; A7ZSI5; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; Q1R612; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; Q57QG6; B7LQ74; B7LQ73; B7MTL9; Q5PIV8; P0A7W7; B7MCS6; B1LE15; B1LE14; P0A7W3; P0A7W2; P0A7W1; P0A7W0; B7N199; B7N198; C0Q1W9; B4F277; C4ZR79; C5BF78; B7LHP9; B7M9G4; P0A7L8; B7MCS1; Q1CME3; B5RFY6; P0A7N1; B5YTM9; B5Y306; B1IPZ6; B7M1M2; P0AG55; B7M1M0; B5EXE1; B7M1M5; B1IPZ0; B7M1M8; B7M1M9; B5BI10; B1IPZ1; B1X6E6; C4ZUG3; B7MJ76; P60724; P0A7S7; B1IPZ3; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P0A7R9; P60726; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; A9MPV4; B5F8E7; Q1RB79; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7L6I9; A8A6G4; B6IBD5; B1X9Z9; B1IQT7; A8AQL8; C4ZSS5; B5RBB1; B1LK73; B7UJ79; B1X6G3; Q1R6R5; Q57JQ0; B1IPV7; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; Q1R620; B1X6G0; A8A501; B7LCR3; A4WFD5; A9N240; B5BKL1; P0A7J7; B7NF20; Q1R626; B7UMH0; A7ZSI8; B5R290; C0Q644; P61177; P0A7J3; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; P0A7S3; Q1RB78; P0A7S1; P0A7S0; P0AG51; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; B7NDT5; Q1R627; B7NDT7; B7NDT6; B7NDT8; P62399; B5R299
DB01210	Levobunolol	approved	39468	-	"For lowering intraocular pressure (IOP) and may be used in patients with chronic open-angle glaucoma or ocular hypertension."	Q99720; P08908; P08588; P31645; P07550; P13945
DB01217	Anastrozole	investigational; approved	2187	-	"For adjuvant treatment of hormone receptor positive breast cancer , as well as hormonal treatment of advanced breast cancer in post-menopausal women. Has also been used to treat pubertal gynecomastia and McCune-Albright syndrome, however, manufacturer states that efficacy for these indications have not been established."	Q6NYC1; P11511; P25103; P03372
DB01216	Finasteride	approved	57363	-	"For the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to: Improve symptoms, reduce the risk of acute urinary retention, reduce the risk of the need for surgery including transurethral resection of the prostate. Also used for the stimulation of regrowth of hair in men with mild to moderate androgenetic alopecia (male pattern alopecia, hereditary alopecia, common male baldness)."	P51857; P31213; Q01415; P18405
DB01215	Estazolam	illicit; approved	3261	-	"For the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings."	Q9UN88; P24046; P28472; P11229; P18505; P28476; A8MPY1; Q16445; O14764; P48169; P78334; Q8N1C3; P31644; P47870; P14867; P47869; P34903; Q99928; O00591; P18507
DB01214	Metipranolol	approved	31477	-	"Indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma."	P07550; P08588
DB01219	Dantrolene	investigational; approved	6914273	-	"For use, along with appropriate supportive measures, for the management of the fulminant hypermetabolism of skeletal muscle characteristic of malignant hyperthermia crises in patients of all ages. Also used preoperatively, and sometimes postoperatively, to prevent or attenuate the development of clinical and laboratory signs of malignant hyperthermia in individuals judged to be malignant hyperthermia susceptible."	P21817; Q15413
DB01218	Halofantrine	approved	37393	-	"For treatment of Severe malaria"	Q12809; P46925
DB00324	Fluorometholone	investigational; approved	9878	-	"For the ophthalmic treatment of corticosteroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe."	P04150; P47712
DB00497	Oxycodone	illicit; investigational; approved	5284603	-	"For the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain."	P41145; P35372; P19652; P41143
DB01039	Fenofibrate	approved	3339	-	"For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)"	P22303; P28223; P37231; P28335; Q01959; Q07869; O75469; P35462; Q03181; P23975; P13945
DB00327	Hydromorphone	illicit; approved	5284570	-	"For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, or burns."	P41145; P35372; P41143; Q9NYK1
DB01033	Mercaptopurine	approved	667490	-	"For remission induction and maintenance therapy of acute lymphatic leukemia."	P12268; Q06203; V9HWH6; P00491; P51580; P00492; P47901; P23219; P37288; P30518
DB00320	Dihydroergotamine	investigational; approved	10531	-	"For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes."	P28566; P28223; P41595; P14416; P18825; P28221; P28222; P35368; P25100; P34969; P30939; P21728; P08913; P08684; P18089; P35462; P08908; P28335; P35348; P01011
DB01031	Ethinamate	illicit; approved; withdrawn	3284	-	"Used for the short-term treatment of insomnia, however, it generally has been replaced by other sedative-hypnotic agents."	P00918; P00915
DB01030	Topotecan	investigational; approved	60700	-	"For the treatment of advanced ovarian cancer in patients with disease that has recurred or progressed following therapy with platinum-based regimens. Also used as a second-line therapy for treatment-sensitive small cell lung cancer, as well as in combination with cisplatin for the treatment of stage IV-B, recurrent, or persistent cervical cancer not amenable to curative treatment with surgery and/or radiation therapy."	P08684; P11387; Q969P6
DB01037	Selegiline	investigational; approved; vet_approved	26757	-	"Monotherapy for initial treatment of Parkinson's disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer's disease and at higher doses, for the treatment of depression."	P21397; Q13177; P27338; P18089; P08913; P35270
DB01036	Tolterodine	investigational; approved	443879	-	"For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence)."	P08172; P08173; P11229; P10635; Q12809; P08912; P20309; Q14833
DB01035	Procainamide	approved	4913	-	"For the treatment of life-threatening ventricular arrhythmias."	P08172; Q12809; P22303; Q14524; P50406; Q9UQD0; P26358; Q01118; Q9UI33; Q9Y6K1; Q9Y5Y9; P35498; Q99250; P35499; Q15858; Q9NY46
DB00493	Cefotaxime	approved	5742673	-	"Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery."	P02768; P24228; P08506; P0A3M6; P0AEB2; P02918; P02919; P42971; P0AD68; Q8DR59; P0AD65
DB00490	Buspirone	investigational; approved	2477	-	"For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression."	P28335; P35462; Q99720; P28223; P25100; P48048; Q12809; P08684; P41595; P14416; P08908; P35348
DB00491	Miglitol	approved	441314	-	"For use as an adjunct to diet to improve glycemic control in patients with non-insulin-dependent diabetes mellitus (NIDDM) whose hyperglycemia cannot be managed with diet alone."	P10253; P04746; Q8IWI9; O43451; Q14697; Q8TET4
DB01329	Cefoperazone	investigational; approved	44185	-	"For the treatment of bacterial infections caused by susceptible microorganisms."	P0AEB2; P08506; P02918; P02919; Q07806; P0AD68; P24228; P0AD65
DB01328	Cefonicid	investigational; approved	43594	-	"For the treatment of bacterial infections caused by susceptible microorganisms."	P24228; P08506; P02918; P02919; P31391; P35354; P0AD68; P0AEB2; P0AD65
DB01327	Cefazolin	approved	33255	-	"Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis, if required metronidazole may be added to cover B. fragilis."	P24228; P08506; P40933; P02918; P02919; P27169; Q16853; P60568; P0AD68; P76577; P0AEB2; P0AD65
DB01454	Midomafetamine	illicit; investigational; experimental	1615	-	"Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used illicit drugs in the U.S."	P28223; P28335; P41595; Q05940
DB01325	Quinethazone	approved	6307	-	"Used to treat hypertension."	P55017; P00918; Q13621; P00915; P55011
DB01324	Polythiazide	approved	4870	-	"Polythiazide is a thiazide diuretic used to decrease edema and decrease blood pressure."	P55017; P17342
DB01321	Josamycin	investigational; approved	5282165	-	"For the treatment of bacterial infections."	P44345
DB01452	Heroin	illicit; investigational; approved	5462328	-	"Used in the treatment of acute pain, myocardial infarction, acute pulmonary oedema, and chronic pain."	P41145; P35372; P23141; P41143
DB01147	Cloxacillin	investigational; approved; vet_approved	6098	-	"Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci."	P00811; P0A3M5; P0AEB3; Q8XJ01
DB01146	Diphenylpyraline	investigational; approved	3103	-	"For use in the treatment of allergic rhinitis, hay fever, and allergic skin disorders."	P35367; P10635; P11229; Q01959
DB01145	Sulfoxone	approved	5351	-	"For the treatment of leprosy and dermatitis herpetiformis"	P34949; P0C0X1
DB01144	Diclofenamide	investigational; approved	3038	-	"For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure"	P00918; P22748; Q9Y2D0; P43166; P23280; Q9ULX7; P00915; Q16790; O43570; P35218; Q8N1Q1; P07451
DB00328	Indomethacin	investigational; approved	3715	-	"For moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis."	Q8N8N7; P37231; P51787; P42330; P43116; P10275; P35354; Q04760; P15382; P15121; Q9Y5Y4; Q96RP8; Q07869; P14555; P23219
DB01142	Doxepin	investigational; approved	667468	-	"**Oral: **
 - Indicated for the treatment of depression and/or anxiety [FDA Label]. 
 - Indicated for the treatment of depression and/or anxiety associated with different conditions, including alcoholism, organic disease and manic-depressive disorders [FDA Label].
 - Indicated for the treatment of insomnia characterized by difficulties with sleep maintenance [L1347].
 
 Topical: 
 - Indicated for the short-term (up to 8 days) management of moderate pruritus in adult patients with atopic dermatitis or lichen simplex chronicus [L1344]."	Q12809; P18825; P28223; P35462; P11229; Q9H3N8; Q99720; P34969; P08912; P21728; P08913; P14416; P23975; P08172; P08173; P28335; P41595; P18089; P35368; P35367; P35348; P25021; P25100; P50406; P20309; P08908; P31645
DB01141	Micafungin	investigational; approved	477468	-	"For use in the treatment of candidemia, acute disseminated candidiasis, and certain other invasive <i>Candida</i> infections, as well as esophageal candidiasis, and prophylaxis of <i>Candida</i> infections in patients undergoing hematopoietic stem cell transplantation. Micafungin is also used as an alternative for the treatment of oropharyngeal candidiases and has been used with some success as primary or salvage therapy, alone or in combination with other antifungals, for the treatment of invasive aspergillosis."	A2QLK4
DB01140	Cefadroxil	withdrawn; approved; vet_approved	47965	-	"For the treatment of the following infections (skin, UTI, ENT) caused by, <i>S. pneumoniae, H. influenzae, staphylococci, S. pyogenes</i> (group A beta-hemolytic streptococci), <i>E. coli, P. mirabilis, Klebsiella</i> sp, coagulase-negative staphylococci and <i>Streptococcus pyogenes</i>"	Q12809; P24228; P08506; P0A3M6; P02918; P02919; P25101; P0AD68; P0AEB2; P0AD65; Q8DR59
DB00496	Darifenacin	investigational; approved	444031	-	"For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency."	P08172; P08173; P11229; P10635; P14416; P08912; P08588; P20309; P07550
DB00325	Nitroprusside	investigational; approved	11963622	-	"For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure"	P16066; O75343; Q14643; Q02153; P33402; Q02108
DB00494	Entacapone	investigational; approved	5281081	-	"Used as an adjunct to levodopa / carbidopa in the symptomatic treatment of patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose \"wearing-off\"."	P21964
DB00495	Zidovudine	approved	35370	-	"Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections."	P28223; Q99720; O14746
DB00492	Fosinopril	approved	55891	-	"For treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy. "	P12821
DB00321	Amitriptyline	approved	2160	-	"- Indicated for the treatment of major depressive disorder in adults
 - Indicated for the management of neuropathic pain in adults
 - Indicated for the prophylactic treatment of chronic tension type headache (CTTH) in adults
 - Indicated for the prophylactic treatment of migraine in adults
 - Indicated for the the treatment of nocturnal enuresis in children aged 6 years and above when organic pathology, including spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including antispasmodics and vasopressin-related products. This medicinal product should only be prescribed by a healthcare professional with expertise in the management of persistent enuresis.
 -Other off-label uses include irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia"	P34969; P35462; P41145; P18825; P10635; P28222; P28223; P35372; Q99250; P04629; O43525; O43526; Q14524; P11229; Q09470; Q9H3N8; Q99720; Q12809; Q01959; P08912; P08913; P14416; P28221; P07949; Q15858; P08172; P08173; Q16620; Q9NZV8; P41143; P41180; P28335; P18089; P41595; P35368; P35367; Q9UK17; P35348; P13945; P23975; P25021; P25100; P50406; P20309; P08908; P31645; P21728
DB01149	Nefazodone	approved; withdrawn	4449	-	"For the treatment of depression."	P28335; P10635; P28223; Q01959; P18089; P49190; Q12809; P08913; P08684; P14416; P35368; P35367; P31645; P23975; P35348; P08908
DB01148	Flavoxate	approved	3354	-	"For symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis."	O60658; P08172; Q13946; P27815; P11229; Q12809; Q9NP56; Q08493; O95263; Q07343; Q08499
DB00611	Butorphanol	illicit; approved; vet_approved	6916249	-	"For the relief of moderate to severe pain."	P41145; P35372; P41143
DB08795	Azidocillin	approved	15574941	-	"For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc"	Q8DR59; P0A3M6
DB08799	Antazoline	approved	2200	-	"Used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis."	P35367
DB00926	Etretinate	withdrawn	3312	-	"For the treatment of severe psoriasis in adults."	P19793; P48443; P28702; P10276; P10826; P13631
DB00927	Famotidine	approved	3325	-	"For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD)."	P35367; P25021; Q86Y34
DB00924	Cyclobenzaprine	approved	2895	-	"For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions."	O14842; P08172; P28335; P11229; P28223; P34969; P41595; P20309; P35367; P31645; P23975; P07949
DB00925	Phenoxybenzamine	approved	4768	-	"For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension."	P0DP24; P0DP25; P0DP23; P18825; P56817; P62158; P25100; P18089; Q9NY46; P08913; B4DJ51; P35498; Q99250; P35368; P07550; P35348
DB00922	Levosimendan	investigational; approved	3033825	-	"For short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease."	P45379; Q14432; P19429; Q14654; Q13370; Q6FGX2; Q15842; P63316
DB00923	Ceforanide	approved	43507	-	"For the treatment of infections caused by susceptible organisms."	P24228; P53779; P02918; P02919; P0AD68; P0AEB2; P0AD65; P08506
DB00920	Ketotifen	approved	3827	-	"Indicated as an add-on or prophylactic oral medication in the chronic treatment of mild atopic asthmatic children. Also used as self-medication for the temporary relief of itching of the eye due to allergic conjunctivitis (ophthalmic)."	P08172; P08173; P52209; P28223; P11229; P25100; P20309; P28335; P25021; P08912; P41595; Q99705; P21728; P08913; P18089; P35462; P08908; P35367
DB00921	Buprenorphine	illicit; investigational; approved; vet_approved	644073	-	"For the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence."	P41145; P35372; Q12809; P41146; P41143
DB00140	Riboflavin	vet_approved; investigational; approved; nutraceutical	493570	-	"For the treatment of ariboflavinosis (vitamin B2 deficiency)."	P0AFU8; P30043; Q969G6
DB00141	N-Acetylglucosamine	investigational; approved; nutraceutical	1738118	-	"For the treatment and prevention of osteoarthritis, by itself or in combination with chondroitin sulfate."	O60909; P51606; P15291; O60512; O60513; Q9UK23; Q9UJ70; P54802
DB00142	Glutamic Acid	approved; nutraceutical	33032	-	"Considered to be nature's \"Brain food\" by improving mental capacities, helps speed the healing of ulcers, gives a \"lift\" from fatigue, helps control alcoholism, schizophrenia and the craving for sugar."	O43424; P07814; Q14831; Q5TDP6; P24298; Q05932; O15382; Q05329; P80404; Q9UPY5; P48507; P48506; O00222; O14841; Q12879; Q9H1K4; P54886; P08243; Q99259; Q8N5Z0; Q5JPH6; O15399; Q13255; Q04609; Q9Y646; P15104; P48664; P48058; Q6IA69; A4D0W4; P49915; Q6YP21; Q8N159; O94925; Q05586; Q13003; Q13002; Q9UDR5; O00341; P00390; P49448; Q07075; O95954; O60391; Q8TD30; P39086; Q9ULK0; Q9UI32; Q14957; O15067; Q14833; P17735; P38435; P17174; Q9ULA0; P43003; P54687; P00367; Q13224; P00505; Q16478; Q8TCU5; P43005; Q16099; Q9H936; P43004; Q9Y617; O75879; P42261; P42262; P42263
DB00143	Glutathione	investigational; approved; nutraceutical	124886	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	Q7RTV2; Q9H4Y5; O95881; Q6FII1; P30711; P09488; Q04760; P15121; P09211; Q16873; Q9Y2Q3; O75715; P22352; P00390; O60760; Q8TED1; Q16772; O14880; P28161; Q16775; O15217; P35754; P46439; P78417; P10768; P10620; P36969; P08684; Q96SL4; P48637; P19440; P14780; P59796; Q6FGJ9; P18283; P21266; P07203; Q99735; Q03013; Q9NS18; O43708
DB00144	Phosphatidyl serine	investigational; approved; nutraceutical	6323481	-	"Phosphatidylserine has demonstrated some usefulness in treating cognitive impairment, including Alzheimer's disease, age-associated memory impairment and some non-Alzheimer's dementias. More research is needed before phosphatidylserine can be indicated for immune enhancement or for reduction of exercise stress."	P49619; Q9UG56; P17252; Q8WTV0; Q9NXE4; Q9NY59; P48651; Q9Y2Q0; Q9BVG9; Q16760
DB00145	Glycine	vet_approved; approved; nutraceutical	750	-	"Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities."	P34896; P34897; Q969I6; Q14957; Q6IB77; Q9H598; V9HW60; P21549; Q7Z2H8; Q14032; Q14749; Q9P0Z9; O75600; Q8WU03; P48167; O75311; P48637; P41250; Q9BYV1; P22557; P48067; P23416; Q9Y345; Q14330; P23415; P23434; P23378; Q969I3; O60391; Q13224; Q12879; Q5T6X5; Q8TCU4; P50440; P13196
DB00928	Azacitidine	investigational; approved	9444	-	"For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia."	Q9Y6K1; P26358
DB00929	Misoprostol	approved	5282381	-	"Indicated for the treatment of ulceration (duodenal, gastric and NSAID induced) and prophylaxis for NSAID induced ulceration.
 Misoprostol is also indicated for other uses that are not approved in Canada, including the medical termination of an intrauterine pregnancy used alone or in combination with methotrexate,as well as the induction of labour in a selected population of pregnant women with unfavourable cervices. This indication is avoided in women with prior uterine surgery or cesarean surgery due to an increased risk of possible uterine rupture. Misoprostol is also used for the prevention or treatment of serious postpartum hemorrhage."	P43119; P43088; P43115; P35408; P43116
DB13139	Levosalbutamol	investigational; approved	123600	-	"Levosalbutamol's bronchodilator properties give it indications in treatment of COPD (chronic obstructive pulmonary disease, also known as chronic obstructive lung disease) and asthma."	P07550
DB04794	Bifonazole	investigational; approved	2378	-	"Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis)."	P20813; P10613; P05093
DB04796	Inecalcitol	investigational; experimental	6915835	-	"Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism."	P11473
DB09552	Thonzonium	approved	5456	-	"Used as a monocationic surfactant and detergent to help penetration of active ingredients through cellular debris for its antibacterial action."	P21283
DB09555	Dexchlorpheniramine maleate	approved	5281070	-	"Dexchlorpheniramine can be used in the treatment of perennial and seasonal allergic rhinitis, vasomotor rhiniti, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, and dermographism."	P35367
DB00812	Phenylbutazone	approved; vet_approved	4781	-	"For the treatment of backache and ankylosing spondylitis"	P23786; P35354; Q16647; P23219
DB00813	Fentanyl	illicit; investigational; approved; vet_approved	3345	-	"For the treatment of cancer patients with severe pain that breaks through their regular narcotic therapy."	P21397; P41145; P41143; Q12809; P27338; P35372
DB00810	Biperiden	investigational; approved	2381	-	"For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy."	P08172; P08173; P11229; Q15822; P08912; P20309
DB00811	Ribavirin	approved	37542	-	"Indicated for the treatment of chronic Hepatitis C virus (HCV) infection in combination with other antiviral agents with the intent to cure or achieve a sustained virologic response (SVR). Typically added to improve SVR and reduce relapse rates [A19644].
 
 The addition of ribavirin in Technivie therapy indicated for treating HCV genotype 1a and 4 infections is recommended in patients with or without cirrhosis. 
 
 Resistance: viral genetic determinants resulting in variable response to ribavirin therapy has not been yet determined. "	P12268; P20839; P12823; P22413; P49902; P11387; P16502; P26676
DB00816	Orciprenaline	approved	4086	-	"For the treatment of bronchospasm, chronic bronchitis, asthma, and emphysema."	P07550
DB00817	Rosoxacin	investigational; approved	287180	-	"For the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients."	P0AES6; P0AFI2; Q02880
DB00814	Meloxicam	approved; vet_approved	54677470	-	"For symptomatic treatment of arthritis and osteoarthritis."	P23786; P35354; P23219
DB00815	Sodium lauryl sulfate	approved	3423265	-	"SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use."	Q9NTG7; P02768; Q8IXJ6; Q96EB6
DB00974	Edetic Acid	approved; vet_approved	6049	-	"For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults."	Q16739
DB00818	Propofol	investigational; approved; vet_approved	4943	-	"Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus. "	O00519; Q99250; P47869; P34903; P23975; P78334; P18507; P18505; Q16445; P28335; P41595; Q8N1C3; P14867; P35499; O00591; P23219; P00918; Q9UN88; P28472; P25025; P25024; O14764; P48169; P00915; P47870; P31644; Q99928
DB00819	Acetazolamide	approved; vet_approved	1986	-	"For adjunctive treatment of: edema due to congestive heart failure, drug-induced edema, centrencephalic epilepsies, chronic simple (open-angle) glaucoma"	P00918; P22748; Q9Y2D0; P43166; P23280; Q9ULX7; P00915; Q16790; O43570; P35218; Q8N1Q1; P07451; P29972
DB06795	Mafenide	approved; vet_approved	3998	-	"Mafenide is indicated in the treatment of severe burns."	P00918; P22748; P0AC13; P43166; P23280; Q9ULX7; P00915; P11413; Q16790; O43570; P35218; Q9Y2D0
DB01132	Pioglitazone	investigational; approved	4829	-	"Pioglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [FDA Label]."	P00918; P21397; P27338; Q07869; P37231; Q03181; Q9HCF6
DB04869	Olcegepant	investigational	6918509	-	"For the treatment of migraine headaches."	Q16602; P01258; P06881; Q03519
DB04868	Nilotinib	investigational; approved	644241	-	"For the potential treatment of various leukemias, including chronic myeloid leukemia (CML)."	P21802; P43166; P23280; P08631; P07947; Q16790; Q16832; P35218; P00519; P07948; P07949; P29317; Q9Y2D0; P07333; P16234; P06213; P11362; P06239; P22309; P09619; Q08345; P12931; O43570; Q02763; P36888; P07451; P35228; P10721; P00918; P22748; P11274; P42684; O60674; Q9ULX7; P00915; P04049; P15056; P06241
DB01133	Tiludronic acid	investigational; approved; vet_approved	60937	-	"For treatment of Paget's disease of bone (osteitis deformans)."	P18031; P08253; P38606; P22894
DB04863	Lefradafiban	investigational	9576916	-	"For the treatment of unstable angina."	P08514; P05106
DB04862	Merimepodib	investigational	153241	-	"For the treatment of hepatitis C virus (HCV) infection."	P0C0H6
DB04861	Nebivolol	investigational; approved	71301	-	"For the treatment of essential hypertension."	P10635; P07550; P08588; P08908
DB04860	Isatoribine	investigational	72231	-	"For the treatment of Hepatitis C."	Q9NYK1
DB04867	Lintitript	investigational	122077	-	"For the treatment of pancreatic cancer and appetite disorders."	P32238
DB04866	Halofuginone	investigational; vet_approved	456390	-	"For the treatment of scleroderma, cancer, and restenosis."	P08253; P02452
DB04865	Omacetaxine mepesuccinate	investigational; approved	285033	-	"Used in patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML.  
 
 "	P39023; P20276
DB04864	Huperzine A	investigational; approved	854026	-	"For the treatment of Alzheimer's disease."	P22303
DB03147	Flavin adenine dinucleotide	approved	643975	-	"Used to treat eye diseases caused by vitamin B2 deficiency, such as keratitis and blepharitis."	P21397; P09063; Q9WYT0; P42593; P10902; P20586; P37747; P00914; Q6GSK2; P40859; P18925; P16640; Q56839; P05327; Q15067; Q16795; P61432; P06715; Q94655; P09622; P9WIQ3; Q9Z4P0; P15559; P38038; P55792; P00438; P16435; P00387; P58558; P24232; P08373; P0C278; Q06319; P16219; P77967; P0A9P4; P83223; P28593; Q92947; O95831; Q888A4; P21890; Q9UHQ9; P14920; P00390; Q12882; O31616; Q16881; P37062; P37063; Q47PU3; P12676; P22570; P19480; P9WHH7; P22637; P06149; P09546; P47989; Q9RC23; P14218; Q9AGP8; P55789; P28861; P16083; Q44532; P11310; P0AEZ1; Q9UKU7; Q96RQ9; P07771; P9WIQ1; P29475; P39662; P09788; P61497; Q86YB8; P26440; P35340
DB06429	Talnetant	investigational	133090	-	"Investigated for use/treatment in schizophrenia and schizoaffective disorders, irritable bowel syndrome (IBS), and chronic obstructive pulmonary disease (COPD)."	P29371
DB00403	Ceruletide	approved	16129675	-	"Caerulein stimulates gastric, biliary, and pancreatic secretion, and certain smooth muscle. As such, it is used in paralytic ileus and as diagnostic aid in pancreatic malfunction."	P32238; P32239
DB00402	Eszopiclone	investigational; approved	969472	-	"For the treatment of insomnia"	Q9UN88; P30536; P18507; P18505; O00591; Q16445; O14764; P48169; P47870; Q8N1C3; P47869; P14867; P28472; P31644; P34903; Q99928; P78334
DB00661	Verapamil	approved	2520	-	"For the treatment of hypertension, angina, and cluster headache prophylaxis."	Q7RTT9; P25021; P35368; Q06432; Q14654; P35462; O60840; Q9Y3Q4; Q14524; O95180; Q16322; Q12809; Q08289; P35348; Q9P0X4; P08913; Q96RP8; Q9ULQ1; O43497; Q01668; P28223; Q99250; Q96PR1; P28335; P41595; Q8NHX9; Q02641; O00305; Q8IZF0; P31645; Q9NY46; P54284; P22001; O00555; P00915; P25100; Q00975; Q13936; P08908; Q13698; P08684; P35498
DB08808	Bupranolol	approved	2475	-	"Used to manage hypertension and tachycardia. Also used to treat glaucoma."	P07550; P08588; P13945
DB05838	OPC-51803	investigational	3038506	-	"Investigated for use/treatment in nocturia (frequent nighttime urination) and urinary incontinence."	P37288; P30518
DB04983	Denufosol	investigational	9875516	-	"For use as an inhaled treatment for cystic fibrosis."	P51582; P41231
DB08804	Nandrolone decanoate	illicit; approved	9677	-	"For the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema."	P10275
DB08807	Bopindolol	approved	44112	-	"For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation."	P10635; P28222; P28223; P41595; P08588; P08908; P07550; P13945
DB08806	Roxatidine acetate	investigational; approved	5105	-	"For the treatment of disorders of the upper gastro-intestinal region that are due to an excess of hydrochloric acid in the gastric juice, i.e. duodenal ulcers, benign gastric ulcers. Also for prophylaxis of recurrent gastric and duodenal ulcers"	P25021
DB05521	Telaprevir	approved; withdrawn	3010818	-	"Telaprevir, when used in combination with [DB00811], [DB00008], and [DB00022] is indicated for use in the treatment of chronic HCV genotype 1 infection in adults [FDA Label]."	P10619; O94956; Q9Y6L6; Q8IZI9; Q9UNI1; P00747
DB08800	Chloropyramine	approved	25295	-	"For the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions."	P35367
DB08802	Isothipendyl	approved	3781	-	"For the topical treatment of itching associated with allergic reactions."	P35367; P32239
DB06335	Saxagliptin	approved	11243969	-	"Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy. "	P08684; P27487
DB02300	Calcipotriol	approved	5288783	-	"For the treatment of moderate plaque psoriasis in adults."	P11473
DB00665	Nilutamide	investigational; approved	4493	-	"For use in combination with surgical castration for the treatment of metastatic prostate cancer involving distant lymph nodes, bone, or visceral organs (Stage D2)."	P10275
DB03783	Phenacetin	withdrawn	4754	-	"Used principally as an analgesic."	P23219
DB04891	Becocalcidiol	investigational	5289547	-	"For topical treatment of psoriasis and psoriatic disorders."	Q15648; P11473
DB00885	Pemirolast	investigational; approved	57697	-	"For the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis"	P35367
DB00884	Risedronate	investigational; approved	5245	-	"For the treatment of Paget's disease of the bone (osteitis deformans), postmenopausal and glucocorticoid-induced osteoporosis"	P14324
DB05786	Irofulven	investigational	148189	-	"Investigated for use/treatment in brain cancer, breast cancer, endometrial cancer, liver cancer, lung cancer, ovarian cancer, pancreatic cancer, pediatric indications, prostate cancer, and sarcoma."	Q96AE4
DB05239	Cobimetinib	investigational; approved	16222096	-	"For the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation. Cobimetinib is used in combination with vemurafenib, a BRAF inhibitor."	O14733; P15056; Q02750; P36507
DB09223	Blonanserin	investigational; approved	125564	-	"Used for the treatment of schizophrenia [L1097]."	Q99720; P28223; P35348; P14416; P35462
DB09220	Nicorandil	investigational; approved	47528	-	"Indicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes. "	P16066; O60706; Q14654
DB09221	Polaprezinc	investigational; approved	6918055	-	"Peptic ulcer disease, dyspepsia [L1308]."	P01138; P08238; P05231; P09619; P17948; P08700; K9JA46; P01375; P07900
DB02546	Vorinostat	investigational; approved	5311	-	"For the treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies."	O75376; Q9UBN7; Q96DB2; Q9Y618; Q9BY41; P56524; Q969S8; Q13547; Q6IT96; Q92769; Q9UKV0; Q8WUI4; Q9UQL6; O15379
DB09227	Barnidipine	approved	443869	-	"Indicated for the treatment of mild to moderate essential hypertension and management of chronic stable angina."	Q01668; Q13936
DB09224	Melperone	investigational; approved	15387	-	"For the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states [L1317, L1319, L1322].  "	P08172; P08173; P28223; P14416; P10635; Q12809; P28221; P08913; P35462; P08908; P35367; P28335; P35348
DB09225	Zotepine	investigational; approved; withdrawn	5736	-	"Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes when discussion with the patient is not possible. Zotepine, as an atypical antipsychotic, is used in patients who are suffering unacceptable side effects from conventional antipsychotics or in relapse patients that were inadequately controlled.[T108] 
 
 It is important to consider that the indications stated above are related to atypical antipsychotics, that zotepine is not currently FDA, Canada or EMA approved and that studies have not shown any additional benefit when compared with other approved atypical antipsychotics.[A31857]
 
 Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels and behaves. It is usually marked for a loose reality perspective delineated by hallucinations, delusions and thought and movement disorders.[L1320]"	P18825; P28221; P28222; P28223; Q01959; P08913; P35462; P46098; P28566; P11229; P34969; P08912; P21728; P08588; P14416; P23975; P35368; P08172; P08173; P28335; P18089; P21918; P31645; P35367; P35348; P21917; P25021; P50406; P20309; P08908; P07550; P01011
DB11359	Guaiacol	approved	460	-	"It is used medicinally as an expectorant, antiseptic, and local anesthetic. Guaiacol is used in traditional dental pulp sedation, and has the property of inducing cell proliferation, guaiacol is a potent scavenger of reactive oxygen radicals and its radical scavenging activity may be associated with its effect on cell proliferation. "	P00918; P02768; P00915
DB09229	Aranidipine	investigational; approved	2225	-	"Aranidipine has been used for many years to treat angina pectoris and hypertension.[A31895]"	Q13698; O60840; Q01668; Q13936; P18825
DB05234	LGD2941	investigational	16750192	-	"For the treatment and prevention of osteoporosis."	P10275
DB12831	Gabexate	investigational	3447	-	"No approved indication."	P00734; P00747; P03952; Q15661; P20231
DB13952	Estradiol acetate	investigational; approved; vet_approved	9818306	-	"Femring is indicated for the treatment of vasomotor and urogenital symptoms associated with menopause. Use of Femring (estradiol acetate) has been shown to improve symptoms caused by atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria)."	Q15596; Q14457; Q92731; Q99527; P03372; P62508; O75469; P00846; P43681; P37059
DB05659	faropenem medoxomil	investigational	6918218	-	"Investigated for use/treatment in bacterial infection, bronchitis, otitis media, and pediatric indications."	Q04707; P0A3M5; P0AD69
DB09142	Sincalide	approved	9833444	-	"As the product Kinevac (FDA), sincalide is used for the following indications: 1) to stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals, (2) to stimulate pancreatic secretion (especially in conjunction with secretin) prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology, (3) to accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract."	P32238; P32239
DB00901	Bitolterol	withdrawn	35330	-	"Used to dilate air passages in the lungs that have become narrowed as a result of disease or inflammation. It is used in the treatment of asthma and chronic obstructive pulmonary disease (COPD)."	P07550
DB09031	Miltefosine	investigational; approved	3599	-	"For the treatment of mucosal (caused by Leishmania braziliensis), cutaneous (caused by L. braziliensis, L. guyanensis, and L. panamensis), and visceral leishmaniasis (caused by L. donovani). In comparing Leishmania drug susceptibility, it has been found that L. donovani is the most susceptible to miltefosine while L. major is the least susceptible.  Off-label use includes treatment of free-living amebae (FLA) infections (unlabeled use, CDC, 2013). "	P04054; P08183
DB09030	Vorapaxar	approved	10077130	-	"Vorapaxar is indicated for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or peripheral arterial disease (PAD). It is usually co-administered with acetylsalicylic acid (ASA) and/or clopidogrel, and should therefore be administered as an addition to these medications as it has not been studied alone. "	O00254; P25116; Q96RI0
DB09034	Suvorexant	investigational; approved	24965990	-	"Suvorexant is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance."	O43614; O43613
DB09039	Eliglustat	approved	23652731	-	"Eliglustat is indicated for the long-term treatment of type 1 Gaucher disease in patients who are CYP2D6 extensive metabolizers (EMs), intermediate metabolizers (IMs), or poor metabolizers (PMs) in treatment-naive and treatment-experienced adult patients. "	P10635; Q16739
DB09038	Empagliflozin	approved	11949646	-	"Empagliflozin is indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes."	P13866; P31639
DB01200	Bromocriptine	investigational; approved	31101	-	"For the treatment of galactorrhea due to hyperprolactinemia, prolactin-dependent menstrual disorders and infertility, prolactin-secreting adenomas, prolactin-dependent male hypogonadism, as adjunct therapy to surgery or radiotherapy for acromegaly or as monotherapy is special cases, as monotherapy in early Parksinsonian Syndrome or as an adjunct with levodopa in advanced cases with motor complications. Bromocriptine has also been used off-label to treat restless legs syndrome and neuroleptic malignant syndrome."	P18825; P28221; P28222; P28223; P08913; P35462; P34969; P21728; P08588; P14416; P28335; P18089; P21918; P08684; P41595; P35368; P35348; P21917; P25100; P50406; P08908; P07550
DB01201	Rifapentine	investigational; approved	6323497	-	"For the treatment of pulmonary tuberculosis."	B5QTY1; B4T9Z3; B1X982; Q0TCG6; A7ZSI4; P0A7Z9; C4ZXP1; Q5PK10; B7NEV3; A7MQB3; B7NQ13; A1AGI6; P0A7Z4; P0A7Z5; P0A7Z6; Q329K7; A8A6B1; A8ARN6; P0A7Z8; A8AQJ0; B1IYV1; P0A8T7; Q1R637; A9MKM3; A1AHI0; P0A7Z7; B7MFL0; P0A800; P0A8V2; A9MVP7; P9WGY7; B1LK86; B7UM71; Q5PC39; B6I3M8; A6TFP8; Q1R4U2; Q57I91; B7M4D4; B5BI24; Q0TBG0; B5XTE8; B5FM73; P0A801; B7N2X2; A8A5A0; B4U000; B7L773; B7LVL1; P0A804; B5EY10; B4SXF1; P0A803; P0A802; B5RG73; C0Q1Y1; A7ZTK1; B5YWE9
DB05013	Ingenol Mebutate	approved	6918670	-	"For the topical treatment of actinic keratosis."	Q04759; Q05513; P24723; P17252; Q05655; Q16512; Q16513; P05129; P05771; Q02156; P41743
DB01203	Nadolol	approved	39147	-	"Used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension."	P07550; P08588; P13945
DB05015	Belinostat	investigational; approved	6918638	-	"Belinostat is indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL) with manageable safety profile. It is a potential alternative therapy for patients who did not experience adequate response to first-line drugs for PTCL. It can be used in patients with baseline thrombocytopenia [A19161]. "	Q969S8; Q9UQL6; Q96DB2; P22309; O15379; Q9BY41; Q13547; Q6IT96; Q92769; Q9UKV0; Q8WUI4; Q9UBN7; P56524
DB01205	Flumazenil	approved	3373	-	"For the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate supportive and symptomatic measures."	Q9UN88; P28472; P18507; P18505; O00591; O14764; P48169; P47870; Q8N1C3; P34903; P14867; P47869; Q16445; Q99928; P31644; P78334
DB01206	Lomustine	investigational; approved	3950	-	"For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin's disease."	Q9H169
DB01207	Ridogrel	approved	5362391	-	"Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction."	P21731; P24557
DB01208	Sparfloxacin	investigational; approved	60464	-	"For the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by <i>Chlamydia pneumoniae</i>, <i>Haemophilus influenzae</i>, <i>Haemophilus parainfluenzae</i>, <i>Moraxella catarrhalis</i>, <i>Mycoplasma pneumoniae</i>, or <i>Streptococcus pneumoniae</i>) and acute bacterial exacerbations of chronic bronchitis (caused by <i>Chlamydia pneumoniae</i>, <i>Enterobacter cloacae</i>, <i>Haemophilus influenzae</i>, <i>Haemophilus parainfluenzae</i>, <i>Klebsiella pneumoniae</i>, <i>Moraxella catarrhalis</i>, <i>Staphylococcus aureus</i>, or <i>Streptococcus pneumoniae</i>)."	P11388; P0AFI2; Q12809; P0AES4; P0AES6; P42345; Q02880; P43700; P43702; P20083
DB01209	Dezocine	investigational; approved	3033053	-	"Indicated in the treatment of moderate to severe pain."	P41145; P35372
DB00940	Methantheline	investigational; approved	4097	-	"For the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children."	P08172; P08173; P11229; P25021; P08912; P20309
DB12742	Amuvatinib	investigational	11282283	-	"Amuvatinib is a selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of c-KIT, PDGFR and FLT3. Amuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA repair in cancer cells."	Q06609; P09619; P16234; P10721; P08581; P36888; P07949
DB01028	Methoxyflurane	investigational; approved; vet_approved	4116	-	"For use in the induction and maintenance of general anesthesia"	P98194; Q09470; P47869; P34903; P78334; P18507; P18505; Q8N1C3; P14867; P28472; O00591; Q9UN88; P48167; P23415; P30049; O14764; P48169; Q16445; P47870; P31644; P03886; Q99928; P42261
DB01029	Irbesartan	investigational; approved	3749	-	"For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (&gt,300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of congestive heart failure."	Q14973; P05412; P30556; P25101
DB01020	Isosorbide Mononitrate	approved	27661	-	"For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction."	P16066; O75343; Q02153; P33402; Q02108; P29400
DB01021	Trichlormethiazide	approved; vet_approved	5560	-	"Used in the treatment of oedema (including that associated with heart failure) and hypertension."	P00918; P22748; Q9Y2D0; P43166; P05023; Q9ULX7; P23280; Q13621; P00915; P55017; Q16790; Q9Y2T6; O43570; P35218; Q12791
DB01022	Phylloquinone	investigational; approved	5284607	-	"For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia."	P38435; P02818
DB01023	Felodipine	investigational; approved	3333	-	"For the treatment of mild to moderate essential hypertension. "	P02585; Q03426; Q01064; P62158; Q99250; O60840; Q99788; O95180; B2RDU6; Q08289; P63316; P13569; B4DJ51; Q01668; P0DP24; P0DP25; P54750; P08235; P0DP23; Q96RI1; P35498; Q9NY47; Q9NY46; P54289; Q13936; Q13698
DB01024	Mycophenolic acid	approved	446541	-	"For the prophylaxis of organ rejection in patients receiving allogeneic renal transplants, administered in combination with cyclosporine and corticosteroids."	P20839; P12268; P00492
DB01025	Amlexanox	investigational; approved	2161	-	"Used as a paste in the mouth to treat aphthous ulcers (canker sores). "	Q14164; P08700; Q9UHD2; P05230; Q08493; P27815; P80511; Q07343; Q99584; Q08499
DB01026	Ketoconazole	investigational; approved	3823	-	"For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis."	P08172; P10613; Q12809; Q16322; P41143; P05093; P23975; P25021; Q01959; P25100; P18089; P10275; P08913; P08684; Q14994; P08686; P31645; O75469; P15538; P11511
DB00243	Ranolazine	investigational; approved	56959	-	"For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates."	Q9Y5Y9; P35499; Q14524; Q15858; Q12809
DB09149	Florbetapir (18F)	investigational; approved	24822371	-	"Florbetapir 18F is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate ?-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline."	P05067
DB00714	Apomorphine	investigational; approved	6005	-	"For the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease."	P28335; P14416; P21917; P18825; P28221; P28222; P28223; P25100; P18089; P21918; P21728; P08913; P41595; P35462; P08908; O75762; Q9NYX4; P35348; P35368
DB09147	Ferric pyrophosphate	experimental	24877	-	"Ferric pyrophosphate is intended to be indicated for the treatment of iron loss or iron deficiency as a formulation with a milder gastrointestinal effect.[L1423, L1433] 
 
 Iron deficiency appears when the dietary intake does not meet the body's requirement or when there is chronic external blood loss. During acute blood loss, body iron stores are sufficient for accelerated erythropoiesis and restoration of iron homeostasis. But when the altered homeostasis remains for weeks to months then some supplement is needed. Some causes of iron deficiency include ectoparasitism, endoparasitism, hematuria, epistaxis, hemorrhagic skin, coagulopathy, thrombocytopenia, thrombocytopathia and gastrointestinal hemorrhage.[A31984]"	P68871; D1MGQ2; P69905; P02792
DB09146	Iron saccharate	approved	91663255	-	"Iron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency."	D1MGQ2; P69905
DB09143	Sonidegib	investigational; approved	24775005	-	"Sonidegib is approved for use in the US and EU for treatment of adults with locally advanced basal cell carcinoma (BCC) that has recurred post surgery or radiation therapy.  It is also approved for adult patients with BCC who are not eligible for surgery or radiation therapy. (2)"	Q99835
DB00241	Butalbital	illicit; approved	2481	-	"Used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain."	Q9UN88; Q13002; P18507; P18505; O00591; Q99928; Q494W8; P48169; P14867; Q8N1C3; P31644; P47870; P28472; P36544; Q16445; P47869; O14764; P34903; P43681; P42262; P78334
DB11093	Calcium Citrate	approved	13136	-	"For use as an over the counter calcium supplement."	Q02818; P04271; O14958; O75838; P0DP25; P28676; P27797; Q15493; P13693; Q99584; P09486; O75340; P80303; P27824; Q99828; Q96FQ6; B4DJ51; Q9ULB1; P62166; P0DP24; Q99653; Q9UBV8; Q86UW7; P0DP23; P41180; P35556; P06703; P31415; P30626; Q9ULU8; P22676; P62158; Q96L12; Q75N90; Q13938; P58400
DB00240	Alclometasone	approved	5311000	-	"For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses."	P04150; P04083; P08185; Q5TZZ9
DB01338	Pipecuronium	approved	50192	-	"Used as a muscle relaxant during anesthesia and surgical procedures."	P08172; P11230; Q15822; P43681; P02708; P07510; P20309; Q04844; P17787; P30926; Q07001
DB01339	Vecuronium	approved	39765	-	"Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia."	P11230; P02708; P30926; Q15822; P07510; Q04844; P17787; P43681; Q07001
DB01442	MMDA	illicit; experimental	26175	-	"MMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present."	P21397; P27338; P28223; Q01959; Q05940; P54219; P31645; P23975
DB00711	Diethylcarbamazine	investigational; approved; vet_approved	3052	-	"Used for the treatment of individual patients with certain filarial diseases including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with <i>Wuchereria bancrofti</i>, <i>Brugia malayi</i>, or <i>Brugia timori</i>."	P09917; P23219
DB01336	Metocurine	approved	21233	-	"Metocurine is a muscle relaxant."	P08172; Q15822; P11230; P07510; P02708; Q04844; Q07001
DB01337	Pancuronium	approved	441289	-	"Used as a muscle relaxant during anesthesia and surgical procedures."	P08172; P11230; P02708; Q15822; P07510; P20309; Q04844; P17787; P43681; Q07001
DB01330	Cefotetan	approved	53025	-	"For prophylaxis and treatment of bacterial infections."	P24228; P08506; P02918; P02919; P03956; P35354; P21964; P0AD68; P0AEB2; P0AD65
DB01331	Cefoxitin	approved	441199	-	"For the treatment of serious infections caused by susceptible strains microorganisms."	P0AFI5; P0AEB2; P08506; P0A3M6; P02918; P02919; P24228; P0AD68; Q8DR59; P0AD65
DB01332	Ceftizoxime	investigational; approved	6533629	-	"For the treatment of infections due to susceptible strains of microorganisms."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB03849	Cilomilast	investigational	151170	-	"Investigated for use/treatment in chronic obstructive pulmonary disease (COPD)."	Q07343; Q08499; P27815
DB01154	Thiamylal	approved; vet_approved	3032285	-	"Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state."	Q9UN88; P28472; P18507; P18505; O00591; O14764; P48169; Q16445; Q14654; Q8N1C3; Q15842; P14867; P47869; P31644; P34903; Q99928; P47870; P78334
DB00318	Codeine	illicit; approved	5284371	-	"For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant."	P10635; P41145; P35372; P41143
DB01156	Bupropion	approved	444	-	"For the treatment of depression and as aid to smoking cessation."	P32297; P10635; Q01959; P29275; P23975; P31645; P17787; P30926; P35348
DB01157	Trimetrexate	investigational; approved	5583	-	"For use, with concurrent leucovorin administration (leucovorin protection), as an alternative therapy for the treatment of moderate-to-severe <i>Pneumocystis carinii</i> pneumonia (PCP) in immunocompromised patients, including patients with the acquired immunodeficiency syndrome (AIDS). Also used to treat several types of cancer including colon cancer."	P00374; B0YJ76; P16184; P30968
DB01150	Cefprozil	approved	5281006	-	"For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by, S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph"	Q04707; P14677; P0A3M5
DB00713	Oxacillin	investigational; approved	6196	-	"Used in the treatment of resistant staphylococci infections."	P0A3M6; Q9NS75; Q8XJ01; Q9Y271; P35354; Q8DR59; P23219
DB01153	Sertaconazole	investigational; approved	65863	-	"For the topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, and <i>Epidermophyton floccosum</i>."	P10613
DB00311	Ethoxzolamide	withdrawn	3295	-	"For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy."	P00918; P22748; P07451; P43166; P23280; Q9ULX7; P00915; Q16790; O43570; P35218; Q8N1Q1; Q9Y2D0
DB00310	Chlorthalidone	approved	2732	-	"For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension."	P00918; P22748; P51684; Q9Y2D0; P43166; Q9ULX7; P23280; Q13621; P00915; P55017; Q16790; O43570; P35218; P07451
DB00313	Valproic Acid	investigational; approved	3121	-	"For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome."	Q02218; Q07869; P42858; P37231; P80404; Q13547; P54098; Q6IT96; Q92769; P51649; Q9UKV0; P04035; Q03181; P45954; Q8IWT1
DB00312	Pentobarbital	investigational; approved; vet_approved	4737	-	"For the short-term treatment of insomnia."	O14764; P50613; O60391; O75469; P11802; O00591; Q12809; P50750; P47869; Q16445; P78334; Q13002; P18507; P18505; Q00534; Q8N1C3; P14867; P24941; Q9UN88; P28472; Q99928; Q494W8; P48169; P34903; P47870; P36544; P31644; P43681; P42262
DB01158	Bretylium	approved	2431	-	"For use in the prophylaxis and therapy of ventricular fibrillation. Also used in the treatment of life-threatening ventricular arrhythmias, such as ventricular tachycardia, that have failed to respond to adequate doses of a first-line antiarrhythmic agent, such as lidocaine."	P05023; P07550; P08588; P23975
DB01159	Halothane	approved; vet_approved	3562	-	"For the induction and maintenance of general anesthesia"	P08100; P48169; P57789; P32239; P48549; Q12879; Q9NPC2; P98194; P48051; P59768; P18505; P03886; P47869; Q16445; P78334; P18507; P00390; Q7Z418; P30049; P14867; P28472; O15554; O95069; O00591; O14649; Q12791; Q8N1C3; Q9UN88; P48167; P23415; O14764; O60391; Q6W5P4; Q8TCU5; P34903; P47870; P31644; Q9HB14; Q99928
DB00317	Gefitinib	investigational; approved	123631	-	"For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies."	P00533; P00519; P08631; P35968; P12931; P04626; P06239; Q15303; P08581; P36888; P07949; P07948; P10721
DB00316	Acetaminophen	approved	1983	-	"For temporary relief of fever, minor aches, and pains."	P00918; P22748; P07451; P43166; O00519; Q9ULX7; P00915; P21554; P23786; Q16790; P35354; O43570; Q8NER1; P21731; P09211; P23219
DB05395	Amibegron	investigational	3035442	-	"Investigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity."	P13945
DB00799	Tazarotene	investigational; approved	5381	-	"Used to treat psoriasis, acne and sun damaged skin (photodamage)."	P28702; P10276; P10826; P13631
DB00798	Gentamicin	approved; vet_approved	3467	-	"For treatment of serious infections caused by susceptible strains of the following microorganisms: <i>P. aeruginosa</i>, <i>Proteus</i> species (indole-positive and indole-negative), <i>E. coli</i>, <i>Klebsiella-Enterobactor-Serratia</i> species, <i>Citrobacter</i> species and <i>Staphylococcus</i> species (coagulase-positive and coagulase-negative)."	A8A5E9; P08164; B4TKM3; B7UK52; B1IPV7; B5RH07; P0A7S3; Q5PIW1; B4SUU8; A1AGM9; B4TXF0; B7N1C3; B7MCV7; P00374; A7ZSL7; A4WFD5; B7NLP7; C0Q0C4; B7M1P3; P98164; B5F8G0; P0A7S8; B7L4L7; Q32B24; Q1R5U1; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B1LHE2; B0YJ76; B7NDV0; B7LS48; Q57J24; B6I242; B5FJM2; B5BGZ4; B5YTP9; B5R299
DB05494	Elacytarabine	investigational	6438895	-	"Investigated for use/treatment in leukemia (unspecified) and melanoma."	P27707
DB00795	Sulfasalazine	approved	5359476	-	"For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent."	P00918; P04054; O15111; P09917; P37231; O95696; P00915; Q9UPY5; P11413; P35354; Q00653; P24752; P21675; P03956; P23219; O14920; P24557
DB00794	Primidone	approved; vet_approved	4909	-	"For the treatment of epilepsy"	O14764; Q9UQD0; Q99250; Q9Y5Y9; Q14524; P47869; Q16445; Q15858; Q01118; P78334; Q13002; P18507; P18505; Q8N1C3; P14867; Q9UI33; P35498; O00591; Q9NY46; Q9UN88; P28472; Q99928; Q494W8; P48169; P34903; P47870; P36544; P31644; P35499; P43681; P42262
DB00797	Tolazoline	approved; vet_approved	5504	-	"For the treatment of pulmonary artery anomalies"	P18825; Q96RJ0; Q13464; P25021; P25100; P08913; P18089; P35368; P35367; Q15418; P35348
DB00796	Candesartan cilexetil	approved	2540	-	"May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Candesartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors."	P00533; P50052; P18089; P04626; P08684; P23975; P30556; P13945
DB00791	Uracil mustard	approved	6194	-	"Used for its antineoplastic properties."	Q9NS75; Q9Y271
DB00790	Perindopril	approved	107807	-	"For the treatment of mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease. "	Q6FHJ7; P12821
DB00793	Haloprogin	approved; withdrawn	3561	-	"Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor."	P41145; P28223; P18825; P28335; Q01959; P18089; P21728; P08913; P35462; P31645; P23975
DB00792	Tripelennamine	approved; vet_approved	5587	-	"Used for the symptomatic relief of hypersensitivity reactions, coughs, and the common cold."	P35367
DB00944	Demecarium	approved	5966	-	"For the topical treatment of chronic open-angle glaucoma."	P22303; P06276
DB01535	Carfentanil	illicit; investigational; vet_approved	62156	-	"Carfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals."	P41145; P35372; P41143
DB00559	Bosentan	investigational; approved	104865	-	"Used in the treatment of pulmonary arterial hypertension (PAH), to improve exercise ability and to decrease the rate of clinical worsening (in patients with WHO Class III or IV symptoms)."	P24530; P25101
DB00558	Zanamivir	investigational; approved	60855	-	"For the prevention and treatment of influenza A and B."	P03474; P06818; P27907; Q9Y3R4; P03468
DB00557	Hydroxyzine	approved	3658	-	"For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria."	P35367; P10635
DB00555	Lamotrigine	investigational; approved	3878	-	"Indicated as adjunctive therapy for the following seizure types in patients ?2 years of age: partial seizures/primary generalized tonic-clonic seizures/generalized seizures of Lennox-Gastaut syndrome [FDA Label].
 
 Indicated for conversion to monotherapy in adults (?16 years of age) with partial seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single antiepileptic drug (AED)[FDA Label]. 
 
 Indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults (?18 years of age) treated for acute mood episodes with standard therapy [FDA Label]."	Q9UQD0; P28223; P08913; Q99250; P46098; Q14524; Q99720; Q9NY46; P08912; P08588; P14416; P29274; P30542; P41145; Q15878; Q01118; P21918; Q9Y5Y9; P35498; P35367; P35348; Q9UN88; Q15858; P35499; Q9UI33; Q99928; P30968
DB00554	Piroxicam	investigational; approved	54676228	-	"For treatment of osteoarthritis and rheumatoid arthritis."	P23786; P11712; P35354; P23219
DB00553	Methoxsalen	approved	4114	-	"For the treatment of psoriasis and vitiligo"	P21397; P22303
DB00552	Pentostatin	investigational; approved	439693	-	"For the treatment of hairy cell leukaemia refractory to alpha interferon."	P00813
DB00551	Acetohydroxamic Acid	approved	1990	-	"Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections."	P00918; Q03284; P39900; Q8WXD0; P18314; Q03282; Q03283; Q8TDU9; Q9NSD7; Q9HBX9
DB05490	T131	investigational	16145453	-	"Investigated for use/treatment in diabetes mellitus type 2."	P37231
DB00777	Propiomazine	approved	4940	-	"Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia."	P08172; P08173; P28335; P14416; P28223; P21728; P25100; P08912; P20309; P35368; P35367; P35348; P21917; P11229
DB00952	Naratriptan	investigational; approved	4440	-	"For the acute treatment of migraine attacks with or without aura in adults."	P30939; P28566; P28222; P08908; P28221
DB00775	Tirofiban	approved	60947	-	"For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy."	P08514; P17301; P05106
DB00774	Hydroflumethiazide	investigational; approved	3647	-	"Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension."	P00918; P22748; P05023; Q13621; P00915; P55017; Q16790; O43570; Q12791
DB00773	Etoposide	approved	36462	-	"For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme."	P11388; Q02880
DB00772	Malathion	investigational; approved	4004	-	"For patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair."	P48039; P22303; P06276
DB00955	Netilmicin	investigational; approved	441306	-	"For the treatment of bacteremia, septicaemia, respiratory tract infections, skin and soft-tissue infection, burns, wounds, and peri-operative infections caused by susceptible strains."	B5YVV7; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; C4ZUG1; C4ZUG3; B1LHB0; P0A7T7; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A8A5B3; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; B5FHU4; B1IRQ1; P68686; B7US99; P68684; P68685; P68682; P68683; P68680; P68681; B7LRT5; B7LS48; B7LRT1; A1ABQ0; B7LRT3; B7LRT2; A7ZTI7; A7MPH5; B7NLN8; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7NLN4; B1IQP9; B5YSV6; C4ZYY0; B7MTL9; B4TUF3; B7UMH0; B4TKM3; B6I1U8; B5R1G3; A9MVN1; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; A7MPH8; A9MN70; B7M1C4; P60625; P60626; Q1R4N3; A6TE47; B4SXD8; B7NDS9; B1IPL1; B7NDS5; B7NDS7; B5FJK8; B5FJK9; B7N0W8; B1LHB3; B5FJK0; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B7NDH0; C4ZS29; A8A539; B1LE15; B1LQM1; B6I208; B7NJS8; A8ARM4; B5BGY5; Q5PK05; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; P0A7W0; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; A7ZSC4; P0AG55; A7MNZ2; B7N199; B1LE14; A4THT0; B7N198; C4ZSS5; B4T4N1; B7M1L8; C0Q6G0; Q57J46; B1LL30; Q57J43; B5RGF1; P0A7V7; Q57J49; B4TGH4; Q0T9J1; B4TAV0; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; P62400; P62401; B4TGH3; B5QUQ1; P0AG47; B5FN11; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; P0C020; B6I2A8; A9N5Y8; A7ZMI4; A7MPI4; Q6D9D4; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; Q0TCE2; Q0TD41; B7MCV7; B1IPY8; B6I242; B5YTP0; A7FE70; B7NKU2; B5YTP9; Q1R6F0; P0A7L6; P0A7L7; P0A7L4; P0A7L5; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A7ZRU7; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; B1IPY3; P0AG66; P0AG67; B1IPY2; Q0TCN6; Q32B55; Q32B54; B7MCT1; A7ZSK5; B7N1A3; A7ZSK3; A7ZSK0; B7N1A0; B5R285; P0A7K2; Q1R632; Q1R635; B5R280; B7LHP9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; B1X9T1; Q5PKX8; A7ZV73; B7M1P3; B7UK52; B7LK45; B5F7F9; B7L759; B1LHE2; B1LGF2; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; P68679; A8A5A8; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8GJV2; B7MCS1; B5F7T9; A7ZSK6; Q32B57; B5F7T1; B5F7T4; B7NR05; P68919; P0A7S3; B7L6J0; A8AQL3; A8AQL2; B7LH01; A8AQL0; A9MX79; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; A1AGI5; Q329M1; P60422; B1X6G3; B1X6G0; B1X6G1; B1X6G6; B1X6G7; P60424; A6TG05; B7LG22; B5F8G0; B6I225; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; Q32FI2; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; A9MN66; B7NKQ3; B2VCV9; B5R0S0; B5EYX3; A6TAI4; B7UK18; A1AGI8; A1AGI7; B7M1N1; B7N0V1; B7NDK8; B4TKL4; B4TKL0; B5RAX1; P0A7M6; B1XG70; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; Q5PGT9; Q57J53; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; B7LRS0; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; Q1RD68; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; A1AGK6; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; B1LHD1; P0A7T9; A9MKN8; B1LHD0; B7LLY4; B4TXF0; B6I437; B7MCT2; B7NEU0; C4ZUE9; B7NLL7; B7L6I9; P0C018; P0C019; B1LF57; P0A7N4; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B7LCR3; B1XHK3; Q2NWE7; P0A7V5; Q0TCF8; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; Q0TCF5; Q0TCF7; C5BF78; P02413; A9MN54; Q1C365; P60624; B7L4K6; A9MN59; Q5PJ56; P0A7M2; P0A7M9; A1AGJ2; A1AGJ3; B7N0U4; A1AGJ7; A1AGJ5; B1IPY0; B1XHG2; P0ADZ0; B1IPY5; B1IPY4; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B6I229; Q1R609; Q1R358; Q1R604; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; B5R5G0; B4T679; A9N520; B7MJ76; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B1LHD3; B7UPA5; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0AG65; B7NLP7; P0AG44; B7MCR9; A1AGM9; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; Q5PKU5; B7N0L5; B1LGQ0; B7L847; A7ZSK8; B7MCS6; B5YXA7; B7NGD6; B7LRT0; Q0THB3; B4SYA9; Q0THB2; B1X6F1; B7NDR8; A7ZSK4; B7UK28; B7MCT0; B7NPE2; B7ULJ1; B7NT61; B7NT60; B5F8F1; B4T9C1; B7N1A1; B5YRA5; B7LI05; Q32B52; B7LQD9; B5YTM5; B7M092; C0Q0A5; A8AQJ9; A8AQJ8; B5BGY1; B5BGY0; B7UK21; P60438; B5YTM9; P60725; A9MJT9; P60727; B5R286; B5FSA3; P60723; P0A7T8; P0A7K6; B7N2E8; B7L4J5; P61179; P61178; B6I3T6; A7ZTQ9; C4ZUH4; B1LGJ6; P61177; C4ZUH1; P61175; Q32B24; B4TUF2; B6I228; P0AG51; B1IPL2; B5BG21; A4WFC2; Q328J7; B4TKK1; B4TKK4; B7UQL1; B4TFD7; B4TKK9; A8A5C2; Q0TCG7; Q2EEQ2; Q0TBH3; P0ADY3; P0A7R9; P0AG48; P0AG49; P0AG46; P0A7R5; Q1R4V6; P0AG45; P0A7R0; A6THB3; Q1R616; B7N1C3; B1X6F8; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; A8AQC0; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; B7MCT4; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; C4ZUF2; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B7LVJ7; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B5RH21; B1X6H0; A9MFK9; A9MGD1; B5REG7; B5FM60; B5BKL1; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q5PC32; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B1IPZ6; B1IPZ0; B1IPZ1; P0A7N6; B1IPZ3; P0A7N8; P0A7N9; B1X6F6; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; B7LRS7; A7ZSI5; A7ZSI6; B6I218; A8APV6; Q57PV1; Q57PV0; B6I210; B6I211; Q1R610; B7LR53; B5BIL5; Q5PIV7; B5XZP7; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B5YTM7; Q5PIV8; P0A7W7; P0A7W6; P0A7W5; P0A7W4; P0A7W3; B7N192; P0A7W1; B7N190; P0A7W9; P0A7W8; C0Q1W9; B4F277; C4ZR79; A8A5A1; A8A5A2; B7M9G4; P0A7L8; B5FJA5; Q1CME3; B5RFY6; B1IPZ5; A8AQJ1; B5Y306; B7LX23; B4TXD1; B7M1M2; B7M1M3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B5QZ45; P60724; Q57IA6; P0A7N7; B1X6E8; B1X6E9; P0A7S6; P02358; P02359; P60726; P0A7X2; P0A7X3; P0A7X0; P0A7X1; P0A7X4; P0A7X5; B7MBZ1; B1X6G8; A9MPV4; B5F8E7; B1LHC8; B5F3B9; B7NDT5; B7NLL4; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; Q1RB78; A8AQL8; B4T4N0; B5RBB1; B1LK73; B7UJ79; B7UK39; Q57JQ0; B1IPV7; B7MST2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; B1IT04; B4SUT9; A8A501; B2VGJ7; A4WFD5; A9N240; A9N241; P0A7J7; B7NF20; C0Q0C4; B7M1C5; B5R290; C0Q644; C4ZUH0; B7NDT6; P61176; P0A7S9; P0A7S8; P0AG59; C4ZUH2; Q1RB79; P0A7S2; P0A7S1; P0A7S0; P0A7S7; P0AG50; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; Q1R620; B7NDT2; Q1R626; Q1R627; B7NDT7; P0A7J3; B7NDT8; B5R299; P62399
DB00770	Alprostadil	investigational; approved	149351	-	"For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology."	P43119; Q8NEC5; Q86XQ3; Q13258; P34995; Q7RTX7; P43115; P35408; P43116; Q96P56; Q9Y5Y4
DB00959	Methylprednisolone	approved; vet_approved	6741	-	"Adjunctive therapy for short-term administration in rheumatoid arthritis."	P04150; P04083; Q5TZZ9
DB00779	Nalidixic Acid	investigational; approved	4421	-	"For the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of <i>E. Coli</i>, <i>Enterobacter</i> species, <i>Klebsiella</i> species, and <i>Proteus</i> species."	P11413; P0AES4; P0AES6; P41595
DB00778	Roxithromycin	investigational; approved; withdrawn	6915744	-	"Used to treat respiratory tract, urinary and soft tissue infections."	P0A7J6; O43193; P08183
DB05885	Seletracetam	investigational	9942725	-	"Investigated for use/treatment in epilepsy."	Q00975; P48167; Q7L0J3
DB04786	Suramin	investigational; approved	5361	-	"For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms."	P24723; Q92736; Q15077; P21817; P05129; P05771; Q05513; P41743; Q05655; P14555; O94806; P00734; P41231; P17252; P47900; Q9NXA8; Q15139; Q04759; P23945; P05230; Q02156; Q9BPV8; Q96G91; P68638
DB00588	Fluticasone propionate	approved	444036	-	"Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma."	P04150; P06401; P08235; P47712
DB03209	Oteracil	approved	4604	-	"Oteracil is used as an adjunct to antineoplastic therapy. When used within the product Teysuno, oteracil is indicated for the treatment of adults with advanced gastric (stomach) cancer when given in combination with cisplatin."	P11172
DB06255	Incadronic acid	investigational; approved	3699	-	"For the treatment of hypercalcemia associated with malignant disease."	P14324
DB00181	Baclofen	approved	2284	-	"For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity."	O75899; Q9UBS5; P18440
DB00947	Fulvestrant	investigational; approved	17756771	-	"For the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy."	P06401; Q96RI1; P03372; Q92731
DB06258	Bimoclomol	investigational	9576891	-	"Investigated for use/treatment in neuropathy (diabetic) and wounds."	Q00613
DB06788	Histrelin	approved	56927879	-	"As the product Supprelin LA (FDA), histrelin is indicated for the treatment of children with central precocious puberty (CPP). As the product Vantas (FDA), histrelin is indicated for the palliative treatment of advanced prostate cancer. "	P30968
DB06789	Hydroxyprogesterone caproate	investigational; approved	169870	-	"Hydroxyprogesterone caproate is indicated for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth. (1) "	P04150; P06401; Q01959; P51679
DB06781	Difluprednate	approved	443936	-	"For the treatment of inflammation and pain associated with ocular surgery."	P04150
DB06782	Dimercaprol	approved	3080	-	"For the treatment of arsenic, gold and mercury poisoning. Indicated in acute lead poisoning when used concomitantly with edetate calcium disodium (DB00974)."	P05067
DB06785	Ganirelix	approved	16130957	-	"For the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation."	P30968
DB06786	Halcinonide	investigational; approved; withdrawn	443943	-	"Indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. "	P04150; Q99835
DB06787	Hexocyclium	approved	24199	-	"The World Health Organization classifies hexocyclium as a drug for functional gastrointestinal disorders [L876]. Like other anti-muscarinic agents, hexocyclium was likely used to treat peptic ulcers or diarrhea."	P08172; P08173; P08912; P11229; P20309
DB04878	Voglibose	investigational; approved	444020	-	"For the treatment of diabetes. It is specifically used for lowering post-prandial blood glucose levels thereby reducing the risk of macrovascular complications."	P14410; P10253; O43451; Q2M2H8
DB04879	Vatalanib	investigational	151194	-	"Used in combination with first- and second-line chemotherapy for the treatment of metastatic colorectal cancer and non-small cell lung cancer (NSCLC)."	P07333; P35968; P16234; P09619; P35916; P17948; P10721
DB04871	Lorcaserin	approved	11658860	-	"For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity."	P28223; P31645; P28335; P41595
DB00739	Hetacillin	withdrawn; approved; vet_approved	443387	-	"Hetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin."	Q8DR59; P0A3M6
DB04873	Piboserod	investigational	177336	-	"For the treatment of atrial fibrillation and irritable bowel syndrome (IBS)."	P18440; O60674; Q14289; P41595; Q13639
DB04875	Pralnacasan	investigational	153270	-	"For the treatment of rheumatoid arthritis (RA)."	P29466
DB04876	Vildagliptin	investigational; approved	6918537	-	"Used to reduce hyperglycemia in type 2 diabetes mellitus."	P27487
DB04877	Voacamine	investigational; approved	11953931	-	"For the treatment of malaria. Also under investigation for the modulation of multidrug resistance in cancer cells."	P08183
DB00175	Pravastatin	approved	54687	-	"For the treatment of hypercholesterolemia and to reduce the risk of cardiovascular disease. "	P04035; Q9Y6L6
DB00174	L-Asparagine	investigational; approved; nutraceutical	6267	-	"Used for nutritional supplementation, also for treating dietary shortage or imbalance."	P25090; Q15758; Q96I59; O43776; Q7L266; Q99624; P08243
DB00177	Valsartan	investigational; approved	60846	-	"May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors."	P30556
DB00176	Fluvoxamine	investigational; approved	3404	-	"Indicated predominantly for the management of depression and for Obsessive Compulsive Disorder (OCD) [FDA Label]. Has also been used in the management of bulimia nervosa [A250]."	P10635; Q99720; Q12809; Q01959; P31645; P23975
DB00171	ATP	investigational; nutraceutical	5957	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	P51582; P31749; Q9UM73; Q15413; Q92736; O95342; O43681; B0LPE5; P12235; O60706; P45844; P00966; P33527; Q8TD43; P08243; Q13131; P53041; P00519; P42684; Q08828; P35626; Q13564; P08183; O15439; Q9NUB1; P37023; P13569; P21817; Q16671; O95477; P68400; P51575; Q96QT4; P41231; P42336; P47900; Q99572; Q04771; O14727; O95255; Q96Q40; P33121; Q9H244; P67870; P25098; Q09428; Q07912; P10398; Q9Y4W6; P36896; Q13304; Q9BPV8; P49902; Q9NR19; Q96G91; Q92887
DB00170	Menadione	approved; nutraceutical	4055	-	"The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification."	P00734; P38435; P00390; P27338; P22891; P15559; P16083; Q9BQB6; P04070; Q06278; P08709; P00740; P07225; P00742; Q8N0U8; P02818; P21397
DB00173	Adenine	approved; nutraceutical	190	-	"For nutritional supplementation, also for treating dietary shortage or imbalance"	P17802; O00763; Q9BY49; P78362; Q5SL87; P07741; P24666; P0AF12; Q05603; Q13126; P47989
DB00172	L-Proline	approved; nutraceutical	145742	-	"L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles."	P23284; O43447; Q7L3T8; Q53H96; P62937; Q32P28; O15460; P30405; Q9UN76; P13674; P07814; O94903; P45877; Q8IVL5; Q8IVL6; V9HWF5; Q13427; P12821; Q99884; P32322; Q96C36; Q96EM0
DB00179	Masoprocol	investigational; approved	71398	-	"Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated)."	P09917; P08069; P04278; P02766; P10275; P03372; P11511
DB00178	Ramipril	approved	5362129	-	"For the management of mild to severe hypertension. May be used to reduce cardiovascular mortality following myocardial infarction in hemodynamically stable individuals who develop clinical signs of congestive heart failure within a few days following myocardial infarction. To reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular events. May be used to slow the progression of renal disease in individuals with hypertension, diabetes mellitus and microalubinuria or overt nephropathy.   "	P12821; P46663
DB06654	Safinamide	investigational; approved	131682	-	"Safinamide is indicated as an add-on treatment to levodopa with or without other medicines for Parkinson?s disease"	P21397; Q01118; Q14524; P53350; P54284; Q15858; Q9UQD0; P27338; P54289; Q00975; Q9UI33; P35498; Q99250; P35499; Q9NY47; Q9NY46; O00305
DB06433	Tezacitabine	investigational	6435808	-	"Investigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer."	Q7LG56; P31350; P23921
DB06436	Semaxanib	investigational	5329098	-	"Investigated for use/treatment in colorectal cancer and lung cancer."	P09619; P17948; P35968; P35916; P15692; P10721
DB00589	Lisuride	investigational; approved	28864	-	"For the management of Parkinson's Disease"	P18825; P10635; P28222; P28223; P08913; P35462; P34969; P21728; P08588; P14416; P28221; P28335; P41595; P21918; P18089; P35368; P35367; P35348; P21917; P25021; P25100; P50406; P08908; P07550
DB06791	Lanreotide	approved	71349	-	"Lanreotide is a somatostatin analog approved for treatment of neuroendocrine tumours and acromegaly. (2)"	P30874; P32745; P35346; P30872; P31391
DB00580	Valdecoxib	investigational; approved; withdrawn	119607	-	"For the treatment of osteoarthritis and dysmenorrhoea"	P00918; P22748; Q16790; Q9Y2D0; P43166; P23280; Q9ULX7; P00915; P41595; P23786; P35354; O43570; P35218; Q8N1Q1; P23975; P23219; P07451
DB08818	Hyaluronic acid	approved; vet_approved	24759	-	"Used to treat knee pain in patients with joint inflammation (osteoarthritis). It is usually used in patients who have not responded to other treatments such as acetaminophen, exercise, or physical therapy. Hyaluronic acid may also be used in plastic surgery to reduce wrinkles on the face or as a filler in other parts of the body. May be used in ophthalmology to assist in the extraction of cataracts, the implantation of intraocular lenses, corneal transplants, glaucoma filtration, retinal attachment and in the treatment of dry eyes. Finally, hyaluronic acid is also used to coat the bladder lining in treating interstitial cystitis."	P10915; Q9BZV3; P05362; P98066; O75330; Q6UX15; Q86UW8; Q5JVS0; O14594; Q07021; Q8WWQ8; P16070; Q14520; Q96S86; P13611
DB01436	Alfacalcidol	approved; nutraceutical	5282181	-	"Alfacalcidol is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism."	P19793; P23975; O15528; P11473
DB05824	CNS-5161	investigational	192711	-	"Investigated for use/treatment in migraine and cluster headaches, neuropathy (diabetic), and pain (acute or chronic)."	Q05586; O15399; O60391; Q13224; Q12879; Q8TCU5; Q14957
DB08810	Cinitapride	investigational; approved	68867	-	"For the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying."	P28223; Q13639; P08908
DB08811	Tofisopam	approved	5502	-	"For the treatment of anxiety and alcohol withdrawal."	O00408; Q14432; P27815; Q9Y233
DB08816	Ticagrelor	approved	9871419	-	"For the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation."	P33261; Q99808; Q9H244
DB08814	Triflusal	investigational; approved	9458	-	"Triflusal is indicated as prophylaxis of thromboembolic disorders.[L1185] It has been registered in Spain and in other countries of Europe, South America and South Korea for the prevention of Stroke and myocardial infarction.[T93]"	P19838; Q96RI0; P23219; P35228; Q9Y233
DB08815	Lurasidone	investigational; approved	213046	-	"Treatment of schizophrenia. "	P34969; P18825; P28223; P08913; P14416; P08908; P01011
DB01501	Difenoxin	illicit; approved	34328	-	"Motofen(R) is a combination of atropine, an anticholinergic drug, and difenoxin, an antidiarrheal drug. It has been used in many countries for many years as a second line opioid-agonist antidiarrheal, which exists an intermediate between loperamide and paragoric. [2]
 
 Diarrhea which is a result of cyclic or diarrhea predominant Inflammatory Bowel Syndrome may not be treated effectively with difenoxin, diphenoxylate, or loperamide. As such, diarrhea and cramping which does not respond to non-centrally acting derivatives or belladonna derivatives such as atropine are often treated with conservative doses of codeine. In patients with acute ulcerative colitis, as induction of toxic megacolon is possible, and thus use of Motofen(R) is cautioned.  
 
 Motofen(R) has been assigned pregnancy category C by the FDA, and is to be used only when the potential benefits outweigh the potential risk to the fetus. The safety of use during lactation is unknown and thus not recommended. "	P35372
DB05223	Pracinostat	investigational	49855250	-	"For the treatment of various forms of cancer."	Q969S8; Q9UQL6; Q8WUI4; O15379; Q9UKV0; Q13547; Q6IT96; Q92769; Q9BY41; Q96DB2; Q9UBN7; P56524
DB05220	Alisertib	investigational	24771867	-	"For the treatment of various forms of cancer."	O14965
DB05229	Beraprost	investigational	23663404	-	"For the treatment of pulmonary hypertension."	P43119; P43115; P35408
DB08964	Gemeprost	approved; withdrawn	5282237	-	"Indicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients in the second trimester of gestation."	P43115; P43116
DB00578	Carbenicillin	investigational; approved	20824	-	"For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria."	P0AEB2; P08506; P02918; P02919; P20309; P0AD68; P24228; P0AD65; P11229
DB01181	Ifosfamide	approved	3690	-	"Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma."	P26358; O75469
DB01180	Rescinnamine	approved	32681	-	"For the treatment of hypertension."	P12821; Q05940
DB05316	Pimavanserin	investigational; approved	10071196	-	"Investigated for use/treatment in neurologic disorders, parkinson's disease, psychosis, schizophrenia and schizoaffective disorders, and sleep disorders."	P28223; P28335; P14416
DB05796	Daglutril	investigational	3038505	-	"Investigated for use/treatment in congestive heart failure and hypertension."	P08473
DB05790	SR 140333	investigational	5311449	-	"Investigated for use/treatment in asthma and inflammatory bowel disease."	P25103
DB00730	Thiabendazole	approved; vet_approved	5430	-	"For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis."	P00363; P62942
DB01189	Desflurane	approved	42113	-	"For use as an inhalation agent for induction and/or maintenance of anesthesia for inpatient and outpatient surgery in adults."	P57789; P28472; Q9NPC2; P03886; P00390; Q09470; P18505; P47869; Q16445; P78334; P18507; Q7Z418; P98194; Q8N1C3; P14867; P23415; O95069; O00591; O14649; Q9UN88; P48167; P34903; P30049; O14764; P48169; P47870; P31644; Q99928; P42261
DB01188	Ciclopirox	investigational; approved	2749	-	"Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to <i>Trichophyton rubrum</i>."	P05023
DB09020	Bisacodyl	approved	2391	-	" Indicated for cleansing of the colon as a preparation for colonoscopy in adults. "	P41145; Q01959
DB09026	Aliskiren	investigational; approved	5493444	-	"For the treatment of hypertension, to lower blood pressure."	P08684; P00797
DB09027	Ledipasvir	approved	67505836	-	"When used in combination with the antiviral medication [DB08934] as the commercially available product Harvoni, ledipasvir is indicated for the treatment of HCV genotypes 1, 4, 5, and 6 with or without [DB00811] depending on the level of liver damage or cirrhosis [FDA Label]. Its use has also proven successful in the treatment of HCV in patients co-infected with HIV [A19627]."	Q8IZI9
DB09028	Cytisine	investigational; approved	10235	-	"Indicated for use in smoking cessation. "	Q15825; P32297; Q494W8; P36544; P17787; P43681
DB01239	Chlorprothixene	investigational; approved; withdrawn	667466	-	"For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders."	P08172; P08173; P28335; P20309; P28223; P08912; P41595; P21728; P14416; P35367; P35462; P11229
DB01238	Aripiprazole	investigational; approved	60795	-	"For the treatment of schizophrenia and related psychotic disorders."	Q12809; P18825; P10635; P28222; P28223; Q01959; P08913; P35462; P46098; P28566; P11229; P34969; P08912; P21728; P08588; P14416; P28221; P23975; P35368; P08172; P08173; P28335; P41595; P21918; P18089; P07550; P35367; P35348; P21917; P50406; P20309; P08908; P31645
DB05009	Apadenoson	investigational	9805430	-	"Investigated for use/treatment in cardiovascular disorders and inflammatory disorders (unspecified)."	P33765; P29274; P0DMS8; P30542
DB01235	Levodopa	approved	6047	-	"For the treatment of idiopathic Parkinson's disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication."	P00533; P35462; P51810; P43405; P21918; P21728; P14416; P43403; P06239; P06241; P21917
DB01234	Dexamethasone	investigational; approved; vet_approved	5743	-	"<B>Injection:</B> for the treatment of endocrine disorders, rheumatic D=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
 <br><B>Ophthalmic ointment and solution:</B> for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
 <br><B>Ophthalmic solution only:</B> for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
 <br><B>Topic cream:</B> for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
 <br><B>Oral aerosol:</B> for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
 <br><B>Intranasal aerosol:</B> for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps"	P04150; P04083; P51843; P05113; Q8TDV5; P06401; P08235; P35354; P10275; P35372; O75469; Q5TZZ9; P35228
DB01237	Bromodiphenhydramine	approved	2444	-	"For management of symptoms related to hay fever and other types of allergy and used to help bring up phlegm, thin secretions, and make a cough productive."	P35367
DB01236	Sevoflurane	approved; vet_approved	5206	-	"Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery."	P57789; Q9NPC2; P98194; Q09470; Q7Z418; P47869; P34903; P78334; P18507; P00390; P18505; P30049; P14867; P28472; O95069; O00591; O14649; Q8N1C3; Q9UN88; P48167; P23415; O14764; P48169; Q16445; P47870; P31644; P03886; Q99928; P42261
DB01231	Diphenidol	investigational; approved; withdrawn	3055	-	"For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases."	P08172; P08173; Q99250; P10635; Q99720; P28223; P08912; P14416; P35498; P20309; P10721; Q9NY46; P35462; P11229
DB05003	Imexon	investigational	68791	-	"Investigated for use/treatment in melanoma, multiple myeloma, ovarian cancer, pancreatic cancer, and solid tumors."	P31350; P23921
DB01233	Metoclopramide	investigational; approved	4168	-	"For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying."	A5X5Y0; P22303; P28223; P11229; Q13639; Q70Z44; P10635; P28335; P41595; P11413; P08913; O95264; P14416; P46098; P35462; Q8WXA8
DB01232	Saquinavir	investigational; approved	441243	-	"For the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues."	P41145; P41143; Q01959; P35372; P08684; P35462; P08908; P37288
DB01579	Phendimetrazine	illicit; approved	30487	-	"Used in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction."	P08908; P23975; P35348; P35368; Q01959
DB01783	Pantothenic acid	vet_approved; approved; nutraceutical	988	-	"Studied for the treatment of many uses such as treatment of testicular torsion, diabetic ulceration, wound healing, acne, obesity, diabetic peripheral polyneuropathy. It has also been investigated for its hypolipidemic effects and as cholesterol lowering agent."	P0A6I3
DB09154	Sodium Citrate	investigational; approved	6224	-	"Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine [FDA Label] [L788] [L789]."	P22748
DB09151	Flutemetamol (18F)	investigational; approved	15950376	-	"Flutemetamol F18 is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate ? amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline. "	P05067
DB09153	Sodium Chloride	approved; vet_approved	5234	-	"This intravenous solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration. Also, designed for use as a diluent and delivery system for intermittent intravenous administration of compatible drug additives. "	P11413
DB01301	Rolitetracycline	approved	54682938	-	"Rolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical."	B6I1U8; Q0TCN6; B7NDK8; B7UJW2; A7ZSC4; B7N102; P0A7X3; A1AGC3; P0A7X4; C4ZSW8; B7MBZ1; B1LGJ6; B1XHK3; A6TEN8; Q1R6B0; A8A539; B1IQP9; B7M0U2; A8AQC0; B7NKU2; P0A7X5; B5YSV6; B7LHT8
DB01303	Oxtriphylline	approved	656652	-	"Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema."	P27815; P33765; Q14432; P0DMS8; Q13370; Q08493; Q92769; Q07343; Q08499; P29274; P29275; P30542; O00329
DB01161	Chloroprocaine	approved	8612	-	"For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia."	Q9UI33; Q01118; Q14524; Q9UQD0; Q9GZZ6; Q01959; Q8TCU5; P35499; P35498; Q99250; P46098; Q9Y5Y9; Q15858; Q9NY46
DB01160	Dinoprost Tromethamine	approved; vet_approved	5282415	-	"Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography."	P43119; P43088
DB01163	Amdinocillin	investigational; withdrawn	36273	-	"Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms."	Q8DR59; P0AD65; P0A3M6
DB01162	Terazosin	approved	5401	-	"For the treatment of symptomatic BPH and mild to moderate hypertension."	Q9NS40; P28223; P18825; Q12809; P25100; P08913; P18089; P35368; Q9Y5Z0; Q9H252; P35348
DB01165	Ofloxacin	approved	4583	-	"For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea."	P48065; P30531; P0AES4; P0AES6; P47869; P31645; P11388; P43700; Q9Y5N1; P43702; P11229
DB01164	Calcium Chloride	approved	5284359	-	"For the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid."	Q99584
DB01167	Itraconazole	investigational; approved	55283	-	"For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis."	P10613; P22888; P51679; Q16850; P50859; P08684; P06241; P30518
DB01166	Cilostazol	investigational; approved	2754	-	"For the reduction of symptoms of intermittent claudication (pain in the legs that occurs with walking and disappears with rest)."	Q14432; Q13370
DB01169	Arsenic trioxide	investigational; approved	261004	-	"For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15,17) translocation or PML/RAR-alpha gene expression"	P28482; P05412; Q12809; P10276; Q13547; Q6IT96; B0LPE5; P29590; P24385; Q16881; P31749; O14920; P38936; P27361
DB01168	Procarbazine	investigational; approved	4915	-	"For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease."	Q15116; P27338
DB01606	Tazobactam	approved	123630	-	"Used in combination with piperacillin to broaden the spectrum of piperacillin antibacterial action."	P62594; P0AD63; P62593
DB01607	Ticarcillin	investigational; approved; vet_approved	36921	-	"For the treatment of bacterial infections."	P24228; P08506; P0AEB2; P02918; P02919; P0AD68; Q02763; P0AD65
DB09481	Magnesium carbonate	investigational; approved	11029	-	"Used as an over the counter antacid [L593]."	O60391
DB00571	Propranolol	investigational; approved	4946	-	"For the prophylaxis of migraine."	P10635; Q9Y3Q4; P28221; Q99720; P28223; P41595; P35367; Q13936; P31645; P08908; P47898; P07550; P28335; Q14973; P08588; P28222; P13945
DB09488	Acrivastine	approved	5284514	-	"For the relief of symptoms associated with seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion."	P35367
DB00788	Naproxen	approved; vet_approved	156391	-	"For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea."	P07332; Q9UM73; P23786; Q99705; P35354; Q51911; P08922; P23219
DB00789	Gadopentetate dimeglumine	approved	55466	-	"For use with magnetic resonance imaging (MRI) in adults, and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues as well as lesions with abnormal vascularity in the head and neck. Also used to facilitate the visualization of lesions with abnormal vascularity in the body (excluding the heart)."	P52209
DB00782	Propantheline	approved	4934	-	"For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder."	P08172; P08173; P11229; P20309
DB00783	Estradiol	investigational; approved; vet_approved	5757	-	"Estradiol is indicated for the treatment of moderate to severe vasomotor symptoms and vulvar and vaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and for the prevention of post-menopausal osteoarthritis. It is also used for the treatment of breast cancer (for palliation only) in appropriately selected women and men with metastatic disease, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only)."	P04150; Q15596; Q14457; Q92731; Q99527; Q01959; P03372; P10275; P62508; O75469; P31645; P00846; P43681; P37059; Q12791
DB00780	Phenelzine	approved	3675	-	"Phenelzine is indicated for the treatment of nonendogenous, neurotic or atypical depression for patients that do not tolerate other forms of therapy.[L1356] 
 
 Atypical depression has a high prevalence rate, starts in early life, tends to last longer, is more likely to occur in people with bipolar disorder, has a high comorbidity with anxiety disorder and carries more risk of suicidal behavior. It is important to specify the atypical feature to predict the clinical course of depression and hence generate the best treatment and service. The featuring symptoms of the atypical feature include mood reactivity, two or more of this symptoms: 1) increased appetite, 2) increased sleep, 3) leaden paralysis and 4) interpersonal rejection sensitivity and should not have melancholic or catatonic features of depression.[A31917]
 
 Neurotic depression is a depression of an emotionally unstable person. It is a secondary condition to major personality disorder, neuroses and drug use disorders. Likewise, a primary depression with a family history of depression spectrum disease would fit in this category.[A31922]
 
 A nonendogenous depression is characterized by a disturbance in mood and general outlook. The physical symptoms tend to be less severe and it often occurs in response to stressful life events that keep occurring over a large period of time generating a continuous stress in the daily living.[A31924]"	P21397; P24298; P27338; P10635; Q01959; P80404; Q8TD30; Q16853; P23975; P08684; P10632; P31645; Q9BXA5
DB00786	Marimastat	investigational; approved	119031	-	"For the treatment of various cancers"	Q9H239; O60882; P09238; Q9NPA2; P09237; Q9NRE1; P51512; Q9Y5R2; P51511; Q99542; Q8N119; P08254; P08253; P50281; P45452; P22894; O75900; P39900; Q9H306; P03956; P14780; P24347; Q9ULZ9
DB00787	Aciclovir	approved	2022	-	"For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox. "	P04293; P03176; P09252
DB00784	Mefenamic acid	approved	4044	-	"For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever."	P51787; P23786; P35354; P15121; P23219; Q9HCF6
DB01015	Sulfamethoxazole	approved	5329	-	"For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections."	P11413; P09211; P08192; P0AC13
DB01014	Balsalazide	investigational; approved	6335412	-	"For the treatment of mildly to moderately active ulcerative colitis."	P35354; P09917; P23219; P37231
DB01017	Minocycline	investigational; approved	54675783	-	"For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by <i>Streptococcus pneumoniae</i> and for the treatment of asymptomatic carriers of <i>Neisseria meningitidis</i>."	B5FJK9; B5YVV7; A7ZSI5; B5RH07; B1XG23; B1XG24; B7L4K8; C0PYY2; Q5PIU7; B4TVU3; A8A7U8; A8A0R0; C4ZUG4; C4ZUG6; B1LHB3; P0A7T8; B5F3B9; P0A7T7; B7UPA5; C0Q0A5; Q57GI9; P0A7T3; B1LHB8; A8A5B1; A7ZSC4; A8A5B4; A8A5B6; A8A5B9; B5YQ05; B5YQ04; C4ZSW8; Q1R4V6; B5FHU4; B1IRQ1; Q0TD41; B7US99; P68684; P68685; P68682; Q2NWE7; P68680; P68681; B7LRT5; B7LS48; B7LRT1; B1X6G0; B7LRT3; B7LRT2; A7ZTI7; Q0TCF8; Q1R610; P60423; B7NLN3; B7NLN0; B7NLN6; B7NLN5; B7LR53; B1IQP9; B5YSV6; C4ZYY0; B4TUF3; B4TUF2; B4TKM3; B6I1U8; B5R1G3; Q57J49; B1IQ03; B1IQ02; B1IQ00; B1IQ05; C4ZQY2; Q57QG6; Q0TCF5; A9MN70; B7M1C4; B7M1C5; P60626; A6TE47; B4SXD8; B7NDS9; B1IPL1; B7NDS5; B1X9T1; B5FJK8; B7UK28; B7N0W8; C4ZUG1; B7UK21; B7UK20; B5FJK3; A4WEK0; B7L4J4; B7L4J7; B4TKK9; P09917; B7NDH0; P0A7W6; A8A539; P0A7W5; B1LQM1; B6I208; B7NJS8; A8ARM4; A8AQC0; C0Q2L0; P0A7W2; A8A5E9; C4ZUG9; B7N190; P0A7P2; P0A7P3; P0A7P0; P0A7P1; P0A7P6; P0A7P7; P0A7P4; P0A7P5; B5BAI4; P0A7P8; P0A7P9; B5R9F0; A8A698; B1JM17; A8AHA8; B5XU21; Q1R612; B4TXD6; B4TXD7; A8A5B3; A7MNZ2; P0A7S2; P0A7W9; A4THT0; Q32FI2; C4ZSS5; B4T4N1; B7M1L8; C0Q6G0; Q57J46; Q57J43; B5RGF1; A9MVN1; B7NLN4; P62401; Q0T9J1; P0C020; B4TAV0; B7LHT8; B6I1Q9; B5QVW5; B4TN08; B5QVW6; A9MN59; P62400; B4TGH4; B4TGH3; B5QUQ1; P0A7R5; B5FN11; A9MFC1; B7NLM3; B7NLM7; B7NLM5; B7NLM8; P0C021; B4TFD7; B6I2A8; P0A7M9; A7ZMI4; A7MPI4; B5R0S0; Q0TCE5; Q0TCE4; Q0TCE7; Q0TCE6; A7ZSL7; B5BGX2; B5RAX0; B5RAX1; P68686; B7N1C3; A1AGJ3; B6I242; B5YTP0; A7FE70; B7NKU2; P15692; Q1R6F0; P68683; P0A7L6; P0A7L7; P0A7L4; P0A7L5; A8A5A8; P0A7L3; P0A7L0; C4ZYH8; C4ZYH9; B7MGC4; A1AGJ5; P0A7L8; A9MSY1; A9MSY7; A9MSY4; B1XDV2; P0AG63; P0AG64; P0AG65; P0AG66; P0AG67; B1IPY2; Q0TCN6; Q0THB3; Q0THB2; Q32B57; B7MCT0; B1IPY4; A7ZSK3; A7ZSK0; Q32B52; B5R285; P0A7K2; Q1R632; Q1R635; P0A7K6; A7ZTQ9; Q1R636; B7LZL5; Q1R638; B6I233; B6I230; B6I231; Q5PKX8; A7ZV73; B7M1P3; B7LK45; B7NLN8; B5F7F9; B7L759; B1LHE2; B1LGF2; P60624; B1IV14; P0A7U5; P0A7U4; P0A7U7; P0A7U6; P0A7U1; P0A7U0; P0A7U3; P0A7U2; B7LHP9; B1IPY3; A8A5A9; B7MCS9; A8A5A4; B5FJA6; B7MCS3; A8GJV2; B5FJA5; B5F7T9; A7ZSK6; P60727; B5F7T1; B5F7T4; B7NR05; P68919; B7L6J0; A8AQL3; B7MST2; B7LH01; A8AQL0; B4SUS6; B4SUS9; B7MBV5; B7UIX3; B7N102; P60429; A1AGI5; Q329M1; P60422; B1X6G3; A1ABQ0; B1X6G1; B1X6G6; B1X6G7; P60424; B6I228; B7LG22; B5F8G0; Q1R604; B5YT13; B5YT15; A9R7E4; B5YT16; B4TZX8; B5QZ45; Q1R6B0; Q1R607; B1IZF7; A8AQK2; Q32BQ2; Q57IA6; A9MN66; B7NKQ3; B2VCV9; Q6D9D4; P0AG55; A6TAI4; B7UK18; A1AGI8; C4ZUF2; A1AGI7; B7M1N1; B7N0V1; Q1R609; B7NDK8; B4TKL4; P68679; B7UMH0; Q0TCE2; B7M1M3; P0A7M6; B1XG70; B4TKL0; P0A7Q1; P0A7Q0; P0A7Q3; P0A7Q2; P0A7Q5; P0A7Q4; P0A7Q7; P0A7Q6; P0A7Q9; P0A7Q8; P0A7X0; P0A7X1; A9MSZ2; A9MSZ3; B4TXE1; B5FJM2; B7NKJ1; B7NDR6; A1JQX1; B5F6A5; Q32EU9; A8A599; B7NDR9; Q0TCS4; B6I9G6; B2VF69; B7LRS4; B7LRS5; C6DKG8; A9MX79; B7LRS2; B7LHZ9; B7LHZ8; B4EW58; B7LHZ6; B1X970; B5RH29; B7M100; B7M103; B4TI60; Q57J38; B5RH26; B5RH21; B5RH20; A7ZZ46; B2K2I4; B7MVJ4; B7MVJ5; B1LHB1; B4TXC8; B1LHD1; A9MKN8; B1LHD0; B7LLY4; B1LHD3; B1LHB0; B6I437; B7MCT2; B7NEU0; B5YTP9; B7NLL4; B7NLL7; B7L6I9; P0C018; P0C019; B1LF57; B4SUT4; B4SUT5; A7MPF5; A4W5T1; B1XHK3; B7UK52; P0A7V5; A7MPH5; A7MPH2; Q0TCF0; B1LI56; Q0TCF3; A7MPH8; B7N198; Q0TCF7; B1X6F8; P02413; A9MN54; Q1C365; B1LL30; P60625; Q5PJ56; P0A7M2; A9N5Y8; A1AGJ2; B1IPY8; B7N0U4; A1AGJ7; C0Q0C4; B1IPY0; B1XHG2; P0ADZ0; B1IPY5; A9MGD1; Q329B5; P0ADZ4; A7ZSJ8; A7ZSJ5; A7ZSJ7; A7ZSJ3; A7ZSJ2; B7MCT1; B6I229; A6TG05; Q1R358; B6I225; B7NTQ7; B7NDV0; B6I220; B6I223; B6I222; A8AQJ8; B5R5G0; B4T679; A9N520; A8A4M2; Q5PIW1; B1X9Z9; B5F7G0; A6TEV6; B7MB01; P0A7V8; P0A7V9; B4TXF0; C4ZUE9; P0A7V0; B7N181; B7N182; P0A7V3; P0A7V4; Q57HZ9; P0A7V6; P0A7V7; B7NLP7; B5RFY6; A1AGM9; A1AGC3; B5QXE5; B7MCR0; B7MCR3; B7MCR2; B7N0L5; B1LGQ0; B7NDS7; P14780; B7L847; A7ZSK5; A7ZSK8; B5YXA7; B7NGD6; B7LRT0; Q32B55; B4SYA9; Q32B54; B1X6F1; B7NDR8; A7ZSK4; B1X6F6; B7MCR9; B7NPE2; B7ULJ1; B7N1A3; B7NT61; B7NT60; B5F8F1; B4T9C1; B5EYX3; B7N1A1; B5YRA5; B7LI05; B7MCT4; P0A7W8; B7LQD9; B5XZP7; B7M092; B5BGY5; A8AQJ9; P99999; B5BGY1; B5BGY0; B5FJK0; B5YTM9; P60725; A9MJT9; B1IT04; B5R286; B5FSA3; P60723; P29466; B5R280; B7N2E8; B7L4J5; P61179; B7LRS7; B6I3T6; C4ZUH4; B7LRS0; B1LGJ6; P61177; P61176; P61175; Q32B24; P0A7T9; B1IPL2; B5BG21; P01584; A4WFC2; Q328J7; B1IPZ0; B4TKK1; B4TKK4; B7UQL1; C4ZUG3; A8A5C2; Q5PC32; Q2EEQ2; A1AGK6; Q0TBH3; P0ADY3; C4ZS29; P0AG48; P0AG49; P0AG46; P0AG47; P0AG44; P0AG45; P0A7R0; A6THB3; B7MCV7; P60438; B7MLK7; B7MFJ7; Q5PK01; B5FJL3; B5YWD4; B7NDU0; B7N276; Q0TIY5; Q5PK05; Q57J33; B7LRR3; B7LRR1; B7N554; B7N553; C4ZXM8; B7LRR4; P0AA10; B7ND54; B7M1N3; Q32BE7; B7M1N0; Q1R5U1; C4ZUF4; Q1RD68; Q57J24; C4ZUF1; B7M102; A8A0Q9; B5RH16; C4ZUF9; B1LHC8; B1LHC9; A8A5C0; A8A5C1; B7M0U2; A8A5C4; B1LHC0; B1LHC2; B1LHC3; B1LHC5; A7ZS83; B1X6H0; A9MFK9; B5REG7; B5FM60; A9N241; B7M4C0; B4SUU8; B7MAS6; B7MAS7; B4TT35; B4T3F3; Q0TCG7; B5YTM7; Q0TCG5; Q0TCG4; Q0TCG2; B7UK43; B7UK41; B7UK40; B7NAW5; Q5PH91; Q5PH90; B7L4L7; A6TEN8; B5YS75; B7M555; Q665U4; P0ADY7; B5BA39; B5BGZ4; C0Q0B5; A9MN48; C0Q0B0; C0Q0B1; P0A7N1; B7LX23; P0A7N4; B1IPZ1; P0A7N6; P0A7N7; P0A7N8; P0A7N9; A1AGK0; A1AGK3; A1AGK2; A1AGK5; A1AGK4; B7UK38; Q1R6R5; A7MM78; B7UK35; B7UK32; B7UK30; A7ZSI8; B7L4K4; B7L4K5; B7L4K3; B7L4K0; A8AMJ6; B7UJW2; A7ZSI3; A8APV6; A7ZSI6; B6I218; Q57PV1; Q57PV0; B6I210; B6I211; A7ZRU7; B7LVJ7; Q1R616; B5BIL5; Q5PIV7; B5YTM5; Q5PIV3; B1IX36; A6TEW1; A6TEW0; B7LQ74; B7LQ73; B7MTL9; Q5PIV8; P0A7W7; B7MCS6; B1LE15; B1LE14; P0A7W3; B7N192; P0A7W1; P0A7W0; B7N1A0; B7N199; Q5PKU5; C0Q1W9; B4F277; C4ZR79; C5BF78; A8A5A2; B7M9G4; B7MCS1; Q1CME3; P0A7W4; B1IPZ5; A8AQJ1; B5Y306; B1IPZ6; B4TXD1; B7M1M2; P0A7S3; B7M1M0; B5EXE1; B7M1M5; B6I3L3; B7M1M8; B7M1M9; B5BI10; P0A7N5; B1X6E6; B7MJ76; P60724; P0AG51; B1IPZ3; B1X6E8; B1X6E9; P0AG50; P02358; P02359; P0A7R9; P60726; P0A7X2; P0A7X3; Q5PGT9; Q57J53; P0A7X4; P0A7X5; B7MBZ1; B1X6G8; A9MPV4; A8A5A1; B5F8E7; B5YTN0; B5YTN2; B5YTN5; B5YTN6; B5YTN7; B5YTN8; B7NLL6; A8A6G4; B6IBD5; B6IBD4; B1IQT7; A8AQL8; B4T4N0; B5RBB1; B1LK73; B7UJ79; B7UK39; Q57JQ0; B1IPV7; P61178; A8AQL2; Q32B32; Q32B37; Q32B36; Q32B35; B5Z2K7; Q1R620; B4SUT9; A8A501; B7LCR3; A4WFD5; A9N240; B5BKL1; P0A7J7; B7NF20; B7NDT6; Q1R626; B7L4K6; B7NDT7; C0Q644; C4ZUH0; Q1R4N3; C4ZUH1; P0A7S9; P0A7S8; P0AG59; C4ZUH2; Q1RB79; Q1RB78; P0A7S1; P0A7S0; P0A7S7; P0A7S6; P0A7S5; P0A7S4; B5XQC9; B5XQC8; Q32B47; Q32B45; Q32B43; Q32B40; Q1R622; B7NDT0; B2VGJ7; B7NDT2; B7NDT5; Q1R627; B5R290; P0A7J3; B7NDT8; P62399; P42574; B5R299
DB01016	Glyburide	approved	3488	-	"Indicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone."	Q09428; P11229; Q12809; Q14654; P50416; P11413; Q15842; P13569; P48048; O60706; O95477; P48544
DB01011	Metyrapone	investigational; approved	4174	-	"Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome."	P08684; P15538; P00183; P30556
DB01010	Edrophonium	approved	3202	-	"For the differential diagnosis of myasthenia gravis and as an adjunct in the evaluation of treatment requirements in this disease. It may also be used for evaluating emergency treatment in myasthenic crises."	P41145; P22303; P06276; P35372; P14416; P35462
DB01013	Clobetasol propionate	approved	32798	-	"For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp."	P04150
DB00570	Vinblastine	approved	13342	-	"For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma."	Q9BVA1; P68366; P05412; P68363; P68371; Q9UJT1; Q9UJT0; Q9BQE3; Q6PEY2; Q71U36; P23258; P07437; Q13885; Q13509; Q5SU16; Q13748; Q3ZCM7; Q9BUF5; P04350; Q9H4B7
DB00544	Fluorouracil	approved	3385	-	"For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid."	Q12882; P04818; Q53Y97; P11229
DB00545	Pyridostigmine	investigational; approved	4991	-	"For the treatment of myasthenia gravis."	P02768; P22303; P06276; Q8IU57
DB00546	Adinazolam	approved	37632	-	"For the treatment of anxiety and status epilepticus."	P24046; P30536; P18507; P28476; A8MPY1; O00591; O14764; P48169; P14867; Q8N1C3; P47869; P47870; P28472; P18505; P31644; P34903; Q16445; Q99928; P78334
DB01548	Diprenorphine	illicit; vet_approved	443408	-	"Diprenorphine is used to reverse the effects of the super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals in veterinary medicine. Not used in humans."	P41145; P35372; O60858; P41143
DB01019	Bethanechol	approved	2370	-	"For the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention."	P08172; P08173; P11229; P20309
DB00731	Nateglinide	investigational; approved	5311309	-	"For the treatment of non-insulin dependent-diabetes mellitus in conjunction with diet and exercise."	Q09428; P78508; Q14654; P48048; O60706; P37231
DB00014	Goserelin	approved	5311128	-	"Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty."	P01148; P22888; P30968
DB00543	Amoxapine	approved	2170	-	"For the relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions. May also be used to treat depression accompanied by anxiety or agitation."	P18825; P10635; P28222; P28223; P35462; P46098; P11229; P42858; Q9H3N8; P34969; Q01959; P21728; P08913; P14416; P23975; P08172; P08173; P18507; P18440; P28335; P18089; P21918; P14867; P41595; P35367; P35348; P21917; Q9UN88; P08912; P25100; P50406; P47870; P20309; P08908; P31645
DB00764	Mometasone	approved; vet_approved	441335	-	"The inhaler is indicated for the maintenance treatment of asthma as prophylactic therapy. The nasal spray is indicated for the treatment of the nasal symptoms of seasonal allergic and perennial allergic rhinitis."	P04150; P06401; Q5TZZ9; P04083
DB00941	Hexafluronium	approved	3601	-	"Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations."	P22303; P06276
DB00766	Clavulanate	approved; vet_approved	5280980	-	"For use with Amoxicillin, clavulanic acid is suitable for the treatment of infections with <i>Staph. aureus</i> and <i>Bacteroides fragilis</i>, or with beta-lactamase producing <i>H. influenzae</i> and <i>E. coli</i>."	P62594; P00807; Q04609; P62593
DB00767	Benzquinamide	withdrawn	2342	-	"Used to prevent and treat nausea and vomiting associated with anesthesia and surgery, administered intramuscularly or intravenously."	P08172; P08173; P35462; P18825; P14416; P35354; P18089; P23786; P08912; P08913; P20309; P35367; P21439; P11229
DB00760	Meropenem	investigational; approved	441130	-	"For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: <b>complicated skin and skin structure infections</b> due to <i>Staphylococcus aureus</i> (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), <i>Streptococcus pyogenes</i>, <i>Streptococcus agalactiae</i>, viridans group streptococci, <i>Enterococcus faecalis</i> (excluding vancomycin-resistant isolates), <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, <i>Proteus mirabilis</i>, <i>Bacteroides fragilis</i> and <i>Peptostreptococcus</i> species, <b>complicated appendicitis and peritonitis</b> caused by viridans group streptococci, <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Pseudomonas aeruginosa</i>, <i>Bacteroides fragilis</i>, <i>B. thetaiotaomicron</i>, and <i>Peptostreptococcus</i> species. Also for use in the treatment of bacterial meningitis caused by <i>Streptococcus pneumoniae</i>, <i>Haemophilus influenzae</i> (b-lactamase and non-b-lactamase-producing isolates), and <i>Neisseria meningitidis</i>."	P0AEB2; P08506; P02918; P02919; P0AD68; P24228; P0AD65
DB00761	Potassium Chloride	approved; withdrawn	4873	-	"For use as an electrolyte replenisher and in the treatment of hypokalemia."	P11413; P22748; Q13621; P00533; Q15303
DB00762	Irinotecan	investigational; approved	60838	-	"For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. "	P08173; P22303; P22309; Q969P6; P03956; P18825; P11387
DB00763	Methimazole	approved	1349907	-	"For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis."	P35270; P07202
DB00948	Mezlocillin	investigational; approved	656511	-	"Used to treat serious gram&ndash,negative infections of the lungs, urinary tract, and skin."	P02918; P02919; P35354; P15121; Q13258; P35408; P34995; P14778; P0AEB2; P08506; P43115; Q8XJ01; P43116; P08684; P0AD68; P24228; P0AD65; P23219; P00918; P09917; P37231; P21554
DB00949	Felbamate	approved	3331	-	"For use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use."	Q05586; O15399; Q03426; Q8NI17; O60391; B2RDU6; Q12879; Q13224; Q8TCU5; Q14957
DB00768	Olopatadine	approved	5281071	-	"For the treatment of ocular itching associated with allergic conjunctivitis."	P04271; P23297; P29034; P80511; P35367; Q99584
DB00769	Hydrocortamate	approved	84088	-	"Used topically as an antiinflammatory in the treatment of steroid-responsive dermatoses"	P04150; P04054; Q5TZZ9; P04083
DB00224	Indinavir	approved	5362440	-	"Indinavir is an antiretroviral drug for the treatment of HIV infection."	P08684
DB04209	Dequalinium	investigational; approved	2993	-	"Effective local treatment as vaginal tablets for infections such as fluor vaginalis, bacterial vaginosis, aerobic vaginitis, vulvo-vaginal candidiasis and trichomoniasis. Used as a topical antimicrobial agent. "	P29973; P31224; P98170; Q16280; Q92952; P0A0N5; Q12791
DB00735	Naftifine	approved	73342	-	"For the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms <i>Trichophyton rubrum</i>, <i>Trichophyton mentagrophytes</i>, <i>Trichophyton tonsurans</i> and <i>Epidermophyton floccosum</i>."	Q99720; Q14534
DB00226	Guanadrel	approved	38521	-	"Used to treat and control hypertension."	P23975; P35348
DB09570	Ixazomib	investigational; approved	25183872	-	"Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy. "	P49721; P28074; P20618
DB09571	Levmetamfetamine	approved	36604	-	"Among its physiological effects are the vasoconstriction that makes it useful for nasal decongestion."	Q96RJ0
DB00306	Talbutal	illicit; approved	8275	-	"For use as a sedative and hypnotic."	Q9UN88; P28472; P18507; P18505; Q99928; Q494W8; P48169; Q16445; P43681; Q8N1C3; P47869; P14867; Q13002; P36544; P31644; O14764; P34903; O00591; P47870; P42262; P78334
DB00307	Bexarotene	investigational; approved	82146	-	"Used orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Also used topically for the treatment of skin lesions in early (stage IA and IB) CTCL in patients who experience refractory or persistent disease with the use of other therapies or are intolerant of other therapies."	P19793; P28702; P48443; P10276; P10826; P13631; P37231
DB00304	Desogestrel	approved	40973	-	"For the prevention of pregnancy in women who elect to use this product as a method of contraception."	P06401; P03372
DB00305	Mitomycin	approved	5746	-	"For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery."	P25103
DB00302	Tranexamic Acid	approved	5526	-	"For use in patients with hemophilia for short term use (two to eight days) to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following tooth extraction. It can also be used for excessive bleeding in menstruation, surgery, or trauma cases."	Q16671; P00747; P00750
DB00303	Ertapenem	investigational; approved	150610	-	"For the treatment the following moderate to severe infections caused by susceptible isolates of the designated microorganisms: (1) complicated intra-abdominal infections due to <i>Escherichia coli</i>, <i>Clostridium clostridioforme</i>, <i>Eubacterium lentum</i>, <i>Peptostreptococcus</i> species, <i>Bacteroides fragilis</i>, <i>Bacteroides distasonis</i>, <i>Bacteroides ovatus</i>, <i>Bacteroides thetaiotaomicron</i>, or <i>Bacteroides uniformis</i>, (2) complicated skin and skin structure infections, including diabetic foot infections without osteomyelitis due to <i>Staphylococcus aureus</i> (methicillin susceptible isolates only), <i>Streptococcus agalactiae</i>, <i>Streptococcus pyogenes</i>, <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Proteus mirabilis</i>, <i>Bacteroides fragilis</i>, <i>Peptostreptococcus</i> species, <i>Porphyromonas asaccharolytica</i>, or <i>Prevotella bivia</i>, (3) community acquired pneumonia due to <i>Streptococcus pneumoniae</i> (penicillin susceptible isolates only) including cases with concurrent bacteremia, <i>Haemophilus influenzae</i> (beta-lactamase negative isolates only), or <i>Moraxella catarrhalis</i>, (4) complicated urinary tract infections including pyelonephritis due to <i>Escherichia coli</i>, including cases with concurrent bacteremia, or <i>Klebsiella pneumoniae</i>, (5) acute pelvic infections including postpartum endomyometritis, septic abortion and post surgical gynecologic infections due to <i>Streptococcus agalactiae</i>, <i>Escherichia coli</i>, <i>Bacteroides fragilis</i>, <i>Porphyromonas asaccharolytica</i>, <i>Peptostreptococcus</i> species, or <i>Prevotella bivia</i>."	P0AEB2; P08506; P0AD68; P02918; P02919; P45059; P44469; P24228; P0AD65
DB00301	Flucloxacillin	investigational; approved	21319	-	"Used to treat bacterial infection by susceptible microorganisms."	P10275; Q8XJ01
DB08687	FG-2216	investigational	6914666	-	"Investigated for use/treatment in anemia and kidney disease."	Q96KS0; D0VY79; Q9GZT9; Q9H6Z9; Q16665
DB00308	Ibutilide	approved	60753	-	"Indicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm."	Q9NS40; Q06432; O00180; Q12809; P54289; Q14654; Q9Y257; Q13936; Q02641; Q9H252
DB00309	Vindesine	investigational; approved	40839	-	"For the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia and acute panmyelosis"	Q9H4B7; P08684
DB06228	Rivaroxaban	approved	9875401	-	"Rivaroxaban is indicated for the prevention of venous thromboembolic events (VTE) in patients who have undergone total hips replacements and total knee replacement surgery, prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), to reduce risk of recurrent DVT and/or PE. Due to a lack of safety studies, it is not recommended for use in those under 18 years old. Its use is also not recommended in those with severe renal impairment (<30mL/min).
 "	P00742
DB04845	Ixabepilone	investigational; approved	6445540	-	"Investigated for use/treatment in breast cancer, head and neck cancer, melanoma, lung cancer, lymphoma (non-hodgkin's), prostate cancer, renal cell carcinoma, and cancer/tumors (unspecified)."	Q9BVA1; P68366; P68363; P07437; Q5SU16; Q9BQE3; Q6PEY2; Q3ZCM7; Q9H4B7; Q13885; Q13509; P68371; Q13748; Q71U36; Q9BUF5; P04350
DB04844	Tetrabenazine	investigational; approved	6018	-	"Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia "	Q99250; P18825; P10635; Q05940; P08913; P35498; P14416; P54219; Q9NY46
DB04847	Roxadustat	investigational	11256664	-	"In clinical development for the treatment of anemia of chronic inflammatory disease."	Q96KS0; Q9GZT9; Q9H6Z9; Q9NXG6
DB04846	Celiprolol	investigational; approved	2663	-	"Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris. "	P18825; P07550; P08588; P08913; P18089
DB04841	Flunarizine	approved	941361	-	"Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy."	P08173; P18825; P28223; P18089; P35372; P35462; P0DP23; O95180; P11229; Q99720; Q12809; Q01959; Q9P0X4; P08912; P08913; B4DJ51; O43497; P23975; P0DP24; P41145; P14416; P41143; P28335; P41595; P35498; P35367; Q9UK17; P0DP25; P62158; P25100; Q00975; P20309; P08908; P31645; P21728; P21554
DB04840	Debrisoquin	investigational; approved	2966	-	"For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension."	P21397; P27338; P18825; P25100; P08913; P18089; P35368; P23975; P35348
DB04843	Mepenzolate	approved	4057	-	"For use as adjunctive therapy in the treatment of peptic ulcer. It has not been 
 shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
 "	P08172; P49019; Q8TDS4; P11229; P20309
DB04842	Fluspirilene	investigational; approved	3396	-	"Used for the treatment of schizophrenia."	P28566; P23415; P14416; P18825; P28221; P28222; P28223; Q06432; P18089; P08588; P41595; P35462; P08908; P35367; P07550; Q12809; P08913
DB04849	Cediranib	investigational	9933475	-	"For the treatment of liver cancer, advanced non-small cell lung cancer (NSCLC), advanced colorectal cancer (CRC) and other solid tumors."	P07333; P35968; P16234; P09619; P35916; P36888; P17948; P10721
DB00162	Vitamin A	vet_approved; approved; nutraceutical	445354	-	"For the treatment of vitamin A deficiency."	P00352; O94788; P12271; Q9NYR8; P49116; O60760; P10745; P05090; Q9HBH5; O75911; Q96NR8; P09455; Q6NUM9; Q92781; P47895; O95237; Q8NBN7; Q9BTZ2; Q8TC12
DB00163	Vitamin E	vet_approved; approved; nutraceutical	14985	-	"Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps."	P09917; O76054; B3KUN1; P17252; P67775; Q9UDX3; P23743; O75469; P62714; Q9UDX4; P05771
DB00160	L-Alanine	approved; nutraceutical	5950	-	"Used for protein synthesis."	Q9Y697; Q9BYV1; Q9UHI5; P24298; P49588; P21549; P80404; Q5T6X5; Q8TD30; Q16719; P43007; Q5JTZ9; Q7Z2H8; Q8IUZ5
DB00166	Lipoic Acid	investigational; approved; nutraceutical	6112	-	"For nutritional supplementation, also for treating dietary shortage or imbalance."	Q9Y289; Q9Y234; O43603; O43766; P47211
DB00167	L-Isoleucine	investigational; approved; nutraceutical	6306	-	"The branched-chain amino acids may have antihepatic encephalopathy activity in some. They may also have anticatabolic and antitardive dyskinesia activity."	P41252; P45954; O15382; Q9NSE4; P54687
DB00165	Pyridoxine	vet_approved; investigational; approved; nutraceutical	1054	-	"For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy."	O00764
DB00168	Aspartame	approved; nutraceutical	134601	-	"Used as a diet supplement and sugar substitute."	Q7RTX0; Q8TE23; Q8NER1
DB00169	Cholecalciferol	approved; nutraceutical	5280795	-	"For the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis."	P23415; Q14416; P11473
DB11793	Niraparib	investigational; approved	24958200	-	"Niraparib is indicated for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy"	P09874; Q9Y6F1; Q9UGN5
DB06684	Vilazodone	approved	6918314	-	"Vilazodone is approved for treatment of acute episodes of major depression. Labeling of vilazodone describes an increased risk of suicidal thoughts in children, adolescents and young adults. The use of vilazodone in pediatrics is not indicated. Its use with monoamine oxidase inhibitors (MAOI) is contraindicated due to increased risk of serotonin syndome. Once the MAOI is discontinued, a 14-day washout period must pass before starting vilazodone."	P35462; P18440; P18825; Q13639; P25100; P08913; P18089; P14416; P35368; P35367; P31645; P35348; P08908
DB06689	Ethanolamine Oleate	approved	5282489	-	"For the treatment of patients with esophageal varices that have recently bled, to prevent rebleeding."	P00748
DB05171	E-2012	investigational	11560787	-	"Investigated for use/treatment in alzheimer's disease."	Q96BI3; Q9NZ42
DB00439	Cerivastatin	approved; withdrawn	446156	-	"Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction of saturated fat and cholesterol and other non-pharmacological measures alone has been inadequate."	P04035
DB09018	Bromopride	investigational; approved	2446	-	"Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the GI tract. "	P22303; P14416
DB05812	Abiraterone	approved	132971	-	"Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer. "	P31213; P05093; Q9H8P0; P18405; P10275; P08684; P15538
DB05814	GPI-1485	investigational	9837656	-	"Investigated for use/treatment in erectile dysfunction and parkinson's disease."	P62942
DB01002	Levobupivacaine	investigational; approved	92253	-	"For the production of local or regional anesthesia for surgery and obstetrics, and for post-operative pain management"	Q9UK17; P10635; P34995; Q12809; Q9Y5Y9; P35498; P46098; P35499; P22460
DB08805	Metiamide	experimental	1548992	-	"Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion."	P25021
DB06145	Spiramycin	approved	6440717	-	"Macrolide antibiotic for treatment of various infections."	Q9A1X4
DB05252	Fenoxaprop-ethyl	investigational	47938	-	"Chronic angina and Coronary Artery Disease 	"	P35228; P29475
DB05255	Ronacaleret	investigational	10345214	-	"Post-menopausal women with osteoporosis"	P41180; Q5T601
DB01003	Cromoglicic acid	approved	2882	-	"For the management of patients with bronchial asthma. Also used in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis."	P25815; Q12791
DB08801	Dimetindene	investigational; approved	21855	-	"Indicated as symptomatic treatment of allergic reactions: urticaria, allergies of the upper respiratory tract such as hey fever and perennial rhinitis, food and drug allergies, pruritus of various origins, except pruritus due to cholestasis, insect bites. Dimethindene is also indicated for pruritus in eruptive skin diseases such as chicken-pox. Dimethindene can also be used as an adjuvant in eczema and other pruriginous dermatoses of allergic origin. "	P08172; P08173; P11229; P08912; P20309; P35367
DB00428	Streptozocin	investigational; approved	29327	-	"For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma)."	Q89ZI2; O60502; P11168
DB00434	Cyproheptadine	approved	2913	-	"For treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, amelioration of allergic reactions to blood or plasma, cold urticaria, dermatographism, and as therapy for anaphylactic reactions adjunctive to epinephrine."	Q12809; P35462; P18825; P28221; P28223; Q99250; Q92633; Q9UBY5; P11229; P35498; P34969; P21728; Q9NY46; P08912; P08913; P14416; P23975; P08172; P08173; P28335; P18089; P41595; P35368; P35367; P35348; P25021; P25100; P50406; P20309; P08908; P31645; P01011
DB13783	Acemetacin	investigational; approved; experimental	1981	-	"Acemetacin is not FDA, Canada or EMA approved, but in the countries where it is marketed it is indicated for the symptomatic treatment of pain and swelling in acute inflammation of the joints in rheumathoid arthritis, osteoarthritis, low back pain and post-surgical pain.[L1045] It is also indicated for the treatment of chronic inflammation of the joints in presence of rheumatoid arthritis, treatment of ankylosing spondylitis, treatment of irritation in the joints and spinal column caused by degenerative disorders, treatment of inflammatory soft-tissue rheumatism syndrome and painful swelling and inflammation caused by injury.[L1044, L1046]"	P35354; P23219
DB05492	Epicept NP-1	investigational	5276854	-	"Investigated for use/treatment in neuropathy (diabetic) and pain (acute or chronic)."	P41146; P28335; P18825; P28223; P41595; P18089; P35372; P08913; P25100; P35368; P35367; P35348
DB00357	Aminoglutethimide	investigational; approved	2145	-	"For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast."	P05108; P11511
DB00424	Hyoscyamine	approved	154417	-	"For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis."	P08172; P08173; P08912; P11229; P20309
DB00423	Methocarbamol	approved; vet_approved	4107	-	"For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions."	P00915
DB06819	Phenylbutyric acid	investigational; approved	4775	-	"Adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in carbamylphosphate (CPS), ornithine transcarbamylase (OTC), or argininosuccinic acid synthetase. it is indicated in all neonatal- onset efficiency presenting within the first 28 days of life. Also indicated in patients with late-onset, presenting after the first month of life with a history of hyperammonemic encephalopathy.  "	Q6IT96; P95468; P00800; Q13547
DB00353	Methylergometrine	approved	8226	-	"For the prevention and control of excessive bleeding following vaginal childbirth"	P28566; P28335; P14416; P10635; P28223; P41595; P30939; P21728; P08913; P18089; P35462; P08908
DB04898	Ximelagatran	investigational; approved; withdrawn	9574101	-	"For the treatment of acute deep vein thrombosis."	P00734; P00747; P00750; P00742
DB00352	Tioguanine	approved	2723601	-	"For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias."	P20839; P12268; P51580; P23219; P47989
DB00647	Dextropropoxyphene	illicit; investigational; approved; withdrawn	10100	-	"For the relief of mild to moderate pain"	P41145; Q14524; P41143; Q16539; P23141; Q8TCU5; P35372; Q07343; Q08499
DB00746	Deferoxamine	investigational; approved	2973	-	"Used to treat acute iron or aluminum toxicity (an excess of aluminum in the body) in certain patients. Also used in certain patients with anemia who must receive many blood transfusions."	P05067
DB06218	Lacosamide	approved	219078	-	"Lacosamide is indicated for adjunctive therapy for partial onset seizures in patients with epilepsy over 17 years old. Injection is indicated for short term use when oral therapy is not feasible. "	P43166; Q9UQD0; P23280; P33261; Q16790; Q99250; P35218; Q8N1Q1; Q14524; Q9Y2D0; Q15858; Q01118; Q9Y5Y9; P35498; O43570; Q9NY46; P00918; P22748; P07451; Q9ULX7; P00915; P35499; Q9UI33; Q16555
DB05076	Fenretinide	investigational	5288209	-	"Investigated for use/treatment in macular degeneration."	P10276; P10826; P13631
DB00644	Gonadorelin	investigational; approved; vet_approved	36523	-	"For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation."	P30968; Q96P88
DB05075	TG-100801	investigational	11973736	-	"Investigated for use/treatment in macular degeneration."	P21802; P12931; P41240; P51451; P42685; P08631; P09619; Q9H3Y6; P17948; P35968; P07947; P35916; P06239; P09769; P54760; P06241; P07948; P11362
DB05676	Apremilast	investigational; approved	11561674	-	"Investigated for use/treatment in psoriasis and psoriatic disorders."	P27815; P29474; Q00534; P01579; Q08493; P60568; P01375; Q07343; P11802; Q08499; P24941
DB12323	Radotinib	investigational	16063245	-	"Radotinib is indicated for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such as patients resistant or intolerant to imatinib."	P00519
DB00125	L-Arginine	approved; nutraceutical	6322	-	"Used for nutritional supplementation, also for treating dietary shortage or imbalance."	Q96A70; P04424; Q8WY07; Q5T6X5; P78540; P30825; O43246; P29474; P00966; P35228
DB00744	Zileuton	investigational; approved; withdrawn	60490	-	"For the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older."	P09917
DB00649	Stavudine	investigational; approved	18283	-	"For the treatment of human immunovirus (HIV) infections."	O60885
DB09014	Captodiame	investigational; approved	10240	-	"Captodiame is indicated for the treatment of anxiety. "	Q99720; P28335; P35462
DB09013	Befunolol	experimental	2309	-	"Used in the management of open angle glaucoma. PMID: 12480285. "	P07550; P08588
DB01228	Encainide	investigational; approved; withdrawn	48041	-	"Encainide is a class Ic antiarrhythmic agent which was used for management of irregular heartbeats, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. "	Q9UI33; P41145; Q14524; Q9UQD0; Q01118; Q9Y5Y9; P35498; Q99250; P35499; Q15858; Q9NY46
DB01229	Paclitaxel	approved; vet_approved	36314	-	"Used in the treatment of Kaposi's sarcoma and cancer of the lung, ovarian, and breast. Abraxane? is specfically indicated for the treatment of metastatic breast cancer and locally advanced or metastatic non-small cell lung cancer."	P68366; P68363; Q6PEY2; P10636; Q3ZCM7; P32238; P10415; O75469; Q13509; Q13748; P04350; P11137; P68371; P11388; Q9BUF5; P41143; Q71U36; P27816; Q9BVA1; Q9H4B7; Q5SU16; P04626; Q9BQE3; P07437; Q13885; P06241
DB01222	Budesonide	approved	5281004	-	"The oral capsule is used for the treatment of mild to moderate active Crohn's disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis."	P04150; P05113
DB01223	Aminophylline	approved	9433	-	"For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis."	P27815; P33765; Q14432; P0DMS8; Q13370; Q08493; Q92769; Q07343; Q08499; P29274; P29275; P30542
DB01220	Rifaximin	investigational; approved	6436173	-	"Rifaximin has multiple indications by the FDA: for the treatment of patients (?12 years of age) with traveller's diarrhea caused by noninvasive strains of Escherichia coli, for the reduction of overt hepatic encephalopathy recurrence in patients ?18 years of age, and in May 2015 it was approved for irritable bowel syndrome with diarrhea (IBS-D) treatment in adult men and women. "	B5QTY1; B4T9Z3; B1X982; Q0TCG6; A7ZSI4; P0A7Z9; C4ZXP1; Q5PK10; O75469; B7NEV3; A7MQB3; B7NQ13; A1AGI6; P0A7Z4; P0A7Z5; P0A7Z6; Q329K7; A8A6B1; A8ARN6; P0A7Z8; A8AQJ0; B1IYV1; P0A8T7; Q1R637; A9MKM3; A1AHI0; P0A7Z7; B7MFL0; P0A800; P0A8V2; A9MVP7; B1LK86; B7UM71; Q5PC39; B6I3M8; A6TFP8; Q1R4U2; Q57I91; B7M4D4; B5BI24; Q0TBG0; B5XTE8; B5FM73; P0A801; B7N2X2; A8A5A0; B4U000; B7L773; B7LVL1; P0A804; B5EY10; B4SXF1; P0A803; P0A802; B5RG73; C0Q1Y1; A7ZTK1; B5YWE9
DB01221	Ketamine	approved; vet_approved	3821	-	"Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior other general anesthetic agents and as a supplement of low potency agents.[L1336, FDA label]
 
 Reports have indicated a potential use of ketamine as a therapeutic tool for the management of depression when administered in lower doses.[A31873] These reports have increased the interest for ketamine in this area and several clinical trials are launched for this indication.[L1337, A31874]"	P41145; Q13224; P35372; P46098; O15399; P06276; P48058; P30939; P08912; P14416; P23975; Q05586; P41143; P28335; Q14957; O60391; P25103; Q12879; Q8TCU5; P29475; P42261; P42262; P42263
DB01226	Mivacurium	approved	5281042	-	"For inpatients and outpatients, as an adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation."	P08172; P11230; P06276; P02708; Q15822; P07510; P20309; Q04844; Q07001
DB01227	Levomethadyl Acetate	investigational; approved	15130	-	"For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients."	P32297; P35372; Q12809; P30926
DB01224	Quetiapine	approved	5002	-	"For the treatment of schizophrenia and related psychotic disorders."	P34969; P18825; P28221; P28222; P28223; P35462; P46098; P28566; P11229; Q99720; Q12809; P08912; P30939; P21728; P08913; P14416; P23975; P08172; P08173; P28335; P18089; P21918; P41595; P35368; P35367; P35348; P21917; P25100; P50406; P20309; P08908; P07550; P08588
DB04931	Afamelanotide	investigational; approved	16197727	-	"Investigated for use/treatment in actinic keratosis, keratoses, skin cell studies, and skin infections/disorders."	Q01726; Q1JUL4
DB04930	Permethrin	investigational; approved	40326	-	"For the treatment of infestation with <i>Sarcoptes scabiei</i> (scabies)."	O75469; P35498; P03372